Clinical trials: Treatment Of Obesity
Muscle Wasting, Obesity & Overweight
Testing the Efficacy, Safety, and PK of 20E in Patients With Obesity Who Are Starting Treatment With the GLP-1 Agonist Semaglutide for Weight Loss.
The goal of this clinical trial is to learn if BIO101 treatment can improve the muscle strength of participants males and females, aged 18 to 84 years old, suffering from obesity (BMI≥30) or overweight (BMI ≥ 27) with one or more…
- Conditions
- Muscle Wasting, Obesity & Overweight, Obesity
- Trial name
- OBA (NCT07411378)
- Testing
- BIO101, Semaglutide
- Volunteers
- 164 people
- Sponsor
- Biophytis
Morbid Obesity
Laparoscopic Gastric Bypass Versus Sleeve Gastrectomy to Treat Morbid Obesity
Bariatric surgery in the treatment of morbid obesity is associated with long-term weight-loss and decreased overall mortality. Long-term results have been reported for laparoscopic gastric bypass procedures but the long-term…
- Trial name
- SLEEVEPASS (NCT00793143)
- Where
- 4 sites in Finland
- Volunteers
- 240 people
- Sponsor
- Turku University Hospital
Overweight, Obesity
Intervention Study for Overweight and Obese Kindergarten Children
The goal of the this study is to create an interdisciplinary program which includes intervention in the fields of nutrition, physical activity and behavior in order to treat obesity and overweight among kindergarten children and…
- Conditions
- Overweight, Obesity, Physical Fitness
- Trial name
- NCT01285063
- Testing
- Multidisciplinary intervention: physical activity, dietary instructions and behavioral treatment.
- Where
- Israel
- Sponsor
- Meir Medical Center
Morbid Obesity
Effect Physical Exercise in Morbid Obesity
This objective study to verify the effect of physical training with and without behavioral cognitive therapy, compared with controls, in functional capacity and cardio-metabolic profile in individuals with morbidly obese
- Trial name
- NCT02406976
- Testing
- G1 -Exercise, G2- Exercise and Lifestyle, G3- Control
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Obesity, Child
Kids Obesity Prevention Program - Study (KOP)
Obesity and its associated comorbidities are becoming a key and rapidly growing public health problem. The cause of obesity is an imbalance between energy intake and energy expenditure in favor of the former.
- Trial name
- KOP (NCT02551978)
- Testing
- The serious game KOP
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Hypertension, Obesity & Overweight
A Trial Within Cohort Feasibility Study Design Comparing Standard of Care Versus Weight Loss (Achieved Through Tirzepatide) for Obesity-related Hypertension in Young Adults
Hypertension is the leading risk factor for death globally, affecting approximately 30% of adults in the United Kingdom. Obesity is also a serious and ongoing epidemic, with global obesity rates having more than tripled in men…
- Trial name
- SOLUTION-Pilot (NCT07364175)
- Testing
- Tirzepatide, Anti-Hypertensive medications
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Weight Gain
Effect of Bitter Melon Seed Oil on Body Weight
To investigate the metabolic benefits of bitter melon seed oil (BMSO), overweight or obese healthy Taiwanese adults (n=60) were randomly assigned to receive capsules containing either olive oil (OO; placebo) or BMSO at 4.5 g/d…
- Trial name
- NCT03785821
- Testing
- BMSO, OO
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Breast Cancer, Obesity
Effects of Mediterranean Diet and Naltrexone/Bupropion Treatment in Obese Breast Cancer Patients
Obesity among breast cancer survivors is known to be associated with recurrence and other co-morbidities. However, there have been no studies on weight reduction program combining diet and anti-obesity drug for obese breast…
- Conditions
- Breast Cancer, Obesity, Overweight
- Trial name
- NCT03581630
- Testing
- naltrexone/bupropion, Mediterranean Diet
- Where
- South Korea
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Prader-Willi Syndrome
Effects of Transcutaneous Vagus Nerve Stimulation on Emotion Regulation and Executive Functioning in Prader-Willi Syndrome
The STIM-PRADER study aims to assess the effectiveness of auricular vagal neuromodulation therapy (aVNT) on emotional, behavioral, and cognitive domains impaired in Prader-Willi Syndrome (PWS).
- Trial name
- STIM-PRADER (NCT06720571)
- Testing
- Auricular vagal neuromodulation therapy (aVNT)
- Where
- 4 sites in France
- Volunteers
- 24 people
- Sponsor
- University of Bordeaux
Obesity
Lose Now North Carolina Community Weight Loss Program
The Lose Now NC research study aims to determine feasibility by delivering a community based weight loss program for 4 months in Kannapolis, NC in a large group format compared with smaller group format, (recruiting approximately…
- Trial name
- Lose Now NC (NCT01615471)
- Testing
- Group weight loss with companion internet
- Where
- United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Obesity, Morbid
Single Anastomosis Sleeve Ileal Bypass Versus Single Anastomosis Sleeve Jejunal Bypass
to compare the results of SASI to SAS-J in treatment of morbid obesity
- Trial name
- NCT05591833
- Testing
- SASI, SAS-J
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Minia University
Obesity, Morbid, Obesity
CiNPT for Abdominoplasties in Post-bariatric Patients Study
The overarching goal of this research is to assess whether the post-operative use of closed-incision Negative Pressure Therapy (ciNPT) accelerates healing of surgical wounds, improves surgical outcomes, and reduces the rate of…
- Conditions
- Obesity, Morbid, Obesity, Obesity, Abdominal, Wound
- Trial name
- CAPS (NCT04214236)
- Testing
- ciNPT group, Control group
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera, Ospedale Civile di Legnano
Obesity
Effects of Red Light LED Therapy on Body Contouring
The purpose of this study is to determine whether red light therapy using LED 650nm red light for body contouring of the waist, hips and thighs is as effective as red light therapy using Laser 635nm red light.
- Trial name
- NCT03242564
- Testing
- Vevazz LED
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Vevazz, LLC
Overweight and Obesity
A Trial to Learn How Safe AZD9550 Monotherapy and Combined With AZD6234 is in People With or Without Type 2 Diabetes Who Are Living With Obesity and Overweight
AZD9550, previously being developed for the treatment NASH, is a dual GCG and GLP-1 receptor agonist. AZD9550 is now being developed in combination with AZD6234, a SARA, for the treatment of overweight and obesity and its…
- Trial name
- CONTEMPO (NCT06151964)
- Testing
- AZD9550, AZD9550 and AZD6234
- Where
- 15 sites in Austria, Canada and 3 more
- Volunteers
- 166 people
- Sponsor
- AstraZeneca
Pediatric Overweight
Examining the Role of Executive Functioning in Family-Based Intensive Health Behavior and Lifestyle Treatment
The objectives of this open trial feasibility study are to examine the impacts of intensive health behavior and lifestyle treatment (IHBLT) on youth and caregiver executive functioning (EF), weight status, health behaviors…
- Trial name
- Healthy LIFT (NCT06969235)
- Testing
- intensive health behavior and lifestyle treatment
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Missouri-Columbia
Child Obesity, Social Determinants of Health
Addressing Social Determinants of Health in Child Obesity Treatment Using Community Health Workers
The goal of this small pilot study is to test the feasibility of combining a three-month intervention of working with a community health worker (CHW) to address social risk factors for patients prior to beginning a group weight…
- Trial name
- NCT06520657
- Testing
- Community Health Worker, Child weight management intervention, Standard of Care referral to resources
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Children's Mercy Hospital Kansas City
Severe Obesity, Bariatric Surgery
Study on Impact of Lifestyle Change and Weight Loss Before Bariatric Surgery
The purpose of the trial is to determine whether a preoperative lifestyle intervention (targeting diet, exercise, and preparation for surgery) will favorably impact obesity-related parameters prior to bariatric surgery and…
- Trial name
- PREP (NCT00623792)
- Testing
- Preoperative lifestyle Intervention
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Duquesne University
Hypertension
Safety and Efficacy Study of BMS-823778 to Treat Uncontrolled High Blood Pressure in Overweight and Obese Patients
The purpose of this study is to determine whether BMS-823778 is safe and effective in the treatment of hypertension in overweight and obese patients.
- Trial name
- NCT01602367
- Testing
- BMS-823778
- Where
- 35 sites in United States, Colombia and 3 more
- Volunteers
- 7 people
- Sponsor
- Bristol-Myers Squibb
Obesity
Efficacy and Safety Study of Combination Therapy to Treat Uncomplicated Obesity
The purpose of this study is to determine the efficacy and safety of 3 combinations of naltrexone and bupropion SR compared to naltrexone alone, bupropion SR alone or placebo.
- Trial name
- NCT00364871
- Testing
- naltrexone and bupropion SR
- Where
- 7 sites in United States
- Volunteers
- 410 people
- Sponsor
- Orexigen Therapeutics, Inc
Triglycerides, Weight Gain Trajectory
Effects of RDX-002 on Postprandial Triglycerides in Patients Discontinuing GLP-1 Agonists
The goal of this clinical trial is to learn if drug RDX-002 works to treat high levels of fat (known as triglycerides, or TGs) in the blood in adults. It will also learn about the safety of drug RDX-002.
- Conditions
- Triglycerides, Weight Gain Trajectory, Cholesterol, Elevated
- Trial name
- NCT06640972
- Testing
- RDX-002
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Response Pharmaceuticals
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