Clinical trials: Treatment Of Obesity
Morbid Obesity
Sleeve-gastrectomy Efficacy in Morbid Obese Patient With a Focus on the Role of Inflammation
Despite the wide range of studies concerning the positive effects of bariatric surgery on metabolic state of morbid obese patient, it is necessary to further investigate the specific role of the "sleeve-gastrectomy" intervention…
- Trial name
- NCT03559842
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Of Perugia
Obesity
A Study to Learn How the Study Medicine Danuglipron is Taken Up Into the Blood and If Danuglipron Changes How the Body Processes Other Study Medicines (Atorvastatin and Rosuvastatin) in Healthy Adults Who Are Overweight or Obese
The purpose of this study is to learn the following about the study medicine, danuglipron, after multiple days of dosing in healthy adults who are overweight or obese: how the study medicine, danuglipron, is taken up into the…
- Trial name
- NCT06567327
- Testing
- Danuglipron, Atorvastatin, Rosuvastatin
- Where
- 3 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Pfizer
NAFLD
Study of Losartan in the Treatment of NAFLD in Children
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease among children and is closely associated with obesity and the metabolic syndrome.
- Trial name
- NCT01913470
- Testing
- Losartan
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Miriam Vos, MD
Haemophilia A, Haemophilia B, Obesity
Awareness, Care, and Treatment In Obesity Management of Patients With Hemophilia (ACTION) to Inform Hemophilia Obesity Patient Empowerment (HOPE)
An online web-based cross-sectional survey in which participants will complete a distinct questionnaire for patients with hemophilia and obesity (PwHO) and/or their carers/spouses/partners, or a distinct questionnaire for…
- Trial name
- ACTION to HOPE (NCT03430154)
- Testing
- No treatment given
- Where
- United States
- Volunteers
- 317 people
- Sponsor
- Novo Nordisk A/S
Obesity
Long-limb or Distal Gastric Bypass for Superobesity - Randomized Study
The main study objective: To evaluate long-limb gastric bypass (150 cm alimentary limb) vs. "distal" gastric bypass (common channel 150 cm) in the treatment of superobesity (BMI 50-60 kg/m2).
- Trial name
- NCT00821197
- Testing
- long-limb gastric bypass, distal gastric bypass
- Where
- Norway
- Volunteers
- 115 people
- Sponsor
- Oslo University Hospital
Asthma, Obesity
Reducing Socioeconomic Disparities in Health at Pediatric Visits
This research project is aimed to assess the effectiveness and impact of a pediatric-based intervention aimed at reducing low-income families' unmet material needs (food, housing, employment, childcare, household heat, education…
- Conditions
- Asthma, Obesity, Health Care Utilization, Health Care Disparities
- Trial name
- WECARE01 (NCT02451059)
- Testing
- WE CARE survey, WE CARE Community Resource Handout, Patient Navigator
- Where
- 6 sites in United States
- Volunteers
- 1,205 people
- Sponsor
- Boston Medical Center
Obesity and Glomerulopathy
A Prospective, Single-center, Randomized, Controlled Study of Sevelamer Carbonate in the Lipid Metabolism and Uric Acid Treatment of Obesity-Related Glomerulopathy
To observe the decreased levels of low-density lipoprotein from baseline in patients with obesity-related glomerulopathy (ORG) after 12 weeks of Sevelamer Carbonate treatment.
- Trial name
- NCT02644486
- Testing
- High dosage Sevelamer Carbonate + Irbesartan, Low dosage Sevelamer Carbonate + Irbesartan, Irbesartan
- Where
- China
- Volunteers
- 4 people
- Sponsor
- Zhi-Hong Liu, M.D.
Bariatric Surgery, Morbid Obesity
Comparison of Three Hypoabsortive Surgical Techniques for Treatment of Type IV Morbid Obesity
Morbid obesity is the first non-traumatic cause of death in the western population and it is also progressively beginning to affect the developing countries.
- Trial name
- BAR-3 (NCT04861961)
- Testing
- DS vs. SADI-S vs. OAGBP
- Where
- Spain
- Volunteers
- 186 people
- Sponsor
- Hospital Universitari de Bellvitge
Obesity
Study of Serum Markers for Cardiovascular Risk in Obese Youth and Impact of Lifestyle and Medication Intervention
In Protocol #2, we will select 30 obese pubertal and 30 obese prepubertal subjects with an abnormal cytokine profile (i.e. fibrinogen and/or hsCRP concentration greater than or equal to 2 Standard Deviations (SD) above the mean…
- Trial name
- NCT00139477
- Testing
- Metformin, Dietary modification with caloric restriction, Establishment of exercise protocol
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Hypothalamic Injury-induced Obesity (HIO)
48 Weeks, Study to Evaluate Overall Safety and Tolerability of Co-administration of Tesofensine and Metoprolol in Subjects With Hypothalamic Injury-induced Obesity (HIO)
Double-blind, randomized, placebo-controlled, single- center study followed by an open-label extension period. The study will have two parts: Part 1: 24 weeks double-blind treatment (DB), followed by Part 2: 24 weeks open-label…
- Trial name
- NCT03845075
- Testing
- Tesofensine/Metoprolol
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Saniona
Obesity
A Phase 2 Study Evaluating the Co-Administration of Bremelanotide With Tirzepatide for the Treatment of Obesity
This is a prospective, randomized, double-blind, placebo-controlled study designed to assess the safety and efficacy of bremelanotide (BMT) used in combination with tirzepatide therapy in the treatment of obesity in subjects with…
- Trial name
- BMT-801 (NCT06565611)
- Testing
- bremelanotide, tirzepatide
- Where
- 4 sites in United States
- Volunteers
- 108 people
- Sponsor
- Palatin Technologies, Inc
Rheumatoid Arthritis, Inflammation
Disulfiram in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent joint inflammation and systemic immune activation.
- Conditions
- Rheumatoid Arthritis, Inflammation, Obesity
- Trial name
- NCT07534332
- Testing
- Disulfiram (DSF)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oklahoma
Insulin Resistance, Inflammatory Markers
Effectiveness of Low Level Laser Therapy on Insulin Resistance and Inflammatory Biomarkers
It is an interventional study in which 60 women estimated to enroll according to random allocation and assigned into two groups equal.
- Trial name
- NCT04477109
- Testing
- low level laser in addition to diet recommendations
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Obesity and Overweight
Thread Embedding Acupuncture Therapy for Weight Loss
Obesity is the most prevalent chronic disease worldwide, affecting approximately 800 million adults. Excess adiposity and its numerous complications, including cardiovascular disease and type 2 diabetes, impose a considerable…
- Trial name
- iSho (NCT06653530)
- Testing
- Thread embedding acupuncture
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Beijing Hospital of Traditional Chinese Medicine
Obesity
Laparoscopic Ileal Interposition and Weight Regain
The investigators will study the Ileal interposition to the treatment of weight regain after Roux-en-Y gastric bypass, assessing weight loss, body composition, quality of life, metabolic biomarkers, inflammatory biomarkers, and…
- Trial name
- NCT05931939
- Testing
- Ileal Interposition, Traditional surgical technique
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Rio de Janeiro State University
Loss-of-Control Eating, Obesity/Overweight
Pharmacological and Behavioral Treatments After Bariatric Surgery: Maintenance Treatment (Stage 2a)
This study will test the effectiveness of naltrexone/bupropion medication as a maintenance therapy for the treatment of loss-of-control eating and weight loss following bariatric surgery.
- Trial name
- NCT04605081
- Testing
- Naltrexone and Bupropion (NB) medication
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Yale University
Weight
A Dose-ranging, Study of the Safety and Efficacy of Subcutaneous Injections of LIPO-102 Compared With Placebo for the Reduction of Abdominal Subcutaneous Adiposity
LIPO-102 is under evaluation for treatment of abdominal adiposity
- Trial name
- NCT01180465
- Testing
- LIPO-102, LIPO-102 Low
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Neothetics, Inc
Obesity
Comparison of Weight Management Programs Delivered in Large Versus Small Groups
The purpose of this study is to compare the 6- and 12-month weight changes associated with lifestyle interventions delivered in a large group or small groups of participants.
- Trial name
- NCT02088749
- Testing
- lifestyle intervention for obesity
- Where
- 2 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cardiovascular Diseases, Obesity
New Health Devices to Improve Adherence to Physical Activity in Overweight Inactive Adults
The purpose of this study is to test in overweight and inactive adults whether the new PAI eHealh APP leads to better adherence to a physical activity regimen than the wearable step counter App from the market leader FitBit, and…
- Trial name
- NCT02774655
- Testing
- Pai APP, FitBit APP
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Norwegian University of Science and Technology
Obese Adults, Overweight , Obesity
ASSESSMENT OF THE NATURAL HISTORY AND PROGNOSTIC FACTORS OF THERAPEUTIC RESPONSE IN SUB-PHENOTYPES OF PATIENTS WITH OBESITY: THE BOLOBE STUDY
The study is observational and single-center and involves (i) the establishment of a retrospective and prospective data collection, and (ii) the development of prognostic and predictive models of response to obesity therapies…
- Trial name
- BOLOBE (NCT07666425)
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
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