Clinical trials: Treatment Of Obesity
Obesity
A Study on Efficacy and Safety of Topiramate in the Treatment of Patients With Obesity
The purpose of this study is to compare the efficacy and safety of topiramate (96, 192, and 256mg daily) with placebo in long-term treatment of obesity.
- Trial name
- NCT00236639
- Testing
- topiramate
- Volunteers
- 1,293 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Overweight and Obesity
Cognitive Therapy Plus Dietary Intervention for Obesity Treatment
This randomized clinical trial was carried out from January 2017 to December 2017 at the facilities of the Catholic University of Murcia. Written informed consent was required from each patient.
- Trial name
- COGNI-OB (NCT03749772)
- Testing
- Cognitive Training
- Volunteers
- 100 people
- Sponsor
- Universidad Católica San Antonio de Murcia
Binge Eating Disorder, Binge Eating Episodes
HALO-TRIAL: High, Medium And LOw Intensity Psychotherapy for Binge Eating Disorder
The HALO trial is designed as a four-armed, assessor-blinded, fidelity-monitored randomized clinical trial. The goal of this randomized controlled study is to investigate the effectiveness of four different psychotherapy programs…
- Conditions
- Binge Eating Disorder, Binge Eating Episodes, Binge Eating/Loss of Control Eating, Binge Eating Disorders
- Trial name
- HALO (NCT07698132)
- Testing
- Cognitive Behavioral Therapy Enhanced - Individual, Cognitive Behavioral Therapy Enhanced - Group, Cognitive Behavioral Therapy - Guided Self Help
- Where
- Denmark
- Volunteers
- 256 people
- Sponsor
- Herlev and Gentofte Hospital
Osteoarthritis, Knee
WATERinMOTION Aquatic Therapy in Obese Men With Knee Osteoarthritis
This RCT evaluates whether WATERinMOTION aquatic therapy improves pain, function, and quality of life more effectively than land-based exercise in obese men with knee osteoarthritis (OA).
- Conditions
- Osteoarthritis, Knee, Obesity
- Trial name
- WATERinMOTION (NCT06946329)
- Testing
- Aquatic Exercise, Land-Based Rehabilitation
- Where
- Iran
- Volunteers
- 100 people
- Sponsor
- University of Sistan and Baluchestan
Obesity, Overweight
Pilot Trial of the Elipse™ Intragastric Balloon System for the Treatment of Overweight and Obese Individuals
This is a prospective, non-randomized, open trial to be conducted in overweight and obese individuals. The primary objective is to evaluate the safety of the Elipse™ Intragastric Balloon System for the treatment of overweight and…
- Trial name
- NCT02802007
- Testing
- Elipse Intragastric Balloon
- Where
- 2 sites in Czechia, Greece
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Allurion Technologies
Obesity
Dance Therapy and Obesity
Title: The effect of dance-therapy on the functional capacity, body image and quality of life of patients with advanced obesity Project duration: 33 months (August 2010 to June 2013) Clinical context: Obesity has reached epidemic…
- Trial name
- NCT01451892
- Testing
- Dance Therapy, patient education
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Osteoarthritis, Overweight and Obesity
Epigenorm Antivir Combined With Acupuncture for the Treatment of Osteoarthritis Patients Who Are Overweight or Obese
The study evaluates analgesic, antiinflammatory and metabolic effects of a supplement Epigenome-Antivir (extracts of glycyrrhiza roots, hippophae rhamnoides leaves, curcumin, green tea, and vitamin C) combined with acupuncture in…
- Trial name
- NCT03540186
- Testing
- Epigenorm Antivir, Acupuncture
- Where
- Russia
- Volunteers
- 15 people
- Sponsor
- Federal State Budgetary Scientific Institution, Research Institute of Fundamental and Clinical Immunology
Diabetes
Surgical Treatment of Type 2 Diabetes in Non-Morbidly Obese Patients
The aim of this study is to assess the short term success and feasibility of ileal transposition with sleeve gastrectomy in non-morbidly obese patients with poorly controlled Type 2 Diabetes Mellitus
- Trial name
- NCT00596973
- Testing
- Surgical Treatment
- Where
- United States
- Sponsor
- Medtronic - MITG
Periodontitis, Periodontal Diseases
The Impact of Obesity on Nonsurgical Periodontal Therapy
The purpose of this study is to investigate the effect that obesity may have on the nonsurgical treatment (with and without the adjunct use of metronidazole) of destructive periodontal diseases (chronic periodontitis).
- Conditions
- Periodontitis, Periodontal Diseases, Obesity
- Trial name
- NCT01405365
- Testing
- Metronidazole, Scaling and root planning
- Where
- Brazil
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Obesity
Gut Microbiota as a Therapeutic Target for CVD
Background: The Mediterranean Diet (MD) is considered an healthy diet useful in the prevention of cardiovascular disease (CVD). High quality extra virgin olive oil (HQ-EVOO, [1]), an essential component of this diet, exerts a…
- Trial name
- oliomicroFDG (NCT03441802)
- Testing
- High quality extra virgin olive oil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Obesity
Effects of Co-administration of Canagliflozin 300 mg and Phentermine 15 mg With Placebo in the Treatment of Non-Diabetic Overweight and Obese Participants
The purpose of this study is to compare the effects of canagliflozin and phentermine to those of placebo to promote on a change in body weight over a 26 week period.
- Trial name
- NCT02243202
- Testing
- Canagliflozin, Phentermine
- Where
- 17 sites in United States
- Volunteers
- 335 people
- Sponsor
- Janssen Research & Development, LLC
Obesity
A Study to Evaluate the Safety and Efficacy of HSG4112 in Overweight and Obese Patients
1. Study Objective To assess the effect of HSG4112 on body weight To evaluate the safety and tolerability of HSG4112 2. Background Glaceum Inc.
- Trial name
- NCT05197556
- Testing
- HSG4112
- Where
- South Korea
- Volunteers
- 81 people
- Sponsor
- Glaceum
Obesity
ZGN-440 (Beloranib for Subcutaneous Injection) for Treatment of Obesity
The purpose of this study is to assess the Pharmacokinetics/Pharmacodynamics (PK/PD), safety, and effectiveness of multiple subcutaneous doses of Beloranib (ZGN-440).
- Trial name
- NCT01507077
- Testing
- ZGN-440, ZGN-440 sterile diluent
- Where
- Australia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Zafgen, Inc.
Barrett's Esophagus, Overweight and Obesity
CAlorie and Protein REstriction PROgram in Barrett's Esophagus Patients (CARE-PRO).
The increasing incidence of Esophageal Adenocarcinoma (EAC) in several Western countries can be primarily ascribed to risk factors such as obesity, chronic gastroesophageal reflux, dietary habits and alcohol intake.
- Trial name
- CARE-PRO (NCT03813381)
- Testing
- Calorie and protein restriction diet
- Volunteers
- 160 people
- Sponsor
- Istituto Oncologico Veneto IRCCS
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
Semaglutide in CFRD
This open label, single arm pilot study, will examine the safety and tolerability of GLP-1RA semaglutide as an add-on therapy to insulin for overweight/obese adult patients with cystic fibrosis related diabetes (CFRD).
- Trial name
- NCT05788965
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Minnesota
Asthma
Antioxidant Therapy in Lean and Obese Asthmatics
This project will assess the effectiveness of antioxidant supplementation with common vitamins A, C, E and selenium in controlling asthma symptoms among lean and obese asthmatics.
- Trial name
- ALOA (NCT01317563)
- Testing
- Vitamins A, E, C & Selenium
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Nemours Children's Clinic
Obesity, Primary
A Feasibility Study for the Treatment of Primary Obesity Cross-over Arm
Cross-over arm of the pilot study evaluating a treatment for obesity.
- Trial name
- NCT05939973
- Testing
- g-Cath EZ Delivery Catheter with Snowshoe Suture Anchors
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- USGI Medical
Overweight and Obesity
Weight Loss Goals and Satisfaction Survey
The goal of this observational survey pilot study is to learn how 3D visualization tools (i.e., personalized avatars) influence weight loss goals, satisfaction, confidence, and commitment compared to numerical weight outcomes in…
- Trial name
- NCT07541872
- Testing
- Personalized 3D Body Visualization
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Healthy
Study Evaluating Effects of Multiple-Dose Administration of Itraconazole on the Single Dose Pharmacokinetics of Conjugated Estrogens/Bazedoxifene in Non-Obese and Obese Postmenopausal Women
This study will assess if itraconazole will affect the blood levels of Duavee when they are given together. This study will also assess if a subject's body size affects the blood levels of Duavee.
- Trial name
- CE/BZA (NCT02100553)
- Testing
- CE/BZA, Itraconazole
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Obesity
Safety Study of the Inhibition of Agouti-related Protein (AgRP) for the Management of Obesity and Weight Loss
Multiple pathways including peripheral and central hormones and neurotransmitters are involved in the regulation of food intake and body weight. One of the most studied pathways involves the melanocortin receptor.
- Trial name
- NCT00779519
- Testing
- TTP435
- Where
- 12 sites in United States, Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- vTv Therapeutics
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