Clinical trials: Treatment Of Obesity
Prediabetic State, PreDiabetes
Feasibility of a Nutrition Intervention for Patients With Prediabetes at a Federally Qualified Health Center
The purpose of the study is to assess the feasibility and acceptability of incorporating hands-on nutritional demonstrations to enhance the Diabetes Prevention Program (DPP) curriculum among patients who are at-risk for…
- Conditions
- Prediabetic State, PreDiabetes, Health Knowledge, Attitudes, Practice, Nutrition, Healthy
- Trial name
- NCT06897982
- Testing
- One-arm feasibility pilot of a nutrition intervention to recruit, engage, and retain DPP participants in the safety-net setting in Los Angeles
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Patients Who Consented to Undergo Laparoscopic Gastric Banding Surgery for Weight Loss and Consent to Participate in This studyBMI ≥35 kg/m2, Confirmed Type 2 Diabetes Treated With Oral Agents and/or Only Diet Therapy
A Pilot Study of Metabolic Effects of Omentectomy
PROTOCOL SUMMARY Type of Study: Pilot, randomized and single center trial Test Procedure: Omentectomy Aim 1. Determine the effect of omentectomy on 1) insulin sensitivity, 2) beta cell function and 3) plasma markers of…
- Conditions
- Patients Who Consented to Undergo Laparoscopic Gastric Banding Surgery for Weight Loss and Consent to Participate in This studyBMI ≥35 kg/m2, Confirmed Type 2 Diabetes Treated With Oral Agents and/or Only Diet Therapy, Age 18-64 Years
- Trial name
- OMT (NCT00565799)
- Testing
- Omentectomy, No intervention
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- NYU Langone Health
Pediatric Obesity
The Role of Parents in Adolescent Obesity Treatment
The study will pilot a randomized control trial to investigate the feasibility and preliminary efficacy of two distinct parent treatments on a dietary intervention for overweight and obese adolescents.
- Trial name
- TEENS+ (NCT02586090)
- Testing
- Parents as Coaches, Parent Weight Loss
- Where
- United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Obesity
A Study Comparing Multiple Doses of VI-0521 With Placebo and Their Single-agent Constituents for Treatment of Obesity in Adults
The objective of this study is to evaluate the safety and efficacy of various doses of VI-0521 compared to both placebo, and the single-agent components that comprise each combination dose.
- Trial name
- NCT00563368
- Testing
- VI-0521, topiramate, phentermine
- Where
- 2 sites in United States
- Volunteers
- 756 people
- Sponsor
- VIVUS LLC
Morbid Obesity
Comparison of Mini Gastric Bypass and Roux-en-Y Gastric Bypass
This study compares Roux-en-Y gastric bypass with single anastomosis gastric bypass in a randomized prospective setting. This study also adresses the issue of bile reflux after MGB.
- Trial name
- RYSA (NCT02882685)
- Testing
- Roux-en-y gastric bypass, Single anastomosis gastric bypass
- Where
- 2 sites in Finland
- Volunteers
- 120 people
- Sponsor
- Helsinki University Central Hospital
Bariatric Surgery Candidate, Obesity
A Preoperative Cognitive Behavioural Therapy Program Based on Self-determination Theory for Bariatric Surgery Candidates
The objective of this study is to evaluate the impact of a pre-surgical intervention program based on Cognitive and Behavioural Emotional Therapies, on the degree of dietary restriction of patients who are candidates for…
- Trial name
- ACRoBAT (NCT03976674)
- Testing
- Cognitive Behavioural Therapy (CBT)
- Where
- France
- Volunteers
- 94 people
- Sponsor
- Lille Catholic University
Obesity, Appetite Regulation
Tailoring Obesity Treatment Trial
The two main aims of this clinical study is; 1. To investigate if the results from a series of physiological tests and questionnaires prior to treatment, can be used to predict the treatment response to obesity medication 2.
- Conditions
- Obesity, Appetite Regulation, PreDiabetes
- Trial name
- TOTT (NCT06619015)
- Testing
- Pramlintide Acetate 1 MG/ML, Semaglutide Pen Injector, Sodium Chloride 0.9% Inj
- Where
- Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Obesity, Morbid
Intragastric Injections of Botox for the Treatment of Obesity
One possible angle for treating obesity could be slowing down the gastric emptying time. By prolonging the gastric emptying time, the person would ideally experience increased sensation of satiety, and in the long run reduce food…
- Trial name
- NCT02035397
- Testing
- Botulinum Toxin Type A, Saline solution
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Norwegian University of Science and Technology
Obesity, Weight Loss, Alcohol Drinking
Alcohol in the Treatment of Obesity
This pilot study looks at the relationship of moderate alcohol consumption on weight loss.
- Trial name
- NCT00594074
- Testing
- white wine
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Duke University
Ketosis Prone Diabetes, Diabetes Ketoacidosis
Ketosis-Prone Diabetes Mellitus (KPDM): Metformin Versus Sitagliptin Treatment
The study intends on enrolling 48 subjects with diabetes. Diabetic subjects that no longer need insulin will be randomly placed (like the flip of a coin) on a diabetes pill called metformin, a diabetes pill called sitagliptin or…
- Conditions
- Ketosis Prone Diabetes, Diabetes Ketoacidosis, Hyperglycemia
- Trial name
- NCT01099618
- Testing
- metformin, Sitagliptin
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dawn Smiley MD
Obesity
First-in-human Study of the Safety, Tolerability, Pharmacokinetics, and Food Effect of ACCG-2671
This first-in-human study will evaluate the safety, tolerability, and pharmacokinetics of single and multiple ascending oral doses of ACCG-2671.
- Trial name
- NCT07815678
- Testing
- ACCG-2671
- Where
- 6 sites in United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Aconcagua Bio, Inc. a wholly owned subsidiary of Structure Therapeutics
Obesity, Diet Modification
Weight Loss Diet in Obesity With Metabolic Syndrome
Concomitant interventions included lifestyle modification with a personally tailored program of diet as detailed below and physical activity adjusted for age and specific physical limitations, targeting engagement in physical…
- Trial name
- NCT03558685
- Testing
- Weight loss diet
- Volunteers
- 120 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Loss-of-control Eating, Obesity/Overweight
Pharmacological and Behavioral Treatment After Bariatric Surgery: Acute (Stage 1)
This study will compare the effectiveness of behavioral and pharmacologic treatments, alone and in combination, for the treatment of loss-of-control eating and weight following bariatric surgery.
- Trial name
- NCT04599478
- Testing
- Naltrexone and Bupropion medication, Behavioral Weight Loss
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Yale University
Pediatric Obesity
Primary Care Pediatrics Learning Activity and Nutrition With Families
This study is designed to translate an evidence-based family-based weight loss treatment for childhood obesity (FBT) into primary care settings using co-located interventionists to serve as a model for care delivered within a…
- Trial name
- PLAN (NCT02873715)
- Testing
- Family-based treatment, Usual Care
- Where
- 4 sites in United States
- Volunteers
- 1,010 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Obesity
Effects of Two Hypocaloric Diets on Weight Loss
The investigators evaluated whether an energy-restricted protein diet with low glycaemic index carbohydrates and soluble fibers (LC-P-LGI) would be more effective than a conventional diet (LC-CONV) on weight-loss and related…
- Trial name
- NCT01312740
- Testing
- LC-P-LGI diet, LC-CONV
- Where
- France
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Ceprodi S.A. Kot
Metabolic Syndrome, Obesity & Overweight
Effect of Empagliflozin on Metabolic Outcomes in Adults Living With HIV Receiving Dolutegravir-Based Therapy
We investigate the role of empagliflozin in the treatment of obesity in PLWH.
- Conditions
- Metabolic Syndrome, Obesity & Overweight, HIV (Human Immunodeficiency Virus)
- Trial name
- NCT07336797
- Testing
- Empagliflozin (oral)
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Abdelrahman Mahmoud
Obese Adolescents
Associations Between Physical Activity and Sedentary Behavior Profiles and Carotid Intima-media Thickness in Adolescents With Obesity
Physical activity behaviors are key and modifiable factors of cardiovascular health from childhood. They encompass both physical activity, defined as any bodily movement produced by skeletal muscles that results in energy…
- Trial name
- CARADO (NCT07811115)
- Where
- France
- Volunteers
- 108 people
- Sponsor
- University of Avignon
Obese, Growth Hormone Secretion Abnormality
Growth Hormone Treatment on Phosphocreatine Recovery in Obesity
Obesity is associated with reduced growth hormone (GH) secretion. Reduced GH secretion in obesity is associated with increased cardiovascular disease risk.
- Trial name
- NCT01421589
- Testing
- Growth hormone treatment
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
Low Back Pain, Obesity
The Effect of Traction Forces in People With Obesity Suffering From Chronic Low Back Pain
The purpose of the research study is to assess the impact of traction forces on changes in systemic markers concentrations of spinal structure damage in people with obesity.
- Trial name
- NCT04507074
- Testing
- lumbar traction therapy
- Where
- Poland
- Volunteers
- 49 people
- Sponsor
- Poznan University of Physical Education
Diabetes, Diabetes Mellitus, Type 1
Observational Study on Levemir® in Obese Diabetic Patients
This study is conducted in Europe. The aim of this observational study is to investigate the effect of switch from other basal insulin treatments to Levemir® on body weight in obese diabetic patients.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- KILOS (NCT00849342)
- Testing
- insulin detemir
- Where
- 2 sites in Netherlands, Slovenia
- Volunteers
- 580 people
- Sponsor
- Novo Nordisk A/S
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