Clinical trials: Treatment Of Obesity
Diabetes Mellitus, Type 2
Effect of Repaglinide Versus Metformin Treatment in Non-Obese Patients With Type-2-Diabetes
Aim: The United Kingdom Prospective Diabetes Study (UKPDS) showed a reduction in cardiovascular events in obese patients with type-2-diabetes treated with metformin compared with other hypoglycaemic treatments with no difference…
- Trial name
- NCT00118963
- Testing
- Metformin, Insulin BIAsp30 (Novolog 70/30), Repaglinide
- Where
- Denmark
- Volunteers
- 102 people
- Sponsor
- Steno Diabetes Center Copenhagen
Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD), Non-Alcoholic Fatty Liver Disease
Fibrosis Lessens After Metabolic Surgery
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), a major global public health concern, is commonly associated with obesity, diabetes, and dyslipidemia.
- Conditions
- Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD), Non-Alcoholic Fatty Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis (MASH), Liver Fibrosis
- Trial name
- FLAMES (NCT06374875)
- Testing
- Metabolic surgery, Incretin-Based Therapy
- Where
- 22 sites in United States, Brazil and 11 more
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Asthma
Antioxidant Therapy in Lean and Obese Asthmatics
This project will assess the effectiveness of antioxidant supplementation with common vitamins A, C, E and selenium in controlling asthma symptoms among lean and obese asthmatics.
- Trial name
- ALOA (NCT01317563)
- Testing
- Vitamins A, E, C & Selenium
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Nemours Children's Clinic
Idiopathic Intracranial Hypertension
Safety and Effectiveness of 11b-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) to Treat Idiopathic Intracranial Hypertension.
Assessing the safety and effectiveness of a 11-βhydroxysteroid dehydrogenase type 1 inhibitor (AZD4017), in a placebo controlled trial, in acute idiopathic intracranial hypertension (IIH) IIH is a condition of young, overweight…
- Trial name
- IIH:DT (NCT02017444)
- Testing
- AZD4017
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- University of Birmingham
Weight Change, Quality of Life
Cost-effectiveness of Family Based Pediatric Obesity Treatment
To determine the cost effectiveness of treating the child alone and parent alone to traditional family-based method of obesity treatment.
- Trial name
- NCT00717132
- Testing
- Individual Behavior Modification, Family-based behavior modification
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Metabolic Diseases, Obesity/Therapy
The Efficacy and Safety of Puerarin in Obesity Treatment
This randomized controlled trial aims to evaluate the therapeutic efficacy of puerarin intervention in weight management and metabolic regulation among obese populations.
- Trial name
- NCT06968208
- Testing
- Puerarin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Ruijin Hospital
Polycystic Ovary Syndrome, Obesity
Time Restricted Eating for the Treatment of PCOS
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility among young women. This syndrome is a reproductive and endocrinological disorder that affects up to 18% of reproductive-aged women.
- Conditions
- Polycystic Ovary Syndrome, Obesity, Overweight
- Trial name
- NCT05629858
- Testing
- 6-h Time restricted eating (TRE), Calorie restriction (CR), Control
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Obesity & Overweight, Obesity
Genetic, Microbiological and Behavioral Factors in Obesity
This study will assess the impact of genetic markers, microbiological (microbiome) and behavioral factors on tolerance, adherence and effectiveness of dual GLP1/GIP RA in the treatment of obesity.
- Conditions
- Obesity & Overweight, Obesity, Genetics
- Trial name
- OPTIMIZE-GEN (NCT07650149)
- Testing
- genetic polymorphism, gut microbiome
- Where
- 2 sites in Poland
- Volunteers
- 200 people
- Sponsor
- Jan Kochanowski University
Achalasia, Gastric Fistula
Outcome Analysis of POEM and Endoluminal Therapies
Evaluation of current and newly developed endoluminal therapies in the management of Upper and Lower GI conditions.
- Conditions
- Achalasia, Gastric Fistula, Weight Gain After Primary Weight Loss Surgery, Marginal Ulcer
- Trial name
- NCT03123835
- Testing
- Endoscopic Intervention
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Breast Cancer Female, Overweight and Obesity
Lifestyle Behavioural Intervention on Breast Cancer Survivors for the Treatment of Overweight/Obesity.
The goal of this clinical trial is to compare a behavioural lifestyle intervention program (BL) to usual care (UC) in breast cancer survivors. The main questions it aims to answer are: 1.
- Trial name
- Nutri-Life (NCT06577545)
- Testing
- Behavioural Lifestyle (BL)
- Where
- Greece
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Obesity
Treatment of Early Childhood Overweight in Primary Care: Pilot Study
Childhood overweight continues to increase at an alarming rate and the need exists to find effective, accessible intervention strategies to prevent and treat children who are at risk for being overweight or are already…
- Trial name
- NCT01662557
- Testing
- Family Behavior Modification, Minimal Nutrition Information
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Obesity
ZGN-440 (Beloranib for Subcutaneous Injection) for Treatment of Obesity
The purpose of this study is to assess the Pharmacokinetics/Pharmacodynamics (PK/PD), safety, and effectiveness of multiple subcutaneous doses of Beloranib (ZGN-440).
- Trial name
- NCT01507077
- Testing
- ZGN-440, ZGN-440 sterile diluent
- Where
- Australia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Zafgen, Inc.
Obesity
ReShape Intragastric Balloon for the Treatment of Obesity
A prospective, non-randomized, open-label, multi-center study designed to implant up to twenty-six (26) CE-marked ReShape™ Balloons in twenty-six (26) patients with body mass index (BMI) 30-40 to assess the effectiveness of the…
- Trial name
- ITALYIII (NCT01024465)
- Testing
- ReShape Duo Balloon
- Where
- 2 sites in Italy
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- ReShape Lifesciences
Obesity
Magnetic Resonance Imaging in Obesity
Obesity and its related conditions account for up to 5%of all health care spending in the UK and this is expected to double by 2030.
- Trial name
- NCT03528187
- Testing
- MRI, Written Consent
- Where
- United Kingdom
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University College, London
Polycystic Ovary Syndrome
Impact of Metformin in Teens With Polycystic Ovary Syndrome (PCOS) on Oral Contraceptive Therapy
Oral contraceptives are known to improve menstrual cycles and symptoms in PCOS, however may increase cholesterol. Metformin, a drug to improve insulin resistance, may benefit metabolic state.
- Trial name
- NCT00283816
- Testing
- Metformin, Oral Contraceptive Pill, Lifestyle Management Program
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Diabetes Mellitus, Type 2
Efficacy of Exenatide-LAR and Dapagliflozin in Overweight/Obese, Insulin Treated Patients With Type 2 Diabetes
The purpose of this study is to see what the effects of using one or two additional diabetes drugs (dapagliflozin and exenatide-LAR) are on blood sugar levels in patients who are taking insulin.
- Trial name
- Dexlar (NCT02811484)
- Testing
- Exenatide-LAR plus Dapagliflozin, Insulin Titration, Behavioral Therapy
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Pediatric Obesity, Pediatric Overweight
BasketballRx: Game Changing Health
The goal of this study is to learn if BasketballRx, a basketball and health program, works well for children and teens who are overweight or have obesity.
- Conditions
- Pediatric Obesity, Pediatric Overweight, Anxiety, Depression Disorders
- Trial name
- NCT07778433
- Testing
- BasketballRx
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Dysmenorrhea Primary, Obesity and Overweight
Bioptron Light Therapy for Dysmenorrhea in Obese Adolesences: RCT
Dysmenorrhea is the most common health problem in women in the reproductive age(Bakhsh et al., 2022). The primary dysmenorrhea starts shortly after the menarche the pain lasting 1 to 3 days that start just before or at the onset…
- Trial name
- NCT06992349
- Testing
- bioptron light therapy
- Where
- Egypt
- Volunteers
- 144 people
- Sponsor
- Alaa Noureldeen Kora
Obesity, Extreme Obesity
Weight Loss Surgery in Adolescents With Extreme Obesity
The use of bariatric surgery in adolescents is controversial. On one side, bariatric surgery is the only effective treatment to achieve sustained weight loss in adults with extreme obesity.
- Trial name
- YES (NCT02062164)
- Testing
- bariatric surgery, conservative care
- Where
- 5 sites in Germany
- Volunteers
- 66 people
- Sponsor
- Prof. Dr. Martin Wabitsch
Obese Adolescents
Associations Between Physical Activity and Sedentary Behavior Profiles and Carotid Intima-media Thickness in Adolescents With Obesity
Physical activity behaviors are key and modifiable factors of cardiovascular health from childhood. They encompass both physical activity, defined as any bodily movement produced by skeletal muscles that results in energy…
- Trial name
- CARADO (NCT07811115)
- Where
- France
- Volunteers
- 108 people
- Sponsor
- University of Avignon
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