Clinical trials: Treatment Of Obesity
Polycystic Ovary Syndrome, Overweight
Time-restricted Feeding for Treating Polycystic Ovary Syndrome (PCOS)
Intermittent fasting is an increasingly popular diet pattern of alternating eating and dieting.One particular form of intermittent fasting is the so-called time-restricted feeding (TRF).
- Conditions
- Polycystic Ovary Syndrome, Overweight, Obesity
- Trial name
- PCOS (NCT04580433)
- Testing
- Time-Restricted Feeding
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Chunzhu Li
Hepatitis
Treating Nonalcoholic Steatohepatitis With Pioglitazone
Nonalcoholic steatohepatitis (NASH) is a common liver disease that resembles alcoholic hepatitis but occurs in persons who drink little or no alcohol.
- Trial name
- NCT00062764
- Testing
- Actos (Pioglitazone)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Childhood Obesity, mHealth
Family Intervention for Treatment of Obesity With Digi-physical Support
Obesity in childhood is a global public health problem which continues to increase. It is associated with type 2 diabetes, high blood pressure, certain types of cancer, decreased psycho-social health and early mortality, among…
- Conditions
- Childhood Obesity, mHealth, Personalized Medicine
- Trial name
- NCT06236906
- Testing
- Device supported behavioural treatment
- Volunteers
- 12 people
- Sponsor
- Karolinska Institutet
Obstructive Sleep Apnea, Obesity
A Study of Surgical Weight Loss to Treat Obstructive Sleep Apnea
Obesity is an increasing problem worldwide. Over 20% of people in western societies are obese (BMI >30kg/m2) and 1-2 % are morbidly obese (BMI >40 kg/m2).
- Trial name
- NCT01080404
- Testing
- Bariatric surgery, Continuous positive airway pressure
- Where
- 9 sites in Finland
- Volunteers
- 197 people
- Sponsor
- Kuopio University Hospital
Lumbar Disc Herniation, Radiculopathy Lumbar
The Effect of Subcutaneous Fat Tissue Thickness on Lumbar Transforaminal Epidural Steroid Injection Treatment Success
Nerve compression due to lumbar disc herniation and related radicular pain is a very common condition when the lifetime prevalence is considered.
- Conditions
- Lumbar Disc Herniation, Radiculopathy Lumbar, Obesity
- Trial name
- NCT05556538
- Testing
- Transforaminal Epidural Steroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Marmara University
Patients Who Consented to Undergo Laparoscopic Gastric Banding Surgery for Weight Loss and Consent to Participate in This studyBMI ≥35 kg/m2, Confirmed Type 2 Diabetes Treated With Oral Agents and/or Only Diet Therapy
A Pilot Study of Metabolic Effects of Omentectomy
PROTOCOL SUMMARY Type of Study: Pilot, randomized and single center trial Test Procedure: Omentectomy Aim 1. Determine the effect of omentectomy on 1) insulin sensitivity, 2) beta cell function and 3) plasma markers of…
- Conditions
- Patients Who Consented to Undergo Laparoscopic Gastric Banding Surgery for Weight Loss and Consent to Participate in This studyBMI ≥35 kg/m2, Confirmed Type 2 Diabetes Treated With Oral Agents and/or Only Diet Therapy, Age 18-64 Years
- Trial name
- OMT (NCT00565799)
- Testing
- Omentectomy, No intervention
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- NYU Langone Health
Obesity, COVID-19 Infection
Efficiency and Security of NIVOLUMAB Therapy in Obese Individuals With COVID-19(COrona VIrus Disease) Infection
Although SARS-CoV-2 (Severe Acute Respiratory Syndrome-associated coronavirus) due to COVID-19 evolves poorly towards ARDS (Acute Respiratory Distress Syndrome) and death, there is to date no validated drug available for severe…
- Trial name
- NIVISCO (NCT04413838)
- Testing
- NIVOLUMAB, Routine standard of care
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hospices Civils de Lyon
Obesity, Morbid
Intragastric Injections of Botox for the Treatment of Obesity
One possible angle for treating obesity could be slowing down the gastric emptying time. By prolonging the gastric emptying time, the person would ideally experience increased sensation of satiety, and in the long run reduce food…
- Trial name
- NCT02035397
- Testing
- Botulinum Toxin Type A, Saline solution
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Norwegian University of Science and Technology
Endoscopic Sleeve Gastroplasty, Obesity
Endoscopic Sleeve Gastroplasty (ESG) for the Treatment of Obesity
The purpose of this study is to evaluate endoscopic sleeve gastroplasty (ESG) for the treatment of obesity. The ESG procedure is an U.S.
- Trial name
- NCT06339320
- Testing
- Endoscopic Sleeve Gastroplasty (ESG), Apollo OverStitch endoscopic suturing device
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- The Methodist Hospital Research Institute
Obesity, Binge-Eating Disorder
A Study of the Effectiveness and Safety of Topiramate in the Treatment of Moderate to Severe Binge-eating Disorder Associated With Obesity
The purpose of this study is to evaluate the safety and effectiveness of topiramate compared to placebo in reducing the number of binge days in patients with moderate to severe binge-eating disorder associated with obesity.
- Trial name
- NCT00210808
- Testing
- topiramate
- Volunteers
- 407 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Tobacco Use
Impact of Semaglutide on Tobacco Use and Related Health Behaviors
This pilot randomized trial will assess the impact of 12 weeks of semaglutide administration (vs placebo) on changes in: (i) tobacco use and related factors (nicotine craving, withdrawal, motivation to quit, etc.) and (ii)…
- Trial name
- ONSET (NCT06986993)
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Oklahoma
Obesity
Preliminary Evaluation Study of Therapeutic Education on Overweight People in Addition to a Hydrotherapeutic Cure
The goal of this study is to assess the effect of a therapeutic education program in addition of a hydrotherapeutic cure on obese patients.
- Trial name
- Educatherm (NCT02284776)
- Testing
- Therapeutic education
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Lille
Type 2 Diabetes
Roux-en-Y-Gastric Bypass vs. Lifestyle Modification and Medical Therapy in the Treatment of Type 2 Diabetes
The study is aimed to compare: Laparoscopic Roux-en-Y-Gastric Bypass (RYGB) + optimal medical therapy versus Intensive lifestyle modification and optimal medical therapy in the treatment of type 2 diabetes in…
- Trial name
- NCT01231308
- Testing
- Roux-en-Y-Gastric Bypass, Intensive lifestyle modification and Optimal medical Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Weill Medical College of Cornell University
Metabolic Syndrome x, Glucose Metabolism Disorders
Evaluation of the Effects Associated With the Administration of Akkermansia Muciniphila on Parameters of Metabolic Syndrome
Overweight and obesity have reached worldwide epidemic level. Both overweight and obesity are characterized by comorbidities such as cardio-metabolic risk factors (i.e., insulin resistance, type 2 diabetes, hypertension…
- Conditions
- Metabolic Syndrome x, Glucose Metabolism Disorders, Dyslipidemias, Obesity
- Trial name
- Microbes4U (NCT02637115)
- Testing
- Live Akk 9, Live Akk 10, Killed Akk
- Where
- Belgium
- Volunteers
- 54 people
- Sponsor
- Patrice D. Cani
Obesity
A Study Using Functional Magnetic Resonance Imaging (fMRI) to Assess the Effects of Naltrexone SR/ Bupropion SR Therapy in Overweight or Obese Subjects
The purpose of this study was to assess the effect of naltrexone SR/bupropion SR (NB) on brain function in response to food cues using functional magnetic resonance imaging in overweight or obese subjects.
- Trial name
- NCT00711477
- Testing
- Naltrexone SR 32 mg/bupropion SR 360 mg/day, fMRI scan
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Orexigen Therapeutics, Inc
Obesity
ZGN-440 (Beloranib for Subcutaneous Injection) for Treatment of Obesity
The purpose of this study is to assess the Pharmacokinetics/Pharmacodynamics (PK/PD), safety, and effectiveness of multiple subcutaneous doses of Beloranib (ZGN-440).
- Trial name
- NCT01507077
- Testing
- ZGN-440, ZGN-440 sterile diluent
- Where
- Australia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Zafgen, Inc.
Periodontitis, Obesity (Body Mass Index >30 kg/m2)
Obesity and Clinical and Cytokine Responses to Periodontal Therapy
This prospective controlled clinical study included 80 participants allocated into four groups according to body mass index (BMI) and periodontal status: obese periodontitis, normal-weight periodontitis, obese periodontally…
- Trial name
- NCT07869277
- Testing
- Scaling and Root Planing (SRP)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emine Çifcibaşı
Obesity
Effects of Concurrent Training on Physical Fitness and Body Composition in Obese Individuals
Ample evidence demonstrates the beneficial role of physical activity combined with a structured dietary plan to counteract obesity.
- Trial name
- CONCOB (NCT05768581)
- Testing
- Concurrent Training, Strength Training, Aerobic training
- Where
- Italy
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Obesity, Binge-Eating Disorder
Analysis of the Effects of the Adana City Training and Research Hospital Obesity Center Training Program on Adult Obese Patients With Binge Eating Disorder. A Prospective, Quasi-experimental Study With Interrupted Time-series Design.
Outcomes of treatments for binge eating spectrum eating disorders are yet to yield desirable results, reporting up to 60-70% of patients remaining symptomatic at post-treatment.
- Conditions
- Obesity, Binge-Eating Disorder, Group Meetings, Weight Loss
- Trial name
- NCT04127136
- Testing
- Multi-disciplinary obesity management therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people
- Sponsor
- Adana City Training and Research Hospital
Obesity, Overweight
Community-based Obesity Treatment in African American Women After Childbirth
The purpose of this study is to determine the effect of the community-based obesity treatment (PP), compared to usual care (UC), on changes in maternal weight over 12 months.
- Trial name
- NCT02829229
- Testing
- Community-based obesity treatment (PP)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Temple University
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