Clinical trials: Treatment Of Obesity
Overweight and Obesity, Cardiovascular Diseases
Beneficial Effects of Dietary and Lifestyle Change in Overweight and Obese Subjects
Obesity and overweight are noncommunicable diseases with increasing incidence in children, adolescents and adults. In 2016, more than 1.9 billion adults aged 18 and over were overweight and over 650 million were obese (WHO).
- Conditions
- Overweight and Obesity, Cardiovascular Diseases, Metabolic Syndrome, Non-Alcoholic Fatty Liver Disease
- Trial name
- Healthy-MET (NCT05447351)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Bari
Metabolic Syndrome, Obesity
Pharmacodynamics and Pharmacokinetics of 3 New Developed Coated Glucose Beads in 20 Obese Healthy Subjects
This single-dose, randomized, open label, five-treatment, five-period, five-sequence crossover study was performed to assess pharmacodynamics (PD) and pharmacokinetics (PK) of three new developed coated Glucose beads formulations…
- Trial name
- NCT05713773
- Testing
- coated beads glucose (8 g) and caffeine anhydrous, coated beads glucose (8 g), uncoated beads glucose (8 g) and caffeine anhydrous
- Where
- Romania
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aphaia Pharma US LLC
Obesity & Overweight, MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis)
Adherence and Tolerability of Four Very Low-Calorie Ketogenic Diet Approaches in Adults With Obesity or Complicated Overweight
This study, called KOBE Study, looks at how well different very low-calorie ketogenic diets (VLCKD) are followed and tolerated by adults with obesity or complicated overweight in routine clinical practice.
- Conditions
- Obesity & Overweight, MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis), Type 2 Diabetes, Insulin Resistance
- Trial name
- KOBE (NCT07389122)
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- University of Bologna
Renal Function, Endothelial Function
Study of Vitamin D and Uric Acid Lowering on Kidney and Blood Vessel Function
The investigators hypothesize that, among non-hypertensive overweight and obese individuals, treatment of vitamin D deficiency and lowering uric acid concentrations (by either xanthine oxidase inhibition or increased renal…
- Conditions
- Renal Function, Endothelial Function, Blood Pressure, Overweight
- Trial name
- MODERATE (NCT01320722)
- Testing
- Vitamin D ergocalciferol, Probenecid, Allopurinol
- Where
- United States
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Obesity
Levothyroxine as Adjuvant to a Hypocaloric Diet for the Treatment of Obesity.
Obesity is a chronic disease with high relapse rates after initial weight loss. Thyroid hormones modulate energy expenditure, body composition, and thermogenesis; higher TSH within the reference range and subclinical…
- Trial name
- NCT07332273
- Testing
- Levothyroxine
- Where
- 5 sites in Spain
- Volunteers
- 286 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Polycystic Ovary Syndrome
Mediterranean Diet Versus Hypocaloric Diet in PCOS
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy of reproductive-aged women that manifests itself with chronic anovulation, hyperandrogenism and insulin resistance.
- Trial name
- NCT02397174
- Testing
- mediterranean diet, restricted calorie, hypocaloric diet, restricted calorie
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera OO.RR. S. Giovanni di Dio e Ruggi D'Aragona
Obesity
Evaluation of Orlistat as Adjuvant Treatment of Obesity in Adults
The purpose of this study is to evaluate efficacy of orlistat 60 mg as adjuvant treatment of Obesity in adults.
- Trial name
- NCT01755676
- Testing
- Orlistat 60 mg
- Where
- 5 sites in Brazil
- Volunteers
- 638 people
- Sponsor
- EMS
Binge-Eating Disorder
EMDR vs. CBT in the Treatment of Inpatients With Obesity and Binge Eating Disorder: the EMDRDCA Study.
Overweight and obesity are linked with Binge Eating Disorder (BED). Traditionally, Cognitive Behavioral Therapy (CBT) is the therapeutic approach indicated both for inpatient and outpatient treatment of BED.
- Trial name
- EMDRDCA (NCT06474689)
- Testing
- EMDR, CBT
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- Istituto Auxologico Italiano
Overweight, Obesity
The Effect of the Treatment Program "Dr. Fedon Lindbergs Vektcoach" on Body Weight and Composition and Hormonal Profile
The background for the trial is a number of previous studies indicating that it is especially important to restrict the intake of carbohydrates when treating overweight and metabolic diseases in general.
- Conditions
- Overweight, Obesity, Metabolic Syndrome
- Trial name
- NCT01235208
- Testing
- The "Dr. Fedon Lindbergs Vektcoach" Treatment
- Where
- Norway
- Volunteers
- 44 people
- Sponsor
- Eurodiet Scandinavia AS
Genetic Obesity, Obesity
Setmelanotide Phase 2 Treatment Trial in Participants With Rare Genetic Disorders of Obesity
The purpose of the study was to determine the effect of setmelanotide (RM-493) on weight, hunger assessments, and other factors in participants with rare genetic disorders of obesity.
- Conditions
- Genetic Obesity, Obesity, Obesity Due to Melanocortin 4 Receptor Deficiency
- Trial name
- NCT03013543
- Testing
- Setmelanotide
- Where
- 58 sites in United States, Canada and 7 more
- Volunteers
- 213 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Cognitive Impairment, Overweight and Obesity
The Effect of Berry Extract Administration on Cognitive Health
The purpose of this study is to investigate the effects of daily supplementation of Brainport for a period of 6 months on cognitive health.
- Trial name
- NCT03236259
- Testing
- Brainport high dose, Brainport low dose
- Where
- Netherlands
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Morbid Obesity
Comparison of Laparoscopic Sleeve Gastrectomy and Roux-Y-gastric Bypass in the Treatment of Morbid Obesity
The laparoscopic sleeve-gastrectomy (SG) compared to laparoscopic proximal Roux-Y-gastric bypass (PGB) is as successful in the treatment of morbid obesity in the majority of patients.
- Trial name
- NCT00356213
- Testing
- sleeve gastrectomy, Roux-Y-gastric bypass
- Volunteers
- 217 people
- Sponsor
- University Hospital, Basel, Switzerland
Obesity & Overweight
Effect of a Food for Special Medical Purposes on Muscle Mass Preservation During GLP-1 RAs Weight Loss Treatment
This study evaluates whether a Food for Special Medical Purposes (FSMP) can help to preserve appendicular skeletal muscle mass (ASMM) in adults undergoing weight loss treatment with GLP-1 receptor agonists or dual GIP/GLP-1…
- Trial name
- MYO-PRESERVE (NCT07393360)
- Testing
- Myosave®
- Where
- 3 sites in Italy
- Volunteers
- 144 people
- Sponsor
- Pharmanutra S.p.a.
Overweight and Obesity, Nutritional and Metabolic Diseases
Treatment of Overweight in General Practice
In this study the investigators want to explore the feasibility and effect of a simple intervention provided by primary care physicians on treatment for overweight in general practice.
- Trial name
- NCT03000062
- Testing
- Intervention group
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Obesity, Emotional Trauma
Effects of EMDR Therapy in Patients With Severe Obesity
The aims of the study are to perform psychological intervention using EMDR Therapy (Eye Movement Desensitization and Reprocessing Therapy) in the preoperative period, evaluate the personality of each patient through the PFB test…
- Trial name
- NCT03555110
- Testing
- Personality Factor Battery Test (PFB Test), Eye Movement Desensitization and Reprocessing Therapy (EMDR)
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Atrial Fibrillation, Heart Failure
Empagliflozin and Atrial Fibrillation Treatment
The primary purpose of this trial is to evaluate the impact of empagliflozin, as compared with placebo, in patients with diabetes mellitus or overweight, heart failure and atrial fibrillation.
- Conditions
- Atrial Fibrillation, Heart Failure, Obesity, Diabetes Mellitus
- Trial name
- EMPA-AF (NCT04583813)
- Testing
- Empagliflozin
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Miulli General Hospital
Obesity
NitiNotes' EndoZip System for the Treatment of Obesity
This is first-in-man safety and performance feasibility study, aimed to provide initial clinical assessment of safety and effectiveness of the EndoZip in the treatment of obesity.
- Trial name
- NCT03472196
- Testing
- EndoZip System
- Where
- Spain
- Volunteers
- 14 people
- Sponsor
- Nitinotes Surgical Ltd.
Surgical Wound Dehiscence, Wound Infection
Prevention of Wound Complications After Cesarean Delivery in Obese Women Utilizing Negative Pressure Wound Therapy
Wound complications after Cesarean section (C-section) are common in obese women. Approximately 25% of obese women having a C-section will have a wound complication.
- Trial name
- NCT00654641
- Testing
- Negative pressure wound closure, Standard wound closure
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- West Virginia University
Obesity & Overweight
Predicting Weight Loss After Pharmacological or Surgical Treatment in Patients With Obesity
As with other nutritional strategies, the clinical response to bariatric surgery can be highly variable, with weight regain being a frequent occurrence.
- Trial name
- NCT07402031
- Testing
- Pharmacological or surgical treament of obesity
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Université Catholique de Louvain
Obesity, Type 2 Diabetes
Effects of Different Surgical Methods to Treat Obesity
Obese patients have an increased risk for developing severe metabolic disorders. This risk can only partly be reduced by weight reduction.
- Conditions
- Obesity, Type 2 Diabetes, Insulin Sensitivity
- Trial name
- DEOSH (NCT01785134)
- Testing
- Omentectomy, Gastric bypass operation
- Where
- 4 sites in Sweden
- Volunteers
- 81 people
- Sponsor
- Karolinska Institutet
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