Clinical trials: Treatment Of Obesity
Breast Cancer, Primary Hormone Receptor Positive Breast Cancer
A Study of the Body's Response to Exercise and a Plant-Based Diet in Overweight Postmenopausal Women With Breast Cancer
The purpose of this study is to find out what effects, if any, exercise and a plant-based diet have on aromatase levels in postmenopausal women who are overweight and being treated with an aromatase inhibitor for their HR+ breast…
- Trial name
- NCT04298086
- Testing
- Exercise Treatment, Plant-Based Diet, Physical activity
- Where
- 7 sites in United States
- Volunteers
- 43 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Obesity
Pregnancy-Related Obesity Prevention Through Education & Communication Technology in AFRICA:The PROTECT-AFRICA STUDY
The purpose of this study is to investigate whether overweight but not obese pregnant African women having unlimited access to a health education-information technology (IT) based intervention package gain weight within the…
- Trial name
- PROTECT-AFRI (NCT01948323)
- Testing
- HEDUAfrica IT package+ standard care
- Where
- 2 sites in South Africa
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Cape Town
Physical Inactivity, Obesity, Childhood
Effectiveness of a Telehealth-based Physical Activity Intervention
This study is a 11 week telehealth intervention focusing on increasing physical activity in adolescents who are receiving medical care for obesity. The participants will be randomized into two groups: control and intervention.
- Trial name
- NCT05123235
- Testing
- Physical Activity
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- East Carolina University
Morbid Obesity
Safety and Efficacy of Laparoscopic Truncal Vagotomy for the Treatment of Obesity
This two site study will evaluate the safety and effectiveness of laparoscopic truncal vagotomy for the treatment of obesity with baseline study and 18 month post op follow up.
- Trial name
- NCT00285220
- Testing
- Laparoscopic Truncal Vagotomy
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Rochester
Hypertension, Obesity
Trial Comparing Metabolic Effects of Telmisartan and Amlodipine on Hypertensive Patients With Obesity and Diabetes
Recent studies have shown that obese people are more prone to high blood pressure. With the co-existence of obesity, hypertension and diabetes, patients were more susceptible to hyperlipidemia, coronary and cerebral…
- Conditions
- Hypertension, Obesity, Diabetes
- Trial name
- HOT-DM (NCT00847262)
- Testing
- Temisartan, Amlodipine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Third Military Medical University
Obesity, Periodontitis
Gingival Crevicular Fluid Vaspin and Omentin Levels in Obese Patients With Chronic Periodontitis
Our objective in this case-control intervention study, therefore, was to explore the effect of nonsurgical periodontal therapy on the GCF levels of vaspin and omentin in patients with chronic periodontitis in order to determine…
- Trial name
- NCT02563171
- Testing
- non surgical periodontal treatment, Gingival crevicular fluid collection
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Umut BALLI
Obesity
Study Examing The Effect of Grapefruit Juice On The Blood And Urine Samples of Study Drug And Its By Product And Safety
CP-945,598 is eliminated primarily by enzyme CYP3A. Grapefruit juice may affect the activity of CYP3A and alter the amount of CP-945,598 in the blood.
- Trial name
- NCT00645216
- Testing
- CP-945,598
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Pfizer
Obesity
Deep Brain Stimulation for the Treatment of Obesity
The purpose of this clinical study is to investigate the safety and efficacy of deep brain stimulation (DBS) as a treatment option for obesity.
- Trial name
- NCT01512134
- Testing
- Deep Brain Stimulation Device
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Ali Rezai, MD
Adenocarcinoma of the Endometrium
A Randomized Pilot Study to Evaluate the Effects of a Short Course of Metformin Versus No Therapy in the Period Prior to Hysterectomy for Grade 1-2 Adenocarcinoma of the Endometrium in Obese Non-Diabetic Women
The purpose of this research is to determine the effects of Metformin, a well tolerated drug widely prescribed for treatment of Type 2 Diabetes Mellitus, on endometrium cancer patients.
- Trial name
- NCT01877564
- Testing
- Metformin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Arkansas
Binge-Eating Disorder, Obesity
Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Medication Change for Non-Responders
This study will test the relative efficacy and effectiveness of the combination of naltrexone and bupropion (NB) medication as a treatment for binge-eating disorder (BED) in patients with obesity.
- Trial name
- NCT03946111
- Testing
- Naltrexone and Bupropion
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Yale University
Craniopharyngioma
Tumor Classification and Its Application in Surgical Treatment of Craniopharyngioma
With the preliminary anatomical and histological study, the membranous structures of the sellar region was considered to be closely related with the growth pattern of Craniopharyngiomas(CP).
- Trial name
- NCT00949156
- Testing
- Different surgical approach and techniques being used to treat three subtype of CP
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Southern Medical University, China
Infertility, Female
The Impact of Body Mass Index on the Endometrial Microbiome in IVF Treatments. Tampere Infertility Microbiome Project (TIMP).
This study project is an observational trial involving 90 patients suffering from male type infertility. The patients are divided in two groups (45 patients per group) based on their body mass index (BMI).
- Trial name
- NCT04168567
- Testing
- Microbiome analysis
- Where
- Finland
- Volunteers
- 91 people
- Sponsor
- Tampere University Hospital
Childhood Obesity, Metabolic Syndrome
Motivational Approach to Treat Childhood Obesity
The treatment of childhood obesity is challenging. Although dietary and physical activity recommendations are widely known, the willingness to change lifestyles within the family is not easy to be achieved.
- Conditions
- Childhood Obesity, Metabolic Syndrome, Body Composition
- Trial name
- OBEMAT20 (NCT03749200)
- Testing
- Obemat2.0 therapy, Regular practise in primary care
- Where
- 4 sites in Spain
- Volunteers
- 319 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Obesity
GLP-1 Therapy After Bariatric Surgery in Chinese Patients With Obesity
Obese patients exhibit considerable heterogeneity and complex comorbidities, making long-term effective management challenging with monotherapy.
- Trial name
- NCT07633639
- Testing
- LSG-Semaglutide group, LSG-Mazdutide group, LSG-Tirzepatide group
- Where
- China
- Volunteers
- 200 people
- Sponsor
- China-Japan Friendship Hospital
Diabetes Mellitus Type 2
A Study of Taspoglutide Versus Placebo for the Treatment of Obese Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin Monotherapy
This 2 arm study will assess the efficacy, safety and tolerability of taspoglutide compared to placebo in obese patients with type 2 diabetes mellitus inadequately controlled with metformin monotherapy.
- Trial name
- NCT00823992
- Testing
- taspoglutide
- Where
- 71 sites in United States, Canada and 8 more
- Volunteers
- 305 people
- Sponsor
- Hoffmann-La Roche
Obesity, Lipid Disorders
A Clinical Study to Evaluate the Safety,Tolerability and PK of ZYT1, Following Oral Administration in Healthy Volunteers
This is a clinical study to evaluate the safety, tolerability and pharmacokinetics of ZYT1, following oral administrations in healthy volunteers. The study shall be divided into four plans as given below: 1.
- Trial name
- NCT01543269
- Testing
- ZYT1
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Zydus Lifesciences Limited
Obesity
Effectiveness of Cognitive Behavioral Therapy vs. Prescriptive Diet in Short and Medium-term Control of Body Weight
Comparison between different treatments of obesity in the short and medium term: prescriptive diet therapy compared to to cognitive-behavioral approach in the treatment of obesity according to the method of clinical trial.
- Trial name
- NCT01686854
- Testing
- Cognitive Behavioral (B), Prescriptive Diet (A)
- Where
- Italy
- Volunteers
- 163 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Obesity, Food Addiction
Impact of a Phone-based Cognitive and Behavioral Therapy on Food Addiction in Patients With Severe or Morbid Obesity
Morbid or severe obesity is a chronic pathology of multifactorial etiology that affects 4.3% of the French population. In these patients, eating disorders are frequent and must be managed as they are considered risk factors with…
- Trial name
- ADALOB (NCT04626570)
- Testing
- Cognitive and Behavioral Therapy
- Where
- 9 sites in France
- Volunteers
- 154 people
- Sponsor
- University Hospital, Tours
Metabolic Associated Fatty Liver Disease, Metabolic Associated-dysfunction Steatohepatitis (MASH)
Characterization and Management of Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD)
The goal of this clinical trial is to improve the treatment of hepatic steatosis associated with obesity with pharmacological and nutritionnal approaches.
- Conditions
- Metabolic Associated Fatty Liver Disease, Metabolic Associated-dysfunction Steatohepatitis (MASH), Obesity
- Trial name
- METAfoie (NCT06764056)
- Testing
- semaglutide, Diet
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Obesity
Bariatric Surgery and Guided Self-help for Binge Eating Disorder
To demonstrate the effectiveness of an easily administered intervention (guided self help) aimed at reducing binge eating in patients undergoing bariatric surgery.
- Trial name
- BED (NCT02094027)
- Testing
- Guided Self Help, Treatment As Usual
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Imperial College London
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