Clinical trials: Treatment Outcomes
Mild Traumatic Brain Injury, Balance; Distorted
Can Early Initiation of Rehabilitation With Wearable Sensor Technology Improve Outcomes in mTBI?
Every year 1.7 million people sustain a traumatic brain injury (TBI) in the United States and of these, 84 % are considered mild TBI (mTBI).
- Conditions
- Mild Traumatic Brain Injury, Balance; Distorted, Gait, Unsteady, Quality of Life
- Trial name
- NCT03479541
- Testing
- Timing of Rehabilitation, Biofeedback
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Blood Levels of Buffered vs Non-buffered Lidocaine, Anesthetics, Local
Clinical Outcomes of Buffered vs. Non-Buffered Lidocaine
Anecdotal reports suggest buffering lidocaine with epinephrine just before intraoral injection reduces time of onset, results in a deeper anesthetic effect, without the "sting" with injection from a low pH.
- Trial name
- BUFFL (NCT02620683)
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Complication of Renal Dialysis, End Stage Renal Disease
A Study Testing the Use of a Perivascular Sirolimus Formulation (Sirogen) in ESRD Patients Undergoing AV Fistula Surgery
The primary study objective is to evaluate the benefit of the Sirolimus eluting Collagen implant (SeCI; Sirogen), a single dose prophylactic treatment delivered intraoperatively at the time of surgical creation of an…
- Conditions
- Complication of Renal Dialysis, End Stage Renal Disease, End Stage Kidney Disease, ESRD
- Trial name
- ACCESS2 (NCT05425056)
- Testing
- Sirolimus
- Where
- 22 sites in United States, United Kingdom
- Volunteers
- 136 people
- Sponsor
- Vascular Therapies, Inc.
ACL Injury
Clinical Outcomes of ACL Reconstruction Augmented by an Injectable Osteoconductive/Osteoinductive Compound
The goal of this study is to determine whether the use of injectable osteoinductive/osteoconductive compounds (OOC) during Anterior Cruciate Ligament (ACL) reconstructive surgery, combined with an accelerated rehabilitation…
- Trial name
- NCT04993339
- Testing
- OOC
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Miami
Wound
Procellera and Negative Pressure Therapy for Acute Wounds
The purpose of this study is to determine if Procellera speeds wound healing. The study will examine colonization (bacterial growth), pain and pain medication and reduced cost of care by using Procellera (an antimicrobial agent)…
- Trial name
- NCT01938066
- Testing
- Procellera, negative pressure therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Gayle Gordillo
Diabetic Foot Ulcer
Clinical Outcomes After Treatment With RestrataTM Wound Matrix in Diabetic Foot Ulcers (DFU)
The primary objective of this study is to determine the outcomes of patients who receive a certain type of skin substitute called RestrataTM Wound Matrix (Restrata™).
- Trial name
- NCT03312595
- Testing
- Restrata TM Wound Matrix
- Where
- 5 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Acera Surgical, Inc.
Diabetic Peripheral Neuropathy
Balancing Treatment Outcomes and Medication Burden Among Patients With Symptomatic Diabetic Peripheral Neuropathy
Painful diabetic peripheral neuropathy (DPN) affects more than 5.5 million people with diabetes. People with painful DPN have trouble sleeping, participating in social events, and conducting daily activities such as going to the…
- Trial name
- NCT02056431
- Testing
- IVR Intervention Group
- Where
- United States
- Volunteers
- 1,270 people
- Sponsor
- Kaiser Permanente
Anemia, Chronic Kidney Disease
STIMULATE Study: Anemia Correction and Health-related Quality of Life (HRQoL) Outcomes in Elderly Chronic Kidney Disease (CKD) Patients
Treatment of anemia associated with chronic kidney disease (CKD) during 36 weeks with safety follow up phase of 52 weeks
- Trial name
- NCT00364845
- Testing
- Darbepoetin alfa
- Volunteers
- 51 people
- Sponsor
- Amgen
Stillbirth, Neonatal Death
Intermittent Auscultation Using Handheld Doppler: a Randomized Controlled Trial Comparing Perinatal Outcomes in Uganda
A novel handheld Doppler has been developed which is rugged and is powered only by a hand crank. This study aims to test the use of this Doppler versus the Pinard horn to monitor the fetal heart rate in labour in a hospital…
- Trial name
- NCT02273037
- Testing
- Fetal heart rate Doppler, Partograph
- Where
- 2 sites in Canada, Uganda
- Volunteers
- 1,987 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Cataract
Intra-Operative Metrics With CENTURION® and INFINITI® Vision Systems
The purpose of this study is to evaluate intra-operative phacoemulsification machine metrics after phacoemulsification with the CENTURION® vision system configuration compared with the INFINITI® vision system configuration.
- Trial name
- NCT01848288
- Testing
- CENTURION® Vision System (CVS), INFINITI® Vision System (IVS)
- Volunteers
- 112 people
- Sponsor
- Alcon Research
HIV Infections
Telephone Support to Improve Adherence to Anti-HIV Medications
This study tested a system of nursing telephone support to determine if it improves adherence to antiretroviral therapy (ART) in at-risk, treatment-experienced people.
- Trial name
- NCT00988442
- Testing
- Enhanced nursing telephone support, Standard care
- Where
- 16 sites in United States
- Volunteers
- 59 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Dental Implants, Alveolar Mucosa
To Compare Free Gingival Grafts and Connective Tissue Grafts Around Implants With Lack of Keratinized Mucosa
This study will compare two commonly used soft tissue grafting techniques (free gingival graft, FGG vs. connective tissue graft, CTG) to augment the soft tissue around dental implants with a lack of keratinized mucosa.
- Trial name
- NCT03338686
- Testing
- Free Gingival Graft (FGG), Connective Tissue Graft followed by Laser Gingivoplasty
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Pulmonary Disease, Chronic Obstructive
Proof of Concept Study Assessing Technology-Assisted Respiratory Adherence Prototype Version 3 in Individuals With COPD
The study's primary aim is to assess whether there is a clinically significant reduction in breathlessness in symptomatic individuals with chronic obstructive respiratory disease (IwCOPD) following engagement with…
- Trial name
- NCT04795323
- Testing
- TARA v3.1, only non-pharmacological self-management support, TARA v3.2, both non-pharmacological and pharmacological self-management support
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Boehringer Ingelheim
Percutaneous Coronary Intervention
Chewed Versus Integral Pill of Ticagrelor
Hypothesis The primary question the investigators propose to answer is whether all patients undergoing percutaneous coronary intervention (PCI) with stent deployment who receive chewed ticagrelor will demonstrate more rapid drug…
- Trial name
- NCT03708588
- Testing
- Ticagrelor
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Wake Forest University Health Sciences
Osteoarthritis
StepRite Evaluation
The purpose of this study is to compare the short-term changes in gait parameters and functional outcomes after total knee arthroplasty between those who use the StepRite device and those who follow a standard therapy program…
- Trial name
- NCT02270684
- Testing
- StepRite
- Volunteers
- 4 people
- Sponsor
- University of Southern California
Major Depressive Disorder
Evaluation of a Mental Health Physician Support Program in Nova Scotia
The aim of this study is to test the program's effectiveness in a primary care setting in reducing stigma among medical personnel, increasing the comfort level of physicians and staff in providing care to those living with mental…
- Trial name
- NCT01975948
- Testing
- Mental Health Practice Support Program, Treatment as Usual
- Where
- Canada
- Volunteers
- 285 people
- Sponsor
- Nova Scotia Health Authority
Obesity, Type2 Diabetes
Cardiovascular Outcomes in Bariatric Surgery Patients With Type 2 Diabetes
The objective of the analysis was to evaluate the relationship between bariatric surgery and cardiovascular outcomes in obese patients with type 2 diabetes.
- Conditions
- Obesity, Type2 Diabetes, Bariatric Surgery Candidate
- Trial name
- NCT03955952
- Testing
- Bariatric Surgery
- Where
- United States
- Volunteers
- 91,700 people
- Sponsor
- The Cleveland Clinic
Drug Use Stigma in HIV Treatment Clinics
Addressing Drug Use Stigma in Human Immunodeficiency Virus (HIV) Care and Treatment Clinics in Tanzania
The goal of this study is to adapt and pilot an effective health facility HIV stigma-reduction intervention to address drug use stigma in human immunodeficiency Virus (HIV) Care and Treatment clinics (CTCs) in Tanzania, a barrier…
- Trial name
- NCT04863898
- Testing
- Drug-use stigma reduction intervention for HIV care and treatment clinic staff
- Where
- 7 sites in Tanzania
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- RTI International
Arthritis Rheumatoid
This Study is to Investigate the Effect of Etanercept in Early Versus Delayed Referral for Management of Rheumatoid Arthritis Patients.
This study is to investigate the effect of etanercept in early versus delayed referral for management of rheumatoid arthritis patients assessing real-world patient data entered in the Iraq National Center of Rheumatology database…
- Trial name
- NCT04267614
- Testing
- Etanercept
- Where
- Iraq
- Volunteers
- 1,226 people
- Sponsor
- Pfizer
Pregnancy, Smoking
Self-Monitoring of Carbon Monoxide to Enhance Reproductive Outcomes in Women
Our goal is to study self-monitoring of smoking as a means to reduce smoking in pregnant women. Investigators hypothesize that more regular self-monitoring, text messages and feedback as provided by home carbon monoxide…
- Conditions
- Pregnancy, Smoking, Smoking Cessation
- Trial name
- NCT02246114
- Testing
- piCO+ Smokerlyzer® monitor, Text messages
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
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