Clinical trials: Treatment Outcomes
Depression
Maternal Depression Treatment in HIV
Cluster randomized controlled trial to compare the effects of task-shifted, evidence-based depression care vs. usual care on adherence to each step of the prevention of mother-to-child-transmission (PMTCT) care cascade at 8…
- Trial name
- M-DEPTH (NCT03892915)
- Testing
- evidence-based depression treatment
- Where
- Uganda
- Volunteers
- 391 people
- Sponsor
- RAND
Acute Respiratory Distress Syndrome, Vitamin D Deficiency
Vitamin D to Improve Outcomes by Leveraging Early Treatment
Vitamin D deficiency is a common, potentially reversible contributor to morbidity and mortality among critically ill patients. We conducted a randomized, double-blind, placebo-controlled, phase 3 trial of early vitamin D3…
- Conditions
- Acute Respiratory Distress Syndrome, Vitamin D Deficiency, Critical Illness
- Trial name
- VIOLET (NCT03096314)
- Testing
- Vitamin D3
- Where
- 47 sites in United States
- Volunteers
- 1,358 people
- Sponsor
- Massachusetts General Hospital
Self-Perception, Body Weight
Effects of Active Video Games in Physically Inactive Children
Inactivity was reported to be high in children and considered to be the fourth common cause of death in all ages. The reason for children is usually the increasing indoor use of sedentary screen time.
- Trial name
- AVGAME (NCT03720938)
- Testing
- Active Video Games
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Actinic Keratoses
PRO With Luxerm® in the Field Treatment of Thin and Non-hyperkeratotic Non-pigmented AK
Interventional open label prospective and multicentre study conducted in Germany in subjects with thin or non-hyperkeratotic and non-pigmented multiple AKs in one anatomical area on the face (e.g., forehead or cheek or chin)…
- Trial name
- SESAME 2 (NCT03511326)
- Testing
- Methyl Aminolaevulinate 16% Cream
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Galderma R&D
Heart Arrest
Resuscitation Outcomes Consortium (ROC) Prehospital Resuscitation Using an Impedance Valve
The purpose of this study is to look at two different treatments during a cardiac arrest that occurs outside of the hospital and whether either or both treatments will increase the number of people who live to hospital discharge.
- Trial name
- NCT00394706
- Testing
- Impedance Threshold Device (ITD), Analyze early, Analyze later
- Where
- 9 sites in United States, Canada
- Volunteers
- 11,738 people
- Sponsor
- University of Washington
Hearing Loss, Presbycusis
Predicting Success With Hearing Aids
The primary complaint of individuals with hearing loss is difficulty understanding speech in the presence of background noise. Although hearing aids help individuals understand speech in background noise better, there is a high…
- Trial name
- NCT00371449
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Knee Arthropathy, Allergic Reaction
Nickel Sensitivity
The purpose of this study is to compare clinical outcomes of patients with self reported nickel sensitivity undergoing primary total knee arthroplasty (TKA) with conventional, standard-of-care vs nickel-free implants.
- Trial name
- NCT04058743
- Testing
- TKA with nickel free components, TKA with standard cobalt chromium components
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Rush University Medical Center
Osteoarthritis
A Study to Determine the Difference in Low Contact Stress (LCS) Duofix Versus Low LCS Porocoat Knee Systems
The primary objective of this investigation is to test the hypothesis that the Duofix Tibial component results in a reduction of immediate postoperative pain compared to the LCS Porocoat version.
- Trial name
- NCT00733499
- Testing
- LCS Complete Duofix, LCS Complete Porocoat
- Where
- Ireland
- Volunteers
- 206 people
- Sponsor
- DePuy International
Traumatic Brain Injury
Using the Xbox Kinect for Chronic TBI
This study will evaluate the potential for improving balance for a single individual with a history of traumatic brain injury (TBI). The participant will engage in supervised therapy using commercial games on the Xbox Kinect.
- Trial name
- NCT02889289
- Testing
- Xbox One Kinect Gaming
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Washington D.C. Veterans Affairs Medical Center
Quality of Life, Anxiety
EMR Outcomes: Anxiety and Depression in Epilepsy
The purpose of this research is to find out how people with epilepsy and possible symptoms of anxiety or depression are doing for 6 months after a regular epilepsy clinic visit.
- Conditions
- Quality of Life, Anxiety, Depression, Epilepsy
- Trial name
- NCT03879525
- Testing
- EMR-based-interventional method, Telephone-based-standard method
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Wake Forest University Health Sciences
Hypertension
Diuretic Comparison Project
The Diuretic Comparison Project aimed to evaluate whether chlorthalidone, as compared with hydrochlorothiazide, would reduce the risk of major nonfatal cardiovascular disease outcomes and non-cancer-related deaths in older…
- Trial name
- DCP (NCT02185417)
- Testing
- Hydrochlorothiazide (HCTZ), Chlorthalidone (CTD)
- Where
- 70 sites in United States, Puerto Rico
- Volunteers
- 20,723 people
- Sponsor
- VA Office of Research and Development
Atrial Fibrillation, Bleeding
HEAL-LAA Clinical Trial
The primary objective of this study is to collect real-world data on WATCHMAN FLX™ Pro Left Atrial Appendage Closure (LAAC) Device in patients with non-valvular atrial fibrillation.
- Conditions
- Atrial Fibrillation, Bleeding, Stroke
- Trial name
- HEAL-LAA (NCT05809596)
- Testing
- WATCHMAN FLX Pro LAAC Device
- Where
- 45 sites in United States
- Volunteers
- 949 people
- Sponsor
- Boston Scientific Corporation
Scoliosis
Posterior Spinal Fusion With Two Energy Dissection Techniques
The OSTEOVUE™ Spine Dissector is a new ultrasonic energy device, specifically designed for soft tissue removal from vertebral surfaces.
- Trial name
- NCT02465099
- Testing
- Ultrasonic Dissection (UD), Electrocautery Dissection (ED)
- Where
- 5 sites in United States
- Volunteers
- 64 people
- Sponsor
- Ethicon Endo-Surgery
Presbycusis
Impact of Hearing Aid Service-delivery Model and Technology on Patient Outcomes
Age-related hearing loss is a big problem in the United States because many people have it and it affects their quality of life. Hearing aids can help, but not many people use them.
- Trial name
- NCT03579563
- Testing
- AUD fitting, OTC+ fitting, OTC fitting
- Where
- 2 sites in United States
- Volunteers
- 290 people
- Sponsor
- Yu-Hsiang Wu
Depression
Behavioral Medicine Intervention With Depressed Patients in a Community Health Center Setting
The linkage between the Massachusetts General Hospital (MGH)-Community Health Associates and the MGH-Benson Henry Institute for Mind-Body Medicine began in order to address the concern of providing affordable, easily accessible…
- Trial name
- NCT01330420
- Testing
- Relaxation Response Resiliency Program for Depression
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Breast Cancer, Hepatitis C
Association of Hepatitis C Virus With Breast Cancer
Hepatitis C viral infection is a major health problem in Egypt. The management of breast cancer patients is often complicated by the presence of associated HCV infection.
- Trial name
- NCT04090164
- Where
- Egypt
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Mansoura University
School-based Mental Health Treatment Services
Feedback and Outcomes for Clinically Useful Student Services (FOCUSS)
The purpose of the study is to examine the implementation outcomes (i.e., feasibility, appropriateness, acceptability, and fidelity) of MBC in school-based mental health treatment services.
- Trial name
- NCT05039671
- Testing
- Measurement-based care (MBC)
- Where
- 2 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Yale University
Surgery, Hip Osteoarthritis
Two Year Study With Robotic-Arm Assisted Hip Surgery.
This study will involve a quantitative assessment of prospectively collected computed tomography, radiographic and patient outcomes data from multiple centers.
- Trial name
- NCT03891199
- Testing
- Robotic-Arm Assisted THA
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Lumbar Spinal Stenosis
Long Term Outcomes of Lumbar Epidural Steroid Injections for Spinal Stenosis
Spinal stenosis is one of the most common causes of low back pain among older adults and can result in significant disability. Despite this, it still isn't known which treatments are most effective or what outcomes are most…
- Trial name
- LESSER (NCT02260401)
- Testing
- Individualized report
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- University of Washington
Aging
REMAP Trial for Optimizing Surgical Outcomes at UPMC
The purpose of this project is to determine the effect of various interventions to improve patient outcome as defined by hospital free days at day 90 for adult patients undergoing elective surgery.
- Trial name
- UPMCREMAP (NCT03861767)
- Testing
- Metformin ER
- Where
- United States
- Volunteers
- 302 people
- Sponsor
- Matthew Neal MD
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