Clinical trials: Treatment Resistant
Pneumonia
Ceftobiprole in the Treatment of Patients With Community-Acquired Pneumonia
The purpose of this study is to compare the clinical cure rate (ratio of clinically cured patients to the total number of patients) of ceftobiprole medocaril versus a comparator in the treatment of patients with…
- Trial name
- NCT00326287
- Testing
- Ceftobiprole medocaril, Ceftriaxone with or without Linezolid
- Volunteers
- 638 people
- Sponsor
- Basilea Pharmaceutica
HIV Infections
A Study to Demonstrate That Anti-HIV Drug Therapy Can be Stopped Without Causing Viral Resistance, and to Characterize Drug Elimination From the Body
The purpose of this study is to find out if anti-HIV drugs can be stopped without the virus becoming resistant to the drugs. The study will also examine how fast anti-HIV drugs leave the body.
- Trial name
- NCT00029341
- Testing
- Treatment Interruption
- Where
- 7 sites in United States
- Volunteers
- 36 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Treatment-resistant Depression
The Mechanisms of Underlying Accelerated Repetitive Transcranial Magnetic Stimulation for Treatment-resistant Depression
In this project, the investigators evaluate an accelerated schedule of repetitive transcranial magnetic stimulation for treatment-resistant depression.
- Trial name
- NCT05607654
- Testing
- active iTBS
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Metastatic Castration-Resistant Prostate Adenocarcinoma, Stage IVB Prostate Cancer AJCC v8
Pluvicto for the Treatment of African American Men With Metastatic Castration-Resistant Prostate Cancer
This phase II trial tests how well Pluvicto works in treating African American patients with prostate cancer that has spread from where it first started (primary site) to other places in the body (metastatic) and that has…
- Trial name
- PluvEquity (NCT07860554)
- Testing
- Biopsy Procedure, Biospecimen Collection, Bone Scan
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Emory University
Prostate Cancer
Rituximab Neoadjuvant Therapy in Patients With Prostate Cancer Scheduled to Undergo Radical Prostatectomy
There is now substantial evidence that B cells are recruited into prostate cancers by CXCL13 released by the tumor cells. B cells release lymphotoxin which drives malignant cell proliferation through the NFkB pathway.
- Trial name
- NCT01804712
- Testing
- rituximab
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Christopher Kane
Malaria
Impact of Artemisinin-based Combination Therapy and Quinine on Treatment Failure and Resistance in Uncomplicated Malaria
This is a bi-centric phase IIIb, randomized, open label, 3-arm clinical trial performed to investigate the impact of retreatment with an Artemisinin-Based Combination (ACT), for example Arthemeter-Lumefantrine (AL) in Uganda (Ug)…
- Trial name
- QuinAct (NCT01374581)
- Testing
- Artemether/Lumefantrine, Artesunate/Amodiaquine, Quinine + Clindamycin
- Where
- 2 sites in Republic of the Congo, Uganda
- Volunteers
- 2,117 people
- Sponsor
- Universiteit Antwerpen
Advanced Solid Tumor
Safety and Efficacy of Radiotherapy Combined with Immunotherapy for Advanced Malignant Tumors.
The goal of this clinical trial is to find a new radioimmunotherapy regimen for advanced malignancies with multiple metastatic after standard treatment failure/drug resistance.
- Trial name
- NCT06173219
- Testing
- Radiotherapy combined with immunotherapy
- Where
- China
- Volunteers
- 38 people
- Sponsor
- China-Japan Friendship Hospital
HIV-1-infection
Ndovu RCT: Investing the Optimal Management of Dolutegravir Resistance
This clinical trial will address the gap in published data on the effect of dolutegravir (DTG)-associated drug-resistant mutations on viral suppression among people remaining on DTG-based antiretroviral therapy.
- Trial name
- NCT06747507
- Testing
- Dolutegravir Pill, Darunavir+Ritonavir
- Where
- 9 sites in Kenya, Lesotho and 2 more
- Volunteers
- 392 people
- Sponsor
- University of Nairobi
Pneumonia, Pulmonary Tuberculosis
Interferon Gamma for Drug Resistant Tuberculosis
This study will determine what dose of recombinant interferon-gamma is safe and effective for treating multiple drug-resistant tuberculosis.
- Trial name
- NCT00001407
- Testing
- Interferon Gamma
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Platinum-resistant Recurrent Ovarian Cancer
A Study of QL1706 (an Anti-PD-1/CTLA-4 Combined Antibody) Combined With Albumin-bound Paclitaxel and Bevacizumab in the Treatment of Platinum-resistant Recurrent Ovarian Cancer
Major objectives To evaluate the efficacy of QL1706 combined with albumin-binding paclitaxel and bevacizumab in the treatment of platinum-resistant recurrent ovarian cancer.
- Trial name
- NCT06509971
- Testing
- QL1706
- Volunteers
- 39 people
- Sponsor
- West China Second University Hospital
Lymphoma, B Cell
Anti-CD19:TCRζ Chimeric Antigen Receptor-T Cells in the Treatment for CD19+ B Cell Lymphoma
This study aims to evaluate the safety, efficacy and duration of response of CD19 Chimeric Antigen Receptor (CAR) redirected allogeneic T-cells in patients with chemotherapy-resistant or refractory CD19+ B cell lymphoma.
- Trial name
- NCT02992834
- Testing
- IL-2 pre-treated CD19 cells, IL-7/IL-15 pre-treated CD19 cells
- Where
- China
- Volunteers
- 10 people
- Sponsor
- jiangjingting
Obesity, Insulin Resistance
Pioglitazone Therapy in Obese Children With Insulin Resistance: A Randomized, Controlled Pilot Study
The primary objective of this study is to examine the effects of four months of pioglitazone vs. metformin treatment on HDL cholesterol, triglycerides, blood pressure, insulin resistance, endothelial function, arterial stiffness…
- Trial name
- NCT00775164
- Testing
- pioglitazone, Metformin
- Sponsor
- University of Minnesota
Glucose Metabolism Disorders
Acute Metabolic Effects of Melatonin Treatment
Modern living is associated with an epidemic of type 2 diabetes mellitus (T2DM). Sleep disturbances are strong independent risk factors for incident diabetes.
- Trial name
- NCT03204877
- Testing
- Melatonin
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Whiplash Injury of Cervical Spine
The Efficacy and Safety of Non-resistance Manual Therapy in Inpatients With Acute Neck Pain Caused by Traffic Accidents: a Randomised Controlled Trial
Non-resistance therapy is a combination of muscle compression relaxation technique and joint mobilization in patients with acute neck pain caused by traffic accidents.
- Trial name
- NCT04660175
- Testing
- non-resistance therapy, acupuncture, chuna
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Jaseng Medical Foundation
Nephrotic Syndrome
Efficacy of Anti-CD20 Ab Associated With Anti-CD38 in the Childhood Multidrug Dependent and Resistant Nephrotic Syndrome
Nephrotic syndrome is considered a disease caused by an interplay of immunological stimuli with adaptive immunity(CD80/CD40) as trigger and Treg in the mid between co-stimulatory molecules and effectors.
- Trial name
- NCT05704400
- Testing
- Rituximab Biosimilar ABP 798, Daratumumab
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Giannina Gaslini
Treatment-resistant Schizophrenia
Hippocampus DBS in Treatment-resistant Schizophrenia
The goal of this clinical trial is to assess the efficacy and safety of hippocampus-targeted deep brain stimulation (DBS) in treatment-resistant schizophrenia.
- Trial name
- NCT05694000
- Testing
- On-Stimulation, Off-Stimulation
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Shanghai Mental Health Center
Granulocyte Colony-Stimulating Factor, PD-1 Inhibitor
G-CSF in Patients With Anti-PD-1-axis Therapy-resistant Recurrent or Metastatic Nasopharyngeal Carcinoma
Recurrence and metastasis are the main causes of treatment failure of NPC. Immunotherapy is an emerging cancer treatment method, which has less adverse reactions and longer duration compared with chemotherapy.
- Trial name
- NCT05222009
- Testing
- PEG-rhG-CSF
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Sun Yat-sen University
Type 1 Diabetes Mellitus
The Role of FTO Gene Polymorphism and Insulin Preparation in Obesity in Children With Type 1 Diabetes Mellitus
The project aims at assessment of the effect of the FTO gene polymorphism and the type of treatment on the development of overweight/obesity and features of metabolic syndrome in children with type 1 diabetes.
- Trial name
- FTO_T1DM (NCT01279161)
- Where
- 6 sites in Poland
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Bialystok
Migraine Disorders, Chronic Migraine
Biochemical Profiling of Migraine Patients
Aim of the study was to assess a potential dysfunction of the endocannabidiome system (eCBome) in migraine patients. Migraine patients who will undergo preventive therapy with monoclonal antibodies directed against the calcitonin…
- Conditions
- Migraine Disorders, Chronic Migraine, Episodic Migraine
- Trial name
- SPHERA_WP1_1 (NCT06549270)
- Testing
- MAbs
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Metabolic Syndrome
Assessment of Therapeutic Potential of Stigma Maydis (Cornsilk) on Metabolic Syndrome
Over the past two decades, there has been an increase in the number of people with nutrition related maladies due to changes in their dietary habits and lifestyle.
- Trial name
- cornsilk (NCT06240273)
- Testing
- Corn silk powder
- Volunteers
- 50 people
- Sponsor
- University of Veterinary and Animal Sciences, Lahore - Pakistan
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