Clinical trials: Treatment Resistant
Alopecia Areata
Follicular Revival in Treatment-resistant Alopecia Areata: Evaluating Use of Micro-needling
The investigators propose to study the efficacy of micro-needling via the SOL Nova Device in generating hair growth in patients with Alopecia Areta (AA) who are either non-responsive or only partially responsive to combination…
- Trial name
- NCT04338295
- Testing
- Tattoo machine (SOL Nova Device)
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Yale University
Obsessive-Compulsive Disorder
rTMS in Treatment Refractory Obsessive-Compulsive Disorder
This study will evaluate the effectiveness of rTMS as a potential treatment for refractory OCD in a randomized, crossover design.
- Trial name
- NCT02450695
- Testing
- rTMS
- Where
- Canada
- Sponsor
- McMaster University
Lung Cancer
Dasatinib in Treating Patients With Advanced Lung Cancer That Is No Longer Responding to Erlotinib or Gefitinib
RATIONALE: Dasatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying how well dasatinib works in treating patients with advanced lung cancer that…
- Trial name
- NCT00570401
- Testing
- dasatinib
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Metastatic Melanoma, Recurrent Cutaneous Melanoma
Ibrutinib in Treating Patients With Refractory Metastatic Cutaneous Melanoma
This phase II trial studies how well ibrutinib works in treating patients with stage IV melanoma of the skin that has not responded to previous treatment.
- Conditions
- Metastatic Melanoma, Recurrent Cutaneous Melanoma, Stage IV Cutaneous Melanoma AJCC v6 and v7
- Trial name
- NCT02581930
- Testing
- Ibrutinib, Laboratory Biomarker Analysis, Pharmacogenomic Study
- Where
- 13 sites in United States
- Volunteers
- 18 people
- Sponsor
- National Cancer Institute (NCI)
Refractory Schizophrenia
The Synergistic Effect of Hypoglycemic Index Diet on Refractory Schizophrenia
This experiment was conducted to investigate the improvement of hypoglycemic index diet (LGIT) as a potential new intervention scheme for treatment-resistant schizophrenia, and to further explore the mechanism of efficacy.
- Trial name
- NCT04302636
- Testing
- Low glycemic index diet
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Prostate Cancer
A Study of the Safety and Efficacy of Single-agent Carlumab (an Anti-Chemokine Ligand 2 [CCL2]) in Participants With Metastatic Castrate-Resistant Prostate Cancer
The purpose of this study is to determine the safety and effectiveness of the study drug carlumab in participants with metastatic castrate-resistant prostate cancer (cancer of the gland that makes fluid that aids movement of…
- Trial name
- NCT00992186
- Testing
- Carlumab
- Where
- 13 sites in United States, Belgium and 2 more
- Volunteers
- 46 people
- Sponsor
- Centocor Research & Development, Inc.
Solid Tumors, B Cell Lymphoma
Lower Dose Decitabine Based Therapy in Patients With Refractory and/or Chemotherapy Resistant Solid Tumors or B Cell Lymphomas
Determine alone or in combination with chemotherapy or autologous cytokine induced killer cells are effective and safe in the treatment of patients with relapsed and/or refractory solid tumors or B Cell lymphomas.
- Trial name
- CIK (NCT01799083)
- Testing
- Decitabine, cytokine-induced killer cell
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Han weidong
Metabolic Syndrome
Assessing The Treatment Effect in Metabolic Syndrome Without Perceptible diabeTes (ATTEMPT)
The objective of this protocol is to improve awareness, treatment, and control of metabolic syndrome, within primary prevention of cardiovascular disease, by implementing guidelines, after training of the participating physicians.
- Trial name
- ATTEMPT (NCT00416741)
- Testing
- Implementation of guidelines
- Where
- Greece
- Volunteers
- 2,000 people
- Sponsor
- Hellenic Atherosclerosis Society
Gram Negative Infections, Antimicrobial Resistance (AMR)
PK/PD Relationship of CAZ/AVI and FOS in the Treatment of Patients With Infections Due to CRE
A multicenter international prospective observational pharmacological study in adult patients (≥18 years) treated with ceftazidime/avibactam (CAZ/AVI) alone or with CAZ/AVI plus fosfomycin (FOS) for infection due to…
- Trial name
- CAVIFOS (NCT06717594)
- Where
- 2 sites in Italy, Spain
- Volunteers
- 60 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Schizophrenia
Histamine H2 Antagonism as Adjuvant Therapy in Treatment Resistant Schizophrenia
The purpose of the study is to investigate whether blockade of the histamine H2 receptors in the brain will have any beneficial effect on the symptoms of subjects with schizophrenia.
- Trial name
- NCT00565175
- Testing
- famotidine
- Where
- 5 sites in Finland
- Volunteers
- 30 people
- Sponsor
- Jesper Ekelund
Gram-Negative Bacterial Infections
Quantifying Gram-negative Resistance to Empiric Therapy in the Intensive Care Unit
Antimicrobial resistance is a global health emergency estimated to be responsible for 700,000 deaths per year worldwide, and it is well known that previous antibiotic exposure is the single most contributing factor.
- Trial name
- RESTART (NCT05171257)
- Testing
- IV antibiotic treatment from prior, differing IV antibiotic treatment
- Where
- United States
- Volunteers
- 197 people
- Sponsor
- Methodist Health System
Obesity
Effect of Intranasal Insulin on Cognitive Processes and Appetite
This study investigates the effect of intranasal insulin on cognitive processes (behavioural and neural) in healthy lean and obese female adults.
- Trial name
- NCT03632681
- Testing
- Intranasal Insulin
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Recurrent Fallopian Tube Cancer, Recurrent Ovarian Epithelial Cancer
SJG-136 in Treating Patients With Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer That Did Not Respond to Previous Treatment With Cisplatin or Carboplatin
This phase II trial is studying how well SJG-126 works in treating patients with epithelial ovarian, primary peritoneal, or fallopian tube cancer that did not respond to previous treatment with cisplatin or carboplatin.
- Conditions
- Recurrent Fallopian Tube Cancer, Recurrent Ovarian Epithelial Cancer, Recurrent Primary Peritoneal Cavity Cancer
- Trial name
- NCT01200797
- Testing
- SJG-136, laboratory biomarker analysis
- Where
- 6 sites in United States
- Volunteers
- 19 people
- Sponsor
- National Cancer Institute (NCI)
Endometriosis, Uterine Diseases
SIRT-1 Antagonism for Endometrial Receptivity
Progesterone resistance is mediated through epigenetic modification through SirT1 activation and is thought to contribute to infertility and progression of endometriosis.
- Conditions
- Endometriosis, Uterine Diseases, Endometrial Diseases, Infertility Unexplained
- Trial name
- SAFER (NCT04184323)
- Testing
- EX-527 (Selisistat)
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Depression
AZD6765 for Treatment Resistant Depression
The purpose of this study is to determine whether treatment with AZD6765 will have an antidepressant effect with patients who have treatment resistant depression.
- Trial name
- NCT00491686
- Testing
- AZD6765
- Where
- 5 sites in United States
- Volunteers
- 34 people
- Sponsor
- AstraZeneca
Treatment Resistant Disorders, Post Traumatic Stress Disorder
Investigating the Therapeutic Effects of Psilocybin in Treatment-Resistant Post-Traumatic Stress Disorder
Post-traumatic stress disorder (PTSD) is a complex disorder expressed as a variety of neurobiological symptoms, including anxiety, re-experiencing, hyperarousal, and avoidance symptoms, along with comorbidities such as anxiety…
- Trial name
- NCT05243329
- Testing
- Psilocybin
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Halucenex Life Sciences Inc.
Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma
Testing the Addition of Copanlisib to Usual Treatment (Fulvestrant and Abemaciclib) in Metastatic Breast Cancer
This phase I trial studies the effects (good and bad) of adding copanlisib to the usual therapy of fulvestrant and abemaciclib in treating patients with hormone receptor positive and HER2 negative breast cancer that has spread…
- Conditions
- Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma, Metastatic HER2-Negative Breast Carcinoma, Metastatic Hormone Receptor-Positive Breast Carcinoma
- Trial name
- NCT03939897
- Testing
- Abemaciclib, Biopsy Procedure, Biospecimen Collection
- Where
- 14 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Diabetes Mellitus Type 2
Lispro Mix 25 vs. Glargine in Type 2 Diabetics
In patients with type 2 diabetes who have not been on insulin therapy before the study will achieve better glycemic control by the treatment regiment consisting of two times daily insulin lispro mix 25 than by the treatment…
- Trial name
- IOOL (NCT00551356)
- Testing
- Insulin lispro mix 25, Glargine
- Where
- Mexico
- Volunteers
- 53 people
- Sponsor
- Eli Lilly and Company
Ovarian Cancer
Intraperitoneal tgDCC-E1 and Intravenous Paclitaxel in Women With Platinum-Resistant Ovarian Cancer
The goal of this clinical research study is to find the highest safe dose of intraperitoneal tgDCC-E1A that can be given in combination with paclitaxel as a treatment for patients with recurrent, platinum-resistant ovarian…
- Trial name
- NCT00102622
- Testing
- Intraperitoneal tgDCC-E1A, Paclitaxel
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- M.D. Anderson Cancer Center
Osteoarthritis, Knee
The Difference Between Rehabilitation With or Without Strength Training After Total Knee Replacement
Background and purpose: In the early phase after a total knee replacement (TKA), patients experience a decrease in leg muscle strength with up to about 80%.
- Trial name
- TKA (NCT01351831)
- Testing
- Rehabilitation with strength training, Rehabilitation without strength training
- Where
- Denmark
- Volunteers
- 72 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
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