Clinical trials: Treatment Resistant
Depressive Disorder, Treatment-Resistant
Glutamate and Opioid Mechanisms of Antidepressant Response to Ketamine
The overarching aim of this research is to determine the acute effects of ketamine on brain glutamate, functional connectivity and cerebral blood flow in treatment-resistant depression, explore whether the effects are attenuated…
- Trial name
- GO-MARK (NCT04977674)
- Testing
- Naltrexone, Ketamine
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- King's College London
Overactive Bladder, Incontinence, Daytime Urinary
Botulinum Neurotoxin Type A (BoNT-A) in Paediatric Non-neurogenic Therapy Resistant Overactive Bladder (OAB)
A non-intervention cohort study on the use of Botulinum Neurotoxin Type A (BoNT-A) in Paediatric Non-neurogenic Therapy Resistant Overactive Bladder (OAB). Primary endpoint was the reduction of urinary incontinence.
- Conditions
- Overactive Bladder, Incontinence, Daytime Urinary, Incontinence, Nighttime Urinary
- Trial name
- NCT06569342
- Testing
- Intradetrusor BoNT-A
- Where
- Denmark
- Volunteers
- 43 people
- Sponsor
- University of Aarhus
Glucose Metabolism Disorders, Diabetes Mellitus, Type 2
Evaluating the Efficacy and Safety of Empagliflozin Addition to Insulin and Oral Antidiabetic Medication (OAD) Regimen in Poorly Controlled Type 2 Diabetes and Obese Patient
The primary aim of this study is to assess the impact of incorporating Empagliflozin, an oral sodium-glucose co-transporter 2 (SGLT2) inhibitor, into the existing therapeutic regimen of Insulin+Metformin+Dipeptidyl peptidase 4…
- Conditions
- Glucose Metabolism Disorders, Diabetes Mellitus, Type 2, Hypoglycemic Agents, Empagliflozin
- Trial name
- NCT06145360
- Testing
- Empagliflozin 10 MG, Insulin+Metformin+DPP4 inhibitor (DPP4I)
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- SINA Health Education and Welfare Trust
Chronic Hepatitis B
Efficacy of Clevudine Plus Lamivudine for Lamivudine-resistant Chronic Hepatitis B Patients
The purpose of this study is to determine the optimal antiviral treatment for lamivudine resistant hepatitis B patients.
- Trial name
- NCT00798460
- Testing
- adefovir, clevudine, lamivudine
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Inje University
Prostate Cancer Metastatic
Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)
This is a phase 3, randomized, open-label study of opevesostat compared to alternative abiraterone acetate or enzalutamide in participants with metastatic castration-resistant prostate cancer (mCRPC) with respect to overall…
- Trial name
- OMAHA-003 (NCT06136624)
- Testing
- Opevesostat, Abiraterone acetate, Enzalutamide
- Where
- 288 sites in United States, Argentina and 34 more
- Volunteers
- 1,310 people
- Sponsor
- Merck Sharp & Dohme LLC
MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis), Diabetes Mellitus
Effect of Sinbiotic With Multispecies Probiotics on Liver Parameters Liver Enzymes, Ultrasound, Elastography and Adipokines in Same Cases) in Patients With Metabolic Associated Steatotic Liver Disease.
Scientific hypothesis: the use of a synbiotic preparation with a multi-strain probiotic in patients with MASLD can lead to a decrease in non-invasive elastographic parameters of hepatic steatosis and fibrosis and an improvement…
- Conditions
- MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis), Diabetes Mellitus, Hypertension, Hyperlipidaemia
- Trial name
- NCT07025980
- Testing
- The test product is a ready-to-use sinbiotic preparation of multispecies probiotics, ca-butyrate and FOS
- Where
- Croatia
- Volunteers
- 114 people
- Sponsor
- Eva Cubric
Prostatic Neoplasms, Castration-Resistant
64Cu-SAR-BBN and 67CU SAR-BBN for Identification and Treatment of Gastrin Releasing Peptide Receptor (GRPR)-Expressing Metastatic Castrate Resistant Prostate Cancer in Patients Who Are Ineligible for Therapy With 177Lu-PSMA-617 (COMBAT)
The aim for this study is to determine the safety and efficacy of 67Cu-SAR-BBN in participants with Gastrin Releasing Peptide Receptor (GRPR)-expressing metastatic castrate resistant prostate cancer in patients who are ineligible…
- Trial name
- COMBAT (NCT05633160)
- Testing
- 64Cu-SAR-BBN, 67Cu-SAR-BBN
- Where
- 6 sites in United States
- Volunteers
- 4 people
- Sponsor
- Clarity Pharmaceuticals Ltd
Refractory Solid Tumors
A Phase II Study of Epigenetic Therapy to Overcome Chemotherapy Resistance in Refractory Solid Tumors
Chemotherapy resistance, either innate or acquired requires for its development, expression changes on a large number of genes therefore, it has been hypothesized that epigenetic-mediated changes could be the responsible driving…
- Trial name
- NCT00404508
- Testing
- Hydralazine and magnesium valproate
- Where
- Mexico
- Volunteers
- 15 people
- Sponsor
- National Institute of Cancerología
Treatment-Resistant Depression, Treatment-resistant Depression (TRD)
Focused Ultrasound Neuromodulation in Patients With Treatment-Resistant Depression
The goal of this clinical trial is to evaluate the safety and initial effectiveness of Magnetic Resonance-guided focused ultrasound neuromodulation using the Next Generation Dome Helmet (NGDH) device in patients with…
- Trial name
- NCT07094789
- Testing
- Next Generation Dome Helmet (NGDH)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Sunnybrook Health Sciences Centre
Prostatic Neoplasms, Castration-Resistant
Efficacy of Rotations Between Abiraterone Acetate and Apalutamide in mCRPC Patients
A randomized phase II study comparing the sequential use of abiraterone followed after progression by apalutamide with alternating cycles of abiraterone and apalutamide
- Trial name
- AERA (NCT03173859)
- Testing
- Abiraterone, Apalutamide
- Sponsor
- University of Athens
HIV-1
A Phase 2B Multicenter, Randomized, Comparative Trial Of UK-453,061 Versus Etravirine In Combination With Darunavir/Ritonavir And A Nucleos(t)Ide Reverse Transcriptase Inhibitor For The Treatment Of Antiretroviral Experienced HIV-1 Infected Subjects With Evidence Of NNRTI Resistant HIV-1
This is a 96 week study to determine if UK- 453,061 in combination with Darunavir /ritonavir and a Nucleos(t)ide Reverse Transcriptase inhibitor is as efficacious, safe and tolerable as etravirine in combination with Darunavir…
- Trial name
- NCT00823979
- Testing
- UK-453,061 Dose 1, UK-453,061 Dose 2, Etravirine
- Where
- 63 sites in United States, Brazil and 11 more
- Volunteers
- 105 people
- Sponsor
- Pfizer
Hypertension
A Study to Evaluate the Efficacy and Safety of LCI699 Compared to Placebo in Participants With Resistant Hypertension
This study assessed the blood pressure effect, safety and tolerability of LCI699 compared to placebo and eplerenone in participants with resistant hypertension.
- Trial name
- NCT00817635
- Testing
- LCI699, Eplerenone
- Where
- 38 sites in United States, Iceland
- Volunteers
- 155 people
- Sponsor
- Novartis
Peritoneal Mesothelioma, Fallopian Tube Adenocarcinoma
Intraperitoneal MCY-M11 (Mesothelin-targeting CAR) for Treatment of Advanced Ovarian Cancer and Peritoneal Mesothelioma
This is a phase 1 dose escalation study to characterize the feasibility, safety and tolerability of MCY-M11 when administered as an intraperitoneal (IP) infusion for 3 weekly doses for women with platinum resistant high grade…
- Conditions
- Peritoneal Mesothelioma, Fallopian Tube Adenocarcinoma, Adenocarcinoma of the Ovary, Primary Peritoneal Carcinoma
- Trial name
- NCT03608618
- Testing
- MCY-M11, Cyclophosphamide
- Where
- 4 sites in United States
- Volunteers
- 14 people
- Sponsor
- MaxCyte, Inc.
Prostate Cancer
Efficacy Study of ABR-215050 to Treat Prostate Cancer
To investigate ABR-215050 as a possible treatment for prostate cancer.
- Trial name
- NCT00560482
- Testing
- ABR-215050, tasquinimod
- Where
- 65 sites in United States, Canada and 1 more
- Volunteers
- 206 people
- Sponsor
- Active Biotech AB
Obstructive Sleep Apnea
Comparison of Physical Activity Regimens as Treatments for Obstructive Sleep Apnea
The purpose of this study is to compare the efficacy of two different physical activity regimens as complementary or alternative treatment options for the treatment of obstructive sleep apnea.
- Trial name
- NCT00956423
- Testing
- moderate-intensity aerobic and resistance training, low-intensity stretching
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Type 2 Diabetes
Safety and Efficacy Study of Umbilical Cord/Placenta-Derived Mesenchymal Stem Cells to Treat Type 2 Diabetes
The purpose of this study is to evaluate the safety and efficacy of mesenchymal stem cells (MSCs) derived from human umbilical cord/placenta at a dose of 1.0E+6 MSC/kg for type 2 diabetes.
- Trial name
- NCT01413035
- Testing
- MSC
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shandong University
EGFR-TKI Resistant Mutation
Weekly Use First-generation EGFR-TKI in the Treatment of EGFR-TKI Acquired Resistance Non-small Cell Lung Cancer (NSCLC)
EGFR-TKI is the main is the first line therapy for local advanced or metastatic non-small cell lung cancer with EGFR gene mutation. The median progression free survival time is around 11 months with the first generation EGFR-TKI.
- Trial name
- NCT02575560
- Testing
- history data
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Qingdao Central Hospital
HIV/AIDS
Effectiveness of Intensive Adherence Counselling Among People Living With HIV/AIDS With Low-level Viraemia in Uganda.
Uganda uses a threshold of 1,000 copies/ml to determine HIV viral non-suppression among people living with HIV/AIDS (PLHIV) on treatment, which is indicative of either poor adherence or HIV virologic treatment failure; as per the…
- Trial name
- NCT05514418
- Testing
- Intensive Adherence Counselling (IAC)
- Where
- 8 sites in Uganda
- Volunteers
- 136 people
- Sponsor
- Makerere University
Obesity, Type 2 Diabetes
Hyperbaric Oxygen Therapy and Insulin Resistance (HOTAIR2) - Effect of One HBO Session.
Obesity is an epidemic in Western society and is the biggest risk factor for insulin resistance and type 2 diabetes. The investigators have recently shown that exposure to hyperbaric oxygen (HBO) leads to an increase insulin…
- Trial name
- HOTAIR2 (NCT02009813)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- Australia
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
Migraine Disorders, Chronic Migraine
Searching for Novel Biological Phenotypes in Migraine Patients Resistant to Treatments
The investigators aim to define the neurofunctional phenotype of migraine patients who did not respond to at least 3 preventive treatments, including monoclonal antibodies (mAbs) targeting calcitonin gene-related peptide (CGRP)…
- Conditions
- Migraine Disorders, Chronic Migraine, Episodic Migraine
- Trial name
- SPHERA_WP1_2 (NCT06562413)
- Testing
- MAbs
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation