Clinical trials: Treatment Resistant Depressive Disorder
Major Depressive Disorder, Deep Brain Stimulation
The Efficacy and Prediction of Deep Brain Stimulation for Treatment-resistant Depression
Several open-label trials have shown the therapeutic promise of deep brain stimulation (DBS) targeted to striatal and surrounding capsular areas in treatment-resistant depression (TRD).
- Trial name
- NCT04530942
- Testing
- Deep brain stimulation(Active)
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Ruijin Hospital
Borderline Personality Disorder
Magnetic Seizure Therapy for the Treatment of Borderline Personality Disorder
Suicide is a major public health crisis for which effective new interventions are needed. An innovative new brain stimulation technique called magnetic seizure therapy (MST) shows promise for treating suicidal thinking in…
- Trial name
- NCT03361826
- Testing
- MagPro MST with Cool TwinCoil, DBT
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- Centre for Addiction and Mental Health
Depression - Major Depressive Disorder, Treatment Resistant Depression
ipRGC as a Potential Biomarker for Predicting Transcranial Magnetic Stimulation Treatment Response in Major Depressive Disorder
This research explores the potential of retinal ganglion cells (RGCs), particularly intrinsically photosensitive RGCs (ipRGCs), as biomarkers for predicting response to transcranial magnetic stimulation (TMS) in…
- Trial name
- BRIGHT (NCT07474974)
- Testing
- Repetitive transcranial magnetic stimulation (rTMS)
- Where
- Portugal
- Volunteers
- 44 people
- Sponsor
- Polytechnic Institute of Porto
Depression
Brain Activity Changes and Treatment Response in Depressed People Who Are Receiving Antidepressant Medication
This study will examine how brain activity is affected by antidepressant treatment and how changes in brain activity relate to treatment response in people with depression.
- Trial name
- NCT00375843
- Testing
- Escitalopram, Sertraline
- Where
- 3 sites in United States
- Volunteers
- 118 people
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder
Adjunct Minocyline in Treatment-resistant Depression
This study examines the antidepressant efficacy of minocycline as an adjunct to an antidepressant standard treatment (AD-ST), for patients with unipolar major depressive disorder (MDD).
- Trial name
- Mino-TRD (NCT02456948)
- Testing
- Minocycline
- Where
- 9 sites in Germany
- Volunteers
- 168 people
- Sponsor
- Charite University, Berlin, Germany
Treatment Resistant Depression, Major Depressive Disorder
Predictors of Intravenous Ketamine Response in TRD
For patients with treatment-resistant depression (TRD), a single low dose of intravenous (IV) ketamine can help relieve symptoms as quickly as 24 hours later.
- Conditions
- Treatment Resistant Depression, Major Depressive Disorder, Bipolar Disorder
- Trial name
- NCT05625555
- Testing
- Ketamine, Midazolam
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Abraham Nunes
Treatment Resistant Depression, Depression
Ketogenic Diet for Treatment-Resistant Depression: Dietary Interventions for MEntal Health Study (DIME)
Depression is a debilitating chronic illness affecting 1 in 6 adults in the United Kingdom (UK) at any one time. Antidepressants and psychological therapy are the main treatments, but some people do not respond to these.
- Conditions
- Treatment Resistant Depression, Depression, Mental Illness, Mental Disorder
- Trial name
- DIME (NCT06091163)
- Testing
- Ketogenic Diet, Phytonutrient Diet
- Where
- United Kingdom
- Volunteers
- 88 people
- Sponsor
- University of Oxford
MDD, Treatment Resistant Depression
Three Dosing Regimens of Dextromethorphan (DXM) Reportedly Used in Major Depressive Disorder
This is an open-label dosing pilot study of 15 patients aged 18-50 years of age with diagnoses of Major Depressive Disorder (MDD) randomized to 1 of 3 treatment arms.
- Conditions
- MDD, Treatment Resistant Depression, Smoking Cessation, Smoking
- Trial name
- NCT04226352
- Testing
- Dextromethorphan
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Bipolar Depression
Brexpiprazole Treatment for Bipolar I Depression
Bipolar disorder (BD) is a frequent and lifelong recurrent mood disorder with treatment-resistant depressive episodes. Importantly, depressive symptoms and cognitive decline are major determinants of functionality and quality of…
- Trial name
- NCT04569448
- Testing
- Brexpiprazole
- Where
- 3 sites in Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Unipolar Depression
Lamotrigine Augmentation in Resistant Depression
This study is intended to evaluate the efficacy and safety of lamotrigine as an antidepressant augmentation agent in a sample of individuals with major depression and a history of both prior non-response and prospective failure…
- Trial name
- NCT00901407
- Testing
- lamotrigine, paroxetine
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Treatment Resistant Depression, Depressive Disorder, Treatment-Resistant
Long Term Follow-up of Deep Brain Stimulation for Treatment-Resistant Depression
The long term follow up of a pilot study in which the investigators proposed to test whether high frequency stimulation of the subcallosal cingulate (SCC) is a safe and efficacious antidepressant treatment in five TRD patients…
- Conditions
- Treatment Resistant Depression, Depressive Disorder, Treatment-Resistant, Depression, Bipolar
- Trial name
- NCT03360942
- Testing
- SCC DBS
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Depression, Bipolar Depression
Efficacy of Convulsive Therapies During Continuation
This trial aims to assess the efficacy and tolerability of Magnetic Seizure Therapy (MST) and two different forms of electroconvulsive therapy (ECT) in sustaining response during and after a course of continuation treatment.
- Conditions
- Depression, Bipolar Depression, Unipolar Depression, Treatment Resistant Depression
- Trial name
- CORRECT-C (NCT03711019)
- Testing
- Magnetic Seizure Therapy (MST), RUL-UB ECT, Bitemporal ECT
- Where
- 3 sites in Canada
- Volunteers
- 106 people
- Sponsor
- Centre for Addiction and Mental Health
Depressive Disorder, Treatment-Resistant
DBS for Treatment Resistant Depression
The purpose of this study is to examine the effects of sub-callosal cingulate (SCC) deep brain stimulation (DBS) in patients with treatment resistant depression (TRD).
- Trial name
- CRIO-DBS (NCT01983904)
- Testing
- deep brain stimulation with short & long pulse width
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- University of Calgary
Treatment Resistant Depression
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale…
- Trial name
- RECOVER (NCT03887715)
- Testing
- Vagus Nerve Stimulation (VNS)
- Where
- 101 sites in United States
- Volunteers
- 6,800 people
- Sponsor
- LivaNova
Depressive Disorder, Treatment-Resistant
e-PAT Neuromod Evaluation of Personalized rTMS for Resistant Depression
Although repetitive trans-cranial magnetic stimulation (rTMS) is an effective therapy for resistant depression, it still fail to remit up to 70% of these patients.
- Trial name
- NCT02410421
- Testing
- Functional magnetic resonance imaging used to individualize rTMS protocol using robotic coil positioning
- Sponsor
- University Hospital, Strasbourg, France
Treatment-resistant Depression
Action of Ketamine in Treatment-Resistant Depression
Depression carries the largest burden of all medical disorders in middle to high income countries, as determined by the World Health Organization.
- Trial name
- NCT01945047
- Testing
- Ketamine, Midazolam
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- University of Ottawa
Treatment Resistant Depression, Undergoing Deep Brain Stimulation (DBS) Surgery
Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression
Treatment resistant depression remains a major problem for individuals and society. Surgical procedures may provide relief for some of these patients.
- Trial name
- NCT03952962
- Testing
- Abbott Laboratories Infinity™ implantable deep brain stimulation system
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Nader Pouratian
Treatment Resistant Depression
The Safety and Efficacy Of Psilocybin as an Adjunctive Therapy in Participants With Treatment Resistant Depression
The Safety and Efficacy of Psilocybin as an Adjunctive Therapy in Participants with Treatment-Resistant Depression
- Trial name
- NCT04739865
- Testing
- Psilocybin
- Where
- 2 sites in United States, Ireland
- Volunteers
- 19 people
- Sponsor
- COMPASS Pathways
Treatment Resistant Depression, Elderly Depression (≥65y.o.)
Randomized Controlled Trial Testing the Efficacy of Transcranial Magnetic Stimulation by Accelerated & High-dose Theta-burst, Functional Imaging Guided, in the Treatment of Depression in Elderly Subjects With Cognitive Impairment
This trial aims at testing a new intensive, personalized functional targeting, transcranial magnetic stimulation technique for elderly patients (aged ≥ 65 years) suffering from a current treatment resistant depressive episode to…
- Trial name
- OLDEP-TBS (NCT07188753)
- Testing
- transcranial magnetic stimulation by accelerated & high-dose theta-burst, functional imaging guided, i
- Volunteers
- 186 people
- Sponsor
- Rennes University Hospital
Treatment Resistant Depression, Problem Management Plus
An Intervention Study of Anhedonia and Pain Empathy in Depression
Brain Network Mechanism of Pain Empathy and Anhedonia in Patients With Depression by Group Problem Management Plus Intervention.
- Conditions
- Treatment Resistant Depression, Problem Management Plus, Event-Related Potentials
- Trial name
- NCT05355142
- Testing
- PM+
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Anhui Medical University