Clinical trials: Treatment Resistant Depressive Disorder
Treatment-Resistant Depression
Efficacy and Safety of TAK-653 in Treatment-Resistant Depression
The purpose of this study is to evaluate the efficacy of TAK-653 compared with placebo in maintaining the effect of ketamine treatment on depressive symptoms.
- Trial name
- NCT03312894
- Testing
- TAK-653
- Sponsor
- Millennium Pharmaceuticals, Inc.
Major Depressive Disorder
Sumor as Adjuvant Therapy in Treatment-resistant Major Depression
Sumor is a food supplement that combines the main coenzymes of the S-Adenosyl methionine (SAMe) cycle, namely vitamins B6, B12 and folate, with SAMe and betaine.
- Trial name
- SUSCA (NCT04832178)
- Testing
- SUMOR
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Depressive Disorder, Treatment-Resistant, Memory Deficits
SAINT® Therapy for Memory Problems in Older Adults With Treatment-Resistant Depression
The goal of this clinical trial is to learn whether Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT®), a type of transcranial magnetic stimulation (TMS), is safe and may improve memory and thinking in adults aged…
- Trial name
- NCT07876908
- Testing
- Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT®) with the Magnus Neuromodulation System
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- BrainHealth Solutions, Inc.
MDD, Major Depressive Disorder
rTMS Therapy for Treatment-Resistant Depression With Different Targets Guided by pBFS
To explore the effectiveness and safety of rTMS intervention with different targets in the left prefrontal cortex defined using the pBFS method, in adult patients with moderate and severe depressive disorder.
- Conditions
- MDD, Major Depressive Disorder, Treatment Resistant Depression
- Trial name
- NCT06095778
- Testing
- active rTMS
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Changping Laboratory
Major Depressive Disorder
E-field Guided iTBS for Treatment Resistant Depression
The purpose of this study is to establish how personalization of repetitive transcranial magnetic stimulation (rTMS) can change markers of brain activity and improve treatment response.
- Trial name
- NCT05583747
- Testing
- iTBS
- Where
- 2 sites in Canada
- Volunteers
- 110 people
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder, Treatment Resistant Depression
Sustained Mood Improvement With Laughing Gas Exposure
Multi-centre, parallel group, blinded, 1:1 randomized controlled trial to determine the effect of nitrous oxide on reducing symptoms of depression in patients with treatment resistant depression.
- Trial name
- SMILE (NCT07262008)
- Testing
- Inhalation of Nitrous oxide (Laughing gas) + intravenous saline, inhalation of %100 oxygen + intravenous midazolam
- Where
- 5 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Women's College Hospital
Memory Deficits, Electroconvulsive Therapy
Cognitive Training for Memory Deficits Associated With Electroconvulsive Therapy
Although electroconvulsive therapy (ECT) remains the most effective treatment for people with severe depression, patients may experience a significant degree of persistent and/or permanent memory problems following ECT.
- Trial name
- NCT01876758
- Testing
- Cognitive Intervention: Memory Training, Comparable general mental stimulation
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- New York State Psychiatric Institute
Treatment Resistant Depression
Comparison of Antidepressant Augmentation With Amantadine vs Pramipexole vs Quetiapine in Treatment Resistant Depression
The present study has been designed to compare the efficacy and safety of augmentation of SSRIs with Amantadine vs Pramipexole vs the recommended Quetiapine augmentation in Treatment-Resistant Depression (TRD) and correlate the…
- Trial name
- APQ-TRD (NCT04936126)
- Testing
- Quetiapine, Amantadine, Pramipexole
- Where
- India
- Volunteers
- 150 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Major Depression
Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression
The purpose of this multi-site randomized controlled trial is to evaluate the efficacy and risks of psilocybin for the treatment of depression in U.S.
- Trial name
- PIVOT (NCT07226232)
- Testing
- Psilocybin
- Where
- 5 sites in United States
- Volunteers
- 240 people
- Sponsor
- VA Office of Research and Development
Treatment Resistant Depression
Working Mechanisms and Effectiveness of IV Ketamine-assisted Psychotherapy on Depression in TRD Clients
Ketamine-Assisted Psychotherapy (KAP) is an innovative treatment that combines intravenous ketamine with psychotherapy in a carefully monitored clinical setting.
- Trial name
- NCT07706478
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- Senz
Major Depressive Disorder (MDD), Treatment Resistant Depression (TRD)
Ketogenic Diet and Neuromodulation in Treatment Resistant Depression
The goal of this clinical trial is to learn if combining a ketogenic diet with a personalized, accelerated brain stimulation treatment (iTBS) works better than iTBS with a standard healthy diet to reduce depression symptoms in…
- Trial name
- ALIGN (NCT07376018)
- Testing
- Accelerated Intermittent Theta Burst Stimulation (iTBS), Ketogenic Diet, Canadian Food Guide-Aligned Diet
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Depression
A Study to Evaluate the Efficacy, Safety and Tolerability of Fixed Doses of Intranasal Esketamine in Japanese Participants With Treatment Resistant Depression
The purpose of this study is to evaluate the efficacy of fixed dosed intranasal esketamine compared to intranasal placebo, as an add-on to an oral antidepressant in Japanese participants with treatment-resistant depression (TRD)…
- Trial name
- NCT02918318
- Testing
- Intranasal esketamine (28 mg), Intranasal esketamine (56 mg), Intranasal esketamine (84 mg)
- Where
- 43 sites in Japan
- Volunteers
- 202 people
- Sponsor
- Janssen Pharmaceutical K.K.
Treatment Resistant Depression
IV Ketamine vs. IN Esketamine for MDD TRD
The goal of this observational study is to learn about the comparative acute effects of ketamine vs esketamine in participants over the age of 18 for the treatment of their severe depression and suicidal ideations.
- Trial name
- NCT06488586
- Testing
- Low dose IV Ketamine vs. IN Esketamine
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Gustavo Vazquez
Major Depressive Disorder
Closed-Loop Deep Brain Stimulation for Major Depression
Neurons are specialized types of cells that are responsible for carrying out the functions of the brain. Neurons communicate with electrical signals. In diseases such as major depression this electrical communication can go awry.
- Trial name
- PReSiDio (NCT04004169)
- Testing
- Stimulation-ON, Stimulation-OFF, Stimulation-ON Active Control
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Andrew Krystal
Treatment-Resistant Depression
Functional and Neurochemical Correlates of Treatment Response in Major Depressive Disorder
This is an ancillary study to a clinical trial that is being conducted at Massachusetts General Hospital. Investigators at MGH are conducting a clinical trial to test the efficacy of ziprasidone together with escitalopram for…
- Trial name
- NCT01598324
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mclean Hospital
Depression
A Study of RO4917523 in Patients With Treatment Resistant Depression
This study will evaluate the safety, tolerability and efficacy of RO4917523, in comparison to placebo, in patients with treatment-resistant depression.
- Trial name
- NCT00809562
- Testing
- RO4917523
- Where
- 9 sites in United States
- Volunteers
- 46 people
- Sponsor
- Hoffmann-La Roche
Bipolar Disorder
Magnetic Seizure Therapy in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TRD)
The purpose of this study is to compare the efficacy and side effects magnetic seizure therapy (MST) and electroconvulsive therapy (ECT) in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TRD).
- Trial name
- NCT04080778
- Testing
- magnetic seizure therapy (MST), electroconvulsive therapy (ECT)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Joao L. DeQuevedo
Treatment Resistant Depression (TRD), Depression - Major Depressive Disorder
2-Year Study of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression: Clinical Outcomes and Policy Recommendation
The goal of this observational study is to evaluate whether vagus nerve stimulation (VNS) intervention can reduce depressive symptoms and suicidality in adults with higher-grade treatment-resistant depression (HG-TRD)-individuals…
- Conditions
- Treatment Resistant Depression (TRD), Depression - Major Depressive Disorder, Bipolar Depression
- Trial name
- VNS TRD HG-TRD (NCT07097025)
- Testing
- vagus nerve stimulation
- Where
- 2 sites in Israel
- Volunteers
- 19 people
- Sponsor
- Dr.Yoav Domany
Major Depression
Transcranial Magnetic Stimulation (rTMS) Accelerates the Response to Escitalopram in Major Depression
A doubleblind randomised trial with active versus sham rTMS in combination with escitalopram in patients with prior treatment resistant depression in an acute 12 weeks trial with subsequent 24 weeks study phase with active versus…
- Trial name
- NCT00149071
- Testing
- rTMS, TMS
- Where
- Denmark
- Volunteers
- 61 people
- Sponsor
- Hillerod Hospital, Denmark
Major Depressive Disorder
Aripiprazole Augmentation of SSRI Therapy in Treatment Refractory Depression
Our target population will have been adequately treated with one of three selective serotonin reuptake inhibitors (SSRIs; escitalopram, citalopram, or sertraline) for at least 8-12 weeks and continue to experience symptoms of…
- Trial name
- NCT00608543
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Texas Southwestern Medical Center