Clinical trials: Treatment With Proton Beam Radiation Therapy
Helicobacter Pylori Infection
Lactobacillus Reuteri ProGastria in Helicobacter Pylori-infected Adult Subjects on Proton Pump Inhibitors
The purpose of the study is to confirm that simultaneous use of L. reuteri ProGastria and omeprazole for 28 days can eradicate H. pylori in humans in the absence of antibiotics.
- Trial name
- NCT01456728
- Testing
- Progastria
- Where
- Bulgaria
- Volunteers
- 56 people
- Sponsor
- St Marina University Hospital, Varna, Bulgaria
Chordoma, Tumor
Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Chordoma of the Skull Base
This study is a prospective randomised clinical phase III trial. The primary objective of this study is to evaluate, if the innovative therapy (carbon ion irradiation) in chordomas is superior to the standard proton treatment…
- Conditions
- Chordoma, Tumor, Treatment
- Trial name
- HIT-1 (NCT01182779)
- Testing
- Carbon ion, Protons
- Where
- Germany
- Volunteers
- 319 people
- Sponsor
- Heidelberg University
Prostate Cancer
Radiation Therapy in Treating Patients With Stage I or Stage II Prostate Cancer
RATIONALE: Radiation therapy uses high energy x-rays to damage tumor cells. PURPOSE: Randomized phase III trial to compare the effectiveness of conventional radiation therapy with high-dose radiation therapy in treating men with…
- Trial name
- NCT00002703
- Testing
- high-LET heavy ion therapy, low-LET photon therapy
- Where
- 2 sites in United States
- Volunteers
- 390 people
- Sponsor
- Proton Radiation Oncology Group
High Risk of Recurrence
Innovative Diagnosis and Therapy in LDLT Patients With High-risk Hepatocellular Carcinoma
The challenge of LDLT to HCC is that tumors with a high risk of recurrence have a high rate of recurrence after liver transplantation, and there is no appropriate treatment to prevent HCC recurrence after transplantation in these…
- Trial name
- NCT06327269
- Testing
- Lenvatinib 10 mg
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital
Resectable Lung Non-Small Cell Carcinoma
Proton Beam Radiation Therapy After Treatment for Resected N2 Non-Small Cell Lung Cancer
This clinical trial tests proton beam radiation therapy in patients with non-small cell lung cancer who have undergone surgical resection and have lymph nodes involving the middle of the chest.
- Trial name
- NCT06008730
- Testing
- Biospecimen Collection, Proton Beam Radiation Therapy, Radiology, Treatment Planning
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Emory University
Upper Gastrointestinal Bleeding
Anticoagulation With Enhanced Gastrointestinal Safety (AEGIS) Trial
This is a pragmatic, single center, feasibility pilot cluster randomized trial with embedded individual randomization to evaluate implementation strategies to increase the use of evidence-based practices to reduce upper…
- Trial name
- AEGIS (NCT05085405)
- Testing
- Clinician notification, Clinician Notification with Nurse Facilitation, Clinician Notification / Patient Activation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Michigan
Locally Advanced Pancreatic Cancer
Phase I Nab-Paclitaxel Plus Gemcitabine With Proton Therapy for Locally Advanced Pancreatic Cancer (LAPC)
The purpose of this study is to determine the maximum tolerated dose of the chemotherapy drugs nab-paclitaxel and gemcitabine when combined with hypofractionated ablative proton therapy for the treatment of locally advanced…
- Trial name
- NCT03652428
- Testing
- Gemcitabine, Hypofractionated Ablative Proton Therapy
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of Maryland, Baltimore
Glioblastoma
Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma
This randomized phase II trial studies how well dose-escalated photon intensity-modulated radiation therapy (IMRT) or proton beam radiation therapy works compared with standard-dose radiation therapy when given with temozolomide…
- Trial name
- NCT02179086
- Testing
- Photon Beam Radiation Therapy, Proton Beam Radiation Therapy, Temozolomide
- Where
- 237 sites in United States, Canada
- Volunteers
- 624 people
- Sponsor
- NRG Oncology
Glioma
Proton vs. Photon Radiotherapy for Patients With WHO Grade 2-3 Glioma
Patients with grade 2 and 3 gliomas who received photon radiation therapy as part of their standard treatment are at risk of developing cognitive impairments, depending on the tumor's location and the size of the target volume.
- Trial name
- GliProPh (NCT07750457)
- Testing
- Proton therapy, Photon therapy
- Where
- 2 sites in Germany
- Volunteers
- 80 people
- Sponsor
- University Hospital, Essen
Peptic Ulcer Hemorrhage
Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding
A large dose of PPI is effective in preventing peptic ulcer rebleeding. The investigators hypothesize that 40 mg/q6h pantoloc is equivalent to 8mg/h pantoloc in preventing rebleeding.
- Trial name
- PPI (NCT00731601)
- Testing
- pantoprazole
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Lotung Poh-Ai Hospital
Prostate Cancer
Semen Analysis After Proton Therapy for Prostate Cancer
The purpose of this study is to evaluate semen for changes following treatment with proton radiation therapy.
- Trial name
- PR08 (NCT01072513)
- Testing
- Semen analysis
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Florida
Proton Pump Inhibitor
Evaluation of the Long-term Tolerance of Proton Pump Inhibitor (PPI) Discontinuation in Geriatric Patients Treated With Long-term Therapy Without a Recognized Indication
Proton pump inhibitors (PPIs) are widely prescribed in France as anti-ulcer drugs. The indications currently approved in France, with variations according to molecules, are as follows: eradication of Helicobacter pylori, active…
- Trial name
- EGERIPP 2 (NCT03980899)
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Peptic Ulcers
Oral Versus IV Proton Pump Inhibitor in High-risk Bleeding Peptic Ulcers After Endoscopic Hemostasis
Endoscopic hemostasis has been documented by a number of clinical studies to be effective in decreasing rebleeding, need for emergency surgery, and hospitalization days.
- Trial name
- NCT01182597
- Testing
- Pantoprazole (Pantoloc), Lansoprazole (Takepron OD)
- Where
- 2 sites in Taiwan
- Volunteers
- 190 people
- Sponsor
- National Taiwan University Hospital
Positive Helicobacter Pylori Serology, Coronary Thrombosis
Effectiveness of the Eradication of Helicobacter Pylori and an Inhibitor of Pump With Proton Versus Control
Low dose of aspirin is the main cause of gastro-duodenal ulcer. The best prevention is not definite particularly in patients without history of ulcer and infected by H.
- Conditions
- Positive Helicobacter Pylori Serology, Coronary Thrombosis, Supra-aortic Artery Thrombosis
- Trial name
- Aspylori (NCT00713947)
- Testing
- during one week for the active treatments, Pantoprazole
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Barretts Esophagus With Low Grade Dysplasia
Argon Plasma Coagulation for Barrett's Esophagus
Background and study aims. To evaluate the impact of power setting and proton pump inhibitor (PPI) dose on the efficacy and safety of argon plasma coagulation (APC) of Barrett's esophagus (BE) with low-grade dysplasia (LGD).
- Trial name
- NCT04154748
- Testing
- Argon Plasma Coagulation 90W power, Argon Plasma Coagulation 60W power, Omeprazole 120 mg
- Volunteers
- 71 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology