Clinical trials: Treatment for Opioid Use Disorder
Standard of Care, Standard of Care + CBT4CBT
An Integrated Intervention Involving Recovery Coaching and Cognitive Behavioral Therapy for Opioid Use Disorder
The Overcome II study is a randomized controlled trial among adults receiving sublingual buprenorphine to help prevent or reduce illicit drug use.
- Conditions
- Standard of Care, Standard of Care + CBT4CBT, Standard of Care + CBT4CBT + RC
- Trial name
- OVERCOME 2 (NCT06102200)
- Testing
- CBT4CBT, RC, Sandard of care
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Prisma Health-Upstate
Colorectal Disorders, Anorectal Disorder
A Multimodal Enhanced Recovery Program in Anorectal Surgery
The goal of this study is to establish whether an opioid-sparing Enhanced Recovery After Surgery (ERAS) program in ambulatory anorectal surgery can be safely introduced at a single tertiary referral center without an increase in…
- Conditions
- Colorectal Disorders, Anorectal Disorder, Patient Satisfaction, Pain, Postoperative
- Trial name
- ARSE (NCT03992079)
- Testing
- ReCOVER Enhanced Recovery Protocol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Columbia University
Opioid-use Disorder
Evaluating Adaptive Dispenser Initiation Protocols for MySafeRx During Post-detox Buprenorphine Treatment- a Pilot Study
Opioid overdoses are a significant problem nationwide and novel interventions that can prevent overdose by improving buprenorphine treatment for opioid use disorder are a public health priority.
- Trial name
- NCT04449744
- Testing
- MySafeRx Inspire Plus, MySafeRx Inspire Flex
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Opiate Substitution Treatment
Extended-release Pharmacotherapy for Opioid Use Disorder
The primary objective is a clinical superiority effectiveness contrast to standard of care. Reported following SPIRIT and CONSORT standards, the study will determine whether extended-release injectable depot Buprenorphine…
- Trial name
- EXPO (NCT05164549)
- Testing
- Buprenorphine Injectable Product, Methadone, Buprenorphine
- Where
- 5 sites in United Kingdom
- Volunteers
- 342 people
- Sponsor
- King's College London
Opioid Use Disorder
Peer-led, Mobile App Supported Linkage to Opioid Use Disorder Treatment
This is the third phase of the mPeer4Life study - the Trial Phase, will be evaluating the intervention that was developed based on the Formative and Pilot Phases.
- Trial name
- mPeer4Life (NCT07900828)
- Testing
- Mobile phone-assisted intervention, Peer navigator, Standard of care referral for out-patient MAT
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Johns Hopkins University
Chronic Pain, Analgesics, Opioid
Tapering From Long-term Opioid Therapy in Chronic Pain Population. Randomized Controlled Trial With 12 Months Follow up
This randomized controlled study compares tapering of long-term opioid therapy in a population with chronic non-cancer pain with control group constituted of waiting list.
- Conditions
- Chronic Pain, Analgesics, Opioid, Opioid Withdrawal, Opioid Use
- Trial name
- TOPIO (NCT03485430)
- Testing
- Tapering
- Where
- 3 sites in Sweden
- Volunteers
- 140 people
- Sponsor
- Lund University Hospital
Substance Abuse, Criminal Behavior
Feasibility of Mobile and Technology Assisted Aftercare Services for Crisis Stabilization Units
In this study investigators are examining the feasibility and acceptability of an expanded and technology-assisted aftercare program with persons released from a crisis stabilization unit (CSU) who were brought to the CSU by…
- Conditions
- Substance Abuse, Criminal Behavior, Mental Disorder
- Trial name
- NCT04899934
- Testing
- mobile and technology assisted aftercare, Treatment as usual
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Florida State University
Opioid-use Disorder, Substance Use Disorders
Patient-Centered Care for Opioid Use Disorders in Federally Qualified Healthcare Centers and Specialty Care Settings
This study evaluates the effectiveness of integrating empirically-supported treatments for an opioid use disorder into a primary care setting.
- Trial name
- NCT03367234
- Testing
- Individual Therapy Sessions, Cognitive Behavioral Therapy (CBT), Medication-Assisted Treatment
- Sponsor
- Public Health Management Corporation
Opioid Use Disorder
Patient Decision Aid for Opioid Use Disorder
The aim of the study is to test the effectiveness of the Patient Decision Aid for Opioid Use Disorder (PtDA-MAT) by conducting a stepped-wedge cluster-randomized trial in CA H\&SS (stratified by rural vs.
- Trial name
- PtDA-MAT (NCT03568552)
- Testing
- Patient Decision Aid
- Where
- United States
- Volunteers
- 7,554 people
- Sponsor
- University of California, Los Angeles
Depression, Anxiety
Microcurrent Neurofeedback as an Adjunct to Standard Care for Substance Use Disorders
The goal of this clinical trial is to learn whether adding Microcurrent Neurofeedback (MCN) to standard residential treatment helps adults with substance use disorder more than standard treatment alone.
- Conditions
- Depression, Anxiety, Substance Use Disorder (SUD), Post Traumatic Stress Disorder
- Trial name
- NCT07737652
- Testing
- Microcurrent Neurofeedback (MCN), Standard Care for Substance Use Disorder
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Alabama, Tuscaloosa
Opioid Use Disorder
Computerized Anxiety Sensitivity Treatment for Opioid Use Disorders
The primary aim of the current project is to test the acceptability and feasibility of a computerized intervention, titled Computerized Anxiety Sensitivity Treatment (CAST), delivered to Veterans seeking treatment for an opioid…
- Trial name
- CAST-O (NCT03944850)
- Testing
- Computerized Anxiety Sensitivity Treatment
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Southeast Louisiana Veterans Health Care System
Opioid Use Disorder
A Stepped-Wedge Cluster Randomized Trial of a Digital App to Support Medication-Assisted Treatment in Individuals With Opioid Use Disorder
The goal of this clinical trial is to learn if a mobile health app called Recovery Connect can help people stay in treatment for opioid use disorder.
- Trial name
- SMART-OUD (NCT07140926)
- Testing
- Recovery Connect
- Where
- 9 sites in United States
- Volunteers
- 1,524 people
- Sponsor
- Bright Therapeutics
Opioid Use Disorder, Peer Recovery Supporters
Peer Recovery Support for Opioid Use Disorder Treatment Retention
The goal of this clinical trial is to learn whether adding peer recovery support services to standard opioid use disorder (OUD) treatment in primary care helps patients stay in treatment longer.
- Conditions
- Opioid Use Disorder, Peer Recovery Supporters, Peer Recovery Coaching, Primary Care
- Trial name
- NCT07620171
- Testing
- Peer Support
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Opioid Use Disorder
Light Needle for Opioid Use Disorder
This randomized-controlled study investigates the effect of adjuvant light needle in the treatment of heroin addicts. One hundred heroin addicts older than 20 years old enrolled from the Addiction Treatment Center at Kaohsiung…
- Trial name
- OUD (NCT05341219)
- Testing
- Light needle therapy
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
Opioid Use Disorder, Fentanyl
Comparing Outpatient Treatment Retention Among Individuals Using Fentanyl Randomized to Low-dose and Direct-to-inject Buprenorphine Initiation
The goal of this pragmatic randomized controlled trial is to compare treatment outcomes of two strategies for initiating buprenorphine treatment (low-dose initiation and direct-to-inject) in adults with opioid use disorder (OUD)…
- Trial name
- COPILOT (NCT07469501)
- Testing
- Injectable buprenorphine, Sublingual Buprenorphine (SUBOXONE, Zubsolv, or generic tablets)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Chronic Pain, Pain, Musculoskeletal
Physical Therapy Integrated With Mindfulness for Patients With Chronic Pain and Opioid Treatment
This study will use multiple methods to assess the feasibility of conducting a fully powered multisite clinical trial to test the effectiveness of integrating mindfulness-based interventions into physical therapy for patients…
- Conditions
- Chronic Pain, Pain, Musculoskeletal, Opioid Use, Physical Therapy
- Trial name
- PT-IN-MIND (NCT05875207)
- Testing
- Mindfulness based practice, Control/Standard Physical Therapy
- Where
- 2 sites in United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Utah
Usage of Prescription Opioids
Determining Genetic Biomarkers Predictive of the Development of Prescription Opioid Addiction
This is a clinical study on patients who have been prescribed opioids (narcotic pain relievers) for the treatment of pain, to determine what genetic factors influence outcome of treatment.
- Trial name
- NCT01562353
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Analgesic Solutions
Opioid-use Disorder
Treatment for Opiate Addiction: Prognostic fActors of Responsiveness to Maintenance Treatment
A global and integrative treatment of opioid-use disorders (OUD) with opiate maintenance therapy (OMT) and psychosocial interventions is recommended by all current guidelines.
- Trial name
- TOPAZE (NCT03729388)
- Testing
- Prognosis factor associated with good outcome.
- Where
- 2 sites in France
- Volunteers
- 29 people
- Sponsor
- Nantes University Hospital
Opioid-use Disorder
Feasibility of Pediatric Emergency Department-Initiated Treatment for Adolescents With Opioid Use Disorder
ED-initiated buprenorphine with brief intervention and facilitated referral to treatment has been shown to be highly successful in increasing treatment engagement rates and reducing opioid use among adults.
- Trial name
- PEDsTREATOUD (NCT04737603)
- Testing
- ED-Initiated treatment with buprenorphine / naloxone
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Davis
Human Immunodeficiency Virus, Opioid Use Disorder
Combined Injectable Treatment for HIV and OUD
This is study seeks to evaluate perspectives of a combined injectable treatment for HIV and OUD. Specifically, with the development of new long-acting medications such as cabotegravir co-administered with rilpivirine (CAB/RPV)…
- Trial name
- CHOICE (NCT05991622)
- Testing
- Combined LAI Treatment: Cabenuva and Sublocade
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rhode Island Hospital