Clinical trials: Treatment for Opioid Use Disorder
Opioid Use Disorder, Treatment Adherence
Digital Health Intervention to Support Opioid Use Disorder Treatment
In prior studies, the investigative team developed a combined computer- and text message-delivered personalized-feedback intervention (iENDURE) designed to enhance motivation and improve tolerance of distress to support the early…
- Trial name
- iENDURE (NCT03842384)
- Testing
- iENDURE
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Cannabis Use Disorder, Stimulant Use Disorder
Emotional Brain Training for Addiction Medicine Treatment - A Pilot Study
The goal of this clinical trial is to determine whether Emotional Brain Training (EBT), a behavioral modification method, can help manage stress and health problems related to addiction.
- Conditions
- Cannabis Use Disorder, Stimulant Use Disorder, Opioid Use Disorder, Tobacco Use Disorder
- Trial name
- NCT07001371
- Testing
- Emotional Brain Training, Standard addiction counseling and medical therapy
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Loma Linda University
Cancer Pain, Opioid Use
Psychological Intervention Using Smartphone Technology to Alleviate Malignant Pain
The purpose of this study is to develop and pilot test a novel medical intervention (STAMP+CBT app) that will help patients track their pain, mood, opioid use and side effects while delivering tailored education and…
- Conditions
- Cancer Pain, Opioid Use, Cognitive Behavior Therapy
- Trial name
- STAMP+CBT (NCT05774197)
- Testing
- Cognitive Behavioral Therapy for pain
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Oklahoma
Opioid-use Disorder
reSET-O RCT (Randomized Controlled Trial)
This randomized controlled trial research study will be evaluating an app, reSET-O, owned by Pear Therapeutics, Inc., to evaluate treatment retention rates in individuals with opioid use disorder after initiating medication…
- Trial name
- NCT04129580
- Testing
- reSET-O app
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Milton S. Hershey Medical Center
Post Traumatic Stress Disorder, Opioid-use Disorder
Prolonged Exposure Therapy for PTSD and Opioid Use Disorder
Among patients with opioid use disorder (OUD), 90% report lifetime trauma exposure and 33% meet criteria for posttraumatic stress disorder (PTSD).
- Trial name
- NCT04104022
- Testing
- Prolonged Exposure Therapy, Attendance-based monetary incentives
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Vermont
Opioid-use Disorder, Medication Adherence
CoMBAT Opioid Use Disorder: A Combined Medication and Behavioral Activation Treatment for People Living With Opioid Use Disorder
This study seeks primarily to test, in a two-arm randomized controlled trial (RCT), the feasibility, acceptability, and preliminary efficacy of CoMBAT OUD, an intervention that integrates Behavioral Activation (BA) and substance…
- Conditions
- Opioid-use Disorder, Medication Adherence, Health Care Utilization
- Trial name
- CoMBAT_OUD (NCT04240093)
- Testing
- Behavioral Activation (BA) Therapy, Substance Abuse and Health Navigation Counseling, Medications for Opioid Use Disorder
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Brown University
Opioid Withdrawal, Opioid Use Disorder (OUD)
Sparrow Link Neuromodulation Device for Opioid Withdrawal Management in Hospitalized Adults With Opioid Use Disorder
This study is evaluating the Sparrow Link, a wearable device that delivers gentle electrical signals to nerves in the outer ear (a technique known as transcutaneous auricular neurostimulation, or tAN).
- Trial name
- NCT07079826
- Testing
- Sparrow Link (Active tAN)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Payel Roy
HIV, Drug Addiction
Treating South African Pregnant Women for Methamphetamine
The purpose of this study was to develop and initially evaluate an efficacious, comprehensive, culturally sensitive, women-centered model of care for pregnant South African women by adapting and refining PI Jones'…
- Trial name
- NCT01386138
- Testing
- Psycho-education, Experimental
- Where
- South Africa
- Volunteers
- 60 people
- Sponsor
- RTI International
Opioid Use Disorder, Stimulant Use Disorder
Suvorexant for Opioid/Stimulant Co-use
This study will evaluate whether Suvorexant 20mg reduces drug use and craving, and improves sleep and stress among persons with co-occurring opioid use disorder and stimulant use disorder.
- Trial name
- NCT05546515
- Testing
- Suvorexant (dual orexin receptor antagonist)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Opioid Use Disorder, Chronic Pain
Pain Self-Management and Patient-Oriented Dosing for Pain and in Retention Opioid Treatment
This study seeks to improve the treatment of chronic pain in people who are taking buprenorphine (also known as Suboxone, Subutex, Zubsolv).
- Trial name
- TREETOP (NCT06367387)
- Testing
- Patient-Oriented Dosing (POD), Pain Self-Management (PSM), Usual Care
- Where
- 13 sites in United States
- Volunteers
- 273 people
- Sponsor
- Erin Winstanley
Opioid-use Disorder
Mobile Medication Adherence Platform for Buprenorphine-Naloxone During Treatment of Opioid Use Disorder: Phase I Study
The investigators will conduct a phase I study involving 41 participants selected randomly among patients prescribed buprenorphine-naloxone for opioid misuse as a feasibility trial of the study of the Pillsy device.
- Trial name
- MAP4BUP (NCT04656899)
- Testing
- Reminders messages to improve adherence.
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Washington State University
Opioid Use Disorder
NET Device for Treating Opioid Use Disorder
This prospective, randomized, double-blind, parallel-group, sham-controlled, superiority study will evaluate the effectiveness of the NET Device in treating persons with Opioid Use Disorder (OUD) without use of Medications for…
- Trial name
- NCT04916600
- Testing
- NET
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Wayne State University
Drug Interaction, Analgesics
Drug-drug Interaction Study of Lemborexant as an Adjunctive Treatment for Buprenorphine/Naloxone for Opioid Use Disorder
The purpose of this research study is to test the safety, tolerability, drug interactions with buprenorphine-naloxone, and effectiveness lemborexant when used to treat Opioid Use Disorder.
- Conditions
- Drug Interaction, Analgesics, Opioid Use Disorder
- Trial name
- NCT04818086
- Testing
- Lemborexant, Buprenorphine-naloxone
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Virginia Commonwealth University
Opioid Use Disorder, Opioid Use
HMP for Addictions Study
The goal of this clinical trial is to see whether the Healthy Minds Program for Addictions could be used to help veterans with moderate-severe opioid use disorder and post-traumatic stress disorder stay on buprenorphine…
- Conditions
- Opioid Use Disorder, Opioid Use, Buprenorphine Dependence
- Trial name
- NCT06063499
- Testing
- Healthy Minds Program for Addictions
- Sponsor
- University of Wisconsin, Madison
Opioid Use Disorder
Supporting Treatment for Opioids and Recovery Capital (STORC) - R61 Phase
We are studying whether training an identified support person and providing patient navigation (i.e. a peer recovery specialist assisting you with finding the right support) after delivery can increase "recovery capital"-the…
- Trial name
- STORC R61 (NCT07787039)
- Testing
- STORC
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Friends Research Institute, Inc.
Opioid-use Disorder, Chronic Pain
Advancing STOP: Self-regulation Therapy for Opioid Addiction and Pain
The public health relevance of this proposed project is substantial given the current opioid abuse epidemic as identified by the Centers for Disease Control (CDC).
- Trial name
- NCT03363243
- Testing
- STOP Therapy Treatment group, Treatment as usual (TAU) group
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Colorado, Denver
Opioid Use Disorder
Expanding the Youth Opioid Recovery Support (YORS) Intervention for MOUD Adherence to Adolescents With OUD
Despite rising rates of fatal opioid overdoses in the United States, adolescents with OUD are far less likely than adults to receive and be retained on medication for opioid use disorder (MOUD).
- Trial name
- YORS (NCT06774248)
- Testing
- Youth Opioid Recovery Support (YORS)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Potomac Health Foundations
Opioid-use Disorder, Depression, Anxiety
Transcranial Photobiomodulation for the Treatment of Opioid Cravings
The investigators wish to test the hypothesis that transcranial photobiomodulation (tPBM) (i.e., 4-minutes of 810nm near-infrared light at 250 mW/cm2 by LED to the forehead at F3 or F4 versus an indistinguishable placebo…
- Conditions
- Opioid-use Disorder, Depression, Anxiety, Craving
- Trial name
- NCT04417738
- Testing
- unilateral transcranial photobiomodulation, near infrared mode
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- MindLight, LLC
Community Reinforcement And Family Training, Family Health
Phase II: Scalable Digital Delivery of CRAFT Training for Professionals to Maximize Treatment Rates of OUD in Families
The goal of this project is to demonstrate digital training efficacy at scale and commercial readiness. This pilot project will advance piloted digital training programs for CRAFT and maximize scalability.
- Conditions
- Community Reinforcement And Family Training, Family Health, Substance-Related Disorders
- Trial name
- NCT06685003
- Testing
- Digital Tutorial overview, Digital Tutorial plus training Materials, Digital Tutorial plus training Materials plus feedback and Coaching
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- We The Village, Inc.
Opioid-use Disorder, Addiction
Competitive Revision for CLARO: Collaboration Leading to Addiction Treatment and Recovery From Other Stresses
The purpose of this study is to develop and then test an enhanced version of the parent study's collaborative care intervention for co-occurring disorders (CC-COD) to reduce the risk of suicide and overdose among individuals with…
- Conditions
- Opioid-use Disorder, Addiction, Depression, Post Traumatic Stress Disorder
- Trial name
- NCT04634279
- Testing
- Collaborative care Plus
- Where
- 12 sites in United States
- Volunteers
- 68 people
- Sponsor
- RAND