Clinical trials: Treatment of Bleeding
Bleeding Ulcer
Platelet Rich Plasma in Bleeding Peptic Ulcer
The most common cause of acute upper gastrointestinal bleeding (UGIB) is non-variceal, where peptic ulcer bleeding (PUB) remains the single most common cause, accounting for 25% to 67% of the causes of non-variceal upper…
- Trial name
- PRP (NCT03733171)
- Testing
- PLATELET RICH PLASMA, diluted epinephrine, hemoclips
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Zagazig University
Idiopathic Thrombocytopenic Purpura, Thrombocytopenia
Romiplostim (AMG 531) Versus Medical Standard of Care for Immune (Idiopathic) Thrombocytopenic Purpura
This is a phase 3b, multi-center, randomized, Standard of Care (SOC)-controlled, open-label, 52-week treatment study to compare romiplostim to medical SOC for Idiopathic Thrombocytopenia Purpura (ITP), with a 6-month Safety…
- Conditions
- Idiopathic Thrombocytopenic Purpura, Thrombocytopenia, Thrombocytopenia in Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP), Thrombocytopenic Purpura
- Trial name
- NCT00415532
- Testing
- Medical Standard of Care for ITP, Romiplostim
- Volunteers
- 234 people
- Sponsor
- Amgen
Hemophilia A, Hemophilia B
Study of the Efficacy and Safety PF-06741086 in Adult and Teenage Participants With Severe Hemophilia A or Moderately Severe to Severe Hemophilia B
Treatment with PF-06741086 is anticipated to demonstrate a clinically relevant advantage and/or a major contribution to patient care in comparison to current methods of treatment for hemophilia A or B because it works differently…
- Trial name
- NCT03938792
- Testing
- PF-06741086
- Where
- 62 sites in United States, Bulgaria and 18 more
- Volunteers
- 188 people
- Sponsor
- Pfizer
Periodontal Disease
Periodontal Disease Treatment of a Physically Challenged Population
Many physically handicapped patients at the dental department, Toronto Rehabilitation Institute(TRI) have considerable gingival inflammation and breath odour because of the inability to effectively handle a toothbrush.
- Trial name
- PDT (NCT01718912)
- Testing
- metronidazole-nystatin oral rinse
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Oravital Inc
Urge Incontinence, Overactive Bladder
The Effect of Local Anesthetic Solution in the Bladder Prior to Botox Injections in the Bladder
The purpose of this study is to investigate the effect of Lidocaine solution versus placebo (isotonic Sodium Chloride NaCl) disposed inside the urinary bladder as intravesical anesthesia prior to onabotulinum toxin A injections…
- Conditions
- Urge Incontinence, Overactive Bladder, Anesthesia, Local, Pain, Procedural
- Trial name
- NCT05415865
- Testing
- Alkalinized Lidocaine
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Herlev and Gentofte Hospital
Aneurysmal Subarachnoid Hemorrhage
Clazosentan in Reducing Vasospasm-related Morbidity and All-cause Mortality in Adult Patients With Aneurysmal Subarachnoid Hemorrhage Treated by Surgical Clipping
The aim of this study is to demonstrate that clazosentan, administered as a continuous intravenous infusion at 5 mg/h until Day 14 post aneurysmal subarachnoid hemorrhage (aSAH), reduces the incidence of cerebral vasospasm…
- Trial name
- CONSCIOUS-2 (NCT00558311)
- Testing
- Clazosentan
- Where
- 117 sites in United States, Australia and 27 more
- Volunteers
- 1,157 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Atrial Fibrillation
A Real-World Comparison of Safety and Effectiveness of Novel Oral Anti-Coagulant (NOAC) Naïve and Warfarin Naïve Non-Valvular Atrial Fibrillation (NVAF) Patients With Medicare Advantage Coverage
The primary purpose of this study is to evaluate the risk of major bleeding and stroke/systemic embolism (SE) among novel oral anti-coagulant (OAC) naïve and warfarin naïve Medicare Advantage patients with non-valvular atrial…
- Trial name
- NCT03189069
- Testing
- Apixaban, Dabigatran, Rivaroxaban
- Volunteers
- 36,000 people
- Sponsor
- Bristol-Myers Squibb
Atrial Fibrillation, Atrial Appendage
Assessment of Dual Antiplatelet Therapy Versus Rivaroxaban In Atrial Fibrillation Patients Treated With Left Atrial Appendage Closure
Evaluation of 2 doses of rivaroxaban (10 and 15 mg) compared to dual anti platelet therapy (aspirin+clopidogrel) after left atrial appendage closure.
- Conditions
- Atrial Fibrillation, Atrial Appendage, Hemorrhage
- Trial name
- ADRIFT (NCT03273322)
- Testing
- Rivaroxaban 10 mg qd, Rivaroxaban 15 mg qd, DAPT
- Where
- France
- Volunteers
- 105 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Subarachnoid Hemorrhage
S100B Kinetic During the Occurrence and Treatment of Delayed Cerebral Ischaemia After a Subarachnoid Haemorrhage.
Nearly half of the survivors of subarachnoid haemorrhage (SAH) retain irreversible neurological damage resulting from the early lesions associated with the initial bleeding, and the occurrence of possible delayed cerebral…
- Trial name
- SKinDCI (NCT04795362)
- Testing
- blood sample
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Cerebral Vasospasm
Milrinone in Addition to Hyperdynamic Therapy in the Treatment of Vasospasm Following Aneurysmal Subarachnoid Hemorrhage
The purpose of this study is to evaluate the usefulness of adding Milrinone to the current standard treatment for cerebral vasospasm.
- Trial name
- NCT02712788
- Testing
- Milrinone
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Indiana University
Liver Cirrhosis
Evaluation of Gastrointestinal Transit Pre and Pos Treatment With Non Selective Betablocker in a Population of Cirrhotics
The purpose of this study is to evaluate the influence of non betablockers in gastrointestinal motility (transit time) in patients with liver cirrhosis.
- Trial name
- NCT02923336
- Testing
- non selective beta blocker
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- ALDO TORRE DELGADILLO
Coronary Occlusion/Thrombosis, Peptic Ulcer Hemorrhage
Systematic Screening for Risk-factors for Ulcer Bleeding Before Anti-thrombotic Treatment
In a prospective randomised study design to investigate, if a systematic risk factor screening for bleeding ulcer in patients, who following percutaneous coronary intervention (PCI) commence a one year combination treatment with…
- Trial name
- NCT01447498
- Testing
- Screening for risk factors for ulcer bleeding
- Where
- Denmark
- Volunteers
- 2,024 people
- Sponsor
- Odense University Hospital
Postmenopause
Endometrial Safety Study
The study is designed to investigate the safety of the investigational product for the lining of the uterus (endometrium).
- Trial name
- NCT00522873
- Testing
- 0.25mg DRSP / 0.5mg E2 (BAY86-4891), 0.5mg NETA / 1.0mg E2 (Activella)
- Where
- 59 sites in United States, Argentina and 6 more
- Volunteers
- 662 people
- Sponsor
- Bayer
Pain, Postoperative, Postoperative Hemorrhage
The Effect of Topical Administration of Common Drugs on Postoperative Bleeding and Pain
After surgical procedures, interventions to reduce postoperative pain and bleeding are of great importance. In this study, the effect will be investigated of smearing common drugs, which are designed for injection, directly onto…
- Trial name
- NCT01964781
- Testing
- Tranexamic Acid, Bupivacaine, Adrenaline
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- St. Olavs Hospital
Acute Bleeding Esophageal Varices, Portal Hypertension
A Trial of Somatostatin With Endoscopic Variceal Ligation (EVL) in Control of Acute Variceal Bleeding
Background: Efficacy of endoscopic variceal sclerotherapy in achieving initial control of acute variceal bleeding and five-day haemostasis has been shown to significantly improve when vasoactive drug is added.
- Conditions
- Acute Bleeding Esophageal Varices, Portal Hypertension, Cirrhosis
- Trial name
- AVB-EVL+S (NCT01267669)
- Testing
- Somatostatin
- Where
- India
- Volunteers
- 61 people
- Sponsor
- Govind Ballabh Pant Hospital
Venous Thromboembolism
Comparison of Bleeding Risk Between Rivaroxaban and Apixaban: The Pilot Study
This vanguard pilot study compares rivaroxaban and apixaban, two of the new oral blood thinners for the treatment of blood clots. Half of the patients will receive apixaban and half will receive rivaroxaban.
- Trial name
- COBRRA Pilot (NCT02559856)
- Testing
- Apixaban, Rivaroxaban
- Where
- 4 sites in Canada
- Volunteers
- 71 people
- Sponsor
- Ottawa Hospital Research Institute
Immune Thrombocytopenia
TPO-RA Treatment on Immune Tolerance Induction of ITP Patients With Sustained Platelet Recovery After Treatment Termination
The aim of this study was to observe whether maintaining a high level of platelet count after TPO-RA in patients with primary immune thrombocytopenia (ITP) can induce immune tolerance, develop immune balance in ITP patients, and…
- Trial name
- NCT06478537
- Testing
- Hetrombopag Olamine, Aspirin
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Peking Union Medical College Hospital
Cirrhosis, Esophageal and Gastric Varices
Efficacy of Rifaximin in Treatment of Cirrhotic Gastroesophageal Variceal Bleeding
The purpose of the study is to evaluate the efficacy of Rifaximin in the treatment of cirrhotic gastroesophageal variceal bleeding.
- Conditions
- Cirrhosis, Esophageal and Gastric Varices, Gastrointestinal Hemorrhage
- Trial name
- EoR-GEVB (NCT02964195)
- Testing
- Rifaximin
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Shanghai Zhongshan Hospital
Haemorrhage, Haemostasis
TachoSil® Versus Standard Haemostatic Treatment of Haemorrhage in Cardiovascular Surgery (TC-023-IM)
To demonstrate efficacy and safety of TachoSil® in cardiovascular surgery
- Conditions
- Haemorrhage, Haemostasis, Cardiovascular Surgery
- Trial name
- NCT00440401
- Testing
- fibrinogen (human) + thrombin (human), Standard haemostatic treatment in cardiovascular surgery
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Nycomed
Bleeding of Subgingival Space
Treatment of Peri-implant Mucositis on Incongruous Dental Prostheses Versus Congruous
The aim of the present study was to test the hypothesis that non-surgical periodontal therapy on peri-implant mucositis resolution results in a greater clinical improvement in patients with congruous versus non-congruous single…
- Trial name
- NCT05923554
- Testing
- Changes in Probing Depth to non-surgical periodontal therapy
- Where
- Italy
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Catania