Clinical trials: Treatment of Periodontitis
Periodontal Diseases, Periodontitis
Clinical Study of a Formulation Containing Phtalox® in Periodontal Disease
Periodontitis is a chronic and destructive inflammation that leads to the loss of tissue supporting the teeth, the periodontium, and possibly tooth loss and edentulism.
- Conditions
- Periodontal Diseases, Periodontitis, Bone Loss
- Trial name
- NCT05119283
- Testing
- Scraping and straightening of the crown and root and rinsing with mouthwashes
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade Federal de Alfenas
Apical Periodontitis, Inflammatory Markers
The Efficacy of Two Different Irrigation Methods on PGE2, NO and IL-6 Levels
Today, debates about the effectiveness of Passive Ultrasonic Irrigation (PUI) and Sonically Activated Irrigation (SAI) techniques used to increase the success of endodontic treatment in chronic apical periodontitis (AP) are still…
- Trial name
- NCT06629545
- Testing
- irrigation activation with PUI, irrigation with sonic activation
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Chronic Periodontitis
Clinical Efficacy Of 810 Nanometer Diode Laser As An Adjunct To Mechanical Periodontal Treatment Of Residual Periodontal Pockets
Background: Aim of this randomized controlled parallel-designed study was to evaluate the effects of diode laser as an adjunct to mechanical periodontal treatment on clinical parameters and gingival crevicular fluid (GCF) volume…
- Trial name
- NCT02531555
- Testing
- 810 Nanometer Wavelenght GaAlAs Diode Laser, Gracey curettes
- Where
- Turkey (Türkiye)
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Marmara University
Periodontitis
Effect of Spirulina on Periodontitis
The purpose of this study is to assess the clinical and immunological effect of spirulina in treatment of stage II periodontitis.
- Trial name
- NCT06016933
- Testing
- spirulina gel, SRP of all teeth
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Kafrelsheikh University
Parodontitis
Periodontal Gel in NSPT
This retrospective case series included patients with stage II/III periodontitis treated with non-surgical periodontal therapy combined with a topical postbiotic gel.
- Trial name
- NCT07534449
- Testing
- Periodontal Gel as an Adjunct to NSPT
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- University of Roma La Sapienza
Biomarkers
Accuracy of Host-derived Biomarkers in Diagnosing Symptomatic and Asymptomatic Apical Periodontitis
Apical lesions usually present clinically as a chronic infection, remaining as asymptomatic apical periodontitis(AAP). Because the balance among inflammation and bacteria is a dynamic process, AAP may undergo an acute…
- Trial name
- NCT06187324
- Testing
- biomarkers
- Where
- Iraq
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Periodontitis, Adult, Periodontitis
Evaluation of Changes in Oral Health-related Quality of Life During the Treatment of Periodontitis.
Periodontitis is a chronic inflammatory disease affecting the supporting tissues of the teeth and may negatively affect patients' oral health-related quality of life.
- Conditions
- Periodontitis, Adult, Periodontitis, Oral Disease, Quality of Life
- Trial name
- PAROQoL (NCT07868042)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Periodontitis
Photodynamic Therapy Plus Root Debridement in Gum Disease Treatment V2
Gum disease is a common disease, which affects 45% of the UK adult dentate population. It is caused by bacteria in dental plaque, which produces inflammation and a deepening of the natural crevice between the gum and the tooth…
- Trial name
- PDTV2 (NCT03270254)
- Testing
- light activated dye photodynamic therapy (PDT)
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Periodontitis
Efficacy of Azithromycin as an Adjunct to Non-Surgical Periodontal Treatment
This study evaluates the effect of the systemic administration of azithromycin as a therapy associated with non-surgical periodontal treatment, in the clinical and microbiological variables of patients with Severe Periodontitis…
- Trial name
- NCT03629288
- Testing
- Lactose tab, Azithromycin
- Where
- Chile
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Andres Bello
Diabetes Mellitus, Periodontitis
Effect of Antioxidant Intake on Resistin Levels In Patients With Gum Disease and Diabetes
To evaluate the effectiveness of non surgical periodontal therapy in addition to antioxidant(ALA) on resistin levels in patients with type 2 diabetes and periodontal disease
- Trial name
- EARGD (NCT02775266)
- Testing
- Alpha lipoic acid, Scaling and Root planing
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Periodontitis
Effects of PRF and i-PRF on Clinical and Biochemical Parameters in Non-Surgical Periodontal Therapy
The goal of this clinical trial is to learn if adding platelet-rich fibrin (PRF) or injectable platelet-rich fibrin (i-PRF), obtained from the participant's own blood, to standard non-surgical periodontal treatment helps improve…
- Trial name
- PRF-NSPT (NCT07525531)
- Testing
- Non-surgical periodontal therapy (NSPT), Platelet-rich fibrin (PRF), Injectable platelet-rich fibrin (i-PRF)
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Arthritis, Rheumatoid, Periodontitis
Periodontal Therapy in Patients With Rheumatoid Arthritis
Aim: A prospective randomized, controlled clinical trial comparing two groups of a cohort of Rheumatoid Arthritis (RA) patients with periodontal disease will be carried out to identify if the effect of non-surgical periodontal…
- Trial name
- NCT05502601
- Testing
- Non-surgical periodontal treatment
- Where
- Peru
- Volunteers
- 42 people
- Sponsor
- Federal University of Rio Grande do Sul
Peridontal Disease, Furcation Defects
PRF Versus Emdogain for Class II Furcation Defects of Mandibular Molars
This study evaluated the regenerative potential of platelet-rich fibrin (PRF) compared with enamel matrix derivative (Emdogain®) in the surgical treatment of Class II (F2) furcation defects of mandibular molars.
- Trial name
- NCT07841301
- Testing
- Platelet rich fibrin, Emdogain
- Where
- Bulgaria
- Volunteers
- 21 people
- Sponsor
- Medical University of Sofia
Periodontal Diseases, Periodontitis
Inflammation-resolution Therapy in MINST of Periodontal Intrabony Defect: a Pilot Randomised Controlled Trial
The aim of this study is to assess whether and how a mouthwash containing an ingredient that reduces inflammation in combination with a recently developed treatment is more effective at improving advanced gum disease.
- Trial name
- AIRTIM (NCT07203872)
- Testing
- IsoDent Paro Strong (Isodent Ltd. Valtakatu 4 D, 96100 Rovaniemi, Finland) mouthwash
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Periodontitis, Diabetes Mellitus, Type 2
Effect of Periodontal Treatment on Adipokine Levels
The present study aimed to determine the effect of non-surgical periodontal treatment (NSPT) on serum and salivary adipokine and interleukin-1β levels in periodontitis patients with or without type 2 Diabetes Mellitus (T2DM).
- Trial name
- NCT06225154
- Testing
- Non-surgical periodontal treatment
- Where
- 2 sites in Finland, Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Marmara University
Periodontal Diseases
Treatment of Advanced Periodontitis Using an Oscillating Chitosan Device Versus Regular Curettes Alone
40 patients diagnosed with localised periodontitis will be included at each center, 20 patients will be treated with the control treatment, 20 patients will be treated by test treatment.
- Trial name
- NCT04173156
- Testing
- Labrida Bioclean, Gracey Periodontal curettes
- Where
- 3 sites in Norway, Turkey (Türkiye)
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Labrida AS
Periodontal Diseases
Controlled Study Comparing REPaiR® and MIST Therapies for Treatment of Periodontitis
A comparison of laser (REPaiR) compared with minimally invasive surgical therapy for moderate to severe periodontal disease.
- Trial name
- NCT04169139
- Testing
- MIST (minimally invasive surgical therapy)
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- McGuire Institute
Periodontitis, Periodontal Pocket
Ultrasonic Versus Ultrasonic+ for Effective Sanative Therapy
Periodontitis is a chronic oral infection that results in the breakdown of connective tissue and alveolar bone that support the teeth.
- Trial name
- NCT03074565
- Testing
- Ultrasonic alone, Ultrasonic+
- Where
- 2 sites in Canada
- Volunteers
- 42 people
- Sponsor
- Brock University
Root Canal Sealers, Post Operative Pain
Evaluation of Post Obturation Pain Associated With Calcium Hydroxide-based Root Canal Sealers and Resin-based Root Canal Sealer: a Single Visit Root Canal Treatment
The objective of this study is to evaluate the post obturation pain associated with calcium hydroxide-based root canal sealer and resin-based root canal sealer after single visit root canal treatment following endodontic…
- Conditions
- Root Canal Sealers, Post Operative Pain, Irreversible Pulpitis
- Trial name
- NCT06798467
- Testing
- Endodontic sealer, post obturation pain
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jinnah Sindh Medical University
Chronic Periodontitis
Randomized Clinical Trial of Enamel Matrix Derivative: Radiographic Analysis
This is a split-mouth, double-blind randomized controlled trial. Computerized linear radiographic measurements were used to detect infrabony defects treated with open flap debridement (OFD) or OFD associated with enamel matrix…
- Trial name
- NCT02195765
- Testing
- enamel matrix derivative, Open flap debridement
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- University of Sao Paulo
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