Clinical trials: Treatment of Periodontitis
Periodontitis, Fistula
Evaluation of Photodynamic Therapy in Pieces With Presence of Fistula.
The goal of this clinical trial is to learn if adjuvant antimicrobial photodynamic therapy (aPDT) can help in the treatment in patients with pieces with apical periodontitis and the presence of fistula, in terms of reducing…
- Trial name
- aPDT (NCT06413836)
- Testing
- aPDT, Endodontic treatment
- Where
- Uruguay
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Chronic Periodontitis
Evaluation of Antimicrobial Photodynamic Therapy in Multiple Applications as a Coadjuvant in the Surgical Therapy of Access to Scaling
Chronic periodontitis is an infectious disease resulting in inflammation of the teeth support structures, progressive periodontal attachment loss and bone loss.
- Trial name
- NCT03498404
- Testing
- Photodynamic Therapy, scaling and root planing
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Periodontitis
Effectiveness of Periodontal Therapy on Periodontal Bacteria
In light of the controversy that are already approved but that however still exists regarding the efficacy and influence of the protocols for the management of Periodontitis, the aim of this study was to evaluate, at 6 months…
- Trial name
- NCT04735692
- Testing
- Full mouth or quadrant SRP
- Where
- Italy
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Catania
Periodontitis
Effect of Novel Oral Hygiene Regimen on Non-surgical Treatment of Stage II and III Periodontitis
Achievement of adequate oral hygiene standards is critical to the successful treatment of gum disease. The improvement of the patient's adherence to good oral hygiene is of great importance to obtain the satisfactory treatment…
- Trial name
- NCT05137392
- Testing
- oral hygiene instruction
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Apical Periodontitis, Coronary Artery Disease
hsCRP & CH Indices in Patients With Coronary Artery Disease With and Without Apical Periodontitis
Endodontic treatment is done in Patients with chronic pulp exposure in patients with Coronary Artery Disease and systemic inflammatory markers recorded before and and after treatment and compared with patients with Coronary…
- Trial name
- NCT06270693
- Testing
- Endodontic treatment
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis (Stage 3), Minimally Invasive Surgical Procedures
Bone Substitutes and NIPSA in Intrabony Periodontal Defects: A Randomized Controlled Trial
This multicenter randomized controlled clinical trial aims to compare the clinical, radiographic, microbiological and molecular outcomes of two collagenated xenogeneic bone substitutes (GTO® and GenOs®) used in combination with…
- Conditions
- Periodontitis (Stage 3), Minimally Invasive Surgical Procedures, Bone Substitutes
- Trial name
- NCT07671963
- Testing
- GTO® with NIPSA surgical approach, GenOs® + NIPSA
- Where
- 2 sites in Italy, Serbia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Periodontal Disease, Diabetes Mellitus, Type 2
Serum Hs-CRP in Periodontitis Patients With or Without Diabetes
the aim of this study was to assess serum levels of high sensitivity c reactive protein in periodontitis patients with and without type 2 diabetes in a trial to analyze its prognostic effect following non-surgical periodontal…
- Trial name
- NCT03908606
- Testing
- Scaling and root planing
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis
Impact of C-reactive Protein on Non Surgical Periodontal Treatment
In light of the controversy that are already approved but that however still exists regarding the efficacy and influence the management of Periodontitis, the aim of this study was to evaluates, at 12-months follow-up, the…
- Trial name
- NCT05836298
- Testing
- Non-surgical periodontal treatment
- Where
- Italy
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Catania
Periodontitis
Impact of Periodontal Bacteria on the Effectiveness of Periodontal Therapy
In light of the controversy that are already approved but that however still exists regarding the efficacy and influence of the protocols for the management of periodontitis, the aim of this study was to evaluate, at 6 months…
- Trial name
- NCT05558293
- Testing
- Scaling and root planing
- Where
- Italy
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Catania
Chronic Periodontitis, Probiotics
Adjunctive Probiotics in Chronic Periodontitis
This study will assess clinical and microbiological efficacy of probiotics and antibiotics in patients of chronic periodontitis as an adjunctive to scaling and root planing (SRP) in reducing bacterial count and in improving…
- Trial name
- NCT03499184
- Testing
- P Flor locally delivered, P Flor systemically administered, Amoxil 500 mg Oral Capsule
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ziauddin Hospital
Diabetes Mellitus, Type II, Periodontitis
Impact of Periodontal Therapy on Patients With Diabetes
With poorly controlled diabetes, periodontal status often worsens, and with severe periodontal conditions there is often poorer glycemic control.
- Trial name
- DMRCT (NCT04830969)
- Testing
- Chlorhexidine gluconate oral rinse, Scaling & Root Planing, Soft Picks
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- State University of New York at Buffalo
Chronic Periodontitis
Effect of Tooth Cleaning in Smokers and Non Smokers With Gum Disease.
This study is intended to measure hepatocyte growth factor levels in smokers and non smokers with periodontitis before and after non surgical periodontal therapy.
- Trial name
- ETCSNSGD (NCT02930356)
- Testing
- NSPT, Scaling and root planing
- Volunteers
- 40 people
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Periodontitis
Assessment the Efficacy of Curcumin Local Delivery Gel in Treatment of Periodontitis in Smokers
Smokers usually respond less favourably to non-surgical periodontal treatment compared to non-smokers. Numerous studies reported that smoker patients exhibited less reduction in probing depth and less gains in clinical attachment…
- Trial name
- NCT06653231
- Testing
- local delivery of Curcumin gel
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis, Periodontal Diseases
Clinical and Radiographic Evaluation of PPF With or Without NCHA Bone in Treatment of Intrabony Defects
This study is meant to assess clinically and radiographically the possible predictable results regarding the use of nanocrystalline hydroxyapatite bone graft substitute together with papilla preservation flap versus papilla…
- Conditions
- Periodontitis, Periodontal Diseases, Periodontal Pocket, Intrabony Periodontal Defect
- Trial name
- NCT03588507
- Testing
- PPF+NCHA bone graft substitute
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cairo University
Apical Periodontitis
Effect of Intraorifice Barrier on Healing of Apical Periodontitis
Based on various in-vitro studies intraorifice barrier has been suggested as an effective mean to provide seal against coronal microleakage.
- Trial name
- NCT03409887
- Testing
- Intraorifice barrier of GIC, Base of GIC, Direct composite restoration
- Volunteers
- 75 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periapical Periodontitis, Polymerase Chain Reaction
Quantitative Assessment of the Efficacy of Two Irrigation Activation Systems
Aim of the present study was to determine the intraradicular microbiota of previously root canal-treated teeth with apical periodontitis using droplet digital polymerase chain reaction (ddPCR) and to investigate the antibacterial…
- Conditions
- Periapical Periodontitis, Polymerase Chain Reaction, Enterococcus Faecalis Infection, Irrigation Activation
- Trial name
- NCT05690763
- Testing
- XP-endo Finisher to use irrigation activation, EndoActivator to use irrigation activation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Seyda Ersahan, DDS, PhD
Aggressive Periodontitis
The Affect of Orthodontic Treatment on the Periodontal Status of Patients With Aggressive Periodontitis
Orthodontic Treatment will affect the periodontal status of periodontally treated Aggressive Periodontitis patients.
- Trial name
- NCT01510808
- Testing
- orthodontic treatment
- Where
- Israel
- Volunteers
- 25 people
- Sponsor
- Hadassah Medical Organization
Periodontitis
Polynucleotide + Hyaluronic Acid Gel With Xenogeneic Graft for Intrabony Periodontal Defects
Over the last 30 years, the prevalence of periodontitis (PE) has increased substantially, including among younger populations, highlighting the need to improve the management of this condition as a chronic disease and to develop…
- Trial name
- NCT07522684
- Testing
- Polynucleotide and hyaluronic acid-based gel, Control, Xenogeneic bone graft
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- University of Sao Paulo
Periodontitis, Hyaluronic Acid
Adjunctive Use Of A Novel Hyaluronic Acid/Chlorhexidine Gel In The Non Surgical Treatment Of Periodontitis
General Objective : To evaluate the outcome of non surgical periodontal therapy with local drug delivery adjunct to scaling and root planning Specific Objective : To determine the effect of intra-pocket application of hyaluronic…
- Conditions
- Periodontitis, Hyaluronic Acid, Chlorhexidine
- Trial name
- NCT05682833
- Testing
- Non surgical periodontal therapy
- Where
- United Arab Emirates
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sharjah
Apical Periodontitis, Postoperative Pain
Sealers in Chronic Apical Lesions
This clinical study evaluated whether different root canal sealers influence postoperative pain and early periapical healing in patients with apical periodontitis.
- Conditions
- Apical Periodontitis, Postoperative Pain, Periapical Healing
- Trial name
- NCT07339579
- Testing
- Root Canal Treatment With Sealapex, Root Canal Treatment With MTA Fillapex, Root Canal Treatment With AH Plus
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Kahramanmaras Sutcu Imam University
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