Clinical trials: Treatment of Periodontitis
Chronic Periodontitis
Evaluation of Antimicrobial Photodynamic Therapy as an Adjunct to Periodontal Treatment in Smokers
The study proposes to assess the effect of multiple applications of antimicrobial Photodynamic Therapy (aPDT) as an adjunct to non-surgical periodontal treatment (nsPT) in smokers without use of antibiotics.
- Trial name
- NCT03039244
- Testing
- Photodynamic therapy, Control Group, Diode Laser
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Periodontitis, Periodontal Pocket
Efficacy of Amoxicillin-metronidazole Compared to Clindamycin in Patients With Periodontitis and Diabetes
Periodontitis is an inflammation of the supporting structures of the teeth, usually caused by specific or groups of microorganisms that results in the progressive destruction of the periodontal ligament and alveolar bone.
- Conditions
- Periodontitis, Periodontal Pocket, Diabetes Mellitus
- Trial name
- NCT03374176
- Testing
- Amoxicillin 500 mg / Metronidazole 250 mg, Clindamycin 300 mg
- Volunteers
- 42 people
- Sponsor
- Centro Universitario de Tonalá
Periodontitis
Performance of the Treatment of Periodontitis According to the Bioperio® Protocol
This multicenter, prospective, single-arm observational study evaluated the clinical performance of the Bioperio® protocol, a standardized, patient-centered framework for managing periodontitis.
- Trial name
- BIOPERIO (NCT07507474)
- Testing
- Periodontal non surgical treatment, Oral Hygiene Instructions, Surgical Periodontal Treatment
- Where
- Italy
- Volunteers
- 5,000 people
- Sponsor
- University of Pisa
Apical Periodontitis, Postoperative Pain
Effectiveness of Different Obturation Techniques
Aim: Evaluation of the effect of different obturation techniques on postoperative pain level and radiographic healing on non-surgical endodontic retreatment (NSER) applied in a single visit in teeth with single root canal and…
- Conditions
- Apical Periodontitis, Postoperative Pain, Endodontically Treated Teeth
- Trial name
- NCT06226740
- Testing
- Single Visit Non Surgical Root Canal Treatment Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Periodontitis
Clinical and Immunological Evaluation of HA in Treatment of Periodontitis
To evaluate the immunological effectiveness of Hyaluronic acid as adjunction treatment to scaling and root planning and scaling and root planning alone. Comparison between clinical measurement before and after treatment.
- Trial name
- NCT06324474
- Testing
- Hyaluronic acid, scaling and root planning
- Where
- Yemen
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sana'a University
Periodontitis
Effect of Intensive Periodontal Therapy on Vascular Function
The hypothesis of the existence of a causal association between the systemic infectious/inflammatory burden represented by periodontitis and endothelial function assessed by flow mediated dilatation of the brachial artery (FMD)…
- Trial name
- NCT00327561
- Testing
- Intensive periodontal therapy, Community based periodontal therapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 120 people
- Sponsor
- Eastman Dental Insitute and Hospital
Endodontic Disease, Periodontitis
Endo-perio Disease - Treatment Outcomes Using Conventional and Hydraulic Calcium Silicate Sealer With or Without LPRF
The endodontic periodontal-disease is characterized by the involvement of the pulp and periodontal disease in the same tooth. The anatomic connections between the dental pulp and the periodontium provide a pathway for perio-endo…
- Trial name
- NCT05681754
- Testing
- Experimental: RCT using hydraulic calcium silicate sealer and L-PRF + GTR, Experimental: RCT using conventional sealer and L-PRF + GTR, Experimental: RCT using hydraulic calcium silicate sealer and GTR
- Where
- United Kingdom
- Volunteers
- 115 people
- Sponsor
- King's College London
Periodontal Pocket, Pain
The Use of Submucosal Dexamethasone After Periodontal Surgery
The aim of this study is to evaluate the effectiveness of submucosal 8 mg (2 mL) dexamethasone on postoperative pain, swelling, chewing efficiency, trismus, healing, and discomfort after periodontal flap surgery
- Conditions
- Periodontal Pocket, Pain, Swelling/ Edema, Patient Satisfaction
- Trial name
- NCT06119893
- Testing
- submucosal 8 mg (2 mL) dexamethasone application, submucosal 2 mL 0.9% isotonic sodium chloride application
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Periodontitis
Evaluating the Efficacy of Resveratrol Containing Mouthwash as Adjunct Treatment Periodontitis:
To evaluate the effectiveness of resveratrol mouthwash as adjunct to NSP treatment of periodontitis
- Trial name
- resveratrol (NCT05874882)
- Testing
- resveratrol mouthwash as adjunct to scaling and root planing in periodontitis patients, chlorhexidine mouthwash as adjunct to scaling and root planing in periodontitis patients
- Where
- Iraq
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Periodontal Diseases, Chronic Periodontitis
Photodynamic Therapy During Supportive Periodontal Therapy
27 subjects on SPT, each with at least two residual pockets ≥5mm, were recruited for this randomised, split-mouth controlled trial, providing a total of 72 sites.
- Conditions
- Periodontal Diseases, Chronic Periodontitis, Periodontal Attachment Loss
- Trial name
- NCT02666573
- Testing
- Fotosan 630, CMS Dental, Copenhagen, Denmark, Scaling and root planing
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Periodontal Diseases
Minimally Invasive Non Surgical Therapy Versus Conventional Scaling and Root Planing for Treatment of Periodontitis
Minimally invasive non-surgical therapy (MINST) is a new approach towards regeneration of deep periodontal defects. Important part of MINST procedure, besides usage of magnification loupes and piezo-electric devices seems to be…
- Trial name
- MINST (NCT04036513)
- Testing
- MINST, Conventional SRP
- Where
- Slovenia
- Volunteers
- 20 people
- Sponsor
- University of Ljubljana
Peridontal Disease, Rheumatic Arthritis
Nonsurgical Periodontal Treatment Combined With Anti-TNF-α in Patients With Rheumatoid Arthritis and Periodontitis
Periodontitis is a multifactorial disease of the periodontium that can lead to destruction of the alveolar bone and supporting connective tissue and subsequent tooth loss.
- Trial name
- NCT06818045
- Testing
- Non Surgical Periodontal Treatment, Periodontal measurements will be performed, biochemical measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Hatice Yemenoğlu
Periodontal Diseases
Bone Remodeling and Non-surgical Periodontal Therapy
Previous studied have investigated the pathophysiological role and expression of Cathepsin K (Ctsk) , receptor activator of the NF-κB ligand (RANKL) and periostin in active periodontitis and peri-implantitis lesions.
- Trial name
- NCT05636683
- Testing
- Root surface debridement
- Where
- Iraq
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Chronic Periodontitis, Diabetes Mellitus
Chemerin and IL-6 Levels in Diabetes and Periodontitis
The aims of the present study were to determine the gingival crevicular fluid (GCF) chemerin and interleukin-6 (IL-6) levels and to analyse the relationship between chemerin and IL-6 in periodontal health and in chronic…
- Trial name
- NCT02596581
- Testing
- non-surgical periodontal treatment
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Pulp Necrosis, Apical Periodontitis
Antibacterial Efficacy and Outcomes of Root Canal Irrigation Methods
This randomized clinical trial aims to evaluate the antibacterial efficacy and treatment outcomes of three different final irrigation protocols during root canal therapy: 2.5% sodium hypochlorite alone, sodium hypochlorite with…
- Conditions
- Pulp Necrosis, Apical Periodontitis, Endodontic Treatment
- Trial name
- ENDOABG (NCT06959602)
- Testing
- Final Irrigation with 2.5% Sodium Hypochlorite, Passive Ultrasonic Irrigation (PUI) with Sodium Hypochlorite, XP-Endo Finisher Activation with Sodium Hypochlorite
- Where
- Greece
- Volunteers
- 66 people
- Sponsor
- National and Kapodistrian University of Athens
Periodontitis
Study of Scaling and Root Planing With PerioWave Versus Scaling and Root Planing Alone in Chronic Periodontitis
This study is to determine whether scaling and root planing (SRP) followed by photodynamic disinfection results in improved outcomes that persist over time in adults with chronic periodontitis when compared with subjects with SRP…
- Trial name
- NCT00297531
- Testing
- PerioWave, Scaling and Root Planing
- Where
- 4 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Ondine Research Laboratories
Periodontal Pocket, Peri-implantitis
Treatment of Periodontal and Peri-Implant Pockets With a Novel Collagen Hydrogel, H42 Medical Device
A retrospective, observational, non-profit study designed to evaluate the use of the H42 medical device in patients with periodontitis or peri-implantitis.
- Trial name
- H42 (NCT07700628)
- Where
- 3 sites in Italy
- Volunteers
- 52 people
- Sponsor
- Studio Odontoiatrico Dott. G. Tarquini
Diabetes, Gingivitis
Study on Periodontal Treatment in Diabetic Patients
Diabetes is a metabolic disorder that affects the uptake of glucose into cells. This causes a cascade of systemic alterations that may lead to kidney failure, cardiovascular complications, altered tissue healing, retinopathies…
- Conditions
- Diabetes, Gingivitis, Periodontitis
- Trial name
- NCT01271231
- Testing
- Scaling and root planing plus azythromycin, Prophylaxis plus azythromycin
- Where
- Colombia
- Volunteers
- 90 people
- Sponsor
- Universidad de Antioquia
Intra-bony Pockets, Periodontitis
Biologicals in Management of Intra-Bony Defects
The aim is of this study is to evaluate and compare the effects (clinical and radiological) of different biomaterials on the repair of bone defects around the teeth.
- Trial name
- NCT07292870
- Testing
- Minimally invasive surgical treatment of the intra-bony defects, Use of the xenograft Bio-Oss® Collagen during the surgery, Use of enamel matrix derivative (Emdogain®)
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Periodontitis Chronic Generalized Severe, Intrabony Periodontal Defect
Clinical and Radiograhic Evaluation of NIPSA With and Without Allograft Plus Platelet Rich Fibrin in the Treatment of Intraosseous Defects in Stage III Periodontitis Patients
Several minimal invasive techniques have been proposed since the last decade aiming to enhance and provide adequate environment for periodontal regeneration.
- Trial name
- NCT04444063
- Testing
- Non-Incised Papilla Surgical Approach
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
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