Clinical trials: Treatment of Periodontitis
Periodontal Diseases, Periodontal Inflammation
Minimally Non Surgical Periodontal Therapy Compared to Traditional Approach
This study aims to evaluate the clinical results of non-surgical periodontal therapy performed with micro-instruments compared to traditional approach (standard curettes) after 6 months of follow-up.
- Trial name
- NCT05060601
- Testing
- Gracey micro-curettes, Standard Gracey curettes
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federico II University
Periapical Periodontitis, Periapical Abscess
A Retrospective Cohort Study on the Non-Surgical Treatment of Periapical Inflammatory Lesions With Vitapex Paste
Background: Periapical inflammation is a common clinical condition, classified into periapical periodontitis, periapical granuloma, and periapical cyst.
- Conditions
- Periapical Periodontitis, Periapical Abscess, Periapical Radiolucency
- Trial name
- NCT07907367
- Testing
- Vitapex Paste
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The Affiliated Hospital of Jinggangshan University
Asymptomatic Apical Periodontitis
Postoperative Pain and Quality of Life Following Root Canal Treatment With Two Different Sealers
This study compares two different root canal sealers, AH Plus and BioRoot Flow, to determine whether the type of sealer used during root canal treatment affects pain after treatment and oral health-related quality of life.
- Trial name
- NCT07884799
- Testing
- AH Plus, BioRoot Flow
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Karadeniz Technical University
Periodontitis
Evaluation of Clinical and Radiological Outcomes Following the Treatment of Periodontal Intraosseous Defects Using Autogenous Tooth-derived Graft or Autogenous Bone Graft With Enamel Matrix Derivatives. A 12-month Randomized Controlled Clinical Trial.
This clinical study aims to evaluate and compare two different materials used to treat bone defects caused by periodontitis. Periodontitis is a chronic inflammatory condition that damages the supporting structures of teeth…
- Trial name
- NCT06991998
- Testing
- Autogenous bone graft with enamel matrix derivative, Autogenous tooth-derived graft with enamel matrix derivative
- Where
- Hungary
- Volunteers
- 60 people
- Sponsor
- Semmelweis University
Periapical Periodontitis
Effect of Corticosteroid Injection in Symptomatic Pulpitis Cases
This randomized clinical trial compared standard single-visit root canal treatment with adjunctive submucosal betamethasone and gentamicin in 100 patients with symptomatic irreversible pulpitis, assessing postoperative pain and…
- Trial name
- (SCIP) (NCT07704398)
- Testing
- Corticosteroid, Standard endodontic treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Periodontitis
Impact of Guided Biofilm Therapy on Epithelial and Mesenchymal Biomarkers in Periodontitis Patients
The goal of this clinical trial is to investigate the clinical and biochemical effects of the guided biofilm therapy protocol as an alternative to the conventional non-surgical periodontal therapy in patients with periodontitis.
- Trial name
- NCT07286916
- Testing
- Root surface debridement, Guided Biofilm Therapy
- Where
- Iraq
- Volunteers
- 18 people
- Sponsor
- University of Baghdad
Apical Periodontitis, Healhty
Inflammation-Related Endothelial Barrier Dysfunction in Patients With Apical Periodontitis
Inflammation is a common factor in chronic periodontitis and systemic diseases. However, to date, there is no scientific evidence supporting a causal effect of inflammation caused by apical periodontitis on endothelial barrier…
- Trial name
- NCT07292363
- Testing
- Apical lesions cure
- Where
- 2 sites in Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Periodontal Pocket, Periodontitis
Use of Ozone Gel as an Antimicrobial in Treatment of Periodontitis
Periodontitis is an inflammatory disease that destroys tooth-supporting structures through oral bacterial plaque. ozone gel's act as an antimicrobial effect as an adjunct to conventional periodontal therapy (scaling and root…
- Trial name
- NCT05905445
- Testing
- ozone gel
- Where
- Iraq
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Ghufran Falih Hassan
Furcation Defects, Periodontitis
Non-surgical vs. Surgical Therapy for Periodontal Furcations
Periodontitis is an inflammatory disease of the tooth-supporting apparatus, which leads to attachment and bone loss and eventually to tooth loss if treatment is not provided.
- Conditions
- Furcation Defects, Periodontitis, Surgical Procedure, Unspecified
- Trial name
- NCT05237401
- Testing
- Non-Surgical Periodontal treatment (NSPT), Surgical Periodontal treatment/ Open Flap Debridement (OFD)
- Where
- United Kingdom
- Volunteers
- 59 people
- Sponsor
- King's College London
Periodontitis
Non-Surgical Treatment of Periodontitis With Adjunctive Sodium Hypochlorite/Amino Acids and Cross-Linked Hyaluronic Acid
The goal of this clinical trial is to learn if using sodium hypochlorite/amino acid gel, with or without cross-linked hyaluronic acid, as an addition to standard non-surgical periodontal therapy works to treat periodontitis in…
- Trial name
- NCT07474272
- Testing
- Standard Non-Surgical Periodontal Therapy, tandard Therapy + Sodium Hypochlorite/Amino Acid Gel, Standard Therapy + Sodium Hypochlorite/Amino Acid Gel + Cross-Linked Hyaluronic Acid
- Where
- Lebanon
- Volunteers
- 78 people
- Sponsor
- Marwan El Mobadder
Periodontal Inflammation
Saliva Levels of S100A12, CRP, Fetuin-A in Periodontal Disease Patients
Hs-CRP, Fetuin-A and S100A12 are acute phase proteins associated with many systemic diseases and conditions. The aim of this study was to determine the clinical parameters and salivary Hs-CRP, Fetuin-A and S100A12 levels before…
- Trial name
- NCT03345745
- Testing
- salivary samples
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ordu University
Periodontal Diseases Inflammation, Periodontal Disease
Timing of Oral Hygiene Improvement Relative to Subgingival Instrumentation
This single-centre, randomized split-mouth trial assessed clinical periodontal changes and acute systemic inflammatory responses when supra- and subgingival instrumentation was performed concurrently with oral hygiene instruction…
- Conditions
- Periodontal Diseases Inflammation, Periodontal Disease, Periodontal Attachment Loss, Periodontal Pocket
- Trial name
- NCT07914400
- Testing
- Nonsurgical periodontal treatment
- Where
- Slovenia
- Volunteers
- 10 people
- Sponsor
- University of Ljubljana
Periodontal Therapy, miRNA-223
The Effects of Smoking on miRNA-223 Before-After Non-Surgical Periodontal Therapy
Periodontal diseases are one of the most common inflammatory diseases. Periodontal disease results from a complex interplay between the subgingival biofilm and the host immune-inflammatory events that develop in the gingival and…
- Conditions
- Periodontal Therapy, miRNA-223, Periodontitis, Biomarker
- Trial name
- NCT05372965
- Testing
- experimental-periodontitis-mirna-223-gingival tissue-saliva samples, control-clinical healthy mirna-223-gingival tissue-saliva samples
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Biruni University
Periodontitis, Adult, Periodontal Diseases
Profiling Gingival Crevicular Fluid β-Catenin Level With 8-OHdG and Total Antioxidants Capacity During Healing of Periodontal Pockets: A 3-month Clinical Trial
Background: To profile gingival crevicular fluid (GCF) β-Catenin, 8-OHdG, and total antioxidants capacity (TAC) in periodontitis patients during healing of periodontal pockets following non-surgical periodontal therapy…
- Trial name
- NCT07596667
- Testing
- scaling and root planing
- Volunteers
- 21 people
- Sponsor
- Zeyad Nazar
Periodontitis
PLATELET RICH FIBRIN COMBINED WITH 1.2% ATORVASTATIN FOR TREATMENT OF INTRABONY DEFECTS IN CHRONIC PERIODONTITIS
Current study was designed to evaluate the combined efficacy of PRF and 1.2% ATV gel with open flap debridement (OFD) in treatment of intrabony defects in chronic periodontitis subjects.
- Trial name
- NCT02119520
- Testing
- Platelet rich fibrin +Atorvastatin, Platelet rich fibrin, open flap debridement
- Where
- India
- Volunteers
- 96 people
- Sponsor
- Government Dental College and Research Institute, Bangalore
Periodontitis, Hypertension
Study of the Effects of Intensive Treatment of Periodontitis on Blood Pressure Control
Hypertensive patients with chronic periodontitis will be randomized to either intensive treatment or supragingival hygienic treatment and the effects on blood pressure will be identified.
- Trial name
- PerioBP (NCT02131922)
- Testing
- Intensive Treatment, Dental Hygienization Treatment, Chlorhexidine (Intensive Treatment)
- Where
- 2 sites in Poland
- Volunteers
- 100 people
- Sponsor
- Jagiellonian University
Periodontitis
Gingival Crevicular Fluid Levels of Sclerostin, Osteoprotegerin (OPG) and RANKL in Health, Disease and After Treatment
The primary objective of this case-control intervention study to explore the effectiveness of non surgical periodontal therapy on the gingival crevicular fluid (GCF) levels of sclerostin in patients with chronic periodontitis…
- Trial name
- NCT02390479
- Testing
- non surgical periodontal treatment
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Umut BALLI
Localized Aggressive Periodontitis
Nigella Sativa Oil Extract and Xenograft Bone Graft in Treatment of Infra-bony Defects
The aim of this study will be to evaluate, clinically, and radiographically the effect of Nigella Sativa oil extract Mixed with xenograft versus xenograft alone in the treatment of intra-bony defects in patients with aggressive…
- Trial name
- NCT04722380
- Testing
- periodontal regenerative surgery
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Tanta University
Chronic Periodontitis
Study to Compare Laser Assisted New Attachment Procedure (LANAP) to Traditional Treatments of Chronic Periodontitis
The purpose of this study is to compare the Laser Assisted New Attachment Procedure (LANAP protocol) using the Free-running (FR) Pulsed Neodimium: Yttrium aluminium garnet (Nd:YAG) laser to Scaling and Root Planing (SRP) alone…
- Trial name
- LANAP (NCT01282229)
- Testing
- LANAP
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Institute for Advanced Laser Dentistry
Periodontitis
Efficacy of Nano-Curcumin and Nano-Hyaluronic Acid as an Adjunct to Scaling and Root Planing in the Treatment of Periodontitis
to evaluate Efficacy of Locally Applied Nano-Curcumin and Nano-Hyaluronic Acid as an Adjunct to Scaling and Root Planing in the Treatment of Periodontitis patients Materials and methods: forty patients (n=40) were selected from…
- Trial name
- NCT06777303
- Testing
- curcurmin loaded on chitosan nano-particles, hyaluronic acid loaded on chitosan nano-particles, scaling and root planning
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University
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