Clinical trials: Treatment of Periodontitis
Periodontitis
Comparative Evaluation of Omega-3 and Resveratrol Supplementation in Periodontitis Patients
This retrospective comparative study aims to evaluate the effects of resveratrol and omega-3 supplementation as adjuncts to non-surgical periodontal treatment on clinical periodontal parameters in patients with periodontitis.
- Trial name
- NCT07827391
- Testing
- trans-resveratrol, Omega-3 (EPA+DHA), No supplementation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Izmir Katip Celebi University
Rheumatoid Arthritis, Chronic Periodontitis
Impact of Photodynamic Therapy as an Adjunct to Non-surgical Periodontal Treatment on Clinical and Biochemical Parameters Among Patients Having Mild Rheumatoid Arthritis With Periodontitis
Purpose: To evaluate the efficacy of photodynamic therapy (PDT) as an adjunct to non-surgical periodontal therapy on the clinical periodontal and biochemical parameters among patients with rheumatoid arthritis (RA) having…
- Trial name
- NCT05122117
- Testing
- Methylene blue mediated Photodynamic therapy, Non-surgical periodontal therapy
- Where
- Saudi Arabia
- Volunteers
- 50 people
- Sponsor
- Zohaib Akram
Periodontal Pocket, Xerostomia
Periodontal Outcomes After Sanative Therapy
Salivary gland hypofunction, or dry mouth, is a damaging oral condition that affects salivary gland production. Absence of saliva causes bad breath, dental decay, increased plaque accumulation, dry lips, mouth sores, and the…
- Conditions
- Periodontal Pocket, Xerostomia, Dry Mouth, Periodontal Diseases
- Trial name
- NCT03649789
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Brock University
Periapical Diseases, Periapical Periodontitis
Postoperative Pain After Conservative Root Canal Preparation
The goal of this clinical trial is to compare the pain experienced by healthy participants after root canal treatment with small versus large root canal sizes. The main questions it aims to answer are: 1.
- Conditions
- Periapical Diseases, Periapical Periodontitis, Postoperative Pain, Pulp Necroses
- Trial name
- NCT06545773
- Testing
- Root Canal Treatment with ProTaper Next Nickel-Titanium File (PTN), Root Canal Treatment withTruNatomy Nickel-Titanium File (TN)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Apical Periodontitis, Pulp Disease, Dental
A New Clinical Use of Ferumoxytol Nanoparticles: An Antibiofilm Treatment
The goal of this observational is study is to develop a protocol for root canal biofilms disinfection using a clinically approved and commercially available iron oxide nanoparticle formulation Ferumoxytol/H2O2 treatments.
- Trial name
- NCT06110494
- Testing
- Iron oxide nanoparticles treatment Ferumoxytol/H2O2, NaOCl, NaCl
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Endodontically Treated Teeth, Calcium Hydroxide
Multiple-Visit RCT in Teeth With SAP: Interappointment Dressing or Not?
The aim of the study is to evaluate the effectiveness of calcium hydroxide as an intracanal medicament in the clinical and radiographic healing of periapical tissues in teeth diagnosed with symptomatic apical periodontitis.
- Trial name
- RCTCa(OH)2 (NCT06447519)
- Testing
- Ca(OH)2 as intracanal medicament
- Where
- Greece
- Volunteers
- 110 people
- Sponsor
- Aristotle University Of Thessaloniki
Temporomandibular Disorders (TMD), Acute Apical Periodontitis of Pulpal Origin
The Role of Root Canal Treatment in Alleviating Endodontic Pain-Induced Asymmetry and Restoring Muscle Balance
The study hypothesizes that masticatory laterality caused by acute apical periodontitis pain result in muscle asymmetry. Furthermore, it posits that successful root canal treatment, by restoring normal bilateral chewing function…
- Trial name
- NCT06853028
- Testing
- ultrasound measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Cukurova University
Periodontitis
Evaluation of iPRF With Vitamin C in StageII Grade A Periodontitis
Comparing the effect of using vitamin C with injectable PRF as a locally delivered adjunct to scaling and root planing versus scaling and root planing with local delivery of injectable PRF and scaling and root planing alone on…
- Trial name
- NCT05129267
- Testing
- Group B, Group C
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Cairo University
Chronic Periodontitis, Diabetes Mellitus, Type 2
Clinical and Microbiological Evaluation of Periodontal Treatment of Diabetic Patients: A Longitudinal Study
The purpose of this study is to determine whether periodontal treatment improves the periodontal clinical parameters in the periodontal patients with diabetes regarding non-diabetics: two years follow-up.
- Trial name
- NCT02643771
- Testing
- Full Mouth Scaling and Root Planing
- Where
- Brazil
- Volunteers
- 144 people
- Sponsor
- Eduardo Aleixo Figueira
Pulpitis, Periapical Lesions
Success of Endodontic Treatment With Different Obturation Techniques and Sealer Cements
The present study aims to compare the radiographic success of endodontic treatment using Orstavik's criteria between two sealers: AH Plus (Dentsply DeTrey, Konstanz, Germany) and Neosealer Flo (Avalon Biomed, Bradenton, Florida…
- Conditions
- Pulpitis, Periapical Lesions, Periapical Periodontitis, Periapical Pathology
- Trial name
- NCT07019298
- Testing
- AH Plus (Dentsply Sirona, Charlotte, NC, USA), NeoSealer Flo, Continuous Wave Condensation
- Where
- Spain
- Volunteers
- 270 people
- Sponsor
- University of Siena
Periodontitis
Diode Laser Application With Non-Surgical Periodontal Treatment
Periodontitis is an infectious disease that causes destruction of periodontal tissues with complex etiology that develops due to local and systemic factors.
- Trial name
- NCT04908098
- Testing
- diode laser, scaling - root planning
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Chronic Periodontitis, Smoking, Cigarette
GCF IL-17 Levels and Oxidative Status of Smoking and Non-smoking Individuals With Periodontitis
This study was performed to evaluate the effects of both periodontal treatment and smoking on the gingival crevicular fluid(GCF) levels of interleukin (IL)-17A, IL-17E, Total oxidative stress(TOS) and total antioxidant…
- Trial name
- GCF (NCT04115176)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ondokuz Mayıs University
Periodontal Disease, Periodontitis
Effect of Nano-Hyaluronic Acid in Intrabony Defects Treated With Minimally Invasive Non-Surgical Technique
This randomized controlled clinical trial aims to evaluate the effectiveness of using nano-hyaluronic acid (nano-HyA) gel alongside a minimally invasive non-surgical technique (MINST) to treat deep intrabony defects in patients…
- Trial name
- NCT07595757
- Testing
- Minimally invasive non-surgical technique (MINST), nano-hyaluronic acid
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Cairo University
Generalized Aggressive Periodontitis
Effects Of Adjunctive Photodynamic Therapy To Non-Surgical Periodontal Treatment In Patients With Generalized Aggressive Periodontitis
Generalized aggressive periodontitis (GAgP) is a distinct type of periodontal disease characterized by rapid loss of attachment and alveolar bone occuring in young individuals.
- Trial name
- NCT03412331
- Testing
- Ultrasonic, Hand Instruments, LED Source
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Marmara University
Alveolar Bone Loss, Chronic Periodontitis, Lovestatin Gel, Regeneration
The Effect of Lovastatin Gel in the Treatment of Chronic Periodontitis
Aim: dis double-blind split-mouth clinical trial study was performed to evaluate teh clinical and radiographic effect of local delivery of lovastatin gel as an adjunct to scaling and root planning (SRP) in teh treatment of…
- Trial name
- NCT03178526
- Testing
- Lovastatin gel
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Stage III Periodontitis
Injectable Platelet-Rich Fibrin (i-PRF) and Oxygen-Releasing Gel in the Treatment of Stage II Periodontitis.
Periodontitis is a chronic multifactorial inflammatory disorder affecting the periodontium, often implicated with microbial dysbiosis.
- Trial name
- NCT07859358
- Testing
- Injectable Platelet-Rich Fibrin (i-PRF, Peroxoborate Oxygen-Releasing Oral Gel, Sterile 0.9% Saline Solution
- Where
- 2 sites in Egypt
- Volunteers
- 24 people
- Sponsor
- Assiut University
Periodontal Disease, Halitosis
"Study of Halitosis in Patients With Advanced Chronic Periodontitis"
The objective of this study was to evaluate whether short-term full mouth disinfection protocol could have a greater reduction in the levels of halitosis and volatile sulfur compound or not, when compared to quadrant-wise scaling…
- Conditions
- Periodontal Disease, Halitosis, Periodontitis
- Trial name
- HACP (NCT02368678)
- Testing
- Scaling and Root Planning (SRP), Full Mouth Scaling (FMS)
- Volunteers
- 30 people
- Sponsor
- Federal University of Minas Gerais
Cryotherapy
Effect of Cryotherapy on Post-endodontic Pain
The goal of this clinical trial is to compare Cryotherapy with occlusal reduction in the reduction of post-endodontic pain in molars with symptomatic apical periodontitis.
- Trial name
- NCT05722704
- Testing
- Cryotherapy, Occlusal reduction
- Where
- United Arab Emirates
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Periodontal Disease, Gingival Inflammation and Bleeding
Efficacy of Oral Hygiene Regimens in Patients Undergoing Non-Surgical Periodontal Treatment
The objective of this clinical study is to evaluate the efficacy of multi-component oral hygiene regimens as adjunctive to non-surgical periodontal treatment in patients with stage II periodontitis.
- Trial name
- PEREG (NCT07803484)
- Testing
- Active Oral Hygiene Regimen
- Where
- 2 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- Colgate Palmolive
Periodontal Diseases, Periodontitis
Home Use of Dual-light Photodynamic Therapy for Chronic Periodontitis
This early-stage research is designed to determine the efficacy of the Lumoral method in chronic periodontitis patients. Improved supragingival plaque control can help to also sustain the subgingival plaque management in the long…
- Conditions
- Periodontal Diseases, Periodontitis, Plaque, Dental, Plaque Induced Gingivitis
- Trial name
- NCT05425784
- Testing
- Lumoral treatment, Standard oral hygiene self care
- Where
- 3 sites in Finland
- Volunteers
- 41 people
- Sponsor
- Koite Health Oy
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