Clinical trials: Treatment of Periodontitis
Periodontitis, Dysbiosis
Gut Microbial Changes After Periodontal Treatment
Periodontitis is a chronic inflammatory disease of the tooth supporting structures induced by a dysbiosis in the oral and subgingival microenvironment of susceptible patients.
- Conditions
- Periodontitis, Dysbiosis, Intestinal Disease
- Trial name
- NCT04982302
- Testing
- Non-surgical periodontal treatment
- Where
- Italy
- Volunteers
- 94 people
- Sponsor
- University of Turin, Italy
Periodontitis, Intrabony Periodontal Defect
Clinical Evaluation of Nano-Hydroxyapatite as an Adjunctive to Minimally Invasive Non-Surgical Technique in the Treatment of Deep Intra-bony Defects
This randomized controlled clinical trial aims to evaluate the effectiveness of using nano-hydroxyapatite (nHA) gel alongside a minimally invasive non-surgical technique (MINST) to treat deep intra-bony defects in patients with…
- Trial name
- MINST (NCT07608783)
- Testing
- Minimally invasive non-surgical technique (MINST), nano-hydroxyapatite
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Cairo University
Periodontal Diseases
The Effects of Subgingival Air-polishing, as an Adjunct to Non-surgical Periodontal Treatment on Periodontal Parameters and Patient Satisfaction in Patients With Periodontitis
Periodontal disease is serious and global chronic disease. The prevalence of periodontal diseases in United Arab Emirates is not clear but data from Dubai Health Authority showed that one in five patients has received periodontal…
- Trial name
- NCT04477070
- Testing
- Air-polishing with ultrasonic debridement, Conventional scaling and root planing
- Where
- United Arab Emirates
- Volunteers
- 22 people
- Sponsor
- Mohammed Bin Rashid University of Medicine and Health Sciences
Chronic Periodontitis
Dose Parameters for Photodynamic Therapy on Periodontal Disease
Due to the phenomenon of bacterial resistance, photodynamic therapy (PDT) has been studied as an alternative to the use of antibiotics on the periodontal treatment.
- Trial name
- NCT03262077
- Testing
- Methylene Blue, Methylene Blue Oral Product
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Periodontitis
Hyaluronan in the Treatment of Residual Pockets in Periodontitis Patients.
Aim To evaluate the clinical and microbiological effects of a hyaluronan (HY) as adjunct to scaling and root planning of residual pockets during supportive periodontal therapy.
- Trial name
- NCT04792541
- Testing
- HY containing gel; GUM® Afta Clear Gel, Sunstar, saline solution
- Volunteers
- 66 people
- Sponsor
- Malmö University
Periodontitis
Hydroxyapetite Nanoparticles, Tricalcium Phosphate Nanoparticles, and PRF for Treatment of Gingival Recession
The aim of the present study was to compare between nanocrystalline hydroxyapatite and tricalcium phosphate carried on PRP membrane in treatment of Miller's class 1 gingival recession in human.
- Trial name
- NCT06016894
- Testing
- coronally advanced flap, Nanocrystalline hydroxyapatite loaded in PRF, Nanocrystalline tricalcium phosphate loaded in PRF
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- October 6 University
Diabete Type 2
Pocket-X Gel Non-surgical Periodontal Therapy
Evaluate from a clinical and microbiological point of view the effect of an adjunctive therapy based on a thermal-gelling device Pocket-X® Gel (Hyaluronic acid, Poloxamer, 2-Phenoxyethanol, Octedine HCL, Water), in the…
- Trial name
- DEFECT_PERIO (NCT07372677)
- Testing
- Gel therapy after non surgical therapy
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Periodontitis
Salivary Proteome in Response to Non-surgical Periodontal Treatment
This study aims to investigate salivary proteome changes in periodontitis patients before and after non-surgical treatment. Ten systemically healthy and non-smoker individuals with stage III, grade C periodontitis underwent…
- Trial name
- NCT05952895
- Testing
- Conventional quadrant-wise scaling and root planing (SRP)
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Severe Chronic Periodontitis
Effect of Azithromycin on Failure Proportion of Severe Periodontitis Non-surgical Treatment
Primary purpose: Evaluate the effect of azithromycin on failure proportion of severe chronic periodontitis non-surgical treatment; failure characterized by the persistence of at least one periodontal pocket> 5mm at 6 months…
- Trial name
- AZITHROPARO (NCT04198649)
- Testing
- Non-surgical periodontal treatment and azithromycin treatment
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Strasbourg, France
Necrotic Pulp, Regenerative Endodontic Procedures
Periapical Bleeding Versus PRF Techniques in Regenerative Endodontic Therapy: A Randomized Controlled Trial
This study investigates a biological approach that allows infected and necrotic teeth to heal themselves instead of being treated with traditional root canal therapy.
- Conditions
- Necrotic Pulp, Regenerative Endodontic Procedures, Mature Teeth, Apical Periodontitis
- Trial name
- NCT06886438
- Testing
- RVS, L-PRF, i-PRF
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Saglik Bilimleri Universitesi
Symptomatic Apical Periodontitis, Temporomandibular Disorders (TMDs)
Effect of Anterior Disc Displacement With Reduction on Postoperative Pain After Root Canal Treatment
The aim of this study is to evaluate the impact of anterior disc displacement with reduction (ADDR) on postoperative pain following root canal treatment in patients diagnosed with symptomatic apical periodontitis.
- Conditions
- Symptomatic Apical Periodontitis, Temporomandibular Disorders (TMDs), Anterior Disc Displacement
- Trial name
- TMD-POSTOP (NCT07329413)
- Testing
- Single-Visit Conventional Root Canal Treatment Using Nickel-Titanium Rotary Instruments (Endoart Smart Gold), Ibuprofen 400 mg (if necessary)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Recep Tayyip Erdogan University
Gingivitis and Periodontal Diseases
Comparison of Serum Trefoil Factor 3 in Patients With Gingivitis and Periodontitis After Scaling and Root Planing
This study is intended to measure serum trefoil factor 3 at baseline and 3 months after, following nonsurgical periodontal therapy in patients with Gingivitis and Chronic Periodontitis.
- Trial name
- CSTF3PGPSR (NCT03620396)
- Testing
- Scaling and root planing
- Volunteers
- 40 people
- Sponsor
- Dr.K.Sai Priyanka
Chronic Apical Periodontitis, Necrosis of Pulp
Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth
This study aims to evaluate the antibacterial effects of injectable platelet-rich fibrin (i-PRF) in vitro, and to assess the clinical and radiographic outcomes of using advanced platelet-rich fibrin (A-PRF+) and i-PRF in…
- Conditions
- Chronic Apical Periodontitis, Necrosis of Pulp, Acute Apical Periodontitis of Pulpal Origin, Periapical Abscess
- Trial name
- NCT07192289
- Testing
- Using advanced platelet-rich fibrin (A-PRF+) or injectable platelet-rich fibrin (i-PRF) in regenerative endodontic treatment in mature permanent teeth.
- Where
- Vietnam
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Periodontal Regeneration, Minimally Invasive Surgical Technique
Efficacy of the Entire Papilla Preservation Technique With and Without the Use of L-PRF as a Regenerative Material for the Treatment of Infrabony Defects
The goal of this clinical trial is to evaluate the efficacy of using L-PRF (leukocyte and platelet rich fibrin clot) as an autologous filling material in conjunction with the EPP (entire papilla preservation) technique for the…
- Conditions
- Periodontal Regeneration, Minimally Invasive Surgical Technique, Platelet Rich Fibrin, Microsurgery
- Trial name
- NCT06694168
- Testing
- Periodontal Regeneration, clinical and radiographic results, modified minimal invasive surgery, REGEND001 Autologous Therapy Product
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Universidad de los Andes, Chile
Periodontal Intrabony Defect
Regenerative Potential of Cultured Gingival Fibroblast- Mesenchymal Stem Cells in Treatment of Periodontitis
clinical trial was conducted to evaluate regenerative potentials of cultured gingival fibroblasts and GMSCs carried in beta tri calcium phosphate scaffold into intrabony periodontal defects in human by clinical and radiographic…
- Trial name
- NCT03638154
- Testing
- GF+GMSCs carried on β TCP, β TCP bone substitute only
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Diabetes Mellitus., Chronic Periodontitis
Periodontal Treatment in Non-controlled Type 2 Diabetes Mellitus Patients. Clinical Trial
Periodontitis is an infectious disease that destroys the tooth supporting tissues and triggers a local and systemic immune response.
- Trial name
- FONIS12I2106 (NCT01904422)
- Testing
- conventional periodontal treatment
- Where
- Chile
- Volunteers
- 87 people
- Sponsor
- Universidad de los Andes, Chile
Periodontitis
The Efficacy and Safety of Flurbiprofen Chip Versus Chlorhexidine Chip (Periochip®) in Therapy of Adult Chronic Periodontitis
The purpose of the study is to assess efficacy and safety of Flurbiprofen Chip versus Chlorhexidine chip (Periochip®) in therapy of adult chronic periodontitis.
- Trial name
- NCT01040286
- Testing
- Flurbiprofen, Chlorhexidine
- Where
- Israel
- Sponsor
- Dexcel Pharma Technologies Ltd.
Chronic Periodontitis
Autologous Alveolar Bone Marrow Mesenchymal Stem Cells for the Reconstruction of Infrabony Periodontal Defects
Systemically healthy periodontitis patients are recruited from new referrals to the Department of Periodontology and Biology of Implants, AUTh.
- Trial name
- PerioRegen (NCT02449005)
- Testing
- BM-MSCs/fibrin glue/collagen fleece, Fibrin glue/collagen fleece, Open flap debridement
- Where
- Greece
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Apical Periodontitis
Effect of Sodium Hypochlorite Concentration on Success of Non-surgical Root Canal Treatment
.There is no general agreement regarding the optimal concentration of sodium hypochlorite to be used in endodontic treatment.Therefore, this study aims to evaluate the effect of sodium hypochlorite concentration on the success of…
- Trial name
- NCT03288467
- Testing
- Root canal treatment with 5% NaOCl, Root canal treatment with 1% NaOCl
- Volunteers
- 90 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Oxidative Stress, Chronic Apical Periodontitis
Effect of Different Root Canal Sealers on Oxidative Stress Markers
The goal of this clinical trial is to primary purpose investigate and compare oxidative stress markers in patients with chronic apical periodontitis treated with different root canal paste in a single session.
- Trial name
- NCT07059481
- Testing
- Root Canal Treatment and Sample Collection, PAI Score Comparasion
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- bengi gülgü
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