Clinical trials: Treatment-as-usual
Panic Disorder, Agoraphobia
Clinical Trial of a Group Self-management Support Program for Anxiety Disorders
Background. Self-management support is a complementary approach to treatment that aims to educate participants on the nature of anxiety and to improve their strategies to manage symptoms and well-being, thus presenting the…
- Conditions
- Panic Disorder, Agoraphobia, Social Anxiety Disorder, Generalized Anxiety Disorder
- Trial name
- NCT05124639
- Testing
- Group self-management support program for anxiety disorders
- Where
- Canada
- Volunteers
- 414 people
- Sponsor
- Université de Sherbrooke
Complex Post-Traumatic Stress Disorder
RESTORE Trial: A Pilot RCT of Enhanced Skills Training in Affective and Interpersonal Regulation (ESTAIR) for Veterans With CPTSD
Complex Post traumatic Stress Disorder (CPTSD) is now recognized as a separate trauma-based psychological condition to PTSD. CPTSD is a broader diagnosis that includes the core PTSD symptoms (re-experiencing in the here and now…
- Trial name
- NCT04752072
- Testing
- Enhanced Skills Training in Affective and Interpersonal Regulation, Treatment as usual
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Combat Stress
Alcohol Use Disorder
Virtual Reality Exposure Therapy in the Treatment of Alcohol Use Disorder
This study aims to compare the efficacy of virtual reality exposure therapy (VRET) with treatment-as-usual (TAU) for alleviating psychological dependence on alcohol and preventing relapse.
- Trial name
- NCT05841823
- Testing
- Virtual reality exposure therapy (VRET)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Universiti Sains Malaysia
Hypertension, SMS-text
Effectiveness of SMS-text Message Support for Patients With Hypertension to Improve Blood Pressure
General synopsis for SMS-text Adherence Support (*StAR) Study and associated preparatory and pilot work Background: High blood pressure is an important risk factor for heart disease, stroke and chronic kidney disease.
- Conditions
- Hypertension, SMS-text, mHealth
- Trial name
- *StAR (NCT02019823)
- Testing
- Informational SMS-text, Interactive SMS-text, Enhanced usual care
- Volunteers
- 1,372 people
- Sponsor
- University of Oxford
Behavior Therapy + MI Intervention (Supporting Teens' Academic Needs Daily), Treatment as Usual
Increasing Academic Success in Middle School Students With ADHD
Broadly, the purpose of the proposed study is to test the efficacy of a parent-coordinated, parent-teen-teacher collaborative intervention for middle school students with ADHD and academic impairment (STAND; Supporting Teens'…
- Trial name
- STAND (NCT02048579)
- Testing
- Behavior Therapy + Motivational Interviewing
- Volunteers
- 126 people
- Sponsor
- Florida International University
Bipolar I Disorder, Depression, Anxiety
Efficacy and Safety of Magnesium Vitamin B6 in First Episode Bipolar Disorder
This is a randomized, double-blind, placebo-controlled proof-of-concept clinical trial to assess the efficacy and safety of Magnesium-vitamin B6in combination with treatment as usual for treating symptoms of depression, stress…
- Conditions
- Bipolar I Disorder, Depression, Anxiety, Stress
- Trial name
- NCT05837104
- Testing
- Magnesium vitamin B6
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mclean Hospital
Individual Psychiatric Disorder, Couple Dysfunction
Assessing Psychotherapy Outcome With Feedback
This study is a comparison of client outcomes in two different types of psychotherapy treatment. In one condition clients will receive treatment-as-usual (TAU); the therapy that they would normally receive.
- Conditions
- Individual Psychiatric Disorder, Couple Dysfunction, Family Dysfunction
- Trial name
- NCT02023736
- Testing
- Systemic Therapy Inventory of Change (STIC), Treatment as Usual
- Where
- 4 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- The Family Institute at Northwestern University
Methamphetamine Abuse, Methamphetamine-dependence
Clinical Trial of High Dose Lisdexamfetamine and Contingency Management in MA Users
The goal of this clinical trial is to learn if administering a high dose stimulant with Contingency Management reduces days of use in adults who use methamphetamine better than the usual treatment provided by the clinic.
- Conditions
- Methamphetamine Abuse, Methamphetamine-dependence, Addiction, Substance, Addiction
- Trial name
- NCT05854667
- Testing
- Treatment as Usual plus lisdexamfetamine (LDX-01), Treatment as Usual plus lisdexamfetamine (LDX-01) plus Contingency Management
- Where
- 4 sites in Canada
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Eye Diseases, Quality of Life
Automatic Self Transcending Meditation (ASTM) in Patients With Dry Eye Disease
Patients with dry eye disease (DED) will be randomized to Automatic Self Transcending Meditation (ASTM) plus Treatment as Usual (TAU) or TAU alone to assess changes in Health-related quality of life (HRQoL).
- Conditions
- Eye Diseases, Quality of Life, Depression, Anxiety
- Trial name
- NCT03087006
- Testing
- Automatic Self Transcending Meditation (ASTM), Treatment as Usual
- Where
- Canada
- Volunteers
- 256 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Trauma and Stressor Related Disorders, Post-traumatic Stress Disorders
Posttraumatic Stress Disorders in Police, Correctional Service Officers, and 911 Operators
Police officers, correctional service officers, and 911-operators are at increased risk for suffering from trauma-related disorders due to their direct and indirect exposure to life-threatening events, such as shootings, violent…
- Conditions
- Trauma and Stressor Related Disorders, Post-traumatic Stress Disorders, Adjustment Disorders, Acute Stress Disorder
- Trial name
- NCT03152175
- Testing
- Propranolol Hydrochloride
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Douglas Mental Health University Institute
Anxiety, Anxiety Disorders
Transdiagnostic, Cognitive and Behavioral Intervention for in School-aged Children With Emotional and Behavioral Disturbances
Background Impairing emotional and behavioural problems are common in children and adolescents and mark a three-fold increased risk of mental disorder in young adulthood.
- Conditions
- Anxiety, Anxiety Disorders, Depressive Symptoms, Depressive Disorders
- Trial name
- MindMyMind RCT (NCT03535805)
- Testing
- Mind My Mind (MMM), Treatment as Usual (TAU)
- Where
- Denmark
- Volunteers
- 396 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Headache
Acceptance and Commitment Therapy vs Medical Treatment as Usual Wait-list Control for Primary Headache Sufferers
Research to date suggests that individuals with headache use avoidance as a way to manage their pain. Despite the wide use of avoidance as a coping mechanism of headache triggers, very little empirical evidence exist to support…
- Trial name
- ALGEA (NCT02734992)
- Testing
- ACT+ MTAU, Waitlist Control +MTAU
- Where
- Cyprus
- Volunteers
- 100 people
- Sponsor
- University of Cyprus
Major Depressive Disorder, Treatment Resistant Depression
The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.
Over 28 million people suffer from current depressive disorder in the European Union. Major depressive disorder (MDD) is one of the most common psychiatric illnesses.
- Trial name
- INTENSIFY MDD (NCT05973851)
- Testing
- Esketamine Nasal Product, Ketamine Hydrochloride, Esketamine hydrochloride
- Where
- 12 sites in Austria, Germany and 4 more
- Volunteers
- 418 people
- Sponsor
- Dr. Inge Winter
Mother-infant Relational Disturbances
Mother-Infant Psychoanalysis Project of Stockholm
Mother-infant relationship disturbances broadly comprise three areas; maternal distress, infant functional problems, and relationship difficulties.
- Trial name
- MIPPS (NCT00923559)
- Testing
- Treatment as Usual at Child Health Centre, Mother-Infant Psychoanalytic treatment (MIP)
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Post Traumatic Stress Disorder
Brief SEE FAR CBT Intervention Compared With Treatment as Usual for Adults With PTSD
This clinical intervention study evaluates a newly developed Brief SEE FAR CBT protocol for adults aged 18 years and older with posttraumatic stress disorder (PTSD), compared with dynamic psychotherapy treatment as usual.
- Trial name
- NCT07710573
- Testing
- Brief SEE FAR CBT Intervention, Dynamic Psychotherapy Treatment as Usual
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Community Stress Prevention Center
Insomnia Chronic
Protocol - Your Answers When Needing Sleep in New Brunswick
New Brunswick has an aging population with Canada's highest rate of sleeping pill use. The rate of long-term (chronic) use among NB seniors is 25%, well in excess of the Canadian average of 10%.
- Trial name
- YAWNS NB (NCT04406103)
- Testing
- Sleepwell, Empower
- Where
- Canada
- Volunteers
- 594 people
- Sponsor
- David Gardner
Anxiety, Mental Disorders
Keeping Well:Online Cognitive Behavioral Therapy (CBT) for Pregnant Women With Depressive Symptoms
Most depression during pregnancy is undetected and untreated although it is known to be harmful both to the woman herself and her future child.
- Conditions
- Anxiety, Mental Disorders, Postpartum Depression, Depressive Symptoms
- Trial name
- OnCBTDep (NCT01909167)
- Testing
- Online Cognitive Behavioral Therapy (CBT), Treatment as usual
- Where
- United Kingdom
- Sponsor
- Imperial College London
Clinical High Risk for Psychosis (CHR)
Interventions for Clinical High Risk Youth in Tunisia
Study participants will take part in one of the two types of treatments aimed at improving daily functioning as follows: either a Cognitive Training (CT) Program or an Enhanced - Treatment as Usual (E-TAU) Group.
- Trial name
- CHRTUNISIA (NCT06582901)
- Testing
- Cognitive training (CT) plus the neuropsychological educational approach to cognitive remediation (NEAR) model and an Enhanced - Treatment as Usual (E-TAU), Enhanced - Treatment as Usual
- Where
- Tunisia
- Volunteers
- 54 people
- Sponsor
- University of California, Los Angeles
Vulvodynia, Vestibulodynia
Somatocognitive Therapy in Treatment of Provoked (Localized) Vestibulodynia - Randomized Clinical Trial (ProLoVe Study)
This is a two-arm randomized clinical trial assessing effectiveness of somatocognitive therapy versus treatment as usual for provoked vestibulodynia (PVD).
- Trial name
- ProLoVe (NCT04613713)
- Testing
- Somatocognitive physiotherapy, Treatment as usual
- Where
- Norway
- Volunteers
- 128 people
- Sponsor
- Oslo Metropolitan University
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
Effects of Adding Quercetin or Alpha Lipoic Acid to Usual Care on Symptoms and Blood Markers in Iraqi Women With Polycystic Ovary Syndrome
This study will investigate whether the addition of Quercetin or Alpha-Lipoic Acid (ALA) to standard metformin therapy can improve symptoms, hormone levels, metabolic health, and quality of life in women with polycystic ovary…
- Trial name
- NCT07182526
- Testing
- Quercetin, Alpha Lipoic Acid 600 MG Oral Tablet, MetFORMIN 500 Mg Oral Tablet
- Where
- Iraq
- Volunteers
- 150 people
- Sponsor
- Al-Mustansiriyah University