Clinical trials: Treatment-as-usual
Lung Trasplant, Lung Transplantation
Study of Tacrolimus Melt-Dose® for Lung Transplant Patients
To evaluate, under usual clinical practice conditions and with a 12-month follow-up , the most relevant pharmacokinetic parameters of tacrolimus metabolism and safety, in patients with recent lung transplant (unilateral or…
- Trial name
- ESENCIAL (NCT07042035)
- Where
- 2 sites in Spain
- Volunteers
- 240 people
- Sponsor
- Chiesi España, S.A.U.
Carpal Tunnel Syndrome
Non-surgical Treatment of Carpal Tunnel Syndrome by Means of Mechanical Traction
The objective of this study is to evaluate the effectiveness of mechanical traction in patients with Carpal Tunnel Syndrome compared to care as usual.
- Trial name
- MT-CTS (NCT01949493)
- Testing
- mechanical traction, Care as usual
- Where
- Netherlands
- Volunteers
- 181 people
- Sponsor
- Tilburg University
Fear of Cancer Recurrence, Colorectal Cancer
Reducing Fear of Cancer Recurrence in Danish Colorectal Cancer Survivors
Cognitive therapy has been shown to reduce fear of cancer recurrence (FCR), mainly in breast cancer survivors. The accessibility of cognitive behavioural interventions could be further improved by Internet delivery, but…
- Conditions
- Fear of Cancer Recurrence, Colorectal Cancer, Anxiety, Health Anxiety
- Trial name
- NCT04287218
- Testing
- TG-iConquerFear, aTAU
- Where
- Denmark
- Volunteers
- 95 people
- Sponsor
- Vejle Hospital
Depression Suicidal
Diclofenac add-on to Treatment as Usual for Suicidal Patients
The purpose of this study is to determine whether diclofenac is effective in the treatment of depressed patients with a recent suicide attempt.
- Trial name
- NCT01413854
- Testing
- sugar pill, Diclofenac
- Where
- Sweden
- Sponsor
- Region Skane
Gambling, Pathological
Adding Contingency Management to Treatment as Usual for Disordered Gambling.
The aim of this study is to conduct a trial to investigate the efficacy of adding Contingency Management (CM) to Treatment as Usual (TAU) for the treatment of Disordered Gambling.
- Trial name
- NCT02613754
- Testing
- Contingency Management, Treatment as Usual
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Lethbridge
Depression
The Early Medication Change (EMC) Trial
The EMC trial investigates for the first time prospectively whether Major Depression Disorder patients with non-improvement after 14 days of antidepressive treatment with EMC are more likely to become remitters compared to…
- Trial name
- EMC (NCT00974155)
- Testing
- Escitalopram, venlafaxine, lithium, Escitalopram, venlafaxine
- Where
- Germany
- Volunteers
- 889 people
- Sponsor
- K. Lieb
Early Intervention, Child of Impaired Parents
VIA Family - Family Based Early Intervention Versus Treatment as Usual
This RCT aims to investigate the effect of an early family-based intervention (VIA Family) focusing on reducing risk and increasing resilience for children in families where at least one parent has a severe mental illness.The…
- Conditions
- Early Intervention, Child of Impaired Parents, Child, Adolescent
- Trial name
- NCT03497663
- Testing
- VIA Family intervention, Treatment As Usual
- Where
- Denmark
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Common Mental Disorders (CMD)
Transdiagnostic Online CBT vs. Care as Usual for Primary Care Patients With Common Mental Disorders
The goal of this randomized controlled trial is to investigate if online transdiagnostic cognitive behavior therapy (CBT) can be effective in the treatment of common mental disorders in adult primary care patients.
- Trial name
- PRIMARITA-1 (NCT06804941)
- Testing
- Online transdiagnostic CBT, Primary care as usual
- Where
- Sweden
- Volunteers
- 500 people
- Sponsor
- Karolinska Institutet
Major Depressive Disorder
Feasibility of Internet-delivered CBT for Adolescents With Depression
Prior to a properly powered randomized controlled study, evaluating efficacy and cost-effectiveness of ICBT, we will conduct a pilot study to investigate if the trial design is feasible, if therapist-guided and self-guided…
- Trial name
- NCT04117789
- Testing
- Therapist-guided internet-delivered cognitive behavior therapy for depression in adolescents, Self-guided internet-delivered cognitive behavior therapy for depression in adolescents, Treatment as usual
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Karolinska Institutet
Schizophrenia
CAE for Poorly Adherent Individuals With Schizophrenia
This project aims to evaluate the feasibility, acceptability and preliminary efficacy of remotely delivered CAE among patients with schizophrenia (CAE-S).
- Trial name
- CAE-S (NCT06061952)
- Testing
- Customized Adherence Enhancement for Schizophrenia (CAE-S), Enhanced Treatment as Usual (eTAU)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University Hospitals Cleveland Medical Center
Personality Disorders
The Personal Concerns Inventory Study (PCI)
Services for people with personality disorders are challenged by how to engage clients in therapy. High non-completion rates have major cost-efficiency implications, but more worrying is that drop-out may be associated with…
- Trial name
- PCI (NCT01132976)
- Testing
- Personal Concerns Inventory, Treatment as usual
- Where
- United Kingdom
- Volunteers
- 76 people
- Sponsor
- Nottinghamshire Healthcare NHS Trust
Intimate Partner Violence
Evaluating Interventions for Intimate Partner Violence Use in Washington State
Intimate partner violence (IPV), specifically physical and psychological aggression toward an intimate partner, represents a public health crisis that affects millions of Americans each year.
- Trial name
- NCT06526247
- Testing
- Strength at Home (SAH), Treatment as usual for IPV
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Boston University
Chronic Insomnia, Cancer
Impact of Homeopathy for Persistent Insomnia in Patients With Cancer
Persistent insomnia is highly prevalent complaint in cancer survivors, but is seldom satisfactorily addressed. The adaptation to cancer care of a validated, cost-effective intervention may offer a practicable solution.
- Trial name
- NCT02515006
- Testing
- Homeopathy Medicine
- Where
- 2 sites in India
- Volunteers
- 160 people
- Sponsor
- Adwin Life Care
Autism Spectrum Disorder (ASD), Anxiety
Adapted Group Therapy Compared With Usual Care for Anxiety and Depression in Adults With an Autism Diagnosis
The goal of this clinical trial is to learn whether an adapted group therapy works to treat anxiety and depression in adults with an autism diagnosis. The therapy is a form of cognitive behavioral therapy (CBT).
- Conditions
- Autism Spectrum Disorder (ASD), Anxiety, Depression
- Trial name
- CoMind (NCT07880028)
- Testing
- Autism-adapted group cognitive behavioral therapy
- Volunteers
- 154 people
- Sponsor
- Lovisenberg Diakonale Hospital
Major Depressive Disorder
Genecept Assay™ vs. Treatment-as-Usual to Evaluate Efficacy of Assay-Guided Treatment in Adults With MDD
In this randomized clinical trial, subjects will be assigned to either an assay-guided treatment condition (AGT) or a treatment-as-usual condition (TAU).
- Trial name
- NCT02634177
- Testing
- Assay-guided treatment (AGT), Treatment-as-usual (TAU)
- Where
- 23 sites in United States
- Volunteers
- 305 people
- Sponsor
- Genomind, LLC
Opioid-use Disorder, Opioid Misuse
Comparing a Patient Self-Assessment Software to Treatment as Usual in Opioid Prescriber and Patient Opioid Outcomes
The Care Continuity Program (CCP), a product of Sure Med Compliance, is a novel, online patient self-assessment used by prescribers of opioids to better identify patient risk factors and therapy benefit.
- Conditions
- Opioid-use Disorder, Opioid Misuse, Opioid Use, Chronic Pain
- Trial name
- NCT04945525
- Testing
- Care Continuity Program
- Where
- United States
- Volunteers
- 1,840 people
- Sponsor
- Sure Med Compliance
Affective Disorder, Major Depressive Disorder
The Effect of IPS-MA- A Modified Early Supported Employment Intervention for Individuals With Mood or Anxiety Disorders
The aim of the present study, is to evaluate the effect of a supported employment intervention, IPS-modified for people with mood and anxiety (IPS-MA) on employment or education, when offered to people with onset mood or anxiety…
- Conditions
- Affective Disorder, Major Depressive Disorder, Bipolar Disorder, Anxiety Disorder
- Trial name
- NCT01721824
- Testing
- The IPS-MA method
- Where
- Denmark
- Volunteers
- 326 people
- Sponsor
- Amager Hospital
Obesity, Extreme Obesity
Low-level Intervention for Adolescents With Extreme Obesity
While adolescents with obesity and extreme obesity are at increased risk for health complications, especially adolescents with extreme obesity rarely seek medical care, and sustained weigh loss is hardly ever achieved.
- Trial name
- STEREO (NCT01703273)
- Testing
- manual based low key group intervention (innovation), standardized, manual based routine care
- Where
- 6 sites in Germany
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Martin Wabitsch
Anxiety Disorders, Depressive Disorder
Problem Management Plus (PM+) in Chile: a Pilot Randomized Controlled Trial of a Psychological Transdiagnostic Intervention Delivered in Primary Health Care
This study aims to evaluate the implementation outcomes of a pilot randomized controlled trial and to assess the preliminary efficacy of Problem Management Plus (PM+) in reducing symptoms of depression and anxiety among users at…
- Trial name
- NCT06988332
- Testing
- Problem Management Plus (PM+)
- Where
- Chile
- Volunteers
- 56 people
- Sponsor
- University of Chile
Disruptive Behavior, Behavior Problems
A Randomized Controlled Trial on Brief Behavioral Parent Training
RATIONALE: The access to and uptake of evidence-based behavioral parent training for children with behavioral difficulties (i.e., oppositional, defiant, aggressive, hyperactive, impulsive, and inattentive behavior) are currently…
- Conditions
- Disruptive Behavior, Behavior Problems, Behavioral Problems, Problem Behaviors
- Trial name
- PAINT-GGZ (NCT05591820)
- Testing
- Brief behavioral parent training with optional booster sessions, Care as usual
- Where
- Netherlands
- Volunteers
- 93 people
- Sponsor
- Accare