Clinical trials: Treatment-as-usual
Psychotic Episode, Psychological Trauma
A Rater-blinded RCT to Compare Effectiveness of EMDR vs TAU in Patients With First Episode Psychosis and History of Psychological Trauma
The main objective of this project is to analyze whether EMDR therapy, as an adjuvant to usual treatment, is effective in reducing post-traumatic stress and psychotic/affective symptoms in patients with a FEP and comorbid…
- Trial name
- NCT03991377
- Testing
- Eye movement desensitization and reprocessing therapy, Treatment as usual
- Where
- Spain
- Volunteers
- 71 people
- Sponsor
- Parc de Salut Mar
Asthma
Evaluation of Tiotropium 5 µg/Day Delivered Via the Respimat® Inhaler Over 48 Weeks in Patients With Severe Persistent Asthma on Top of Usual Care (Study II)
The trial is a randomised, double-blind, placebo-controlled, parallel-group trial to evaluate the efficacy and safety of 5 µg tiotropium over a 48-week treatment period as compared to placebo.
- Trial name
- NCT00776984
- Testing
- tiotropium 5mcg/day
- Where
- 75 sites in United States, Australia and 13 more
- Volunteers
- 453 people
- Sponsor
- Boehringer Ingelheim
Mild Traumatic Brain Injury, Suicide Prevention
Crisis Response Planning in Military Personnel With Mild Traumatic Brain Injury
The study purpose is to test the effect of Crisis Response Planning (CRP) when used as the second method of suicide prevention in military service members who are at risk for suicide due to mild traumatic brain injury (mTBI).
- Conditions
- Mild Traumatic Brain Injury, Suicide Prevention, Suicide Risk | Patient, Suicide Risk
- Trial name
- NCT07327567
- Testing
- Crisis Response Planning
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Depression, Anxiety, Cancer of the Head and Neck
Mindfulness-based Stress Reduction Effects on Depression, Anxiety and Internalized Stigma Compared With Treatment-As-Usual Among Head and Neck Cancer Patients
Head and neck cancer patients are vulnerable to various psychological complications due to the effects of both cancer itself and cancer treatment on patients' appearance and physical well-being.
- Conditions
- Depression, Anxiety, Cancer of the Head and Neck, Psycho-Oncology
- Trial name
- NCT06991309
- Testing
- MBSR
- Where
- Malaysia
- Volunteers
- 110 people
- Sponsor
- Universiti Sains Malaysia
Posttraumatic Stress Disorders, Borderline Personality Disorders
A Randomized Control Trial of Narrative Exposure Therapy Versus Treatment as Usual in the Therapy of Borderline Personality Disorder
Definition of the efficacy of NET compared with "treatment as usual" in the treatment of patients with complex traumatic disease (borderline personality disorder (BPD) and posttraumatic stress disorder (PTSD)) as assessed by…
- Trial name
- NET (NCT01033708)
- Testing
- narrative exposure therapy
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Zentrum für Integrative Psychiatrie
Major Depression
Stress Management and Resiliency Training for Depression vs Treatment as Usual in the Treatment of Major Depression
Researchers are trying to find out if a Stress Management and Resiliency Training (SMART-D) therapy will help with major depression treatment.
- Trial name
- NCT04388748
- Testing
- Stress Management and Resiliency Training for Depression (SMART-D) Therapy
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- Mayo Clinic
Social Anxiety Disorder
RESCCUE4 - Group CBT for Social Anxiety in Adolescents
This randomized controlled trial aims to evaluate the efficacy of a 2-month group Cognitive Behavioral Therapy (CBT) intervention compared to a structured psychoeducational treatment as usual (TAU) in adolescents diagnosed with…
- Trial name
- NCT07464561
- Testing
- Group Cognitive Behavioral Therapy, Psychoeducational Group Intervention
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Depression
BEAT-IT: Behavioural Activation and Severe Learning Disabilities
Depression is common, but no psychological interventions have been tested to see if they work for adults with severe intellectual disabilities.
- Trial name
- NCT04744259
- Testing
- Behavioural Activation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- NHS Greater Glasgow and Clyde
Depressive Disorder
Study to Evaluate the Safety and Efficacy of PEER Interactive Versus Treatment as Usual in Subjects With a Primary Diagnosis of Depression
This is a prospective, multicenter, randomized, double-blind, controlled study to evaluate the effectiveness of PEER Interactive to inform treatment in subjects with a primary diagnosis of depression with comorbidity of…
- Trial name
- NCT01794559
- Testing
- PEER Interactive Report
- Where
- 2 sites in United States
- Volunteers
- 1,922 people
- Sponsor
- MYnd Analytics
Dyslipidemias
Study to Evaluate the Safety of the Fixed-dose Combination Rosuvastatin/Ezetimibe for Patients With Dyslipidaemia
Retrospective, analytical, longitudinal, multicenter study to evaluate the safety of the fixed-dose combination of rosuvastatin / ezetimibe as treatment for patients with dyslipidemia in routine medical practice.
- Trial name
- TREZETE (NCT04862962)
- Testing
- Rosuvastatin 10 or 20mg /Ezetimibe 10 mg Fixed Dose
- Where
- Mexico
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Laboratorios Silanes S.A. de C.V.
Asthma
Evaluation of Tiotropium 5 µg/Day Delivered Via the Respimat® Inhaler Over 48 Weeks in Patients With Severe Persistent Asthma on Top of Usual Care (Study I)
The trial is a randomised, double-blind, placebo-controlled, parallel-group trial to evaluate the efficacy and safety of 5 µg tiotropium over a 48-week treatment period as compared to placebo.
- Trial name
- NCT00772538
- Testing
- tiotropium 5mcg/day
- Where
- 73 sites in United States, Australia and 12 more
- Volunteers
- 459 people
- Sponsor
- Boehringer Ingelheim
Schizophrenia
Neurocognitive Training Integrated in OPUS Treatment Versus OPUS Treatment-as-usual
The study examines the effect of cognitive training on cognitive functioning and everyday competencies of patients with schizophrenia.
- Trial name
- NEUROCOM (NCT00472862)
- Testing
- Cognitive training
- Where
- Denmark
- Volunteers
- 117 people
- Sponsor
- Neurocom
Schizophrenia, Dual Diagnosis
Treatment of Schizophrenia and Comorbid Cannabis Use Disorder: Comparing Clozapine to Treatment-as-Usual
Many individuals with schizophrenia also suffer from marijuana addiction. Clozapine, an atypical antipsychotic medication, may prove useful at preventing drug relapse in schizophrenic individuals who are seeking treatment for…
- Conditions
- Schizophrenia, Dual Diagnosis, Schizoaffective Disorder, Psychotic Disorder
- Trial name
- NCT00498550
- Testing
- Clozapine, Treatment as usual
- Where
- 4 sites in United States
- Volunteers
- 31 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Depression
Halifax Treatment Refractory Depression Trial
This study will use a randomized parallel group design to examine the effects of Intensive Short-term Dynamic Psychotherapy (ISTDP) for depressed patients non-remitting following at least one course of antidepressants.
- Trial name
- NCT01141426
- Testing
- Intensive Short-term Dynamic Psychotherapy, Secondary Care Treatment as Usual
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Joel Town
Anorexia Nervosa, Bulimia Nervosa
Eating Disorders: Online Self-help & Usual Treatment (TAU) vs TAU Only
A pilot study exploring whether individuals receiving usual treatment (CBT) from the specialist NHS Tayside Eating Disorders Service and accessing the online self-help "Smart Eating" programme have improved treatment outcomes…
- Conditions
- Anorexia Nervosa, Bulimia Nervosa, Binge Eating Disorder, Other Specified Feeding or Eating Disorder
- Trial name
- NCT03107221
- Testing
- "Smart Eating" internet-based self-help programme
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Edinburgh
Marijuana Abuse, Psychotic Disorders
Specialized Addiction Treatment Versus Treatment as Usual for Young Patients With Cannabis Abuse and Psychosis
The purpose of the trial is to investigate the effect of specialized treatment of cannabis abuse among young people with psychosis. The specialized treatment consists of manualized individual treatment and group therapy.
- Conditions
- Marijuana Abuse, Psychotic Disorders, Schizophrenia
- Trial name
- CapOpus (NCT00484302)
- Testing
- Cognitive behavioral therapy with motivational interviewing, Non-manualized standard treatment
- Where
- Denmark
- Volunteers
- 103 people
- Sponsor
- Bispebjerg Hospital
Substance Use Disorders
EMDR Versus Treatment As Usual in Patients With Substance Use Disorder
The main objective of this project is to test whether EMDR therapy is effective in reducing substance use and improving clinical and trauma-related symptoms in SUD patients with a history of psychological trauma.
- Trial name
- NCT03517592
- Testing
- EMDR, Treatment as Usual
- Where
- 2 sites in Spain
- Volunteers
- 142 people
- Sponsor
- Parc de Salut Mar
Anxiety, Depression
Effectiveness of a Transdiagnostic Internet-based Treatment for Emotional Disorders
The aim of this study is to assess the efficacy of a Transdiagnostic Internet-based Protocol (Emotion Regulation Protocol) for the treatment of unipolar mood disorders (major depression and dysthimia) four anxiety disorders…
- Trial name
- NCT02345668
- Testing
- Emotion Regulation Protocol, Treatment as Usual (Pharmacological Treatment), Treatment as Usual (Psychological Treatment)
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Universitat Jaume I
Suicidal Ideation/Behavior, Depression
Randomized, Placebo-controlled Multicenter Trial of Lithium Plus Treatment as Usual (TAU) for Acute Suicidal Ideation and Behavior in Patients With Suicidal Major Depressive Episode
The primary hypothesis of this confirmatory study is that lithium therapy will acutely decrease suicidal ideation and/or suicidal behaviour in inpatients with a major depressive episode (MDE, unipolar and bipolar disorder…
- Trial name
- NCT02039479
- Testing
- Lithium Carbonate
- Where
- 5 sites in Germany
- Volunteers
- 254 people
- Sponsor
- Technische Universität Dresden
Atrial Flutter Typical
Cryoballoon Ablation as First Line Treatment of Atrial Flutter
Current guidelines recommend radiofrequency catheter ablation of the cavotricuspid isthmus as treatment for symptomatic/drug-refractory atrial flutter, in spite of the fact that recurrences of flutter and incidence of…
- Trial name
- CRAFT (NCT03401099)
- Testing
- Radiofrequency ablation of CTI, Cryoballoon PVI
- Where
- 10 sites in Switzerland, United Kingdom
- Volunteers
- 113 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust