Clinical trials: Treatment-refractory Schizophrenia
Schizophrenia
Evaluation of the Role of Neurodegeneration in Schizophrenia
Schizophrenia is a progressive psychiatric disorder with a lifetime prevalence of 1%, its etiology is not fully understood, and it progresses with relapses.
- Trial name
- NCT05257720
- Testing
- GFAP, S100B
- Where
- Turkey (Türkiye)
- Volunteers
- 178 people
- Sponsor
- Istanbul Saglik Bilimleri University
Hallucinations, Schizophrenia
Multimodal MRI-guided rTMS to Treat Refractory Hallucinations
The efficacy of neuro-navigated rTMS for patients with schizophrenia suffering from drug-resistant multisensory hallucinations will be tested by the implementation of a double-blind randomized controlled trial (RCT) This study…
- Conditions
- Hallucinations, Schizophrenia, Perceptual Disorders
- Trial name
- MULTIMODHAL (NCT01373866)
- Testing
- MagPro X100 repetitive Transcranial Magnetic Stimulation
- Where
- 2 sites in France
- Volunteers
- 85 people
- Sponsor
- University Hospital, Lille
Schizophrenia
Treating Refractory Schizophrenia With rTMS
Symptomatic treatment of the negative symptoms in schizophrenia (such as social withdrawal, affective flattening, poor motivation, and apathy) with medications and psychotherapy are almost non-existent, whereas treatment of the…
- Trial name
- NCT02242578
- Testing
- 1 Hz rTMS, 10 Hz rTMS
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Seton Healthcare Family
Schizophrenia
Effectiveness of Clozapine Versus Olanzapine for Treatment-resistant Schizophrenia
This study will determine the effectiveness of clozapine versus olanzapine in treating people with schizophrenia that has not improved with treatment.
- Trial name
- COES (NCT00169065)
- Testing
- Clozapine, Olanzapine
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Harvard Medical School (HMS and HSDM)
Schizophrenia Disorders, Schizo Affective Disorder
SEEG-Guided DBS for Schizophrenia
This is a prospective, randomized, interventional study designed to evaluate the efficacy and safety of SEEG-guided deep brain stimulation (DBS) for symptom improvement in patients with treatment-resistant schizophrenia.
- Trial name
- NCT07671261
- Testing
- SEEG implantation, Deep brain stimulation
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Ruijin Hospital
Schizophrenia, Treatment Resistant Schizophrenia
Effectiveness of Exercise Alone and tDCS+Exercise on Cognitive Function Improvement in Patients With Treatment Resistant Schizophrenia
Cognitive impairment is a major determinant of disability in schizophrenia. Aerobic exercise improves global cognition in schizophrenia, particularly working memory and attention/vigilance.
- Conditions
- Schizophrenia, Treatment Resistant Schizophrenia, Cognitive Impairment
- Trial name
- TRACE (NCT07404319)
- Testing
- Aerobic Exercise, Stretching/Education Control, Active tDCS
- Where
- Hong Kong
- Volunteers
- 160 people
- Sponsor
- Kit Wa Chan
Schizophrenia
Treating Drug-Resistant Childhood Schizophrenia
This study will compare clozapine and olanzapine (Zyprexa®) for the treatment of children and adolescents who have failed standard antipsychotic treatment for schizophrenia.
- Trial name
- NCT00048828
- Testing
- Olanzapine, Clozapine
- Where
- 3 sites in United States
- Volunteers
- 41 people
- Sponsor
- Northwell Health