Clinical trials: Tremor Essential
Laser Interstitial Thermal Therapy, Parkinson Disease
Possibilities of Use MRI-Guided Laser Interstitial Thermal Therapy in Medically Intractable Tremor
Medically intractable tremors are a common difficult clinical situation. Deep brain stimulation decreases Parkinson's disease tremor and essential tremor, but not all patients are candidates from a diagnostic, medical, or social…
- Conditions
- Laser Interstitial Thermal Therapy, Parkinson Disease, Essential Tremor, Movement Disorders
- Trial name
- PossibiLITT (NCT06799923)
- Testing
- laser electrode
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Essential Tremor, Parkinson's Disease
Home Use Study of Targeted Mechanical Stimulation for Tremor Relief
Subjects will receive prototype devices to be used for participation. The study comprises three phases: 1. Alpha phase: Two remote study visits and an in-home period to gather device usability data on the alpha system.
- Trial name
- NCT07078422
- Testing
- Encora Pulse
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Encora, Inc.
Essential Tremor
Dual Lead Thalamic Deep Brain Recording (DBR)-DBS Interface for Closed Loop Control of Severe Essential Tremor
This is a feasibility study based on physician-initiated Investigational Device Exemption (IDE) including intraoperative experiments and chronic testing of implanted dual thalamic DBS lead systems.
- Trial name
- NCT04212780
- Testing
- Medtronic Summit Rechargable (RC)+S, ipsilateral thalamic (VIM+VO) DBS, standard ET DBS
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Florida
Parkinson's Disease, Essential Tremor
RECHARGE Sub-Study to the Implantable Systems Performance Registry (ISPR)
The purpose of this study is to assess the recharge feature of the Activa RC System in patients who are receiving Deep Brain Stimulation (DBS) for Parkinson's Disease (PD), Essential Tremor (ET), or dystonia.
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia
- Trial name
- RECHARGE (NCT00998660)
- Testing
- Activa RC
- Where
- 11 sites in United States, Austria and 4 more
- Volunteers
- 100 people
- Sponsor
- MedtronicNeuro
Essential Tremor
Simultaneous Bilateral Radiofrequency Thalamotomy for Medication-Refractory Essential Tremor
This study aims to evaluate the safety and effectiveness of simultaneous bilateral radiofrequency thalamotomy for patients with medication-refractory essential tremor (ET).
- Trial name
- NCT07066358
- Testing
- Simultaneous Bilateral RF Thalamotomy
- Where
- Japan
- Volunteers
- 5 people
- Sponsor
- Tokyo Women's Medical University
Essential Tremor
RWE Study Utilizing the Cala Trio Device in Patients With Essential Tremor
The study objective is to evaluate hand tremor relief in the treated hand following stimulation with the Cala Trio Device in adults with essential tremor, and healthcare resource utilization and total healthcare costs over a…
- Trial name
- NCT05540626
- Testing
- Cala Trio
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- Cala Health, Inc.
Essential Tremor
Continued Access Protocol: ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors
The objective of this prospective, multi site, single-arm study is to capture the efficacy of treatment using the ExAblate Transcranial System and to further demonstrate safety in medication-refractory tremor in patients with…
- Trial name
- NCT02289560
- Testing
- Transcranial ExAblate
- Where
- 7 sites in United States
- Volunteers
- 61 people
- Sponsor
- InSightec
Essential Tremor
Continuous Tremor Assessment During Daily Activities
The specific aim of this study is to evaluate if tremor severity and quality of life can be improved more using continuous home monitoring along with traditional assessments versus traditional assessments alone.
- Trial name
- NCT01978080
- Testing
- Kinesia HomeView
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- Great Lakes NeuroTechnologies Inc.
Tremor, Parkinson Disease
Open Label Study for the Use of Transcranial Ultrasound Treatment of Tremor
The purpose of this Phase I open label study is to evaluate longer term tolerability and potential effectiveness of transcranial ultrasound in people with tremor as a results of Parkinson's Disease or Essential Tremor.
- Conditions
- Tremor, Parkinson Disease, Essential Tremor
- Trial name
- NCT05475340
- Testing
- Focused Ultrasound
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Neurological Associates of West Los Angeles
Essential Tremor, Multiple System Atrophy
Defining Phenotypes of Movement Disorders :Parkinson's Plus Disorders (PD), Essential Tremor (ET), Cortical Basal Degeneration (CBD), Multiple Systems Atrophy (MSA), Magnetoencephalography.
Investigators hypothesize that there are specific characteristic of each cognitive and motor condition that can be defined using brains scans.
- Conditions
- Essential Tremor, Multiple System Atrophy, Corticobasal Degeneration, Supranuclear Palsy, Progressive
- Trial name
- PHENO (NCT02132052)
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Colorado, Denver
Tremor, Essential Tremor
Stereotactic Radiosurgery for Essential Tremor and Parkinsonian Tremor
The purpose of this study is to determine the changes in quality of life and degree of tremor for patients with essential tremor or Parkinsonian tremor who are treated by stereotactic radiosurgery (SRS).
- Conditions
- Tremor, Essential Tremor, Parkinson Disease, Radiosurgery
- Trial name
- NCT01734122
- Testing
- Questionnaires / Observational Assessments
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center
Essential Head Tremor
Evaluation of Botulinum Toxin Injection Efficacy in the Treatment of Head Essential Tremor
Essential head tremor (HT) does not usually respond to drug treatment such as propranolol or primidone or to surgical treatment such as deep brain stimulation of the thalamic ventralis intermedius nucleus.
- Trial name
- Btx-HT (NCT02555982)
- Testing
- BOTOX ® 200 Unités
- Where
- 17 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Clermont-Ferrand
Essential Tremor
Chinese ET Registry (CETR)
The purpose of the Chinese Essential Tremor Registry (CETR) is to develop a database of patients with Essential tremor in China.
- Trial name
- NCT04198246
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Xiangya Hospital of Central South University
Parkinson Disease, Essential Tremor
24-months Study to Evaluate Safety and Efficacy of Peroneal Transcutaneous NeuroModulation in Subjects With Parkinson's Disease and Essential Tremor
This study investigates the long-term safety and tolerability of home peroneal eTNM® therapy using the URIS I™ device in subjects with Parkinson's disease (PD) or Essential Tremor (ET).
- Trial name
- NCT06570421
- Testing
- Peroneal electrical transcutaneous neuromodulation (peroneal eTNM®)
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Stimvia s.r.o.
Essential Tremor
Comparison of Botulinum Toxin Injections in Forearm FLexor Plus EXtensor Muscles vs. Flexor Muscles Alone for Treatment of Essential Hand Tremor(FLEX-D ET)
To compare the efficacy of botulinum toxin (BoNT) injections in forearm flexors plus extensor muscles versus flexors alone for the treatment of essential hand tremor (ET).
- Trial name
- FLEX-D ET (NCT02909907)
- Testing
- Botulinum toxin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- The Cleveland Clinic
Essential Tremor
Magnetoencephalography (MEG) Pilot Study
The purpose of this research is to learn more about how the brain works in people with essential tremor, and how it changes after treatment with High-Intensity Focused Ultrasound (HiFU).
- Trial name
- MEG (NCT07446192)
- Testing
- MRI and fMRI scans, MEG, Sensor-based motor assessments
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Florida
Parkinson's Disease, Tremor
Randomised Crossover Trial of DBS of Differential PSA Regions in Parkinson's Disease and Tremor
The posterior subthalamic area holds promise as a target region for deep brain stimulation in tremor and Parkinson's disease. Using the magnetic resonance-directed implantable guide tube surgical technique, subregions of the…
- Trial name
- NCT01945567
- Testing
- Up to 3 mA, 60 us, 130 Hz deep brain stimulation, Empirical unblinded deep brain stimulation programming
- Where
- Australia
- Volunteers
- 39 people
- Sponsor
- The University of Western Australia
Essential Tremor
The Encora X1™ in a Real World Observational Study
This research is a post-market study designed to evaluate the long-term, real-world impact of the Encora X1™ on your daily life.
- Trial name
- NCT07911488
- Testing
- Encora X1
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Encora, Inc.
Essential Tremor
A Clinical Trial of 2 Doses of PRAX-944 in Participants With Essential Tremor
This multi-center, randomized, double-blinded, placebo-controlled, dose-range-finding clinical trial (with an optional Extension comprised of an Extension Double-blind (DB) Lead in Period followed by an Extension Open-label (OL)…
- Trial name
- Essential1 (NCT05021991)
- Testing
- 100 mg PRAX-944, 60 mg PRAX-944, Flexibly dosed 20 mg to 100 mg PRAX-944
- Where
- 39 sites in United States, Canada
- Volunteers
- 133 people
- Sponsor
- Praxis Precision Medicines
Parkinson's Disease, Obsessive Compulsive Disorder
Physiological Brain Atlas Development
The NIH grant has funded the development of a physiological brain atlas registry that will allow us to significantly improve the data collectioin and use of physiological data into a normalized brain volume.
- Conditions
- Parkinson's Disease, Obsessive Compulsive Disorder, Dystonia, Essential Tremor
- Trial name
- Brain Atlas (NCT00575081)
- Testing
- Stereotactic brain procedures
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Vanderbilt University Medical Center