Clinical trials: Tremor Essential
Parkinson's Disease, Essential Tremor
Dexmedetomidine Effects on Microelectrode Recording in Deep Brain Stimulation
To test the hypothesis that sedation induced by Dexmedetomidine at levels appropriate for awake, DBS surgery has no significant effect on electrophysiological parameters of DBS micro-electrode recordings
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia
- Trial name
- NCT00608231
- Testing
- Dexmedetomidine Hydrochloride Infusion, Normal Saline
- Where
- United States
- Sponsor
- Vanderbilt University
Essential Tremor, Essential Tremor, Movement Disorders
A Study to Evaluate the Safety and Efficacy of Staged Bilateral Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for the Treatment of Essential Tremor
The objective of this prospective, single-arm, open-label study is to asses the safety and efficacy of the staged bilateral thalamotomy using transcranial magnetic resonance guided focused ultrasound system ExAblate 4000…
- Trial name
- ET-Bi-MRgFUS (NCT06676501)
- Testing
- ExAblate
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chinese PLA General Hospital
Tremor, Essential Tremor
Stereotactic Radiosurgery for Essential Tremor and Parkinsonian Tremor
The purpose of this study is to determine the changes in quality of life and degree of tremor for patients with essential tremor or Parkinsonian tremor who are treated by stereotactic radiosurgery (SRS).
- Conditions
- Tremor, Essential Tremor, Parkinson Disease, Radiosurgery
- Trial name
- NCT01734122
- Testing
- Questionnaires / Observational Assessments
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center
Essential Tremor
Octanoic Acid for Essential Tremor
Background: Essential tremor (ET) is a condition of out-of-control shaking. Several drugs are used to treat ET. However, they are often only partly helpful and can have side effects.
- Trial name
- NCT01468948
- Testing
- Octanoic Acid
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Essential Tremor
ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors
The objective of this prospective, randomized, double-blind (to subjects, local site's blinded assessor and Tremor Core Lab assessors), crossover, multi-site, two-arm study (ExAblate treated arm Vs ExAblate Sham treated control…
- Trial name
- NCT01827904
- Testing
- Transcranial ExAblate
- Where
- 8 sites in United States, Canada and 2 more
- Volunteers
- 76 people
- Sponsor
- InSightec
Essential Tremor, Movement-related Cortical Potentials
Motor-related Cortical Potential in Patients With Essential Tremor
In this proposal, in addition to the conventional MRCP recording, the dipoles and sources of the different subcomponents of MRCP will also be analyzed with the brain electric source analysis (BESA) to evaluate the difference in…
- Trial name
- NCT01250067
- Testing
- Motor-related cortical potential (Procedure)
- Where
- Taiwan
- Sponsor
- China Medical University Hospital
Essential Tremor
Temporal Interference for Essential Tremor
This single-center prospective study aims to investigate the treatment efficacy of temporal interference (TI) in essential tremor patients aged 30-70.
- Trial name
- NCT07016425
- Testing
- Temporal Interference
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Liankun_Ren
Parkinson Disease, Dystonia
Clinical and Physiological Studies of Tremor Syndromes
Background: Researchers have some data on how the brain controls movement and why some people have tremor. But the causes of tremor are not fully known.
- Conditions
- Parkinson Disease, Dystonia, Essential Tremor
- Trial name
- NCT03027310
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Essential Tremor
Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract
The purpose of this study is to elucidate the structural connectivity of the dentato-rubro-thalamic tract (DRTt) and to detect functional network changes due to DRTt stimulation
- Trial name
- NCT04758624
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Northwell Health
Essential Tremor, Upper Extremity Essential Tremor
Coordinated Reset Deep Brain Stimulation for Essential Tremor
Deep brain stimulation (DBS) is a surgical procedure for the treatment of Essential Tremor (ET). A novel approach to current DBS approaches is called coordinated reset DBS (CR-DBS) which uses different patterns of stimulation at…
- Trial name
- NCT05897775
- Testing
- Deep brain stimulation
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Minnesota
Essential Tremor
Bilateral Treatment of Medication Refractory Essential Tremor
The purpose of this study is to see if the MR-guided focused ultrasound (MRgFUS) thalamotomy procedure can be performed on both sides of the brain safely and effectively to reduce bilateral tremor.
- Trial name
- NCT04112381
- Testing
- Exablate Model 4000 Type 1.0/1.1
- Where
- 7 sites in United States
- Volunteers
- 51 people
- Sponsor
- InSightec
Parkinson Disease, Essential Tremors and Dystonia
DBS in the Treatment of Intractable Movement Disorders
The aim of this study is to observe the efficacy of Deep Brain Stimulation in the treatment of Parkinson's disease,Essential Tremors and Dystonia in our locality.
- Trial name
- NCT03562403
- Testing
- Deep Brain Stimulation
- Volunteers
- 16 people
- Sponsor
- Assiut University
Essential Tremor
A Phase 2 RCT Study of CX-8998 for Essential Tremor
This is a multicenter, double-blind, placebo-controlled, parallel-group study consisting of a screening period of up to 4 weeks (with the exception of participants on primidone at baseline who will be allowed 6 weeks of screening…
- Trial name
- NCT03101241
- Testing
- CX-8998
- Where
- 22 sites in United States
- Volunteers
- 95 people
- Sponsor
- Jazz Pharmaceuticals
Preoperative Anxiety
Evaluating the Impact of Virtual Reality on Mood in Patients Undergoing Magnetic Resonance-Guided Focused Ultrasound for Medication-Refractory Essential Tremor
The primary objective of this randomized study is to evaluate the effect of a virtual reality (VR) video on pre-treatment anxiety levels in individuals undergoing magnetic resonance-guided focused ultrasound (MRgFUS) treatment…
- Trial name
- NCT07287605
- Testing
- VR headset: video number 1, VR headset: video number 2
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Essential Tremor
Neuromodulation Strategies for Treatment-Resistant Essential Tremor Using Chronos™ DBS
The goal of this observational study is to learn whether a new way of programming Deep Brain Stimulation (DBS) can improve and maintain tremor control in adults with essential tremor (ET) who stopped responding to standard DBS…
- Trial name
- NCT07302867
- Testing
- Continuous, Continuous + High Frequency Cycling, High Frequency
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- University of British Columbia
Essential Tremor
Cyclic Deep Brain Stimulation in Essential Tremor
The aim of the study is to prove the efficacy and safety of cyclical deep brain stimulation (DBS) in patients with essential tremor, and demonstrate non-inferiority of cyclical DBS on tremor control when compared to continuous…
- Trial name
- NCT04260971
- Testing
- Abbott St Jude Medical Infinity 7 neurostimulator
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- King's College Hospital NHS Trust
PARKINSON DISEASE (Disorder)
Wearable for Assessing Tremor and Continuous Health in Parkinson's Disease and Essential Tremor
This prospective observational study will examine tremor and upper-limb movement in adults with Parkinson's disease or essential tremor using non-invasive wearable sensors.
- Trial name
- PD-WATCH (NCT07787299)
- Testing
- Device exposure: Wearable inertial sensor monitoring
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Heriot-Watt University
Essential Tremor, Dystonia
The Development of a System for Measurement of Tremor
The goal of this clinical trial is to develop a system which can be used to measure movements in people with Essential Tremor (with or without dystonia).
- Trial name
- NCT05956223
- Testing
- Virtual Reality measurement of essential tremor and dystonia
- Where
- Australia
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- The Bionics Institute of Australia
Parkinson Disease, Essential Tremor
Investigating LFP Correlates of TUS in Patients With Movement Disorders
Transcranial Ultrasound Stimulation (TUS) is an emerging non-invasive brain stimulation(NIBS) technique that can be used on both superficial and deep brain targets with a high spatial resolution as small as a few cubic…
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia
- Trial name
- TUS-LFP (NCT05965960)
- Testing
- TUS Active
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University Health Network, Toronto
Parkinson's Disease (PD), Essential Tremor
LIFUS For Neurological Disorders
Low intensity focused ultrasound (LIFUS) has the potential to be used as a means of non-invasive neuro-modulation. To this day, the use of LIFUS is under investigation.
- Conditions
- Parkinson's Disease (PD), Essential Tremor, Orthostatic Tremor, Dystonia
- Trial name
- NCT07417280
- Testing
- LIFUS
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto