Clinical trials: Tremor Essential
Essential Tremor
Cerebellar Research in Ultrasound Stimulation
Experiment 1: Modulation of Physiological Tremor in Healthy Volunteers Thirty healthy volunteers will undergo TUS targeting the dentate nucleus in a randomized, double-blinded crossover design.
- Trial name
- CERBERUS (NCT07508696)
- Testing
- Transcranial focused ultrasound delivered to the dentate nucleus using the NeuroFUS Pro by Brainbox, Transcranial focused ultrasound delivered to the ventricles (control) using the NeuroFUS Pro by Brainbox
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Essential Tremor of the Upper Limbs
Botulinum Toxin A to Treat Arm Tremor
The objective of this study is to assess the efficacy and safety of a single, kinematic-analysis-based intramuscular injection of NT 201, compared with placebo, in moderate to marked essential tremor of the upper limb.
- Trial name
- NCT02207946
- Testing
- IncobotulinumtoxinA
- Where
- 6 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Merz Pharmaceuticals GmbH
Essential Tremor
Temporal Interference for Essential Tremor
This single-center prospective study aims to investigate the treatment efficacy of temporal interference (TI) in essential tremor patients aged 30-70.
- Trial name
- NCT07016425
- Testing
- Temporal Interference
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Liankun_Ren
Essential Tremor
Double-Blind, Placebo Controlled Pilot Study of Octanoic Acid in Essential Tremor
Background: Essential tremor (ET) is a neurological disorder characterized by uncontrollable shaking. Several medications are used to treat ET; however, they are often only partly effective and can have side effects.
- Trial name
- NCT00848172
- Testing
- Octanoic Acid
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Essential Tremor
Pre-lemniscal Radiation Deep Brain Stimulation for ET
The hypothesis is that prelemniscal radiation (RaPRL) deep brain stimulation (DBS) is more effective for axial (head/neck/voice) tremor, and perhaps, appendicular tremor control in essential tremor patients.
- Trial name
- NCT00634478
- Testing
- Pre-lemniscal Radiation Deep Brain Stimulation
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Essential Tremor
Bilateral Essential Tremor Treatment With FUS
Combined Phase II/III, multi-center, prospective, single-blinded trial. Ten (10) patients with who previously underwent successful and uncomplicated MRgFUS thalamotomy for essential tremor will undergo a contralateral treatment.
- Trial name
- BEST-FUS (NCT04501484)
- Testing
- Magnetic Resonance-guided Focused Ultrasound VIM Thalamotomy
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- University Health Network, Toronto
Tremor, Essential Tremor
ExAblate (Magnetic Resonance-guided Focused Ultrasound Surgery) for Treatment of Tremor
A feasibility Study to Evaluate Safety and Initial Effectiveness of ExAblate Transcranial MR Guided Focused Ultrasound for Unilateral Thalamotomy in the Treatment of Tremor
- Trial name
- NCT01932463
- Testing
- ExAblate Transcranial System
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- InSightec
Essential Tremor
Identifying Markers of Disease Subtypes and Disease Progression in the Syndrome of Essential Tremor
The goal of this observational study is to learn about epidemiology, biologic markers, disease subtypes and possible prognostic factors in essential tremor (ET) patients.
- Trial name
- NCT06349538
- Testing
- Clinical examination, blood draw, cerebral MRI, sonography, tremor analysis, OCT, olfactory mucosa swab.
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Graz
Essential Tremor, Deep Brain Stimulation
Multicentre RCT of Awake Versus Asleep Tractography Based DBS for ET
Rationale: Deep brain stimulation (DBS) of the thalamus is an effective surgical treatment for patients with disabling essential tremor, despite optimal pharmacological treatment.
- Conditions
- Essential Tremor, Deep Brain Stimulation, Diffusion Tensor Imaging, Magnetic Resonance
- Trial name
- TREMBLE (NCT05968976)
- Testing
- Awake DBS, Asleep DBS
- Where
- Netherlands
- Volunteers
- 110 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Deep Brain Stimulation, Directional Lead
Relief From Side Effects: Clinical Use of Electrodes With Direction
Deep Brain Stimulation (DBS) uses electrical pulses sent through a lead (insulated wire) to help stop unwanted symptoms in a variety of brain diseases, including the tremor seen in patients with Essential Tremor (ET).
- Conditions
- Deep Brain Stimulation, Directional Lead, Essential Tremor
- Trial name
- RESCUED (NCT03795935)
- Testing
- No side-effect stimulator settings with directional lead
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University of British Columbia
Essential Tremor, Dystonia
The Development of a System for Measurement of Tremor
The goal of this clinical trial is to develop a system which can be used to measure movements in people with Essential Tremor (with or without dystonia).
- Trial name
- NCT05956223
- Testing
- Virtual Reality measurement of essential tremor and dystonia
- Where
- Australia
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- The Bionics Institute of Australia
Parkinson's Disease
Efficacy and Safety of F-18 FPCIT PET in Parkinson's Disease and Essential Tremor Patients
The purpose of this study is to determine whether F-18 FPCIT is effective and safe radiopharmaceutical for the objective diagnosis of Parkinson's disease.
- Trial name
- FPCIT (NCT00468078)
- Testing
- PET/CT, F-18 FPCIT
- Where
- South Korea
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Essential Tremor
ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors
The objective of this prospective, randomized, double-blind (to subjects, local site's blinded assessor and Tremor Core Lab assessors), crossover, multi-site, two-arm study (ExAblate treated arm Vs ExAblate Sham treated control…
- Trial name
- NCT01827904
- Testing
- Transcranial ExAblate
- Where
- 8 sites in United States, Canada and 2 more
- Volunteers
- 76 people
- Sponsor
- InSightec
Essential Tremor, Movement-related Cortical Potentials
Motor-related Cortical Potential in Patients With Essential Tremor
In this proposal, in addition to the conventional MRCP recording, the dipoles and sources of the different subcomponents of MRCP will also be analyzed with the brain electric source analysis (BESA) to evaluate the difference in…
- Trial name
- NCT01250067
- Testing
- Motor-related cortical potential (Procedure)
- Where
- Taiwan
- Sponsor
- China Medical University Hospital
Parkinson Disease, Essential Tremor
Brain Network Activation in Patients With Movement Disorders
The diagnosis and management of movement disorders, such as Parkinson's disease (PD), parkinson-plus syndromes (PPS), dystonia, essential tremor (ET), normal pressure hydrocephalus (NPH) and others is challenging given the lack…
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia, Normal Pressure Hydrocephalus
- Trial name
- BNA-MDi (NCT03269201)
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Sheba Medical Center
Essential Tremor
Efficacy of Pramipexole Extended Release in the Treatment of Essential Tremor
Aim of the study is to perform a double-blind, crossover, placebo-controlled multicenter study evaluating the efficacy of pramipexole on essential tremor.
- Trial name
- NCT01441284
- Testing
- pramipexole
- Where
- 2 sites in Hungary
- Sponsor
- University of Pecs
Epilepsy, Essential Tremor
Human Cognition During Surgery: Stimulation-based and Cholinergic Modulation
This is a research study to determine how COBENFY KarXT (FDA approved), a drug which has been approved for treatment of certain disorders, affects brain activity and cognitive tasks which may be regulated by the cholinergic…
- Conditions
- Epilepsy, Essential Tremor, Seizures, Memory Consolidation
- Trial name
- NCT07721272
- Testing
- Cobenfy KarXT pill (50/20 mg)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Texas Southwestern Medical Center
Essential Tremor
Cerebello-thalamo-cortical Coupling in Essential Tremor
Essential tremor (ET) is a frequent and disabling disorder with progressive worsening of postural tremor of the upper limbs that impairs most of the manual activities of every day life (feeding, drinking, etc.).
- Trial name
- CERESTIM (NCT02346409)
- Testing
- tACS of the cerebellum
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Essential Tremor, Parkinsonian Disorders
Linac FRACtionated Radiosurgical THALamotomie in Tremors (FRACTHAL)
Radiosurgical thalamotomy on GammaKnife has been shown to be effective in the management of tremors. However, several teams describe a significant risk of severe neurological complications.
- Trial name
- FRACTHAL (NCT04727658)
- Testing
- Radiosurgical thalamotomy on GammaKnife
- Where
- Monaco
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Essential Tremor
Cerebellar rTMS for Essential Tremor
Essential tremor (ET) is a low-mortality, though truly burdensome and debilitating condition which is known to be the second most common movement disorder of the adult population only after restless legs syndrome.
- Trial name
- NCT02704793
- Testing
- Bilateral 1 Hz Cerebellar rTMS
- Where
- Iran
- Volunteers
- 23 people
- Sponsor
- Mashhad University of Medical Sciences