Clinical trials: Trigeminal Autonomic Cephalalgias
Cluster Headache, Sleep
Actigraphy and Nocturnal Heartrate Variability in Cluster Headache Patients
Cluster headache is one of the most painful headaches, characterized by recurring episodes of unilateral, periorbital pain, which is accompanied by autonomic symptoms that seem to be of both sympathetic and parasympathetic…
- Trial name
- NCT03010189
- Testing
- Actigraphy, Heart-rate variability monitoring, Pupillometry
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nordlandssykehuset HF
Migraine, Cluster Headache
Pain Biomarker Study
This study investigates molecular and physical biomarkers of headaches in order to better understand mechanisms of these diseases. There are 3 main parts: 1.
- Conditions
- Migraine, Cluster Headache, Trigeminal Autonomic Cephalgia, Hemicrania Continua
- Trial name
- PBS (NCT03511846)
- Testing
- Oral capsaicin, Topical capsaicin, Intranasal capsaicin
- Where
- United States
- Volunteers
- 371 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Cluster Headache
Efficacy and Safety of Zolmitriptan by Sublingual Administration
The purpose is to evaluate the effectiveness and safety profile of zolmitriptan by Sublingual administration for the acute treatment of Cluster headache.
- Trial name
- NCT03377257
- Testing
- zolmitriptan by sublingual administration, zolmitriptan by oral
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Trigeminal Neuralgia, Facial Pain
Incidence of Intravascular (IV) Injection During Trigeminal Nerve Blocks
The purpose of this study is to investigate the incidence of intravascular injection during trigeminal nerve blocks.
- Conditions
- Trigeminal Neuralgia, Facial Pain, Postherpetic Neuralgia, Cluster Headache
- Trial name
- NCT04467398
- Testing
- trigeminal nerve block
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University
Headache, Cluster
SPG Pulsed Radiofrequency for Chronic Cluster Headache
Cluster headache (CH) is a devastating disorder characterized by ipsilateral headache and associated trigeminal autonomic symptoms, with a yearly prevalence of 0.1%.
- Trial name
- NCT06787677
- Testing
- PRF, NB
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Beijing Tiantan Hospital
Cluster Headache
Pilot Study Evaluating the Use of Nasal Carbon Dioxide for the Treatment of Cluster Headache
This is an open label, investigator-sponsored, pilot study. Subjects agreeing to participate in the study and meeting the eligibility criteria assessed at the screening visit will be enrolled in the study.
- Trial name
- NCT02381795
- Testing
- Nasal Carbon Dioxide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cady, Roger, M.D.
Cluster Headache
Circadian Changes of the Hypothalamic Activity in Patients Suffering From Cluster Headache
Cluster headache attacks do not occur randomly throughout the day, but have a clear circadian rhythmicity. The aim of this study is to investigate circadian changes of the brain, the autonomic nervous system and pain processing…
- Trial name
- NCT04409977
- Testing
- MRI examination
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Cluster Headache
Data Collection on the ATI Neurostimulation System: SPG Stimulation for Cluster Headache
The primary objectives of the Registry are to: 1. Monitor the transfer of the ATI Neurostimulation System and its safety/clinical performance to a larger number of centers in the post market phase and 2.
- Trial name
- NCT01677026
- Where
- 11 sites in Denmark, Germany
- Volunteers
- 150 people
- Sponsor
- Autonomic Technologies, Inc.
Primary Headaches (Migraines, Tension, Cluster Headaches)
Osteopathic Manual Therapy (OMT) and Brain Structure and Function in Primary Headache Patients: A Pilot Study
Chronic headaches are associated with changes in brain structure and function that may be associated with increased suffering and disability.
- Trial name
- NCT06841627
- Testing
- Osteopathic Manipulative Therapy
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Edward Via Virginia College of Osteopathic Medicine
Chronic Cluster Headache
Response to Combined Trigeminal and Occipital Nerve Stimulation for the Preventive Treatment in Chronic Cluster Headache
This is a limited open-label study being performed at two centers in the Netherlands. All participants will receive the same treatment, and both the patients and doctors will know what that treatment is.
- Trial name
- SalviaBio (NCT07113470)
- Testing
- The Salvia PRIMUS implantable neurostimulator System
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Salvia BioElectronics
Cluster Headache
Cluster Headache Treatment Survey
The objective of this study is to survey patients with cluster headache about treatment effectiveness and their views on treatments. Participants will complete one brief questionnaire online.
- Trial name
- NCT06011811
- Where
- United States
- Volunteers
- 2,487 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cluster Headache
Physiotherapy Program for Cluster Headache
This study evaluates the effectiveness of physiotherapy program in the treatment of cluster headaches. Half of participants will receive a program of physiotherapy and usual drugs, while the other will receive an exercise program…
- Trial name
- PhyCH (NCT02460003)
- Testing
- Physiotherapy, Home exercise program
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- AG Clinic
Cluster Headache - Episodic and Chronic, Migraine Headache
Yogabased Movements for Primary Headaches (Migraine and/or Cluster Headache) - YOURHEAD - a Pilot Study
Migraine and/or Cluster Headache: Study Overview Background: Migraine and cluster headache are two primary headache disorders that significantly impact quality of life and functionality in those affected.
- Conditions
- Cluster Headache - Episodic and Chronic, Migraine Headache, Migraine Headache, With or Without Aura, Migraine in Adults
- Trial name
- NCT07292090
- Testing
- Intervention yogabased movements
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
Episodic Cluster Headache
Intranasal Civamide for Episodic Cluster Headache
This is a 49-day study to evaluate the effectiveness of Intranasal Civamide (Zucapsaicin) in the treatment of an episodic cluster headache period compared to placebo (medically inactive substance which does not contain any active…
- Trial name
- NCT00069082
- Testing
- Civamide (Zucapsaicin), Sodium Chloride
- Where
- 6 sites in United States
- Volunteers
- 2 people
- Sponsor
- Winston Laboratories
Cluster Headache
Role of Specific microRNAs in Cluster Headache
Cluster headache (CH) is a primary headache included in the trigeminal autonomic cephalalgias (TACs) according to the International Calssification of Headache Disorder, Third Edition.
- Trial name
- 5*1000 (NCT06503328)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Chronic Cluster Headache
Cephalic Vascular Recording Upon SPG Stimulation
Hypothesis: Stimulation of the SPG at high frequencies (50-200Hz) is believed to cause a physiological parasympathetic block which decreases VMCA oxyHb concentration and cephalic vessel diameter.
- Trial name
- NCT01359631
- Volunteers
- 7 people
- Sponsor
- Autonomic Technologies, Inc.
Primary Headache, Migraine in Adolescence
nVNS for the Prevention and Treatment of Primary Headache
This study is a single-center, single-arm study. All subjects will receive the same treatment. Children and adolescents (7-20 years old) with migraine who met the inclusion criteria will be enrolled as subjects in the…
- Conditions
- Primary Headache, Migraine in Adolescence, Migraine in Children, Cluster Headache
- Trial name
- NCT06277063
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Chronic Cluster Headache
REsponse to Combined SONS and ONS in Chronic Cluster headachE
The purpose of this study is to demonstrate the safe use of the PRIMUS System in subjects with chronic cluster headache. This is a single-centre, open label, prospective, first in human study to collect initial clinical data on…
- Trial name
- RESPONSE (NCT05868044)
- Testing
- PRIMUS
- Where
- Australia
- Volunteers
- 5 people
- Sponsor
- Salvia BioElectronics
Cluster Headache
The Efficacy of L-cysteine in Prevention of Cluster Headache
The purpose of this study is to validate the novel hypothesis that daily use of L-cysteine (Acetium® capsules) is an effective means to decrease the frequency of (or completely abort) the attacks of cluster headache.
- Trial name
- NCT02310828
- Testing
- Acetium
- Where
- 6 sites in Finland
- Volunteers
- 60 people
- Sponsor
- Biohit Oyj