Clinical trials: Trisomy 18
Down Syndrome, Trisomy 18
VAlidation of a Lower Cost aneUploidy scrEen
This study will document the detection rate and false positive rate as well as failure rate of a new prenatal screening approach ('Smart NIPT') as described at www.vanadisdx.com and implemented in an academic laboratory with…
- Conditions
- Down Syndrome, Trisomy 18, Trisomy 13
- Trial name
- VALUE (NCT03087357)
- Testing
- SmartNIPT
- Where
- 16 sites in United States, Canada and 1 more
- Volunteers
- 2,443 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Trisomy 21, 18 and 13 Screening
T21,18 and 13 Screening by Cell Free Fetal DNA in Low Risk Patients
The purpose of this study is to evaluate the performance of non invasive screening in a population of pregnant women with and without in vitro fertilisation (IVF) concomitantly to regular first trimester trisomy 21 (T21)…
- Trial name
- DEPOSA (NCT02424474)
- Testing
- Genetic NIPT, Regular serum screening
- Where
- France
- Volunteers
- 933 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Trisomy 21, Trisomy 18
Prenatal Screening for Down Syndrome With DNAFirst
This study will explore how maternal plasma circulating cell free DNA (ccfDNA) can be used as a primary screening test for Down syndrome as part of routine clinical care in the general pregnancy population.
- Conditions
- Trisomy 21, Trisomy 18, Trisomy 13, Monosomy X
- Trial name
- DNAFirst (NCT01966991)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Pregnancy, Down Syndrome
Comparison of Aneuploidy Risk Evaluations
This is a prospective, multi-center observational study designed to compare the test results of the Verinata Health Prenatal Aneuploidy Test to results of conventional prenatal screening for fetal chromosome abnormalities in…
- Conditions
- Pregnancy, Down Syndrome, Edwards Syndrome, Patau Syndrome
- Trial name
- CARE (NCT01663350)
- Where
- 26 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Verinata Health, Inc.
Alzheimer's Disease, Dementia
Brain Study of Patients With Frontal Lobe Dementia and Parkinsonian Disorders
The Cognitive Neuroscience Section of the National Institute of Neurological Disorders and Stroke proposes to continue its cross-sectional and longitudinal studies of cerebral metabolism in frontal lobe dementias and atypical…
- Conditions
- Alzheimer's Disease, Dementia, Down's Syndrome
- Trial name
- NCT00001178
- Where
- United States
- Volunteers
- 597 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Down Syndrome, Turner Syndrome
Hematological Profile in Children With Numerical Chromosomal Disorders
This cross-sectional study aims to evaluate the hematological profile and determine the frequency and pattern of hematological abnormalities in children with numerical chromosomal disorders attending the Pediatric Department of…
- Conditions
- Down Syndrome, Turner Syndrome, Klinefelter Syndrome, Trisomy 18
- Trial name
- NCT07807540
- Volunteers
- 158 people
- Sponsor
- Assiut University
Pregnancy, Aneuploidy
Noninvasive Screening for Fetal Aneuploidy: A New Maternal Plasma Marker
The purpose of this study is to collect samples for the purpose of developing a prenatal aneuploid test using circulating cell free fetal (ccff) nucleic acid from blood samples from pregnant women who have a high-risk pregnancy…
- Conditions
- Pregnancy, Aneuploidy, Down Syndrome, Edwards Syndrome
- Trial name
- NCT00971334
- Where
- 35 sites in United States, France
- Volunteers
- 2,502 people
- Sponsor
- Sequenom, Inc.
Decision Aid
Scaling a Decision Aid on Prenatal Screening for Trisomy 21, 18 and 13
This research project aims at assessing the effectiveness of a decision aid (DA) scaling intervention within the context of prenatal screening for trisomy 21, 18 and 13.
- Trial name
- PEGASUS-II (NCT05859139)
- Testing
- DA Scaling Strategies
- Where
- Canada
- Volunteers
- 887 people
- Sponsor
- CHU de Quebec-Universite Laval
Down Syndrome (Trisomy 21), Edward's Syndrome (Trisomy 18)
Non-Invasive Determination of Fetal Chromosome Abnormalities
The overall significance of this study is to develop a laboratory developed test (LDT) to use a new marker in the maternal blood to better identify pregnancies that have a child with a chromosome abnormality such as Down syndrome…
- Conditions
- Down Syndrome (Trisomy 21), Edward's Syndrome (Trisomy 18), Patau Syndrome (Trisomy 13), Klinefelter Syndrome (47, XXY)
- Trial name
- NCT00891852
- Where
- 7 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Lenetix Medical Screening Laboratory
Pregnancy
Reducing False Positives in Prenatal Screening
Combined first-trimester screening represents the gold standard of risk assessment for the presence of trisomy 21, 18, and 13. The concept is based on the age risk, the measurement of fetal nuchal translucency (NT), and the…
- Trial name
- ReFaPo02 (NCT03375359)
- Testing
- cfDNA screening
- Where
- Germany
- Volunteers
- 1,127 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Down Syndrome, Patau Syndrome
Clinical Evaluation of the IONA Test for Non-invasive Pre Natal Screening in Twin Pregnancies
The purpose of this study is to evaluate the performance of the IONA® test which is a non-invasive prenatal test (NIPT) for Down's syndrome and other chromosomal abnormalities in twin pregnancies, from a maternal blood sample.
- Conditions
- Down Syndrome, Patau Syndrome, Edward's Syndrome
- Trial name
- TWIN (NCT03200041)
- Testing
- Blood sample
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Premaitha Health
Trisomy 21 in Fetus, Trisomy 18 in Fetus
Serum Sample Collection to Determine Analytical Performance Characteristics of the ADVIA Centaur PAPPA and BhCG Assays
Blood samples collected will be shipped to the sponsor's laboratory to establish analytical performance characteristics of the ADVIA Centaur® Pregnancy Associated Plasma Protein A (PAPP-A) and ADVIA Centaur® Free Beta Human…
- Conditions
- Trisomy 21 in Fetus, Trisomy 18 in Fetus, Trisomy 13 in Fetus
- Trial name
- NCT03629795
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Axis Shield Diagnostics Ltd