Clinical trials: Tropical Disease
Malaria Transmission
Assessing the Effect of Neglected Tropical Diseases on Plasmodium Falciparum Transmission in an Area of Co-endemicity
Assessing the effect of neglected tropical diseases on Plasmodium falciparum transmission in an area of co endemicity.
- Trial name
- TRANSMAL (NCT02769013)
- Testing
- Pre-treatment follow up, S. haematobium treatment, Post treatment follow up
- Where
- 2 sites in Gabon, Ghana
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Melanoma
The Impact of a Prevention Program on Sun Risks in Primary School in Tropical French Region
Sun exposure during childhood can cause the development of skin cancer in later years, in particular melanoma, which is the most lethal.The worldwide incidence of melanoma is on the rise, with nearly 290,000 new cases diagnosed…
- Trial name
- PRESOLRE (NCT05367180)
- Testing
- MISOLRE prevention program on sun risks, "Vivre avec le Soleil" prevention program on sun risks, Sun protection equipment
- Where
- Reunion
- Volunteers
- 1,452 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Lassa Fever
ARN-75039 Lassa Fever Treatment in West Africa
This multicenter, randomized, open-label Phase 2 clinical trial evaluates the safety, tolerability, and virologic efficacy of ARN-75039, a novel oral antiviral, for treating Lassa fever in hospitalized adults in West Africa.
- Trial name
- NCT07419373
- Testing
- ARN-75039 high, Intravenous ribavirin, ARN-75039 low
- Where
- 4 sites in United States, Nigeria
- Volunteers
- 135 people
- Sponsor
- Arisan Therapeutics, Inc.
Malabsorption Syndromes, Granulomatous Enteritis
Plasma Citrulline Concentration in Tropical Enteropathy
Citrulline is an amino acid produced in the intestine and in the liver, but the liver does not contribute significantly to circulating citrulline concentrations.
- Conditions
- Malabsorption Syndromes, Granulomatous Enteritis, Enteritis, HIV Enteropathy
- Trial name
- NCT00816842
- Where
- Zambia
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
HTLV-I Infections, HTLV-II Infections
MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study
This post-market study is intended to assess the performance of the HTLV Blot 2.4 in repository serum/plasma specimens with neurological disorders (n=100) or an HTLV known positive infection (n=50).
- Conditions
- HTLV-I Infections, HTLV-II Infections, Human T-lymphotropic Virus 1, Human T-lymphotropic Virus 2
- Trial name
- NCT03226119
- Testing
- MP Diagnostics HTLV Blot 2.4
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- MP Biomedicals, LLC
Bile Duct Diseases
The Role of Endoscopic Ultrasound in Evaluation of Patients With Indefinite Cause of Bile Duct Dilatation
In the era of diagnostic imaging advances, Bile Duct Dilatation becomes a common incidental finding in patients present with either gastrointestinal symptoms or undergone the imaging study for any other complaints.
- Trial name
- NCT05475964
- Testing
- Endoscopic ultrasound
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- HMHamed
Nutritional and Metabolic Disease
Antioxidant Capacity and Vitamin A Profile in Young Adults Who Consume a Snack Bar Made From Tropical Fruits Treated With UV-C
The objective of the present study was to evaluate the impact of a snack bar on some health indicators associated with diet (plasma antioxidant capacity, lipid profile, vitamin A profile (retinol and carotenoids)) and on the…
- Trial name
- NCT03520725
- Testing
- No Intervention, Pineapple snack bar, Mango snack bar
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centro de Investigación en Alimentación y Desarrollo A.C.
Acute Respiratory Distress Syndrome
Etiology and Outcomes of Tropical Acute Respiratory Distress Syndrome
This is a prospective observational study done to know the etiology and outcomes of Acute Respiratory Distress Syndrome.
- Trial name
- NCT01450527
- Where
- India
- Volunteers
- 64 people
- Sponsor
- All India Institute of Medical Sciences
HIV, Sexually Transmitted Diseases
Zambia One Love Aim 3 Trial
The aim of this study is to determine whether a Strengthening our Vows (SOV) intervention will reduce HIV exposures from concurrent partnership (CP) when compared to the control Good Health Package Plus (GHPP), in addition to…
- Conditions
- HIV, Sexually Transmitted Diseases, Neglected Diseases, Non-communicable Diseases
- Trial name
- NCT02744586
- Testing
- Strengthening Our Vows (SOV), Good Health Package Plus (GHPP)
- Where
- 2 sites in Zambia
- Volunteers
- 3,450 people, healthy volunteers welcome
- Sponsor
- Emory University
Leprosy, Leprosy, Multibacillary
Efficacy and Tolerability of Adjunct Metformin for Multibacillary Leprosy
This trial aims to evaluate the efficacy, tolerability and safety of adjunct metformin added to standard-of-care multi-drug therapy (MDT) in patients with multibacillary leprosy, and explore its effects on immunological…
- Conditions
- Leprosy, Leprosy, Multibacillary, Neglected Tropical Diseases
- Trial name
- MetLep (NCT05243654)
- Testing
- Metformin
- Where
- 6 sites in Indonesia
- Volunteers
- 166 people
- Sponsor
- Oxford University Clinical Research Unit Indonesia
Hookworm Infection, Hookworm Disease
Safety and Immunogenicity of Co-Administered Hookworm Vaccine Candidates Na-GST-1 and Na-APR-1 in Gabonese Adults
Na-GST-1 and Na-APR-1 are proteins expressed during the adult stage of the Necator americanus hookworm life cycle that are thought to play a role in the parasite's degradation of host hemoglobin for use as an energy source.
- Trial name
- NCT02126462
- Testing
- Na-APR-1 (M74)/Alhydrogel®, Na-GST-1/Alhydrogel®, Hepatitis B vaccine
- Where
- Gabon
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Hookworm Infection, Hookworm Disease
Na-GST-1/Alhydrogel With or Without CpG 10104 in Gabonese Adults
Na-GST-1 is a protein expressed during the adult stage of the Necator americanus hookworm life cycle that is thought to play a role in the parasite's degradation of host hemoglobin for use as an energy source.
- Trial name
- NCT03373214
- Testing
- Na-GST-1, CPG 10104
- Where
- Gabon
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Tropical Enteropathy
Trial of Rifaximin in the Treatment of Tropical Enteropathy
The purpose of this study is to determine whether rifaximin is effective in the treatment of tropical enteropathy in a population of African children at high risk for this disease.
- Trial name
- NCT00858988
- Testing
- Rifaximin
- Where
- Malawi
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Tropical Infectious Disease
Trained and Heterologous Induced-immune Responses to Tropical Infectious Diseases
Validation of ex vivo immune assays that are surrogates of complex in vitro assays and animal models studies to identify the occurrence, strength, and kinetics of trained and heterologous immunity may significantly impact public…
- Trial name
- TSH-IMMO (NCT05722054)
- Testing
- Diagnostic tests, Equilibrate diet
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche Médicale de Lambaréné
Paraparesis Spastic Tropical
Use Of Valproid Acid To Treat Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM)
Is the valproic acid efficacy to treat TSP/HAM
- Trial name
- NCT00681980
- Testing
- Valproic acid, costicosteroids, valproid acid plus corticosteroids
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Influenza
Immunogenicity and Safety Trial of Adjuvanted and Non-adjuvanted Trivalent Influenza Vaccine in Tropical Africa
This study will provide the Senegal Ministry of Health with data on the safety and immunogenicity of adjuvanted trivalent inactivated influenza vaccine (adjTIV) and full-dose seasonal non-adjuvanted trivalent inactivated…
- Trial name
- NCT01819155
- Testing
- Adjuvanted seasonal trivalent inactivated influenza vaccine, Seasonal trivalent inactivated influenza vaccine, Saline (bacteriostatic 0.9% sodium chloride for injection)
- Where
- Senegal
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- PATH
HTLV-I Infection, Spinal Cord Disease
Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM)
HTLV stands for human T cell leukemia virus. HTLV-1 is a virus that attacks specific kinds of white blood cells called T cells. T cells are part of the natural defense system of the body.
- Conditions
- HTLV-I Infection, Spinal Cord Disease, Tropical Spastic Paraparesis
- Trial name
- NCT00001785
- Testing
- Recombinant human interferon beta-1a
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Infections
Creation of a Bank of Biological Materials and Associated Data Related to Patients With Infectious and Tropical Diseases
This is the protocol that formalizes the establishment of the TROPICA-BIOBANK biobank
- Trial name
- TropicaBiobank (NCT05770765)
- Where
- Italy
- Volunteers
- 60,000 people, healthy volunteers welcome
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Fecal Carriage of Multidrug-resistant Bacteria
Travel in the Tropics and Acquisition of Multidrug-resistant Bacteria (VOYAG-R)
The purpose of this study is to Measure the fecal carriage of multidrug-resistant bacteria after a travel in the tropics.
- Trial name
- VOYAG-R (NCT01526187)
- Where
- France
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tinea Pedis
Efficacy of Tropical Sertaconazole Nitrate 2% Vs Clotrimazole 1% for Tinea Pedis
This randomized controlled trail study will be carried out on OPD patients in the Department of Dermatology, Jinnah Postgraduate Medical Center.
- Trial name
- NCT06869681
- Testing
- Topical Sertaconazole 2%, Clotrimazole 1%
- Volunteers
- 100 people
- Sponsor
- Jinnah Postgraduate Medical Centre