Clinical trials: Troponin T
Aortic Stenosis, Myocardial Protection
Comparison of Blood and Crystalloid Cardioplegia
The investigators decided to make a study with a cohort of patients as homogenous as possible with a cross clamp time around 70 min.
- Trial name
- NCT01941420
- Where
- Norway
- Volunteers
- 70 people
- Sponsor
- Oslo University Hospital
Aortic Stenosis, Heart Failure
High-Sensitivity Troponin T Plasma Levels in Patients With Aortic Stenosis (Tyrolean Aortic Stenosis Study-2)
TASS-2 (Tyrolean Aortic Stenosis Study-2) aims to characterize the clinical value of minimally elevated troponin T plasma levels both in patients with asymptomatic and symtomatic aortic stenosis.
- Conditions
- Aortic Stenosis, Heart Failure, Syncope, Angina Pectoris
- Trial name
- TASS-2 (NCT02448485)
- Testing
- Aortic Valve Intervention (surgical or transcatheter)
- Where
- Austria
- Volunteers
- 10,000 people
- Sponsor
- Medical University Innsbruck
Emergency Laparotomy, Inflammatory Response
Troponin T and Emergency High-risk Abdominal Surgery
To assess whether perioperatively elevated TnT levels, using high sensitivity troponin T (hsTnT) measurements, are associated with an increased risk of postoperative mortality as well as severe postoperative complications.
- Conditions
- Emergency Laparotomy, Inflammatory Response, Myocardial Injury
- Trial name
- NCT04878159
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Renal Failure Chronic Requiring Dialysis
Assessment the Dosage of Troponin T Hypersensitive Dosage in a Patient Population Hemodialysis and Peritoneal Dialysis
"Troponin T (TnT) is a component of the contractile apparatus of the striated musculature. Although the function of TnT is the same in all striated muscles found in the heart to form a TNT (cardiac TnT) differing significantly…
- Trial name
- ECHOTnT (NCT02446639)
- Testing
- Blood collection
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Nantes University Hospital
Acute Coronary Syndrome, Cardiac Ischemia
Induced Myocardial Ischemia: a Serial Troponin T and Troponin I Measurements
Background Troponin are proteins found in the cardiomyocyte and are a cornerstone in the diagnoses of acute myocardial infarction. Troponin is released to the bloodstream as a result of an cardiomyocyte injury.
- Trial name
- ICE-land (NCT03203057)
- Testing
- coronary occlusion
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- Herlev Hospital
Chest Pain, Acute Coronary Syndrome
IN-HOspital Program to systematizE Chest Pain Protocol (IN-HOPE)
Multicenter Nationwide Study for Analysis of the Potential Impact in Clinical Practice of Early Exclusion Protocols for Acute Myocardial Infarction with High Sensitivity Troponin T
- Trial name
- In-Hope (NCT04756362)
- Where
- Brazil
- Volunteers
- 5,497 people
- Sponsor
- Hospital Samaritano Paulista
Coronary Artery Disease
hsTnT After Elective Coronary Angiography
A prospective Study, aiming to understand and analyse the key role of the novel High Sensitivity Troponin T (hsTnT) within a group of patients undergoing an uncomplicated coronary angiography without receiving any additional…
- Trial name
- NCT01735500
- Where
- Germany
- Volunteers
- 545 people
- Sponsor
- University Hospital Heidelberg
Non-ST Elevation Myocardial Infarction, Acute Coronary Syndrome
One-hour Troponin in a Low-prevalence Population of Acute Coronary Syndrome
This study aims to evaluate if the 1-hour rule-in/rule-out algorithm for a high-sensitivity cardiac troponin T (hs-cTnT) is safe and effective for use in the primary care where the patients have a lower pretest probability of an…
- Conditions
- Non-ST Elevation Myocardial Infarction, Acute Coronary Syndrome, Angina, Unstable, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- OUT-ACS (NCT02983123)
- Testing
- 1-hour hs-cTnT
- Where
- Norway
- Volunteers
- 1,750 people
- Sponsor
- Oslo University Hospital
Mitral Insufficiencies, Myocardial Protection
Comparison of Blood Cardioplegia and Custodiol
Thru the last 20 years it has been a discussion witch solution that gives the best myocardial protection during cardiac arrest by heart operations.
- Trial name
- NCT01941459
- Where
- Norway
- Volunteers
- 76 people
- Sponsor
- Ullevaal University Hospital
Hip Fracture
Troponin T Elevation in Patient Undergoing Hip Fracture Surgery
Background: Patients undergoing hip fracture surgery are elderly and usually have co-morbidities; hence they are at risk for perioperative MI.
- Trial name
- NCT01352754
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Prostaglandin E1, Percutaneous Coronary Intervention
Protective Effect of Lipo-PGE1 on Myocardial Injury Following Percutaneous Coronary Intervention
we hypothesized that periprocedural treatment with intravenous lipo-PGE1 may reduce myocardial injury and improve clinical outcomes in patients undergoing PCI.
- Trial name
- PGEACS (NCT01245855)
- Testing
- lipo-PGE1
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Diagnoses Disease
Reference Interval Validation of High-Sensitivity Cardiac Troponin T Assay in Thai Population
The investigators aimed to study the cut-off of high sensitivity troponin T using SYSMEX HLSCL Machine in Thai population at percentile 99.
- Trial name
- NCT03968016
- Testing
- SYSMEX HLSCL
- Where
- Thailand
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Systemic Lupus Erythematosus
Highly Sensitive Serum Cardiac Troponin T and Cardiovascular Events in Patients With Systemic Lupus Erythematosus
Identification of biological markers able to better stratify cardiovascular risks in systemic lupus erythematosus patients is needed.
- Trial name
- TROPOPLUS (NCT04580108)
- Where
- France
- Volunteers
- 446 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myocardial Infarction
Sixth Generation High-sensitivity Cardiac Troponin T for the Early Rule Out of Myocardial Infarction: a Controlled Before and After Study
Cardiac troponin is a protein released into the blood when the heart muscle is damaged. Measuring this protein helps doctors diagnose a heart attack (also called a myocardial infarction).
- Trial name
- STEREO-MI (NCT07636642)
- Testing
- sixth-generation high sensitivity cardiac troponin T assay, fifth-generation high sensitivity cardiac troponin T assay
- Where
- 3 sites in United Kingdom
- Volunteers
- 19,500 people
- Sponsor
- University of Edinburgh
Coronary Heart Disease
Effect of Remote Ischemic Preconditioning in Patient Undergoing Cardiac Bypass Surgery
During coronary artery bypass graft surgery, injury occurs to the heart muscle. Some of this injury is due to the deprivation of oxygen and nutrients to the heart (a process called ischemia) during the surgery itself.
- Trial name
- NCT00397163
- Testing
- Remote ischemic preconditioning
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University College London Hospitals
Coronary Artery Disease, Myocardial Infarction
Mi-RNAs and Specificity of Hs-TnT in Symptomatic ED Patients
Biomarkers play a key role in the diagnostic workup of patients presenting to an emergency department (ED). European and American guidelines recommend cardiac Troponin (T or I) as the biomarker gold standard for the diagnosis of…
- Trial name
- NCT02116153
- Sponsor
- University Hospital Heidelberg
Myocardial Ischemia
Preliminary Administration of EPO and Markers of Cardiac Ischemia Induced by CPB
The main objective is to observe the effects of erythropoietin administration on different blood markers of ischaemic cardiac lesions induced by cardiopulmonary bypass.
- Trial name
- EPOetCEC (NCT00273767)
- Testing
- epoetin beta
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Grenoble
Acute Coronary Syndrome, Acute Myocardial Infarction
Switching From Cardiac Troponin I to T
Cardiac troponin is central to the diagnosis of myocardial infarction and high-sensitivity cardiac troponin (hs-cTn) assays are the preferred choice for the assessment of patients with suspected acute coronary syndrome.
- Conditions
- Acute Coronary Syndrome, Acute Myocardial Infarction, Acute Myocardial Ischemia, Myocardial Injury
- Trial name
- TWITCH-ED (NCT05748691)
- Testing
- Clinical implementation of hs-cTnT
- Where
- United Kingdom
- Volunteers
- 26,000 people
- Sponsor
- University of Edinburgh
Perioperative Myocardial Infarctions, Pulmonary Embolism
High Sensitive Troponin T (hsTnT) and Copeptin as Prognostic Parameters in Patients With Elective Total Endoprosthesis
Summary: The purpose of the study is to prove if the biomarker high sensitive troponin T (hsTnT) and the biomarker of endogenous stress copeptin can serve as surrogate parameter of prognosis in patients with elective knee and hip…
- Trial name
- NCT01335815
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Atrial Fibrillation
hsTnT in Patients Admitted to the ED With Atrial Fibrillation in the Era of NOACs - Heidelberg Registry of Atrial Fibrillation
The purpose of the Heidelberg Registry of Atrial Fibrillation (HERA-FIB) is to collect data on the prevalence and clinical significance of elevated cardiac troponin in a large registry of unselected patients with atrial…
- Trial name
- HERA-FIB (NCT03344237)
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- University Hospital Heidelberg