Clinical trials: Tuberculin Skin Test
Tuberculosis
Specificity Trial of the Recombinant Tuberculosis Allergen in BCG Vaccinated Healthy Volunteers
The aim of this study is to test the recombinant tuberculosis skin test in the previously BCG vaccinated healthy adults with low risk of TB development, to determine the test specificity.
- Trial name
- NCT05203068
- Testing
- Recombinant tuberculosis allergen (RTA)
- Where
- Russia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Inflammatory Rheumatic Diseases
A Study on Changes in IFN-gamma Levels Following Anti-TNF Treatment in Patients Undergoing Serial QuantiFERON-TB Gold In-Tube
The screening for latent tuberculosis infection (LTBI) prior to the onset of anti-tumor necrosis factor therapy, as well as a watchful monitoring during the treatment, is strongly recommended.
- Trial name
- NCT01475409
- Testing
- QuantiFERON-TB Gold In-Tube (QFT-GIT)
- Volunteers
- 119 people
- Sponsor
- University of Roma La Sapienza
Tuberculosis Identification.
Equivalence Study of Tuberculin Purified Protein Derivative in Comparison With a Reference Standard (PPD-S2)
A study to determine bioequivalence of PPD material versus Reference Standard.
- Trial name
- 02 (NCT01798121)
- Testing
- To compare new PPD to reference standard material, Reference standard
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- JHP Pharmaceuticals LLC
Latent Tuberculosis
Immune Response to Mycobacterium Tuberculosis Infection
This study will examine how the immune system responds to infection with Mycobacterium tuberculosis bacteria (bacteria that cause tuberculosis) in order to better understand how the germ produces infection and how the immune…
- Trial name
- NCT00257907
- Where
- 2 sites in United States, Mali
- Volunteers
- 157 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Rheumatoid Arthritis, Tuberculosis
Comparison of the Tuberculin Skin Test (TST) and QuantiFERON ®-TB Gold Test (QFT-G) In Patients With Rheumatoid Arthritis Being Considered for Anti-TNF-Alpha Therapy
This research will help doctors interested in the usefulness of a new test to discover hidden tuberculosis infections in patients diagnosed with rheumatoid arthritis (RA). This new test is called Quantiferon-Gold (QFT-G).
- Trial name
- NCT00925249
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Tuberculosis, Psoriasis
Sensitivity and Specificity of QuantiFeron -TB Gold Test (QFT-G)in Patients With Psoriasis
The purpose of this study is to determine the level of agreement between QuantiFeron -TB Gold test (QFT-G)and Tubeculin skin test (TST)for screening of latent tuberculosis in patients suffering from psoriasis.
- Trial name
- NCT01223976
- Testing
- Tuberculin skin test and Quantiferon -TB Gold test
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Silicosis, Tuberculosis
Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention
Tuberculosis (TB) remains the most important infectious disease in the world. Preventive treatment plays an important role in successful control of TB.
- Trial name
- NCT02430259
- Testing
- Weekly INH / RRT given by DOT
- Where
- China
- Volunteers
- 566 people
- Sponsor
- Huashan Hospital
Malaria
Revaccination of Young Children With Bacille Calmette Guerin (BCG) Vaccine
BCG has marked immune stimulatory effects in both animal and human studies and observational studies suggest that BCG is associated with a non-specific reduction in mortality in areas with high infant and child mortality.
- Trial name
- NCT00126217
- Testing
- Bacille Calmette Guerin (BCG)
- Where
- Guinea-Bissau
- Volunteers
- 2,871 people
- Sponsor
- Bandim Health Project
Chronic Renal Failure
Detection of Latent Tuberculosis in Hemodialysis Patients
This study aims to compare the performance of the tuberculin skin test, used for more than 50 years as a diagnostic tool for latent tuberculosis infection, with 2 blood tests which have recently become commercially available…
- Trial name
- NCT00695734
- Where
- Switzerland
- Volunteers
- 62 people
- Sponsor
- University Hospital, Geneva
Delayed Type Hypersensitivity
Characterization of the Molecular Mechanisms Involved in Delayed-Type Hypersensitivity Reactions to House Dust Mite, Diphencyprone, Nickel, and Tuberculin Purified Protein Derivative in Healthy Volunteers
This study will be conducted in 2 cohorts. In Cohort A, approximately 40 subjects will participate in a single-center, open-label, non-randomized, parallel-group trial to investigate the molecular mechanisms involved in…
- Trial name
- NCT03625219
- Testing
- Prednisone
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Innovaderm Research Inc.
Anogenital Warts, HIV Infection
Effectivity of Protein Purified Derivative Treatment for Anogenital Warts in HIV Patient
Warts are a common viral infection of the skin and are prevalent throughout the world, with an overall prevalence in the United States estimated at 2-20%.
- Conditions
- Anogenital Warts, HIV Infection, Tuberculin Purified Protein Derivative
- Trial name
- NCT06587542
- Testing
- Injection of protein purified derivative
- Volunteers
- 30 people
- Sponsor
- Universitas Padjadjaran
Advanced Cancer
Latent Tuberculosis Infection in Cancer Patients
Primary Objective: 1. To evaluate the performance of the new T-SPOT.TB test and the conventional TST for screening of Latent Tuberculosis infections in patients with cancer and those undergoing Hematopoietic Stem Cell Transplant.
- Trial name
- NCT00507754
- Testing
- T-SPOT TB test
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- M.D. Anderson Cancer Center
Latent Tuberculosis, HIV
Quantiferon Gold Test for Detecting Tuberculosis (TB) Infection in HIV/AIDS Patients in South Africa
The purpose of this study is to use a cluster randomized trial to compare the effectiveness of linking the Quantiferon-gold in-tube test (QGIT) with routine CD4 testing to the routine use of the tuberculin skin test (TST), the…
- Trial name
- NCT02119130
- Testing
- QGIT
- Where
- 14 sites in South Africa
- Volunteers
- 3,506 people
- Sponsor
- Johns Hopkins University
Tuberculosis, Pulmonary, Interferon-gamma Release Tests
IGRA and Mantoux Response in Children With Suspected Latent or Active TB Infection
The aim of this project is to analyze the potential contribution of IGRA test QuantiFERON-TB Gold In Tube test (QTF-GIT, Cellestis Limited, Carnegie, Victoria, Australia) in the diagnosis of tuberculosis (TB - active or latent)…
- Conditions
- Tuberculosis, Pulmonary, Interferon-gamma Release Tests, Tuberculin Test
- Trial name
- TBTubercolar (NCT02653404)
- Testing
- IGRA test (QTF-GIT)
- Where
- 3 sites in Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Siena
Latent Tuberculosis Infection
QuantiFERON®-TB Gold In-Tube for the Diagnosis of Tuberculosis Infection in Contact Tracing Study.
Hypothesis: a combined strategy of tuberculin skin test (TST) followed by QuantiFERON-TB Gold In-Tube (QFT-IT) to confirm positivity (tuberculosis infection,in contact-tracing study will allow avoiding unnecessary preventive…
- Trial name
- OPTIMIST (NCT01223534)
- Testing
- Preventive treatment with Isoniazid., Preventive treatment with Isoniazid
- Where
- Spain
- Volunteers
- 871 people
- Sponsor
- Hospital Universitari de Bellvitge
Latent Tuberculosis Infection
Interferon Gamma Release Assays (IGRA) Testing Versus Tuberculin Skin Test in Renal Transplant Recipients
Interferon gamma release assays (IGRA) have been shown to be more specific and sensitive for the detection of tuberculosis (latent or active infection) than the tuberculin skin test (TST) in immunocompetent individuals.
- Trial name
- NCT01608685
- Where
- Switzerland
- Volunteers
- 205 people
- Sponsor
- Ligue Pulmonaire Genevoise
Rheumatoid Arthritis, Spondylarthritis
Quantiferon-TB Gold in the Assessment of Latent TB in Patients Candidate to Treatment or Treated With TNFα Antagonists
The purpose of this study is to evaluate the value of Quantiferon-TB Gold (QFT-G) assay in the screening for latent tuberculosis infection (LTBI) in rheumatologic patients due to start or on treatment with TNFα antagonists.
- Conditions
- Rheumatoid Arthritis, Spondylarthritis, Tuberculosis
- Trial name
- TNFTB (NCT00491933)
- Testing
- Quantiferon-TB Gold assay, Tuberculin skin test
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- ASST Fatebenefratelli Sacco
Latent Tuberculosis
GXT - GeneXpert or Chest-X-ray or Tuberculin Skin Testing for Household Contact Assessment
The objective of the study is to compare outcomes from three different strategies for the management of household (HH) contacts of individuals with newly diagnosed microbiologically confirmed active pulmonary TB.
- Trial name
- NCT04528823
- Testing
- Strategy 2: Symptom screen, Genexpert and TST, Strategy 3:Symptom screen, CXR but NO TST
- Where
- 4 sites in Benin, Brazil
- Volunteers
- 1,589 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Tuberculosis
Impact of New Immunological Diagnosis Tests of Latent Tuberculosis Before Anti TNF Therapy
Tuberculosis is a current infection during anti TNF therapy. After infectious contact, some patients will develop tuberculosis and some will only be infected without symptoms, they have Latent Tuberculosis Infection (LTBI) wich…
- Trial name
- ETAT (NCT00811343)
- Testing
- QFTB-G and T-SPOT.TB tests
- Where
- France
- Volunteers
- 430 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Rheumatic Disease, Rheumatoid Arthritis
The Usefulness of Interferon-γ Release Assays and Tuberculin Skin Test for Detection of Latent Tuberculosis Infection
The purposes of this study 1. to compare the positivity of tuberculin skin test(TST) and QuantiFERON-TB Gold (QFT-G), and determine the level of agreement between two tests in patients with rheumatic diseases 2.
- Conditions
- Rheumatic Disease, Rheumatoid Arthritis, Ankylosing Spondylitis, Tuberculosis
- Trial name
- NCT01685905
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Hanyang University