Clinical trials: Tuberculosis, Central Nervous System
Tuberculous Meningitis
Retrospective Real-word Study of Linezolid for the Treatment of Tuberculous Meningitis
Tuberculous meningitis (TBM) is the most serious form of Mycobacterium tuberculosis infection, causing mortality and disability in more than half of the patients.
- Trial name
- NCT03898635
- Testing
- Linezolid
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Huashan Hospital
Tuberculosis, Tuberculous Meningitis
Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial)
The investigators will conduct a randomized, double blind, placebo controlled trial of adjunctive dexamethasone in the initial (6-8 weeks) treatment of tuberculous meningitis in Vietnamese adults.
- Conditions
- Tuberculosis, Tuberculous Meningitis, Drug-Induced Liver Injury, HIV
- Trial name
- NCT03092817
- Testing
- Dexamethasone
- Where
- 6 sites in Indonesia, Vietnam
- Volunteers
- 520 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Asthma, Atrial Fibrillation
Improving Quality by Maintaining Accurate Problems in the EHR
The overall goal of the IQ-MAPLE project is to improve the quality of care provided to patients with several heart, lung and blood conditions by facilitating more accurate and complete problem list documentation.
- Conditions
- Asthma, Atrial Fibrillation, Chronic Obstructive Pulmonary Disease, Coronary Artery Disease
- Trial name
- IQ-MAPLE (NCT02596087)
- Testing
- Problem List Suggestion
- Where
- 4 sites in United States
- Volunteers
- 2,386 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Tuberculous Meningitis
Diagnosis of Tuberculous Meningitis by ESAT-6 in CSF
Early and reliable diagnosis of tuberculous meningitis (TBM) still poses a great challenge. One of the underlying difficulties is due to the fact that tubercle bacilli are mainly not present in the cerebrospinal fluid (CSF) but…
- Trial name
- NCT01371916
- Where
- China
- Volunteers
- 316 people
- Sponsor
- Xijing Hospital
Tuberculosis, Meningeal, Linezolid
Pharmacokinetic Study of Linezolid for TB Meningitis
Tuberculosis meningitis (TBM) is the most severe manifestation of TB, resulting in death or neurological disability in up to 50% of affected patients, despite antibacterial treatment.
- Trial name
- SIMPLE (NCT03537495)
- Testing
- Linezolid
- Where
- Indonesia
- Volunteers
- 36 people
- Sponsor
- Universitas Padjadjaran
Tuberculous Meningitis, Tuberculous Arachnoiditis
Diagnostic Accuracy of Imaging Findings in TBM/Spinal Tubercular Arachnoiditis and Correlation With Outcomes
The goal of this Diagnostic accuracy study is To study sensitivity and specificity of sulcal tuberculomas in the diagnosis of tubercular meningitis and To study the correlation of imaging findings in tubercular meningitis and…
- Trial name
- NCT05636254
- Testing
- MRI Brain and spine, Reference standard diagnostic criteria
- Where
- India
- Volunteers
- 120 people
- Sponsor
- All India Institute of Medical Sciences
Tuberculous Meningitis
Optimizing Antituberculosis Therapy in Adults With Tuberculous Meningitis
The genetically polymorphic N-acetyltransferase type 2 (NAT2) is responsible for isoniazid metabolism, and rapid acetylators were associated with low concentrations of isoniazid based on previous studies.
- Trial name
- NCT03787940
- Testing
- Isoniazid
- Where
- 4 sites in China
- Volunteers
- 676 people
- Sponsor
- Beijing Chest Hospital
Tuberculous Meningitis
Evaluation of New Biomarker-based Approaches for Improving the Diagnosis of Childhood Tuberculous Meningitis
The rapid diagnosis of tuberculosis (TB) in children remains a serious challenge owing to limitations in the existing diagnostic tests.
- Trial name
- TBMBIOMARKER (NCT04308928)
- Where
- South Africa
- Volunteers
- 332 people
- Sponsor
- University of Stellenbosch
HIV Infections, Tuberculous Meningitis
Immediate Versus Deferred Antiretroviral Therapy for HIV-Associated Tuberculous Meningitis
The optimal time to initiate antiretroviral therapy (ART) in HIV-associated tuberculous meningitis (TBM) unknown. There are concerns that immediate ART may worsen rather than improve outcome, because drug interactiond and…
- Trial name
- NCT00433719
- Testing
- Combivir and efavirenz
- Where
- 2 sites in Vietnam
- Volunteers
- 253 people
- Sponsor
- University of Oxford
Tuberculosis Meningitis, HIV-1-infection
Linezolid, Aspirin and Enhanced Dose Rifampicin in HIV-TBM
LASER-TBM is a parallel group, randomized, multi-arm phase IIa trial evaluating the safety of increased dose rifampicin (RIF) plus linezolid (LZD), with or without aspirin (ASA), for the treatment of HIV-infected adults with…
- Trial name
- LASER-TBM (NCT03927313)
- Testing
- Linezolid, High dose rifampicin, Aspirin
- Where
- 4 sites in South Africa
- Volunteers
- 52 people
- Sponsor
- University of Cape Town
Tuberculosis, Meningeal
High-dose Rifampicin for the Treatment of Tuberculous Meningitis: a Dose-finding Study
Tuberculous meningitis (TBM) is the most severe form of tuberculosis infection with high mortality. Current treatment regimens are not based on clinical trials.
- Trial name
- ReDEFINe (NCT02169882)
- Testing
- Rifampicin, Other TB drugs, Adjuvant dexamethasone
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Padjadjaran
Acquired Immunodeficiency Syndrome, Histoplasmosis AIDS
Point of Care Tests to Identify Opportunistic Infections in Advanced HIV Patients in Mexico City
In Mexico City, the main cause of mortality among people living with HIV (PLHIV) continues to be opportunistic infections (OIs). Early detection of OIs allows their timely treatment and improves their prognosis.
- Conditions
- Acquired Immunodeficiency Syndrome, Histoplasmosis AIDS, Tuberculosis Infection, Cryptococcal Meningitis
- Trial name
- PREVALIOCDMX (NCT05685641)
- Testing
- Histoplasma Urine Antigen Lateral Flow Antigen test, Cryptococcal Lateral Flow Antigen test, Tuberculosis-lipoarabinomannan Lateral Flow Antigen test
- Where
- 4 sites in Mexico
- Volunteers
- 211 people
- Sponsor
- National Institute of Respiratory Diseases, Mexico
Tuberculous Meningitis
Rifampicin Explorative PK Study for Tuberculous Meningitis Comparing Oral and Intravenous Preparation
Tuberculous (TB) meningitis is the most severe manifestation of TB infection, leaving up to 50% of patients dead or neurologically disabled.
- Trial name
- REMOVER (NCT01802502)
- Testing
- Rifampicin intravenous, Oral rifampicin
- Where
- Indonesia
- Volunteers
- 30 people
- Sponsor
- Universitas Padjadjaran
Tuberculosis, Tuberculous Meningitis
Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Meningitis
The primary objective is to determine whether Leukotriene A4 hydrolase (LTA4H) genotype, defined at randomisation, determines dexamethasone's clinical effectiveness when added to the first 6-8 weeks of anti-tuberculosis treatment…
- Conditions
- Tuberculosis, Tuberculous Meningitis, Drug-Induced Liver Injury
- Trial name
- NCT03100786
- Testing
- Dexamethasone
- Where
- 3 sites in Vietnam
- Volunteers
- 702 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Tuberculous Meningitis
Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous Meningitis
The purpose of this study is to compare a 6-month regimen of high-dose rifampicin (RIF), high-dose isoniazid (INH), linezolid (LZD), and pyrazinamide (PZA) versus the World Health Organization (WHO) standard of care (SOC)…
- Trial name
- NCT05383742
- Testing
- Rifampicin (RIF), Isoniazid (INH), Linezolid (LZD)
- Where
- 18 sites in Brazil, India and 10 more
- Volunteers
- 330 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Central Nervous System Tuberculosis
A Retrospective Study of Treatment Patterns and Clinical Outcomes in Patients With Central Nervous System Tuberculosis
This is a retrospective clinical study to analyze the clinical characteristics, complications, and effects of different treatment options on long-term prognosis in patients with central nervous system tuberculosis.
- Trial name
- NCT06011915
- Where
- 2 sites in China
- Volunteers
- 638 people
- Sponsor
- Tongji Hospital
Tuberculous Meningitis
A Pilot Study of Adjunctive Aspirin for the Treatment of HIV Negative Adults With Tuberculous Meningitis
Tuberculous meningitis is a severe brain infection which often causes disability and death even when treated with the best available treatment.
- Trial name
- AspirinTBM (NCT02237365)
- Testing
- 81mg aspirin, 1000mg aspirin
- Where
- Vietnam
- Volunteers
- 120 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Tuberculous Meningitis
Xpert MTB/RIF Assay for Diagnosis of Tuberculous Meningitis (TBM) in Maharaj Nakorn Chiang Mai Hospital
Early diagnosis and appropriate treatment of tuberculous meningitis (TBM) are crucial steps to reduce morbidity and mortality. The WHO recommended to use Xpert MTB/RIF assay to diagnose pulmonary TB, pediatrics TB, extra…
- Trial name
- NCT05781646
- Testing
- Xpert MTB/RIF
- Volunteers
- 62 people
- Sponsor
- Chiang Mai University