Clinical trials: Tuberculosis Prevention
Adverse Reaction to Drug, 3HP
Clinical Analysis of Safety in Latent Tuberculosis Infection Prophylaxis Treatment
The treatment of latent TB with 3HP is an important issue for the prevention of active TB. However, significant proportion of subjects receiving 3HP had adverse reaction.
- Trial name
- NCT04655794
- Testing
- 3HP
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- Chang Gung Memorial Hospital
Pediatric HIV Infection, Tuberculosis Infection
Dolutegravir Pharmacokinetics Among HIV/TB Coinfected Children Receiving Standard and High-dose Rifampicin
Tuberculosis (TB) is the leading cause of death among children with HIV, yet insufficient data are available on the pharmacokinetics of newer HIV/TB cotreatment strategies in children.
- Trial name
- NCT05069688
- Testing
- rifampicin
- Where
- Nigeria
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Tuberculosis
Community-based Tuberculosis Tracing and Preventive Therapy
The many gaps observed in the cascade of care of tuberculosis (TB) child contacts occur mostly in the screening, preventive therapy (PT) initiation and PT completion steps and the main drivers of these gaps are considered to be…
- Trial name
- CONTACT (NCT03832023)
- Testing
- Screening and initiating preventive therapy in communities
- Where
- 25 sites in Cameroon, Uganda
- Volunteers
- 1,400 people
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
Tuberculosis (TB), TB Infection
Prevention and Mass Screening of TB in Prisons in Paraguay
The goal of this interventional study is to evaluate three tuberculosis (TB) screening and prevention strategies in prisons in Paraguay.
- Conditions
- Tuberculosis (TB), TB Infection, Prisoners, Epidemiology
- Trial name
- PRESMAP-TB (NCT07520448)
- Testing
- Type 1 - Intensive Intervention, Type 2 - Optimized intervention, Type 3. Control.
- Where
- Paraguay
- Volunteers
- 4,500 people
- Sponsor
- Universidad Nacional de Caaguazu
Latent Tuberculosis
Vitamin D Supplementation in TB Prevention
The goal of this clinical trial is to determine whether vitamin D supplementation reduces risk of acquiring latent tuberculosis infection (LTBI) in school age children in Mongolia.
- Trial name
- NCT02276755
- Testing
- Cholecalciferol (vitamin D3)
- Where
- Mongolia
- Volunteers
- 8,851 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Silicosis Tuberculosis
Short Course Rifapentine and Isoniazid for the Preventive Treatment of Tuberculosis(SCRIPT-TB)
Tuberculosis (TB) remains the most important infectious disease in the world. Preventive treatment plays an important role in successful control of TB.
- Trial name
- TB (NCT03900858)
- Testing
- Isoniazid；Rifapentine
- Where
- China
- Volunteers
- 566 people
- Sponsor
- Huashan Hospital
Tuberculosis Infection, Isoniazid Adverse Reaction
Point-of-care Pharmacogenomic Testing to Optimize Isoniazid Dosing for Tuberculosis Prevention
This trial is designed to determine whether modifying the dose of isoniazid for individuals according to their n-acetyltransferase 2 (NAT2) genotype could increase the probability of achieving equivalence of area-under-the-curve.
- Trial name
- NCT05413551
- Testing
- Low-dose isoniazid, Standard dose of isoniazid, High-dose isoniazid
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- Stanford University
Tuberculosis
A Home-Based Approach to Tuberculosis Preventive Treatment Management
Background: Tuberculosis (TB), though preventable and curable, remains a major public health concern worldwide. While elimination of tuberculosis infection (TBI) is critical to TB elimination, TBI continues to represent a…
- Trial name
- NCT07479030
- Testing
- A home-based approach to TB preventive treatment management
- Where
- Ethiopia
- Volunteers
- 1,300 people
- Sponsor
- Dilla University