Clinical trials: Tumor Angiogenesis
Hepatocellular Carcinoma (HCC)
TACE Plus Bevacizumab for Hepatocellular Carcinoma With Portal Vein Invasion
This is a prospective, randomized study designed to compare the efficacy of transcatheter hepatic artery chemoembolization (TACE) combined with bevacizumab arterial perfusion versus conventional therapy in patients with…
- Trial name
- NCT07075562
- Testing
- Bevacizumab Arterial Perfusion plus TACE, Conventional Therapy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- The First Hospital of Hebei Medical University
Colorectal Neoplasms, Liver Neoplasms
Neo-adjuvant Therapy and the Effect on Synchronous Metastatic Growth
Study Hypothesis As well as in animal models as in patients with colorectal cancer resection of the primary tumor resulted in increase in vascular density, metabolism and secondary tumor growth of the distant metastases.
- Trial name
- NCT00659022
- Testing
- immediate surgery (resection of primary colorectal tumor), neo-adjuvant treatment with bevacizumab, neoadjuvant treatment with capecitabine and oxaliplatin
- Where
- 2 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- Radboud University Medical Center
Colorectal Cancer, Angiogenesis
Micrometastases and Angiogenesis in Colon Cancer. Prognostic Value of VEGF.
According to current clinical guidelines adjuvant treatment in colon cancer is not recommended in patients with stage I and IIA, and in patients with high risk factors (IIB) adjuvant treatment has not shown a clear benefit in…
- Trial name
- VEGF-GC (NCT04145505)
- Testing
- COLORECTAL CANCER SURGERY
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Breast Cancer, Breast Neoplasm Female
Targeting Stress-Driven Inflammatory and Angiogenic Pathways With Brief ACT to Enhance Neoadjuvant Chemotherapy Response in Locally Advanced Breast Cancer
This clinical trial aims to learn whether a brief psychological therapy called Brief Acceptance and Commitment Therapy (Brief-ACT) can improve the effectiveness of neoadjuvant chemotherapy in patients with locally advanced breast…
- Conditions
- Breast Cancer, Breast Neoplasm Female, Locally Advanced Breast Cancer (LABC), Locally Advanced Breast Cancer
- Trial name
- NCT07570368
- Testing
- Brief Acceptance and Commitment Therapy, Standard Counseling, Neoadjuvant Chemotherapy
- Volunteers
- 54 people
- Sponsor
- Universitas Airlangga
NSCLC (Advanced Non-small Cell Lung Cancer)
A Study to Learn the Safety and Efficacy of HLX37 in Combination With Chemotherapy for First-line Treatment in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
This is a Randomized, Double-Blind, Multicenter, Phase II/III Study to Evaluate HLX37 (Recombinant Human Anti-PD-L1 and Anti-VEGF Bispecific Antibody) in Combination with Chemotherapy Versus Pembrolizumab in Combination with…
- Trial name
- NCT07865910
- Testing
- Investigational drug: HLX37 dose1, IV, Q3W, PEMBROLIZUMAB (alone or when added to a regimen above), Carboplatin (Investigator discretion)
- Where
- 16 sites in China
- Volunteers
- 1,438 people
- Sponsor
- Shanghai Henlius Biotech
Recurrent Malignant Glioma
Avastin / Irinotecan in Patients With Recurrent or Progressive Malignant Glioma
Malignant glioma are the most common and aggressive primary brain tumors in adults. Despite advances in multimodal treatment including surgery, radiation and chemotherapy, most patients have a dismal prognosis of 9-15 months…
- Trial name
- AVIRMA01-09 (NCT01144988)
- Testing
- Bevacizumab / Irinotecan
- Where
- 2 sites in Austria
- Volunteers
- 35 people
- Sponsor
- Medical University Innsbruck
Peripheral Arterial Disease (PAD), Diabetes Mellitus (DM)
The Efficacy and Safety of REX-001 to Treat Ischemic Ulcers in Subjects With CLI Rutherford Category 5 and DM
This trial is a pivotal, placebo-controlled, double-blind, parallel-group, adaptive trial conducted in subjects with DM and CLI Rutherford Category 5.
- Conditions
- Peripheral Arterial Disease (PAD), Diabetes Mellitus (DM), Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT03174522
- Testing
- REX-001
- Where
- 15 sites in Czechia, Hungary and 4 more
- Volunteers
- 49 people
- Sponsor
- Ixaka Ltd
Hepatocellular Carcinoma
Biomarker Analyses in Hepatocellular Carcinoma (HCC) Patients Treated With TheraSphere®
To analyze specific angiogenic, inflammatory and immune profiles in hepatocellular carcinoma patients who undergo radioembolization.
- Trial name
- NCT03203837
- Testing
- Plasma collection
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Neovascular Age-related Macular Degeneration
Development of an Optimal Algorithm for the Management of Patients With Retinal Pigment Epithelium Detachment in Neovascular Age-related Macular Degeneration Using Artificial Intelligence
The study involves the development of an algorithm for predicting anatomical and functional results of therapy with angiogenesis inhibitors in patients with retinal pigment epithelium detachments in neovascular age-related…
- Trial name
- NCT05208931
- Testing
- Anti-vascular endothelial growth factor therapy
- Where
- Russia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The S.N. Fyodorov Eye Microsurgery State Institution
Heart Failure, Gastrointestinal Bleeding
Efficacy of Omega-3 Fatty Acid Therapy in Preventing Gastrointestinal Bleeding in Patients With CF-LVAD
This study evaluates the efficacy of high-dose fish oil in decreasing rates of gastrointestinal bleeding in patients with continuous-flow left ventricular assist devices.
- Trial name
- NCT03784963
- Testing
- Omega 3 fatty acids
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Chicago
Cervical Cancer, Precancerous Condition
Cyclooxygenase-2 Expression in Tissue Samples From Patients With a Normal Cervix, Cervical Intraepithelial Neoplasia, or Early Invasive Cervical Cancer
RATIONALE: Studying samples of tissue from patients with or without cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
- Trial name
- NCT00900081
- Testing
- immunohistochemistry staining method, laboratory biomarker analysis, medical chart review
- Sponsor
- Wake Forest University Health Sciences
Sarcopenia in Elderly, Muscle Atrophy
Effects of Cyclical Blood Flow Restriction Exercise on Muscle Hypertrophy and Capillaries in Older Adults
The purpose of this study was to learn if low-load resistance exercise combined with cyclical blood flow restriction (BFR) could improve small blood vessel structure and muscle size in older adults.
- Conditions
- Sarcopenia in Elderly, Muscle Atrophy, Aging
- Trial name
- NCT07689487
- Testing
- Blood Flow Restriction (BFR), Conventional Low-Load Resistance Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
AMD, nAMD
Pivotal 1 Study of ABBV-RGX-314 (Also Known as RGX-314) Gene Therapy Administered Via Subretinal Delivery One Time in Participants With nAMD
ABBV-RGX-314 (also known as RGX-314) is being developed as a novel one-time gene therapy for the treatment of neovascular (wet) age-related macular degeneration (wet AMD or nAMD).
- Conditions
- AMD, nAMD, Wet Age-related Macular Degeneration, wAMD
- Trial name
- ATMOSPHERE (NCT04704921)
- Testing
- ABBV-RGX-314, Ranibizumab (LUCENTIS®)
- Where
- 89 sites in United States
- Volunteers
- 671 people
- Sponsor
- AbbVie
Hypertension, Sleep Apnea
Sleep Apnea and Refractory Hypertension: Prevalence and Effect of CPAP Treatment
A small number of uncontrolled studies have shown a high prevalence of sleep apnea in patients with refractory hypertension and that CPAP treatment achieves a significant reduction of blood pressure in the short term.
- Trial name
- NCT00459914
- Testing
- cpap treatment during sleep
- Where
- Spain
- Volunteers
- 130 people
- Sponsor
- Fundacio Catalana de Pneumologia
Prostatic Neoplasms
Docetaxel, Thalidomide, Prednisone, and Bevacizumab to Treat Metastatic Prostate Cancer
This is a Phase II study of docetaxel, bevacizumab, prednisone and thalidomide in patients with androgen independent metastatic prostate cancer who are previously untreated with chemotherapy.
- Trial name
- NCT00089609
- Testing
- Docetaxel, Thalidomide, Prednisone
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- National Cancer Institute (NCI)
Solid Tumors
Characterisation of Gene Variants in the Angiogenic Pathway
Anti-angiogenic targeted therapies are used in a wide range of solid tumors including NSCLC, breast cancer, GISTs, CRC, renal cell carcinoma and hepatocellular carcinoma.
- Trial name
- NCT00716287
- Where
- Singapore
- Volunteers
- healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Carcinoma, Renal Cell
REGISTRY OF COMPLETE RESPONSES TO SUNITINIB IN SPANISH PATIENTS WITH METASTATIC RENAL CELL CARCINOMA
Observational, retrospective, multicentre study in spanish patients with metastatic Renal Cell Carcinoma (mRCC) treated with sunitinib as a first-line treatment (treatment with previous cytokine therapy is accepted) according to…
- Trial name
- ATILA (NCT03916458)
- Where
- 31 sites in Spain
- Volunteers
- 62 people
- Sponsor
- Pfizer
Polycystic Ovary Syndrome, Vitamin D Deficiency
The Effects of Vitamin D on Angiogenic Factors in Women With Polycystic Ovary Syndrome
Polycystic Ovary Syndrome (PCOS) affects 5 to 10% of women of reproductive age. It is characterized by a cluster of hyperandrogenism, hyperinsulinemia, menstrual dysfunction, hirsutism and infertility.
- Trial name
- NCT02460380
- Testing
- Vitamin D3
- Volunteers
- 93 people
- Sponsor
- Maimonides Medical Center
P1b: Advanced Solid Tumors, P2: Biliary Tract Cancer
A Study of CTX-009 (ABL001) in Combination With Irinotecan or Paclitaxel in Advanced or Metastatic Solid Tumor Patients
This study is a Phase 1b/2 multi-center study to assess the safety, tolerability, pharmacokinetics of CTX-009 (ABL001) in combination with Irinotecan or Paclitaxel in patients with advanced or metastatic solid tumors.
- Trial name
- NCT04492033
- Testing
- CTX-009 (ABL001), Paclitaxel, Irinotecan
- Where
- 4 sites in South Korea
- Volunteers
- 41 people
- Sponsor
- Handok Inc.
Neoplasms, Cancer
Study of VGX-100 Administered Alone and Co-administered With Bevacizumab in Adult Subjects With Advanced Solid Tumors
This is a non-randomized, multi-dose, first-in-human, multicenter, two arm (Arm A: VGX-100 alone; Arm B: VGX-100 co-administered with bevacizumab), open label, dose escalation study in subjects with advanced or metastatic solid…
- Trial name
- NCT01514123
- Testing
- VGX-100, Bevacizumab
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Circadian Technologies Ltd.