Clinical trials: Tumor Burden
Melanoma Stage III
Conservative Nodal Surgery (Node-picking) of Patients With Stage III Melanoma With Low-burden of Nodal Disease (MELCONSURG MULTICENTRE COHORT)
Background: Standard treatment for stage III melanoma with lymph node metastases involves complete lymph node dissection, which is a radical surgical procedure aimed at the removal of the entire regional lymph node basin.
- Trial name
- NCT05445752
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- Hospital Universitario Virgen Macarena
Hematopoietic Stem Cell Transplantation (HSCT)
Comprehensive Palliative Care After Stem Cell Transplantation: a Feasability Study
People who receive an allogeneic stem cell transplant often face important physical and emotional challenges during their recovery.
- Trial name
- COMPAS (NCT07895693)
- Testing
- Early Integrated Palliative Care
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- Lisa Hentsch
Follicular Lymphoma, Tumor
Phase 2 Trial of Obinutuzumab and CC-99282 for Patients With Previously Untreated High Tumor Burden Follicular Lymphoma
To learn if obinutuzumab in combination with CC-99282 can help to control previously untreated, high tumor burden FL
- Trial name
- NCT06108232
- Testing
- Obinutuzumab, CC-99282
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- M.D. Anderson Cancer Center
Quality of Life, Stroke, Acute
Cerebrovascular Disease: Quality of Life (CODE: QoL)
The goal of this observational study is to learn about quality of life, stress and caregiver burden in patients with stroke and their caregivers.
- Conditions
- Quality of Life, Stroke, Acute, Sexual Behavior, Stress
- Trial name
- CODE:QoL (NCT06443268)
- Testing
- questionnaire, hair samples, blood samples, clinical exam
- Where
- Switzerland
- Volunteers
- 680 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Cancer, Cancers, Pain
Impact of Daily Oral Cannabis Doses in Patients With Cancer
This study will enroll patients with cancer and participants will be randomized to receive one dose of cannabis for approximately 4 months.
- Trial name
- NCT06601218
- Testing
- Oral cannabis low THC, Oral cannabis high THC, Oral cannabis THC/CBD
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Shanna Babalonis, PhD
Breast Cancer, Cancer Survivor
Survivorship Booklets With or Without Individual Telephone Sessions in Increasing Knowledge About the Impact of Breast Cancer in African American and Latina Breast Cancer Survivors
RATIONALE: Telephone sessions and survivorship booklets may increase knowledge about the psychological and physical impact of breast cancer and increase awareness of available resources.
- Conditions
- Breast Cancer, Cancer Survivor, Psychosocial Effects of Cancer and Its Treatment
- Trial name
- NCT00932997
- Testing
- telephone-based intervention, counseling intervention, educational intervention
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- City of Hope Medical Center
Cancer Disease, Palliative Therapy
Assessment of Disease Burden and Palliative Care Needs of Patients During the Course of Incurable Cancer Disease
The aim of this non-investigational study is to determine the symptoms and disease burden at the time point of diagnosis and in the further course of an incurable cancer disease.
- Trial name
- APM-Project (NCT02751723)
- Testing
- validated questionnaires
- Where
- 21 sites in Germany
- Volunteers
- 500 people
- Sponsor
- Florian Lordick, MD
Polycystic Ovary Syndrome, Psychological Distress
Development of the Polycystic Ovary Syndrome Symptoms Inventory
Polycystic Ovary Syndrome Symptom Severity and Distress Inventory: Development, Validity and Reliability in Turkey The goal of this observational study is to develop and validate a self-report inventory that assesses Polycystic…
- Trial name
- NCT07402980
- Where
- Turkey (Türkiye)
- Volunteers
- 227 people
- Sponsor
- Abant Izzet Baysal University
Hepatocellular Carcinoma Non-resectable
SIRT or TACE Plus Lenvatinib and PD-(L)1 Inhibitor in High Burden HCC
This multicenter retrospective study evaluated the efficacy and safety of selective internal radiation therapy (SIRT) combined with lenvatinib and PD-(L)1 inhibitors (SIRT-L-P) versus transarterial chemoembolization (TACE)…
- Trial name
- NCT06916546
- Testing
- SIRT-L-P, TACE-L-P
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Cancer, Survivorship
A Dyadic Intervention for Young Adult Patients With Cancer and Their Partner Caregivers
The purpose of this pilot study is to examine the feasibility and acceptability of a brief psychotherapy intervention to improve psychosocial coping and maintain couple relationships among young adults (aged 25-39) with cancer…
- Conditions
- Cancer, Survivorship, Caregiver Burden, Psychological Distress
- Trial name
- YAD (NCT06172907)
- Testing
- Young Adults Coping with Cancer Together Intervention
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Compassion
Compassion-Based Intervention for Lung Cancer Caregivers (CBI-LCC)
Objectives: This 3-year study aims to develop, refine, and evaluate a brief compassion-based intervention specifically designed for family caregivers of lung cancer patients.
- Trial name
- CBI-LCC (NCT06930313)
- Testing
- Brief Compassion-Based Intervention (BCI), Telephone-Based Support and Education (TSE)
- Where
- Taiwan
- Volunteers
- 84 people
- Sponsor
- Taipei Medical University
Acute Lymphoblastic Leukemia, Pediatric
Vaccine Immune Recovery After Leukemia
This observational study aims to assess recovery of the immune system and immunity to vaccine-preventable diseases in children, adolescents, and young adults who recently completed treatment for acute lymphoblastic leukemia…
- Trial name
- VIRAL (NCT05622682)
- Testing
- Observational only: Serology and flow cytometry for ALL cohort participants, Observational only: Infection rates
- Where
- 6 sites in United States
- Volunteers
- 89 people
- Sponsor
- Children's Hospital of Philadelphia
Pancreatic Cancer, Pancreatitis
Pancreatic Disease Burden in Older Adults (1990-2040)
Using data from the Global Burden of Disease Study 2021, the investigators analyzed age-standardized incidence, mortality, and disability-adjusted life-years (DALYs) for pancreatic cancer and pancreatitis in adults aged ≥70 years…
- Trial name
- NCT07177599
- Testing
- Natural history
- Volunteers
- 723,415 people
- Sponsor
- Changhai Hospital
Brain (Nervous System) Cancers
Project MILANO: Connections Between Patients With Brain Tumors and Their Pets: an Analysis of Concerns and Needs
Context and problem In France, 61% of households own a pet, highlighting the significant role pets play in the daily lives. Patients diagnosed with brain tumors face specific challenges that may affect their ability to care their…
- Trial name
- MILANO (NCT06899516)
- Testing
- The Lexington Attachment to Pets Scale (LAPS; Johnson, Garrity, & Stallones, 1992)
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Follicular Lymphoma
A Study of Tazemetostat With Rituximab and Abbreviated Bendamustine in the Frontline Treatment of High Tumor Burden Follicular Lymphoma
This study is planned as a single arm clinical trial of tazemetostat in combination with bendamustine and rituximab with both a phase I and phase II component.
- Trial name
- NCT05551936
- Testing
- Bendamustine, Rituximab, Tazemetostat
- Where
- 5 sites in United States
- Volunteers
- 42 people
- Sponsor
- Vaishalee Kenkre
Oligo-metastatic Prostate Carcinoma
Radiotherapy for Prostate and Oligo-metastatic Lesions in Patients With Low-burden Oligo-metastatic Prostate Cancer
The existing large prospective study demonstrates the benefits of primary radiotherapy in patients with low-volume oligo-metastatic prostate cancer (OMPC), and there is also more evidence of the benefits of local…
- Trial name
- NCT06198387
- Testing
- hormone and RT, ADT combined with abiraterone
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Changhai Hospital
Polycythemia Vera, ET (Essential Thrombocythemia)
MPN PROGRESSion Registry: Observational Study Tracking Symptoms, Treatments, and Disease Progression in People With Myeloproliferative Neoplasms (MPNs)
The MPN PROGRESSion Registry is a multi-year, observational research study designed to improve understanding of myeloproliferative neoplasms (MPNs)-a group of rare, chronic blood cancers that include polycythemia vera (PV)…
- Conditions
- Polycythemia Vera, ET (Essential Thrombocythemia), Polycythemia Vera (PV), Essential Thrombocythemia (ET)
- Trial name
- NCT07362225
- Where
- 2 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- MPN Research Foundation
Myeloma, Monoclonal Gammopathy of Undetermined Significance (MGUS)
The Development and Pilot Testing of a New MR Imaging Protocol to Quantify Myeloma Disease Burden and Bone Loss
In the proposed study, the investigators will aim to develop and pilot a Magnetic Resonance (MR) imaging protocol and assess its ability to achieve the following: quantification of tumour burden and bone loss, detecting…
- Conditions
- Myeloma, Monoclonal Gammopathy of Undetermined Significance (MGUS), Smouldering Myeloma
- Trial name
- LOOMIS (NCT03951220)
- Testing
- Diffusion Weighted Magnetic Resonance Imaging (DWMRI), DXA scan, Bloods and urine
- Where
- United Kingdom
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Caregivers
Care For The Cancer Caregiver: A Meaning-Based Workshop To Help Manage Caregiver Burden
The purpose of this study is to gather information on how easy it is to implement the workshop, as well as whether individuals find this workshop helpful.
- Trial name
- NCT02250911
- Testing
- webcasts, Assessments, Usual care
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Myasthenia Gravis
Burden of Disease in Myasthenia Gravis
Questionnaire-based survey addressed to german patients with the chronic autoimmune muscle disease called myasthenia gravis regarding quality of life, socioeconomic impact, social support, course of disease, complications of…
- Trial name
- Mya-BoD (NCT03979521)
- Where
- Germany
- Volunteers
- 1,680 people
- Sponsor
- Charite University, Berlin, Germany