Clinical trials: Tumor Gastric
Early Gastric Cancer
AI Model for Early Gastric Cancer Diagnosis Using Endoscopic Imaging
Early gastric cancer (EGC) is often difficult to detect accurately during endoscopic examination due to subtle morphological features and variability among endoscopists.
- Trial name
- XAI-EGC (NCT07551466)
- Testing
- No intervention (observational study)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Gastric Neoplasm
Randomized Controlled Trial to Evaluate Surgical Approaches to Gastric Cancer Invading the Esophagus (JCOG9502)
To compare left thoraco-abdominal approach with abdominal and transhiatal approach to cardia or subcardia cancer
- Trial name
- NCT00149266
- Testing
- Surgery: abdominal and transhiatal approach, Surgery: left thoraco-abdominal approach
- Where
- Japan
- Volunteers
- 167 people
- Sponsor
- Japan Clinical Oncology Group
Gastric Adenocarcinoma
Surgical Resection Plus Chemotherapy Versus Chemotherapy Alone in Oligometastatic Stage IV Gastric Cancer
Surgical resection of the primary tumour and treatment of the metastatic site in oligometastatic stage IV metastatic gastric adenocarcinoma enhances survival and improves quality of life with acceptable postoperative morbidity…
- Trial name
- SURGIGAST (NCT03042169)
- Testing
- Preoperative Chemotherapy, Surgery, Postoperative chemotherapy
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Lille
Oesophageal Cancer, Gastric Cancer
Google Location History Following Oesophagectomy and/or Gastrectomy
Surgery is the mainstay of treatment for patients with early-disease esophageal and gastric cancer. Open surgery for oesophageal cancer commonly involves large incisions in the chest, which is associated with a high rate of…
- Conditions
- Oesophageal Cancer, Gastric Cancer, Survivorship, Quality of Life
- Trial name
- NCT05035602
- Testing
- Physical activity assessment
- Where
- United Kingdom
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Advanced Solid Tumor, Gynecologic Cancer
A Phase 1a/1b FIH Study of PY159 and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors
This is an open-label, multicenter, First-In-Human (FIH), Phase 1a/1b study of PY159 in subjects with locally advanced (unresectable) and/or metastatic solid tumors that are refractory or relapsed to Standard Of Care (including…
- Conditions
- Advanced Solid Tumor, Gynecologic Cancer, Breast Cancer, Colorectal Cancer
- Trial name
- NCT04682431
- Testing
- PY159 Single agent dose level 1, PY159 Single agent dose level 2, PY159 Single agent dose level 3
- Where
- 17 sites in United States
- Volunteers
- 127 people
- Sponsor
- Ikena Oncology
Uncut Roux-en-Y, Roux-en-Y
Uncut Roux-en-Y vs Roux-en-Y
Uncut Roux-en-Y vs Roux-en-Y reconstruction after distal gastrectomy for gastric cancer
- Conditions
- Uncut Roux-en-Y, Roux-en-Y, Gastric Cancer
- Trial name
- NCT03349398
- Testing
- Uncut Roux-en-Y reconstruction, Roux-en-Y reconstruction
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Jilin University
Breast Cancer, Gastric Cancer
Phase I Study of Pyrotinib in Patients With HER2-positive Solid Tumors
Part 1: to assess the safety and tolerability of pyrotinib and to define the maximum tolerated dose (MTD) of pyrotinib in patients with Human Epidermal Growth Factor Receptor 2 (HER2)-positive advanced solid tumors (metastatic…
- Conditions
- Breast Cancer, Gastric Cancer, Solid Tumors, NSCLC
- Trial name
- NCT02500199
- Testing
- Pyrotinib
- Where
- 10 sites in United States
- Volunteers
- 50 people
- Sponsor
- Hengrui Therapeutics, Inc.
Stage IV Gastric Cancer With Metastasis, Hyperthermic Intraperitoneal Chemotherapy
Hyperthermic Intraperitoneal Chemotherapy for Advanced Gastric Cancer With Peritoneal Metastatis
The incidence rate of gastric cancer is high in Southeast Asia, so is the mortality rate.Due to the lack of specific performance, about 5%-20% of patients have found peritoneal metastases at the time of first diagnosis.At…
- Conditions
- Stage IV Gastric Cancer With Metastasis, Hyperthermic Intraperitoneal Chemotherapy, Exploratory Behavior
- Trial name
- NCT03604614
- Testing
- Hyperthermic Intraperitoneal Chemotherapy, Without Hyperthermic Intraperitoneal Chemotherapy
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Gastric Cancer
A Benefit Population Atlas of nICT Versus nCT for LAGC
The purpose of this observational study is to evaluate the impact of different neoadjuvant therapies on patients with locally advanced gastric cancer.
- Trial name
- NCT07098104
- Testing
- Immunotherapy
- Where
- China
- Volunteers
- 291 people
- Sponsor
- Cheng Chen
Gastric Cancer
Efficacy of Laparoscopic Subtotal Gastrectomy With D2 Lymph Node Dissection for Locally Advanced Gastric Cancer
It was confirmed that the laparoscopic surgery decreases the postoperative pain and reduces the recovery periods in the various surgical fields such as cholecystectomy and colectomy etc.
- Trial name
- KLASS-02-RCT (NCT01456598)
- Testing
- Laparoscopic gastrectomy, Open gastrectomy
- Where
- 13 sites in South Korea
- Volunteers
- 1,050 people
- Sponsor
- Ajou University School of Medicine
Chemotherapy, Immune Checkpoint Inhibitor
Toripalimab Plus FLOT in Locally Advanced Gastric Cancer
Neoadjuvant chemoimmunotherapy for locally advanced gastric and gastroesophageal junction (G/GEJ) cancer is currently under investigation.
- Conditions
- Chemotherapy, Immune Checkpoint Inhibitor, Locally Advanced Gastric Carcinoma
- Trial name
- NCT04891016
- Testing
- FLOT combined with toripalimab
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Henan Cancer Hospital
Gastric Cancer
Tislelizumab Plus Chemotherapy as Postoperative Adjuvant Therapy in Elderly Patients With LA GC/GEJC
The purpose of study is to evaluate the efficacy and safety of postoperative adjuvant chemotherapy with tislelizumab in combination with tegafur-gimeracil-oteracil potassium (S-1 therapy) or tegafur-gimeracil-oteracil potassium +…
- Trial name
- NCT06238167
- Testing
- Tislelizumab, S-1 therapy, low dose SOX therapy
- Volunteers
- 40 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Gastric Cancer
Extensive Peritoneal Lavage After Curative Gastrectomy for Gastric Cancer: A Randomised Controlled Trial
This study is carried out to determine the merit and reliability of extensive intraoperative peritoneal lavage as a preventive strategy Hypothesis: EPL significantly improve the overall survival of patients by reducing the risk…
- Trial name
- EPL (NCT02140034)
- Testing
- Extensive Peritoneal Lavage
- Where
- Singapore
- Volunteers
- 600 people
- Sponsor
- National University Hospital, Singapore
Helicobacter Pylori Infections
Distribution of Helicobacter Pylori After Gastrectomy
The purpose of this study is to know the distribution of Helicobacter pylori in stomach before subtotal gastrectomy and after subtotal gastrectomy.
- Trial name
- NCT03419936
- Testing
- Endoscopic biopsy
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Asan Medical Center
Esophagogastric Junction Adenocarcinoma, Gastric Adenocarcinoma
A Phase Ib Trial Evaluating the Safety and Activity of Neoadjuvant Combination of Tislelizumab Plus FLOT for Resectable Esophagogastric Adenocarcinoma
With this trial, we aim to evaluate a new combination therapy with tislelizumab and FLOT chemotherapy before surgery (neoadjuvant) for locally advanced, resectable adenocarcinoma of the esophagus or stomach (EGA).
- Conditions
- Esophagogastric Junction Adenocarcinoma, Gastric Adenocarcinoma, Esophageal Adenocarcinoma, Resectable Esophagogastric Adenocarcinoma
- Trial name
- NeoTISLEGA (NCT07059299)
- Testing
- Tislelizumab, FLOT Chemotherapy
- Where
- 4 sites in Germany
- Volunteers
- 18 people
- Sponsor
- Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Gastric Cancer
Bortezomib in Treating Patients With Unresectable or Metastatic Gastric Cancer or Gastroesophageal Junction Adenocarcinoma
RATIONALE: Bortezomib may stop the growth of tumor cells by blocking the enzymes necessary for their growth. PURPOSE: Phase II trial to study the effectiveness of bortezomib in treating patients who have unresectable or…
- Trial name
- NCT00074009
- Testing
- bortezomib
- Where
- 4 sites in United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cancer of Unknown Origin, Cancer Refractory
Genomic Testing and Resulting Medical Decisions
There is no evidence available about which molecular profiling methods are currently used for cancer patients in Austrian clinical practice.
- Conditions
- Cancer of Unknown Origin, Cancer Refractory, Cancer of Stomach, Cancer Head Neck
- Trial name
- NCT03301493
- Testing
- Genomic testing
- Where
- 11 sites in Austria
- Volunteers
- 1,500 people
- Sponsor
- Arbeitsgemeinschaft medikamentoese Tumortherapie
Gastric Cancer
Real World Evidence for the Cycle of Neoadjuvant Chemotherapy in Gastric Cancer With Shared Decision Making
The purpose of the study is to evaluate the maximal cycle of effective neoadjuvant chemotherapy for resectable gastric cancer, to determine what is the best cycle of neoadjuvant chemotherapy for the patients who receive…
- Trial name
- RECOMMEND (NCT03413514)
- Testing
- NACT, SDM, Surgery
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University
Solid Tumor, Renal Cell Carcinoma (Kidney Cancer)
A Study of NDI 1150-101 in Patients With Solid Tumors
This study is to determine the maximum tolerated dose (MTD) and the recommended Phase 2 dose (RP2D) and to investigate the safety, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of NDI-101150 given as…
- Conditions
- Solid Tumor, Renal Cell Carcinoma (Kidney Cancer), Gastric and Gastroesophageal Junction (GEJ) Adenocarcinoma, Non-Small Cell Lung Cancer
- Trial name
- NCT05128487
- Testing
- NDI-101150, Pembrolizumab
- Where
- 19 sites in United States
- Volunteers
- 106 people
- Sponsor
- Nimbus Saturn, Inc.
Adenocarcinoma, Gastric Cancer
Clinical and Pharmacokinetic Trial of Intra-Abdominal Irinotecan
This is a research study for patients that have an advanced cancer that is confined mostly to the abdominal cavity and have failed treatment with conventional therapy, or for which no standard treatment exists.
- Trial name
- NCT00183859
- Testing
- irinotecan
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Southern California