Clinical trials: Tumor Gastric
Gastric Cancer
Efficacy of Irinotecan and Capecitabine Versus(vs) Cisplatin and Capecitabine in Patients With Esophago-Gastric Cancer
The purpose of this study is to determine which Arm (capecitabine + irinotecan versus capecitabine + cisplatin) shows higher response rates in the treatment of advanced gastric-oesophagal cancer Furthermore, comparison of…
- Trial name
- NCT00675194
- Testing
- Cisplatin, Irinotecan, Capecitabine
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Johannes Gutenberg University Mainz
Adenocarcinoma of the Gastroesophageal Junction, Adenocarcinoma of the Stomach
Explorative Phase II Study of Perioperative Treatment in Patients With Adenocarcinoma of the Gastroesophageal Junction or Stomach
The purpose of this study is to determine the rate of complete pathological responses (percentage of patients with pCR referring to the total number of enrolled and eligible patients), as evaluated centrally by a reference…
- Trial name
- HerFLOT (NCT01472029)
- Testing
- 5-FU, leucovorin, docetaxel, oxaliplatin (FLOT), trastuzumab, Post-operative treatment trastuzumab mono therapy
- Where
- Germany
- Volunteers
- 53 people
- Sponsor
- AIO-Studien-gGmbH
Chronic Atrophic Gastritis
Multi-omics Analyses on Etiology and Early Detection of Stomach Cancer Precursor Lesions
The overall aim is to utilize multi-omics approach to identify novel etiopathogenesis and early detection biomarkers for stomach cancer precursor lesions.
- Trial name
- NCT06267703
- Testing
- Metabolomic profiling
- Where
- Sweden
- Volunteers
- 12,599 people
- Sponsor
- Karolinska Institutet
Gastrointestinal Stromal Tumors, Soft Tissue Sarcomas
The Biological Activity of Cediranib (AZD2171) in Gastro-Intestinal Stromal Tumours(GIST).
To determine the anti-tumour activity and biological effects of cediranib (AZD2171) at a dose of 45mg, primarily in Gastrointestinal Stromal Tumour (GIST) patients who are resistant to imatinib mesylate (current standard therapy)…
- Trial name
- NCT00385203
- Testing
- AZD2171
- Where
- 2 sites in United Kingdom
- Volunteers
- 35 people
- Sponsor
- AstraZeneca
Gastric Cancer, Immunotherapy
The Construction of a Predictive Model for Gastric Cancer Immunotherapy Response Based on Tumor-Infiltrating Lymphocytes (TILs) and Histone H3K4me3 in the Tumor Microenvironment
Gastric cancer is one of the cancers with a high mortality rate globally, and its treatment outcomes urgently need to be improved.
- Trial name
- NCT07069842
- Testing
- Multiplex Immunofluorescence Technology, Co-Immunoprecipitation (Co-IP) Technology, Immunohistochemistry
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Changzhi People's Hospital Affiliated to Changzhi Medical College
Early Gastric Cancer, Gastric Adenoma
Performance of Endoscopic Submucosal Dissection According to the Sedation Method
Although proper sedation is mandatory for endoscopic procedures such as endoscopic submucosal dissection, the effects of sedation on ESD performance and complications have not been fully evaluated.
- Trial name
- NCT01806753
- Testing
- Intermittent midazolam/propofol injection controlled by endoscopist, Continuous propofol infusion with opioid administration
- Where
- South Korea
- Volunteers
- 157 people
- Sponsor
- Yonsei University
Gastric Cancer
Annual Hospital Volume and and Short-term Postoperative Outcomes After Gastric Cancer Resection
The effect of centralisation measures on the operative outcomes after gastric cancer resection in Switzerland has not been highlighted yet.
- Trial name
- NCT07072429
- Testing
- Gastric cancer resection
- Where
- Switzerland
- Volunteers
- 3,112 people
- Sponsor
- Cantonal Hospital of St. Gallen
Gastric Adenocarcinoma
An Observational Study on Gastric Cancer in High-risk Individuals
This study is designed as a prospective observational cohort study, aiming to assess the differences in the occurrence of gastric cancer and the progression of gastric cancer-related precancerous lesions between individuals who…
- Trial name
- NCT07438418
- Testing
- The result of fecal multi-target DNA testing
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fudan University
Gastric Cancer Stage IV, Peritoneal Metastases
Systemic Application of Cadonilimab, LM-302, and S-1 Combined With Intraperitoneal Infusion of Paclitaxel for the Treatment of Claudin 18.2-positive Gastric Cancer With Peritoneal Metastasis
In this phase 2 study, we combined Cadonilimab, LM-302, and S-1 combined with intraperitoneal infusion of paclitaxel as regimen to treat gastric cancer patients with peritoneal metastasis.
- Trial name
- NCT06519591
- Testing
- Cadonilimab, LM-302, S-1, paclitaxel
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Ruijin Hospital
Gastric Cancer, Gastroesophageal Junction Adenocarcinoma
A Study of Atezolizumab and Trastuzumab in Combination With Capecitabine and Oxaliplatin in Patients With HER2 Positive Locally Advanced Resectable Gastric Cancer of Adenocarcinoma of Gastroesophageal Junction
This is a phase II, multicenter, randomized, open-label study designed to evaluate the efficacy and safety of perioperative trastuzumab+XELOX with / without atezolizumab in participants eligible for surgery with locally advanced…
- Trial name
- NCT04661150
- Testing
- Atezolizumab, Trastuzumab, Capecitabine
- Where
- 8 sites in China
- Volunteers
- 42 people
- Sponsor
- Hoffmann-La Roche
Hepatocellular Carcinoma (HCC), Cholangiocarcinoma
A Noninvasive and Screening miRNA Signature for Gastrointestinal Cancer
Gastrointestinal (GI) cancers remain a major global health burden, largely due to the lack of effective and accessible early screening strategies.
- Conditions
- Hepatocellular Carcinoma (HCC), Cholangiocarcinoma, Pancreatic Ductal Adenocarcinoma (PDAC), Esophageal Squamous Cell Carcinoma (ESCC)
- Trial name
- MiGIC (NCT07224750)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Gastric Cancer
A Study of Capecitabine (Xeloda) in Combination Chemotherapy Versus Surgery Alone in Participants With Gastric Cancer
This study will compare capecitabine/oxaliplatin as adjuvant chemotherapy versus observation alone in chemotherapy-naive participants who have undergone potentially curative resection for gastric cancer.
- Trial name
- NCT02560974
- Testing
- Capecitabine, Oxaliplatin
- Where
- 36 sites in China, South Korea and 1 more
- Volunteers
- 1,035 people
- Sponsor
- Hoffmann-La Roche
Immune Checkpoint Therapy, Radiotherapy
Node-Sparing Short-Course Radiotherapy Plus First-Line Therapy and PD-1 Inhibitor in Unresectable/Metastastic pMMR/MSS Gastric Cancer (MODIFI-GC)
For patients with unresectable locally advanced or metastatic gastric cancer, systemic anti-tumor therapy remains the mainstay of treatment.
- Conditions
- Immune Checkpoint Therapy, Radiotherapy, Metastatic Gastric Carcinoma
- Trial name
- NCT06980389
- Testing
- Node-Sparing Radiotherapy plus first-line therapy, First-line treatment
- Where
- China
- Volunteers
- 176 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Gastric Cancer
Albumin-bound Paclitaxel Plus S-1 Versus SOX as First-line Treatment in Advanced or Recurrent Gastric Adenocarcinoma
It is a trial to compare the efficacy and safety of Albumin-bound Paclitaxel plus S-1 versus Oxaliplatin plus S-1 (SOX) as first-line treatment in advanced or recurrent gastric adenocarcinoma.
- Trial name
- NCT03801668
- Testing
- Albumin-bound Paclitaxel plus S-1, Oxaliplatin plus S-1
- Where
- China
- Volunteers
- 294 people
- Sponsor
- Huazhong University of Science and Technology
Gastric Cancer
The Efficacy and Safety of Benmelstobart for GC/EGC
The goal of this clinical trial is to evaluate the major pathological response (MPR) rate of locally advanced gastric cancer / gastroesophageal junction cancer treated with bemosumab combined with antiangiogenic drugs and…
- Trial name
- EASOBFGE (NCT06603974)
- Testing
- surgery, Benmelstobart, tegafur
- Volunteers
- 48 people
- Sponsor
- Xijing Hospital
Advanced Gastric Cancer
Biweekly FOLFIRI in Advanced Gastric Cancer (AGC) With Failure of Prior Taxane, Fluoropyrimidine, and Cisplatin
The purpose of this study is: To observe the feasibility of biweekly oxaliplatin and infusional 5-fluorouracil (FU)/Leucovorin (LV) in patients with advanced gastric adenocarcinoma who have prior exposure to taxane…
- Trial name
- NCT00976768
- Testing
- oxaliplatin, 5-fluorouracil
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Asan Medical Center
Early Gastric Cancer, Gastric Dysplasia
Does Early Re-administration of Aspirin/Clopidogrel Increase the Risk of Bleeding From Artificial Ulcer After EMR or ESD?
Aspirin and/or clopidogrel users are increasing due to increased prevalence of cardiovascular or cerebrovascular disease with an aging society in Korea.
- Trial name
- NCT01621451
- Testing
- aspirin and/or clopidogrel
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Asan Medical Center
Postoperative Complications, Anxiety
Effects of Preoperative Anxiety and Depression on Short-term Postoperative Recovery in Early Gastric Cancer
This study aims to investigate preoperative anxiety, depression, and coping strategy of the patients undergoing laparoscopic gastrectomy for early gastric cancer and their effects on short-term postoperative recovery measured by…
- Conditions
- Postoperative Complications, Anxiety, Depression, Coping Behavior
- Trial name
- NCT04599231
- Testing
- Quality of Recovery -15
- Where
- South Korea
- Sponsor
- Seoul National University Hospital
Gastric Cancer
Impact of Robotic Surgery on Systemic Immune-inflammation Index
Robotic surgery has been gaining attention because of the physical and metabolic morbidity of the conventional open technique.The systemic immune-inflammation index(SII) has emerged as a recent and more reliable biomarker.In our…
- Trial name
- NCT06811753
- Testing
- robotic surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Stage IV Gastric Carcinoma, Stage IV Nasopharyngeal Carcinoma
PD-1 Knockout EBV-CTLs for Advanced Stage Epstein-Barr Virus (EBV) Associated Malignancies
This study will evaluate the safety of PD-1 knockout EBV-CTL cells in treating EBV (Epstein-Barr virus) positive advanced stage malignancies. Blood samples will also be collected for research purposes.
- Conditions
- Stage IV Gastric Carcinoma, Stage IV Nasopharyngeal Carcinoma, T-Cell Lymphoma Stage IV, Stage IV Adult Hodgkin Lymphoma
- Trial name
- NCT03044743
- Testing
- Fludarabine, Cyclophosphamide, Interleukin-2
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Yang Yang
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