Clinical trials: Tumor Patients
Lung Neoplasms
Local Therapy in Advanced NSCLC With Non-progressive Disease (PD) After First Line Therapy
This is a prospective single arme real-world study clinical study, which aims to investigate the overall benefit and safety of consolidative therapy in advanced NSCLC (stage III/IV) patients , who do not progress after front line…
- Trial name
- LOCAL (NCT03046316)
- Testing
- local consolidative treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangdong Association of Clinical Trials
Solid Tumors, Metastatic Disease
CPCT-05 Biopsy Protocol Patient Selection
Our knowledge on the genetic mutations in cancer is rapidly expanding and we are increasingly testing drugs in mainly metastatic cancer patient populations with rare mutations.
- Trial name
- NCT01904916
- Testing
- Histological biopsy procedure
- Where
- 3 sites in Netherlands
- Volunteers
- 195 people
- Sponsor
- P.O. Witteveen
Malignant Solid Tumor
Clinical Evaluation of [68Ga]Ga-ELI411 PET Imaging in Adult Patients With Solid Tumors
This is a prospective, single-center, open-label, two-cohort clinical study evaluating the safety, tolerability, biodistribution, radiation dosimetry, and diagnostic performance of [68Ga]Ga-ELI411 PET imaging in adult patients…
- Trial name
- NCT07741006
- Testing
- [68Ga]Ga-ELI411
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Comprehensive Nutritional Geriatric Assessments in Identifying Malnutrition in Older Cancer Participants
This trial studies how well comprehensive nutritional geriatric assessments work in identifying malnutrition in older cancer participants.
- Trial name
- NCT03035604
- Testing
- Comprehensive Geriatric Assessment
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- M.D. Anderson Cancer Center
Brain Tumor, Recurrent, Brain Tumor
Registry of Patients With Brain Tumors Treated With STaRT (GammaTiles)
The objectives of this registry study are to evaluate real-world clinical outcomes and patient reported outcomes that measure the effectiveness and safety of STaRT.
- Conditions
- Brain Tumor, Recurrent, Brain Tumor, Brain Tumor, Primary, Brain Tumor - Metastatic
- Trial name
- NCT04427384
- Testing
- GammaTile
- Where
- 54 sites in United States
- Volunteers
- 600 people
- Sponsor
- GT Medical Technologies, Inc.
Hematologic Malignancies
A Study of HMPL-523 in Relapsed or Refractory Hematologic Malignancies
The purpose of this study is to evaluate the safety and tolerability of HMPL-523 administered to patients with relapsed or refractory Hematologic Malignancies To determine the maximum tolerated dosage/recommended phase 2 dosage…
- Trial name
- NCT02503033
- Testing
- HMPL-523
- Where
- 12 sites in Australia
- Volunteers
- 78 people
- Sponsor
- Hutchison Medipharma Limited
Nelson Syndrome
Pasireotide Therapy in Patients With Nelson's Syndrome
Nelson's syndrome, an expanding pituitary tumour, occurs in up to 30% of adults after bilateral adrenalectomy for Cushing's disease, for which no medical treatment exists.
- Trial name
- NCT01617733
- Testing
- Pasireotide
- Where
- 4 sites in United Kingdom
- Volunteers
- 8 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Sarcoma, Soft Tissue
Ph II Nintedanib vs. Ifosfamide in Soft Tissue Sarcoma
This is a prospective, multicentric, randomized, open label Phase II trial investigating whether the oral angiogenesis inhibitor nintedanib, as compared to the intravenous cytotoxic compound ifosfamide, given for patients with…
- Trial name
- ANITA (NCT02808247)
- Testing
- Nintedanib, Ifosfamide
- Where
- 13 sites in Belgium, France and 5 more
- Volunteers
- 80 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Kidney Medullary Carcinoma, Loss of INI 1 Protein Expression
Phase II Trial of Nivolumab Plus Ipilimumab in Patients With Renal Medullary Carcinoma
This phase II trial studies how well nivolumab and ipilimumab work in treating patients with kidney cancer. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the…
- Conditions
- Kidney Medullary Carcinoma, Loss of INI 1 Protein Expression, Stage III Renal Cell Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v8
- Trial name
- NCT03274258
- Testing
- Ipilimumab, Nivolumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- M.D. Anderson Cancer Center
Endometrial Cancer, Serous Adenocarcinoma
Niraparib in High-grade Endometrial Cancer Trial
The study will investigate the effect of niraparib on tumor tissue in chemotherapy naïve, newly diagnosed, high-grade endometrial cancer patients.
- Conditions
- Endometrial Cancer, Serous Adenocarcinoma, Uterine Neoplasm
- Trial name
- NIREC (NCT05289648)
- Testing
- Niraparib oral capsule
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Metastatic Prostate Cancer
The Effect of Metformin in Patients With Metastatic Castration-resistant Prostate Cancer
The purpose of this study is to assess the effect of the addition of metformin to abiraterone on survival in patients with metastatic castration-resistant prostate cancer (mCRPC).
- Trial name
- NCT04926155
- Testing
- Metformin
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Sun Yat-sen University
Breast Cancer
Studying Tailored Exercise Prescriptions in Breast Cancer Patients
Chemotherapy forms a significant part of many breast cancer patient's treatment and is associated with various common, known adverse effects.
- Trial name
- STEPS (NCT02802826)
- Testing
- Tailored Exercise Prescription
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Loughborough University
Behavior, Motor Activity
Physical Activity Trends in Cancer Survivors Treated at the 'MOvement and REhabilitation' Clinic
An active lifestyle after a cancer diagnosis can reduce the side effects of treatment and improve quality of life, mental health, and survival.
- Trial name
- MOREACTIVE2025 (NCT07373626)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Colorectal Cancer, Unresectable Liver Metastasis
Neoadjuvant FOLFOX6 + Cetuximab in Patients With Colorectal Cancer and Unresectable Liver Metastasis
An innovative therapeutic strategy to increase the complete resection rate is of utmost importance in order to enhance survival in colorectal cancer patients with unresectable liver-only metastasis.
- Trial name
- NCT00743678
- Testing
- FOLFOX6/cetuximab
- Where
- South Korea
- Volunteers
- 73 people
- Sponsor
- Samsung Medical Center
Non Small Cell Lung Cancer, Cancer of the Head and Neck
An Expanded Access Programme With Iressa for Patients With Non-Small-Cell Lung Cancer and Cancer of the Head and Neck
The purpose of this study is to provide ZD1839 for those patients with locally advanced and/or metastatic non-operable non-small cell lung cancer (stage III or IV) or recurrent and/or metastatic squamous cell head and neck cancer…
- Trial name
- NCT00684385
- Testing
- ZD1839
- Where
- 34 sites in Germany, Hungary and 2 more
- Sponsor
- AstraZeneca
Bone Sarcoma, Osteosarcoma
Efficacy of Regorafenib Combined With Best Supportive Care as Maintenance Treatment in High Grade Bone Sarcomas Patients
This is a multicenter phase II study concerning patients with high-grade bone sarcoma (HGBS) without complete remission after standard treatment at diagnosis or at relapse.
- Trial name
- REGOMAIN (NCT04698785)
- Testing
- Treatment by regorafenib and best supportive care
- Where
- 16 sites in France
- Volunteers
- 36 people
- Sponsor
- Centre Leon Berard
Locally Advanced or Metastatic Solid Tumor
A Study of Rebastinib (DCC-2036) in Combination With Carboplatin in Patients With Advanced or Metastatic Solid Tumors
This is an open-label Phase 1b/2 multicenter study of rebastinib (DCC-2036) in combination with carboplatin designed to evaluate the safety, tolerability, and pharmacokinetics (PK) in participants with advanced or metastatic…
- Trial name
- NCT03717415
- Testing
- Rebastinib, Carboplatin
- Where
- 9 sites in United States
- Volunteers
- 70 people
- Sponsor
- Deciphera Pharmaceuticals, LLC
Prostate Cancer, Renal Cancer
Feasibility of a Consumer Based Accelerometer in Monitoring Outpatient Physical Activity: A Study in Patients With Cancer and Amyotrophic Lateral Sclerosis
This is a parallel group, single institution, prospective clinical study. The purpose of this study is to assess whether the Jawbone Up 24, a consumer based accelerometer, can be a feasible tool to study physical activity in…
- Conditions
- Prostate Cancer, Renal Cancer, Brain Cancer, ALS
- Trial name
- NCT02457715
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q)
Vorinostat and Decitabine in Treating Patients With Relapsed, Refractory, or Poor-Prognosis Hematologic Cancer or Other Diseases
This phase I trial is studying the side effects and best dose of vorinostat and decitabine in treating patients with relapsed, refractory, or poor-prognosis hematologic cancer or other diseases.
- Conditions
- Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q), Adult Acute Myeloid Leukemia With Inv(16)(p13;q22), Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)
- Trial name
- NCT00357708
- Testing
- decitabine, vorinostat, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Cancer Institute (NCI)
Non-small Cell Lung Cancer, Mesothelioma
Study of Pemetrexed in Mesothelioma and Lung Cancer Patients With Fluid Around the Lungs or Abdomen
This study will test the effects of pemetrexed on mesothelioma and non-small cell lung cancer patients with fluid around their lungs or abdomen.
- Conditions
- Non-small Cell Lung Cancer, Mesothelioma, Lung Neoplasms
- Trial name
- NCT00316225
- Testing
- pemetrexed
- Where
- 3 sites in Denmark, Germany and 1 more
- Volunteers
- 31 people
- Sponsor
- Eli Lilly and Company