Clinical trials: Tumor of Prostate
Prostate Cancer
Abiraterone-Rechallenge Study for CRPC Patients
To assess activity of abiraterone-re-challenge in patients with advanced prostate cancer and prior response to abiraterone.
- Trial name
- ABI-RE (NCT02656615)
- Testing
- abiraterone acetate
- Where
- 3 sites in Switzerland
- Volunteers
- 4 people
- Sponsor
- Aurelius Omlin
Prostate Cancer
Ultralow Versus Standard Pneumoperitoneum Pressure
The investigators plan to compare insufflation pressures during robotic assisted laparoscopic prostatectomy (RALP). Standard pressure is typically 15 mmHg, while in a previous study the investigators determined that 6 mmHg is…
- Trial name
- Ultralow (NCT03630393)
- Testing
- Pneumoperitoneum Pressure 6 mmHg, Pneumoperitoneum Pressure 15 mmHg
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- OhioHealth
Prostate Carcinoma, Recurrent Prostate Carcinoma
Metabolic Interventions (Time-Restricted Eating, GLP1 Receptor Agonist, and Heart Healthy Diet) to Improve Cardiometabolic Health in Prostate Cancer Patients During Androgen Deprivation Therapy, IMPACT-ADT Trial
This phase II trial compares the effect of time-restricted eating (TRE) and glucagon-like peptide-1 (GLP1) receptor agonists (RA), semaglutide and tirzepatide, to an American Heart Association (AHA) heart healthy diet (HHD)…
- Trial name
- NCT07202247
- Testing
- Antiandrogen Therapy, Behavioral Intervention, Biospecimen Collection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- City of Hope Medical Center
Prostate Cancer
Platelet Rich Plasma During Radical Prostatectomy
Can platelet rich plasma applied to nerve bundles at time of surgery help the nerve bundles heal? Subjects undergoing a Radical Prostatectomy who meet study inclusion/exclusion criteria will be consented to receive an…
- Trial name
- NCT02957149
- Testing
- Autologous Platelet-Rich Plasma, Angel Concentrated Platelet Rich Plasma System
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Mayo Clinic
Androgen Axis Suppression, Prostatectomy
PROSTATE-IQ: Parallel RandOmized STudy of Personalized Apalutamide Treatment and Evaluation to Improve Quality of Life in Post-Operative Radiation With Androgen Axis Suppression. A Phase III Multi-center Study for Men With Detectable PSA After Prostatectomy for Prostate Cancer.
1. Personalize treatment for prostate cancer based on how aggressive the disease is and 2. Learn if apalutamide-based treatment can help to reduce fatigue and other side effects of treatment in participants who are being treated…
- Conditions
- Androgen Axis Suppression, Prostatectomy, Prostate Cancer
- Trial name
- NCT06274047
- Testing
- Apalutamide, Androgen Deprivation Therapy
- Where
- 6 sites in United States
- Volunteers
- 120 people
- Sponsor
- M.D. Anderson Cancer Center
Prostate Cancer
Investigational Study For the Treatment of Localized (T1c/T2a) Prostate Cancer With High Intensity Focused Ultrasound (HIFU) Using the Sonablate 500 (SB-500) System in Canada
An investigational study on the use of HIFU in the management of localized prostate cancer as a primary non-comparative study High intensity focused ultrasound (HIFU) is a non-invasive acoustic ablation technique that uses…
- Trial name
- NCT00537849
- Testing
- Sonablate 500(SB-500)
- Where
- Canada
- Sponsor
- SonaCare Medical
Prostate Cancer
Evaluation of Intraprostatic Fiducial Markers For External Beam Radiation Therapy
The goal of this clinical research study is to evaluate a system for localizing (targeting for treatment) the prostate for external beam radiation therapy.
- Trial name
- NCT00499421
- Testing
- Computed Tomography (CT) Scan
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- M.D. Anderson Cancer Center
Prostate Cancer
Study of Quality of Life for Prostate Proton Therapy
The goal of this research study is to collect information on the side effects of proton radiation therapy given for the treatment of prostate cancer as well as the effect of proton therapy on quality of life.
- Trial name
- NCT00489814
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 1,125 people
- Sponsor
- M.D. Anderson Cancer Center
Cancer Of Prostate, Prostate Neoplasms
A Phase I/II Study of PDS01ADC With Docetaxel and Abiraterone in Adults With Metastatic Castration Sensitive and PDS01ADC With Docetaxel in Castration Resistant Prostate Cancer
Background: Metastatic castration sensitive and castration resistant prostate cancer (mCSPC and mCRPC) are prostate cancers that have spread to other parts of the body.
- Trial name
- NCT04633252
- Testing
- PDS01ADC, Docetaxel, M7824
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- National Cancer Institute (NCI)
Prostatic Neoplasms, PSA
Prostate Impendance Test Project
Impedance-based analysis could provide an adequate response to the need to identify a safe and reliable tool alternative to bioptic diagnosis.
- Conditions
- Prostatic Neoplasms, PSA, Prostatic Biopsy, Impedance Test
- Trial name
- PROSIT (NCT03428087)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Breast Cancer, Prostate Cancer
A Multi-center Investigation of Family Health.
The current healthcare system is unable to identify burdened and vulnerable families affected by cancer, partly due to a lack of knowledge of how cancer affects family health during treatment and survivorship.
- Conditions
- Breast Cancer, Prostate Cancer, Colorectal Cancer, Hematologic Neoplasms
- Trial name
- NCT06433349
- Testing
- Survey and interviews
- Where
- Denmark
- Volunteers
- 240 people
- Sponsor
- Odense University Hospital
Prostate Cancer
The Predictive Value of TMPRSS2-ERG Fusion in High Risk Prostate Cancer Patient
The objective of this study is to evaluate the predictive value of TMPRSS2-ERG gene fusion in patients with prostate cancer treated with radiation and hormonal therapy.
- Trial name
- NCT02588404
- Testing
- LHRH therapy
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Prostate Cancer
Robotic Surgery After Focal Ablation Therapy
The toxicity of traditional prostate cancer therapies including radical surgery and external beam radiation is well known. This has prompted a move towards focal therapy where only the cancerous part of the prostate is treated.
- Trial name
- RAFT (NCT03011606)
- Testing
- Robotic Surgery
- Where
- 2 sites in United Kingdom
- Volunteers
- 24 people
- Sponsor
- Queen Mary University of London
Cancer
Trial of Methoxyflurane With Periprostatic Local Anaesthesia to Reduce the Discomfort of TRUS B
A phase 3 double-blind placebo-controlled randomized trial of methoxyflurane with periprostatic local anaesthesia to reduce the discomfort of transrectal ultrasound-guided prostate biopsy (Pain-Free TRUS B).
- Trial name
- TRUSB (NCT02604225)
- Testing
- Methoxyflurane
- Where
- 7 sites in Australia, New Zealand
- Volunteers
- 420 people
- Sponsor
- University of Sydney
Metastatic Prostate Cancer
Physician- and Patient-based Barriers to NGS Testing
The goal of this study is to improve next-generation sequencing (NGS) testing rates at Johns Hopkins in patients with metastatic prostate cancer.
- Trial name
- NCT07209176
- Testing
- Provider-level and patient education at end of study, Provider-level and patient-level
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Prostate Cancer
Safety and Efficacy Study of Dose-escalated Hypofractionated Radiotherapy For Prostate Cancer
The purpose of this study is to determine the safety and efficacy of a short course of radiotherapy (40 Gy / 5 fractions / 29 days) for the treatment of low- and intermediate-risk prostate cancer.
- Trial name
- PHART6 (NCT01146340)
- Testing
- Hypofractionated radiotherapy
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Sunnybrook Health Sciences Centre
Prostate Cancer
Radiation Therapy in Treating Patients With Relapsed Prostate Cancer After Surgery
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known which radiation therapy regimen is more effective in treating patients with relapsed prostate cancer.
- Trial name
- NCT01272050
- Testing
- radiation therapy
- Where
- 28 sites in Belgium, Germany and 1 more
- Volunteers
- 350 people
- Sponsor
- Swiss Cancer Institute
PSMA Positive Tumors or Tumor Tissues, Prostate Cancer Metastatic
PSMA PET for Treatment Response evaLuation of systemIC Therapies in prostAte caNcer (PELICAN)
This prospective clinical study aims to evaluate the predictive power of PSMA PET imaging in patients with advanced prostate cancer who are receiving systemic drug therapies.
- Trial name
- PELICAN (NCT07089550)
- Testing
- PSMA PET/CT scan
- Where
- 4 sites in Italy
- Volunteers
- 1,300 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Prostate Cancer
Radium 223 Following Intermittent ADT
This is a multicentre, phase II, randomized, open label study to evaluate the efficacy and safety of monthly Radium 223 in prolonging the off treatment interval of men with localized prostate cancer receiving intermittent…
- Trial name
- RAND (NCT02656563)
- Testing
- Radium 223 Dichloride (Xofigo®)
- Where
- Canada
- Sponsor
- Canadian Urology Research Consortium
Leukemia, Myeloid, Acute, Leukemia, Lymphocytic, Chronic, B-Cell
A Rollover Study for Continued Study Treatment and Ongoing Safety Monitoring
The purpose of this study is to collect long-term safety data in participants with cancers including acute myeloid leukemia, non-Hodgkin lymphoma, myelodysplastic syndrome, chronic lymphocytic leukemia (type of cancer of the…
- Conditions
- Leukemia, Myeloid, Acute, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Non-Hodgkin, Myelodysplastic Syndromes
- Trial name
- NCT06788509
- Testing
- JNJ-75348780, JNJ-67856633, JNJ-54179060
- Where
- 39 sites in Australia, Belgium and 13 more
- Volunteers
- 120 people
- Sponsor
- Janssen Research & Development, LLC
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