Clinical trials: Tumors, Breast
Breast Cancer
Ultra High Field MRI and MRS Techniques in Diagnosing Breast Cancer
This pilot clinical trial studies ultra-high field magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) techniques in diagnosing breast cancer.
- Trial name
- NCT01938651
- Testing
- high field strength magnetic resonance imaging, magnetic resonance spectroscopic imaging, chemical exchange saturation transfer magnetic resonance imaging
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Breast Carcinoma
Improving The Breast Cancer Care Delivery Model for Sex and Gender Minority Survivors, Intended for SGM Study
This study evaluates Improving the Breast Cancer Care Delivery Model for Sex and Gender Minority (INTENDED for SGM) in identifying the patient, support person and provider barriers to quality care in SGM breast/chest cancer…
- Trial name
- NCT06205394
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Insulin Sensitivity/Resistance, Breast Cancer
Insulin Sensitivity After Breast Cancer
Epidemiological studies have revealed that 60-80% of women with breast cancer (BC) develop metabolic disorders that are similar to those observed in conditions like type 2 diabetes.
- Conditions
- Insulin Sensitivity/Resistance, Breast Cancer, Survivorship, Metabolic Disturbance
- Trial name
- NCT05010356
- Testing
- Insulin
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
ER-positive and HER2-negative Metastatic or Locally Advanced Breast Cancer, a Germline or Somatic BRCA Mutation, or a Deleterious Alteration of Other Genes Involved in Homologous Recombination Repair (HRR) or in MSI Status
Durvalumab, With Olaparib and Fulvestrant in Advanced ER+, HER2- Breast Cancer Patients.
This study evaluates the efficacy of the combination of olaparib, durvalumab, and fulvestrant for the treatment of patients with ER-positive, HER2-negative, locally advanced or metastatic breast cancer with BRCA gene alterations…
- Trial name
- DOLAF (NCT04053322)
- Testing
- Durvalumab, Olaparib, Fulvestrant
- Where
- 2 sites in France
- Volunteers
- 172 people
- Sponsor
- UNICANCER
Breast Cancer Metastatic
A Study Evaluating The PF-03084014 In Combination With Docetaxel In Patients With Advanced Breast Cancer
This study is aimed to determine the tolerability of the PF-03084014 plus docetaxel combination in patients with advanced breast cancer. Preliminary information about the efficacy of the combination will also be collected.
- Trial name
- NCT01876251
- Testing
- PF-03084014, Docetaxel
- Where
- 16 sites in United States, Belgium and 2 more
- Volunteers
- 30 people
- Sponsor
- Pfizer
Chronic Obstructive Pulmonary Disease (COPD)
Effect of Cyclosporine Drug Interaction on the Absorption, Metabolism and Elimination of CHF6001 in Healthy Volunteers. Drug-Drug Interaction 2 (DDI2) Study
The main goal of this pharmacokinetic study in healthy volunteers is to evaluate the potential effect of cyclosporine (probe inhibitor of P glycoprotein [P-gp] and breast cancer resistance protein [BCRP] transporters) on CHF6001…
- Trial name
- DDI2 (NCT06892756)
- Testing
- CHF6001 dry powder inhaler (DPI), Cyclosporine, CHF6001 DPI
- Where
- Bulgaria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Breast Cancer
Clinical Trial of Evaluating TQB3912 Tablets Combined With Fulvestrant Injection±TQB3616 Capsules for Locally Advanced or Metastatic Hormone Receptor(HR)-Positive and Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Breast Cancer
This trial was designed to evaluate the maximum tolerated dose (MTD) and phase II recommended dose (RP2D) in subjects with TQB3912 tablets combined with fulvestrant injection and TQB3616 capsules for locally advanced or…
- Trial name
- NCT06851442
- Testing
- TQB3912 tablets in combination with fulvestrant injection± TQB3616 capsules
- Where
- 17 sites in China
- Volunteers
- 8 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Breast Cancer Female
Feasibility Study of ABC for Women Treated for Breast Cancer
The investigators aim to assess the feasibility and acceptability of conducting a randomised controlled trial (RCT) to test whether receiving ABC (an online-delivered, Cognitive Behavioural Therapy [CBT], group-based, body image…
- Trial name
- NCT06412341
- Testing
- Accepting your Body after Cancer, Macmillan body image booklet
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of the West of England
Breast Cancer
PEAK PlasmaBlade™ 4.0 Versus Traditional Electrosurgery in Lumpectomy
The purpose of this clinical study is to quantify the difference in thermal injury depth at the surgical margin in breast lumpectomy specimens excised with the PlasmaBlade; to subjectively assess histopathologic sample quality…
- Trial name
- PRECISE (NCT00960154)
- Testing
- PEAK PlasmaBlade, Traditional Electrosurgery with scalpel
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Medtronic Surgical Technologies
Breast Cancer
Short-term Presurgical Study to Assess Molecular Predictors of Lapatinib's Effects in Primary Breast Cancer
To provide an in vivo measure of the activity of lapatinib. To assess the antiproliferative effects of lapatinib in breast cancer, ie how much lapatinib slows down the growth of cancer cells by measuring K167 (a marker of…
- Trial name
- MAPLE (NCT00299286)
- Testing
- Lapatinib
- Where
- United Kingdom
- Volunteers
- 121 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Breast Cancer
Intravenous Ascorbic Acid Supplementation in Neoadjuvant Chemotherapy for Breast Cancer
Forty years ago clinical studies conducted by Ewan Cameron and Linus Pauling suggested that intravenous (IV) and oral ascorbic acid (AA) may diminish symptoms and could improve survival in terminal cancer patients.
- Trial name
- NCT03175341
- Testing
- Ascorbic Acid
- Where
- Romania
- Volunteers
- 30 people
- Sponsor
- Academic Emergency County Hospital Sibiu
Breast Cancer Metastatic, Hormone Receptor Positive Malignant Neoplasm of Breast
Rogaratinib, Palbociclib y Fulvestrant in Patients With Breast Cancer.
This study is an open, multicenter, prospective phase I dose escalation clinical trial followed by an expansion cohort. The aim of this study is to asses the Recommended Phase 2 Dose (R2PD) and the safety profile, among other…
- Trial name
- ROGABREAST (NCT04483505)
- Testing
- Combination, Rogaratinib + palbociclib + fulvestrant
- Where
- 8 sites in Spain
- Volunteers
- 9 people
- Sponsor
- Fundacion CRIS de Investigación para Vencer el Cáncer
Breast Cancer
Letrozole, Anastrozole, Exemestane, or Tamoxifen Citrate in Treating Postmenopausal Women With Breast Cancer
RATIONALE: Estrogen can cause the growth of breast cancer cells. Aromatase inhibitors, such as letrozole, anastrozole, and exemestane, may fight breast cancer by lowering the amount of estrogen the body makes.
- Trial name
- MNEMOSYNE (NCT00893061)
- Testing
- anastrozole, exemestane, letrozole
- Where
- 3 sites in France
- Volunteers
- 44 people
- Sponsor
- Centre Oscar Lambret
Ovarian Cancer, Breast Cancer
A Study of Serum Folate Levels in Patients Treated With Olaparib
This is a study investigating folate deficiency (lack of folic acid in the blood) in patients who take the drug olaparib to treat their advanced ovarian or breast cancer.
- Conditions
- Ovarian Cancer, Breast Cancer, Folic Acid Deficiency
- Trial name
- NCT04024254
- Testing
- Folic Acid Tablet
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Rush University Medical Center
Breast Cancer
Mammography SPECT With Rotating Slant Hole Collimator
The goal is to conduct a pilot study to determine the feasibility of the clinical use of RMSSH SPECT imaging technology for breast imaging and to develop a standardized clinical protocol.
- Trial name
- NCT00328354
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Breast Cancer
Supervised Exercise to Promote Infiltration of NK-cells Into the Tumor
'Supervised exercise to PRomote Infiltration of NK-cells into the Tumor? The objective of this feasibility study is to 1) study trial feasibility in terms of patient enrollment and the percentage of tumor biopsies that can be…
- Trial name
- SPRINT (NCT04704856)
- Testing
- Supervised exercise
- Where
- 2 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- Amsterdam UMC, location VUmc
Distress, Breast Neoplasms
LOL: It's All Improv After Cancer! The Impact of Improvisational Comedy on Well-Being Among Patients With Cancer
Managing distress and improving well-being is critically important for optimal survivorship care. Treatment of distress leads to better adherence to treatment, better communication, fewer calls and visits to the oncologist's…
- Conditions
- Distress, Breast Neoplasms, Quality of Life
- Trial name
- NCT02892006
- Testing
- Improvisational Comedy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Breast Cancer
A Dose Increase Finding Study of Doxorubicin Hydrochloride Liposome Injection for Patients With Breast Cancer
To study the maximum tolerated dose of Doxorubicin Hydrochloride Liposome Injection combination with cyclophosphamide and sequential treatment of docetaxel for patients with locally advanced breast cancer
- Trial name
- NCT03017404
- Testing
- Doxorubicin Hydrochloride Liposome Injection, Cyclophosphamide, docetaxel
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Hebei Medical University Fourth Hospital
Breast Cancer
BMS-247550 in Treating Women With Metastatic Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of BMS-247550 in treating women who have stage IV or…
- Trial name
- NCT00020904
- Testing
- ixabepilone
- Where
- 2 sites in United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer
Capecitabine Metronomic Chemotherapy Plus Aromatase Inhibitor for Postmenopausal Hormone Receptor Positive Breast Cancer
The present study is to determine the adverse effects and clinical efficacy of AI combined with Capecitabine metronomic chemotherapy in postmenopausal breast cancer patients with Estrogen receptor and/or Progestrogen receptor…
- Trial name
- NCT01924078
- Testing
- Capecitabine, aromatase Inhibitors (AIs)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
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