Clinical trials: Twin; Complicating Pregnancy
Pregnancy, Multiple
Perineal Consequences of Twin Pregnancies According to Mode of Delivery
This is an ancillary study to the "JUMODA" (National Prospective and Comparative Study on the Mode of Delivery of Twins) study: please see NCT01987063.
- Trial name
- JUMODA-CP (NCT02059746)
- Testing
- Questionnaires sent by mail
- Where
- 2 sites in France
- Volunteers
- 3,039 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Neonatal SEPSIS, Perinatal Mortality
Outcomes in Spontaneous and ART Twin Pregnancies
During the last decades, assisted reproductive technique has been transformed from a miracle to real and has become widely used for treatment human infertility. this was associated with increased the rate of twin pregnancies
- Conditions
- Neonatal SEPSIS, Perinatal Mortality, Maternal Morbidity
- Trial name
- NCT03590483
- Where
- Iraq
- Volunteers
- 200 people
- Sponsor
- Hawler Medical University
Preterm Birth, Premature Birth
Cervical Pessary Treatment for Prevention of s PTB in Twin Pregnancies on Children's Long-Term Outcome
Preterm birth (PTB) complicates 13% of all pregnancies worldwide and is the most important cause of neonatal morbidity and mortality. Women with a twin pregnancy are at increased risk of preterm delivery.
- Trial name
- Impetus (NCT03418311)
- Testing
- Cervical Pessary-Group
- Where
- 10 sites in Australia, Germany and 2 more
- Volunteers
- 672 people
- Sponsor
- Bürgerhospital Frankfurt
Twin; Complicating Pregnancy
Single Versus Repeat Betamethasone in Twin Pregnancies
Thus far no robust data exist as to the effect of repeted course of antenatal corticosteroids in twin pregnancies. The investigators hypothesized that repeat course of betamethasone would further reduce neonatal morbidity in…
- Trial name
- NCT04212312
- Where
- Israel
- Volunteers
- 2,000 people
- Sponsor
- Rambam Health Care Campus
Fetal Growth Restriction, Cardiac Remodeling, Ventricular
Speckle Tracking Echocardiography as a Tool for Early Diagnosis of Impaired Fetal Growth Twin Pregnancies
In this project there are 2 time points during the pregnancy included, namely at 21 weeks and 30 weeks of gestation, to measure the predictive values of FGR, strain and strain rate.
- Conditions
- Fetal Growth Restriction, Cardiac Remodeling, Ventricular, Placental Insufficiency, Air Pollution
- Trial name
- HEART (NCT05423665)
- Testing
- sample collection
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 360 people
- Sponsor
- University Hospital, Ghent
Pregnancy, Twin
Prospective Twin Pregnancy Cohort at Montpellier University Hospital
This prospective observational cohort study aims to investigate the impact of the maternal and early-life exposome on neonatal and early childhood health outcomes in twin pregnancies followed at University Hospital of Montpellier…
- Trial name
- COGEM (NCT07408973)
- Testing
- Biological samples from the mother, Biological samples from the twins
- Volunteers
- 360 people
- Sponsor
- University Hospital, Montpellier
Polycystic Ovary Syndrome
PCOS Twin Study - Environmental Factors in the Development of Polycystic Ovary Syndrome, Phase 2
Polycystic Ovary Syndrome, or PCOS, is the most common endocrine disorder in women. Depending on the strictness of the diagnostic criteria used, it is thought to occur in about 6-10% of all women, many of whom do not know they…
- Trial name
- NCT00444288
- Where
- United States
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Preterm Birth, Preterm Labor
Is the Vaginal Microbiome and Metabolome Associated With Spontaneous Preterm Birth (sPTB) in Multiple Pregnancies?
The aim of this study is to try and find links between the microscopic organisms (such as bacteria, yeasts and viruses) in the vagina, and twin pregnancies that deliver too early (preterm birth).
- Conditions
- Preterm Birth, Preterm Labor, Multiple; Pregnancy, Complicated, Twin Dichorionic Diamniotic Placenta
- Trial name
- SPRUCE (NCT06053697)
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Preterm Birth
Prediction and Prevention of Twin Premature Birth 2021
Research Objectives: 1. Establish a prediction and scoring system for twin premature birth. 2. To investigate the curative effect of 200mg,400mg and 600mg of vaginal progesterone in the prevention of twin premature birth. 3.
- Trial name
- NCT05061641
- Testing
- Progesterone
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Caixia Liu
Preterm Delivery
Does Progesterone Prevent Very Preterm Delivery in Twin Pregnancies?
The purpose of the study is to determine whether a daily dose of 200 mg progesterone administered vaginally from 20-23 to 34 weeks' gestation will reduce the rate of preterm delivery amongst twin pregnancies.
- Trial name
- NCT00329914
- Testing
- Progesterone
- Where
- 17 sites in Austria, Denmark
- Volunteers
- 677 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Twin; Complicating Pregnancy, Advanced Maternal Age Pregnancy
Birth Cohort Study of China Medical University
The CMUBCS is a birth cohort study located in Shenyang, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology.
- Conditions
- Twin; Complicating Pregnancy, Advanced Maternal Age Pregnancy, Scarred Uterus, Overweight and Obesity
- Trial name
- NCT03561766
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Preterm Birth
17OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triplet Pregnancies
Hypothesis: Among women with twin or triplet pregnancies, weekly injections of 17-alpha-hydroxyprogesterone caproate (17OHP), started before 24 weeks of gestation, will reduce neonatal morbidity by reducing the rate of preterm…
- Trial name
- 170HP (NCT00163020)
- Testing
- 17-alpha-hydroxyprogesterone caproate injectable
- Where
- 18 sites in United States
- Volunteers
- 321 people
- Sponsor
- Obstetrix Medical Group
Twin Pregnancy, Antepartum Condition or Complication, Gestational Diabetes
Diet in Twin Pregnancy: the Wellness of Mother and Babies.
The aim of this study is to evaluate how variations in maternal nutrition may affect twin pregnancy and in particular: incidence of maternal obstetric complications: gestational diabetes gestational hypertension or preeclampsia…
- Conditions
- Twin Pregnancy, Antepartum Condition or Complication, Gestational Diabetes, Gestational Hypertension, Intrahepatic Cholestasis of Pregnancy
- Trial name
- FIT (NCT05773677)
- Testing
- Specific Diet
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Premature Birth
The Trial of Pessary After Laser for TTTS
Placing a cervical pessary in severe twin-to-twin transfusion syndrome (TTTS) cases treated by fetoscopic laser coagulation (FLC) decreases the spontaneous preterm birth rate.
- Trial name
- PECEPLASER (NCT01334489)
- Testing
- Arabin Cervical Pessary
- Where
- 4 sites in Belgium, Germany and 1 more
- Volunteers
- 352 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Absolute Uterine Factor Infertility, Cervical Cancer
Living Donor Uterus Transplantation Between Identical Twins
Living donor uterus transplantation between identical twins, with IVF before and ET several months after transplantation. The donor should have completed childbirth.
- Trial name
- UTx-twin (NCT03138226)
- Testing
- uterus transplantation
- Where
- Sweden
- Volunteers
- 1 people
- Sponsor
- Sahlgrenska University Hospital
Cesarean Section Complications
Sublingual Misoprostol and Tranexamic Acid in Pregnant Women With Twin Pregnancy Undergoing Cesarean Section
Purpose to evaluate the effects of sublingual misoprostol with or without intravenous tranexamic acid (TA) in comparison with placebo on reducing post-partum hemorrhage in pregnant women with twin pregnancy undergoing an elective…
- Trial name
- NCT03774524
- Testing
- Misoprostol, TA
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Aswan University Hospital
Preterm Birth
Progesterone Vaginal Pessary for Prevention of Preterm Twin Birth
Multiple pregnancies accounted for 1 - 6 % of all births in UK during 2007. More than 98% of these multiple births being twin births .
- Trial name
- PPPTP (NCT02350231)
- Testing
- The progesterone vaginal pessary, Tonics group
- Volunteers
- 100 people
- Sponsor
- Assiut University
Twin Pregnancy, Antepartum Condition or Complication, Twin to Twin Transfusion as Antepartum Condition
Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China
Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China (ChiTwiMC) is supported by National Key Research and Development Program of China - Reproductive Health and Women's and Children's Health Protection…
- Conditions
- Twin Pregnancy, Antepartum Condition or Complication, Twin to Twin Transfusion as Antepartum Condition, Pre-Term, Pre-Eclampsia
- Trial name
- ChiTwiMC (NCT06414655)
- Where
- 11 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Postpartum Hemorrhage, Twin
Oxytocin at Elective Cesarean Deliveries: A Dose-finding Study in Women With Twin Pregnancy
Postpartum hemorrhage (PPH) due to uterine atony is a major cause of maternal morbidity and mortality. Uterotonic drugs are used to improve the muscle tone of the uterus after birth and these are effective at reducing the…
- Trial name
- NCT04025658
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Twin; Pregnancy, Affecting Fetus or Newborn
Role of 200 mg Versus 400mg Vaginal Progesterone in Prevention of Preterm Labor in Twin Gestation
The objective of the present study is to evaluate the effectiveness of two doses of vaginal progesterone(200mg versus400mg) and placebo in improving gestational age in twin pregnancy and its subsequent impact on perinatal outcome.
- Trial name
- NCT03781674
- Testing
- progesterone 400mg, progesterone 200mg
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Aswan University Hospital