Clinical trials: Twin Diseases
Migraine With Aura
Women With Migraine With Aura Neuroimaging Study
The purpose of this study is to investigate whether a particular form of migraine, migraine with aura, is associated with structural changes in the brain
- Trial name
- WOMAN (NCT02047695)
- Volunteers
- 345 people
- Sponsor
- Odense University Hospital
Apnea, Airway Obstruction, Nasal
Upper Airway's Pressure Drop Analyses After Mandibular Advancement and Maxillary Expansion
Breathing is a crucial function for everyone. Breathing impairment in children could lead to behavioral and cognitive problems at least.
- Conditions
- Apnea, Airway Obstruction, Nasal, Mandible Small, Maxillary Hypoplasia
- Trial name
- NCT04190953
- Testing
- Twin block then Hyrax, Hyrax then Twin block
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Attention Deficit Disorder With Hyperactivity, Healthy
Brain Imaging in Children With AD/HD
The purpose of this study is to use brain imaging technology to study the connections between brain regions in children with attention deficit hyperactivity disorder (AD/HD), and comparing them to children without AD/HD.
- Trial name
- NCT00008892
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institute of Mental Health (NIMH)
Preterm Birth
Progesterone Vaginal Pessary for Prevention of Preterm Twin Birth
Multiple pregnancies accounted for 1 - 6 % of all births in UK during 2007. More than 98% of these multiple births being twin births .
- Trial name
- PPPTP (NCT02350231)
- Testing
- The progesterone vaginal pessary, Tonics group
- Volunteers
- 100 people
- Sponsor
- Assiut University
Preterm Birth, Twin Pregnancy With Antenatal Problem
Prophylactic Cerclage for Twin Pregnancy With Shortened Cervix
This randomized controlled trial is aimed to evaluate pregnancy and neonatal outcomes in twin pregnancies, in which a cervical cerclage is placed due to the shortening of the cervix with or without visible fetal membranes.
- Conditions
- Preterm Birth, Twin Pregnancy With Antenatal Problem, Cervical Shortening
- Trial name
- NCT05338164
- Testing
- cervical cerclage
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Obese, Overweight
Empowering Healthy Lifestyle Behavior to Prevent and Control Obesity in Young Adults
This human study will be a pilot trial that will precede a planned more long-term intervention trial. It will focus on young adults (age 18 to 25 y).
- Trial name
- HW8YAPilot (NCT06943651)
- Testing
- HealthyW8 Digital Twin of healthy lifestyle recommendations
- Volunteers
- 40 people
- Sponsor
- University of Évora
Frail Elderly Syndrome
Protocols and Guidelines for the Use of Digital Twins in Frail Older People
The Proto-Aging study aims to define experimental protocols and guidelines to enable the development of musculoskeletal models (digital twins) of elderly people, with the ultimate goal to comprehensively characterize frail elders…
- Trial name
- Proto-Aging (NCT05854316)
- Testing
- Comprehensive Biomechanical assessment
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Istituto Ortopedico Rizzoli
Myofascial Pain - Dysfunction Syndrome of TMJ, Trigger Point Pain, Myofascial
Comparison of Therapeutic Effects of Trigger Point Injection and Twin Nerve Block in Chronic Myofascial Pain Patients
To see if there is there any difference in the treatment outcomes/results such as changes in pain intensity in patients with myofascial pain who have been treated with trigger point injections or twin block?
- Conditions
- Myofascial Pain - Dysfunction Syndrome of TMJ, Trigger Point Pain, Myofascial, Nerve Block
- Trial name
- NCT03870191
- Testing
- Injection of either twin block or trigger point injection.
- Volunteers
- 48 people
- Sponsor
- Rutgers University
Obesity, Blood Glucose, High
A Culturally-relevant Micronutrient-dense Plant-rich (mNDPR) Dietary Intervention for Native Americans
The investigators propose to conduct a randomized controlled trial with a wait-list control to determine efficacy in reducing risk of obesity and related disease in Native American employees of Twin Arrows Casino.
- Trial name
- NCT04755062
- Testing
- Micronutrient-dense plant-rich Intervention
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University
Twin Monochorionic Diamniotic Placenta
Safety and Efficacy of Fetoscopes Used in Fetoscopic Selective Laser Photocoagulation
The purpose of this study is to evaluate the safety and efficacy of the investigational fetoscopes used in patients undergoing fetoscopic selective laser photocoagulation for complicated monochorionic-diamniotic pregnancies.
- Trial name
- NCT06022510
- Testing
- Fetoscopy Sets for Anterior and Posterior Placentas
- Where
- United States
- Sponsor
- Michael A Belfort
Complicated Twin Pregnancy
The Value of Prenatal Ultrasound in Complicated Twin Pregnancy and Its Correlation With Chromosomal Anomalies
Recent years, women with infertility have become more and more and thus assisted reproductive technology has been applied in a broad range. And the quantities of twin pregnancies are larger and larger.
- Trial name
- NCT02732717
- Testing
- ultrasound (observation)
- Where
- China
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Hepatocellular Carcinoma
Bipolar RFA Using Twin ICW Electrodes vs. Switching Monopolar RFA for Recurrent HCC
This study was conducted to provide preliminary data for the main trial to compare efficacy between bipolar radiofrequency ablation (RFA) using twin internally cooled-wet electrodes and switching monopolar RFA using separable…
- Trial name
- NCT03806218
- Testing
- Bipolar RFA, SM-RFA, Twin internally cooled-wet electrodes
- Where
- South Korea
- Volunteers
- 77 people
- Sponsor
- Seoul National University Hospital
Obesity and Obesity-related Medical Conditions
Empowering Healthy Lifestyle Behaviour Through Personalised Intervention Portfolios to Prevent and Control Obesity in Children - UEV Pilot Study
This study is being performed under the European Consortium HealthyW8 that has the main objective of developing a digital tool for personalized recommendations for healthy lifestyle and prevention of obesity.
- Trial name
- UEVCh_HW8 (NCT06933121)
- Testing
- Digital twin for personalized recommendations
- Volunteers
- 40 people
- Sponsor
- University of Évora
Twin Dichorionic Diamniotic Placenta, Twin Monochorionic Monoamniotic Placenta
Austrian Registry on the Outcome of Monochorionic Pregnancies
About one third of twin pregnancies are resulting from a single fertilized oocyte. Two third of these monozygotic twins share a common placenta and are therefore called monochorionic.
- Conditions
- Twin Dichorionic Diamniotic Placenta, Twin Monochorionic Monoamniotic Placenta, Twin-To-Twin Transfusion Syndrome, Twin Pregnancy With Antenatal Problem
- Trial name
- MonoReg (NCT03171909)
- Where
- 13 sites in Austria
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Type 2 Diabetes
Study of Metformin Pharmacogenetics in Twins
The trough concentration of metformin will be examined in monozygotic and dizygotic twins. Current twin study will determine the total weight of genetics on the trough concentration of metformin.
- Trial name
- NCT01869621
- Testing
- Metformin
- Where
- Denmark
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Twin Pregnancy With Antenatal Problem, Twin Diseases
Twin Pregnancy: a Challenge for Patients, Families and Health Professionals
Twin pregnancies represent 3-4% of all births and in the last two decades the rate of twin pregnancies has steadily increased, essentially due to the spread of assisted fertilization techniques, the use of drugs that stimulate…
- Conditions
- Twin Pregnancy With Antenatal Problem, Twin Diseases, Twin Placenta
- Trial name
- NCT05761769
- Testing
- no intervention
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Stroke
Developement of Stroke Prognosis Predictive Precision Medicine Based on a Digital Twin
The purpose of this study is to realize customized precision medicine for stroke patients and the visual digitization of patient medical information required in the era of digital transformation.
- Trial name
- NCT06035198
- Testing
- Stroke
- Where
- South Korea
- Volunteers
- 1,192 people
- Sponsor
- Seyoung Shin
Preterm Birth
Prevention of Preterm Birth Using Cervical Pessary in Pregnant Women With Short Cervix in Twins
Placement of a vaginal pessary reduces significantly the rate of spontaneous preterm birth in pregnant women with twins and a short cervical length at 18-22 weeks scan.
- Trial name
- PECEP-TWINS (NCT01242410)
- Testing
- Silicon ring (Arabin Cervical Pessary)
- Where
- Spain
- Volunteers
- 137 people
- Sponsor
- Maternal-Infantil Vall d´Hebron Hospital
Sudden Cardiac Death, Myocardial Infarction
Digital MEDIcal TWIN for the Prediction of Arrhythmic Sudden Cardiac Death After a Myocardial Infarction
TWIN-SCD STEMI is a multicentric prospective, non-randomized pilot study designed to establish a multiparametric model for predicting life-threatening ventricular arrhythmias in patients experiencing their first myocardial…
- Trial name
- TWIN-SCD STEMI (NCT07527494)
- Testing
- Programmed ventricular stimulation, Cardiac CT scan
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Bordeaux
Class II Malocclusion
Effects of Skeletal Anchored Versus Incisal Capped Twin Block Appliance in Class II Malocclusion
: the purpose of this study was to evaluate the dento-skeletal effects of the mini-implant supported Twin Block versus the incisal capped appliance in the treatment of skeletal class II patients with mandibular retrognathism.
- Trial name
- NCT06209086
- Testing
- skeletal anchored twin block
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mansoura University