Clinical trials: Tympanic Membrane Perforation
Tympanic Membrane Perforation
Trans Canal Tympanoplasty With Local Anesthesia Using Fat Graft and "TachoSil"
Eligible participants with chronic tympanic membrane perforation (>6 month) will be given a detailed description and offered to participate in the study.
- Trial name
- NCT06542367
- Testing
- Tympanoplasty performed under local anesthesia using fat graft and "Tachosil".
- Volunteers
- 20 people
- Sponsor
- HaEmek Medical Center, Israel
Chronic Tympanic Membrane Perforation
A Study to Assess ASP0598 Otic Solution Following Topical Application in the Ear in Subjects With Chronic Tympanic Membrane Perforation (CTMP)
The primary purpose of this study was to evaluate the safety and tolerability of ASP0598 Otic Solution. This study also evaluated the efficacy of ASP0598 otic solution.
- Trial name
- NCT04305184
- Testing
- ASP0598
- Where
- 10 sites in United States
- Volunteers
- 36 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Tympanic Membrane Perforation
Tympanoseal (Tympanic Membrane Device) Clinical Study
The purpose of this investigational study is to assess the ability of Tympanoseal (sodium/calcium alginate), an investigational device, to act as a scaffold during healing of the tympanic membrane.
- Trial name
- NCT02918942
- Testing
- Tympanoseal
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Grace Medical, Inc.
Hearing Loss, Sensorineural, Hearing Loss, Conductive
Wide Frequency Band Test of Hearing in Veterans
The accurate assessment of auditory status is critical for planning treatment for Veterans with hearing loss to include medical and audiological management.
- Conditions
- Hearing Loss, Sensorineural, Hearing Loss, Conductive, Hearing Loss, Mixed Conductive-Sensorineural, Otosclerosis
- Trial name
- CWTBAFV (NCT02019888)
- Where
- 2 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Tympanic Membrane Perforation
Endoscopic Tympanoplasty: Single Versus Double Flap Technique
Aim of this study is to compare results of double and single flap techniques for tympanoplasty in chronic suppurative otitis media patients.
- Trial name
- NCT03922295
- Testing
- Endoscopic tympanoplasty
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Tympanic Membrane Perforation, Tempanoplasty
Anatomical and Functional Results of Surgery of the Tympanic Membrane Perforation of the Child
This study is a retrospective cohort of patients minors during the operation of cartilage tympanoplasty for tympanic membrane perforation
- Trial name
- PERFOPED (NCT02296944)
- Testing
- Collection of anatomical and functional results in the appearance of the tympanic membrane after surgery
- Where
- France
- Volunteers
- 980 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Barotrauma;Ear, Tympanum; Perforation
Effectiveness of Sequential Eustachian Tube Maneuvers in Hyperbaric Oxygen Conditions
Middle ear barotrauma represents the predominant complication associated with hyperbaric oxygen therapy, manifesting symptoms ranging from otalgia to tympanic membrane perforation.
- Trial name
- NCT06408363
- Testing
- Maneuver group
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital Felicio Rocho
Conductive Hearing Loss, Perforated Tympanic Membrane
The Anatomic Determinants of Perforation Induced Hearing Loss
The purpose of this study is to identify factors that may contribute to conductive hearing loss. Conductive hearing loss is a type that is due to a problem with the outer or middle ear.
- Trial name
- NCT03271970
- Sponsor
- Duke University
Tympanic Membrane Perforation
Tragal Perichondrium Versus Pretragal Fascial (SMAS) Graft for Endoscopic Myringoplasty
1. Examine the treatment outcomes of the pretragal (SMAS) fascia as a new graft when used in endoscopic myringoplasty. 2. Compare the results when using the tragal pericondrium as a graft in endoscopic myringoplasty regarding…
- Trial name
- NCT04687995
- Testing
- Endoscopic myringoplasty
- Volunteers
- 40 people
- Sponsor
- Assiut University
Tympanic Membrane Perforation
Microscopic Versus Endoscopic Tympanoplasty
In this study, The investigatirs will compare surgical and anatomical outcomes of endoscopic and microscopic tympanoplasty type 1(myringoplasty) using tragal perichondrum and cartilage, and conduct a post-treatment survey…
- Trial name
- NCT06257602
- Testing
- Tragal graft tympanoplasty
- Volunteers
- 80 people
- Sponsor
- Assiut University
Tympanic Membrane Perforation
Fibroblast Growth Factor Regeneration of Tympanic Membrane Perforations
A Phase II randomized trial will be initiated to evaluate closure of the perforated tympanic membrane as the primary measureable outcome.
- Trial name
- NCT02307916
- Testing
- FGF-2
- Where
- 2 sites in United States
- Volunteers
- 57 people
- Sponsor
- D. Bradley Welling, MD, PhD
Tympanic Membrane Perforation, Otitis Media
Does Adding a Fascial Layer to the Cartilage in Tympanoplasty for Large Tympanic Membrane Perforation Affect the Overall Results?
Large tympanic membrane (eardrum) perforations present a surgical challenge and are historically associated with lower graft take rates compared to smaller perforations.
- Conditions
- Tympanic Membrane Perforation, Otitis Media, Suppurative Otitis Media, Chronic Suppurative Otitis Media
- Trial name
- NCT07834892
- Testing
- Conchal Cartilage and Perichondrium Tympanoplasty, Conchal Cartilage, Perichondrium, and Temporalis Fascia Tympanoplasty
- Volunteers
- 50 people
- Sponsor
- Assiut University
Tympanic Membrane Perforation
Fat Graft Myringoplasty With and Without Platelet Rich Plasma (PRP) for Treating Smaller Tympanic Membrane Perforations
The current standard treatment for chronic tympanic membrane perforations (TMP) involves having fat grafted from the patient and inserted into the ear, through the perforation, to promote healing using the fat graft myringoplasty…
- Trial name
- NCT01958749
- Testing
- Fat graft with Platelet Rich Plasma
- Where
- 4 sites in Canada, United Kingdom
- Sponsor
- Nova Scotia Health Authority
Tympanic Membrane Perforation
Composite Cartilage Perichondrium Graft for Air Bone Gap Closure in Chronic Suppurative Otitis Media (CSOM) Without Posterior Meatal Flap
Composite Cartilage Perichondrium Graft for tympanoplasty in chronic suppurative otitis media (CSOM) Air Bone Gap (AB Gap) Closure will be taken as successful outcome Endoscopic technique without posterior meatal flap elevation
- Trial name
- NCT05086718
- Testing
- Endoscopic ear surgery
- Where
- Pakistan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Combined Military Hospital Quetta
Tympanic Membrane Perforation, Tympanic Membrane Inflammation
Effect of Chitodex Gel in Tympanoplasty Surgery
The general purpose of this study is to compare Chitosan-dextran (Chitodex) gel versus current standard of care, Gelfoam, as a middle ear (ME) and external auditory canal (EAC) packing agent as part of tympanoplasty…
- Conditions
- Tympanic Membrane Perforation, Tympanic Membrane Inflammation, Surgery, Otitis Media
- Trial name
- NCT06260618
- Testing
- Gelfoam, Chitodex
- Where
- 2 sites in Australia
- Volunteers
- 44 people
- Sponsor
- Central Adelaide Local Health Network Incorporated
Tympanic Membrane Perforation
Fibroblast Growth Factor Regeneration of Tympanic Membrane Perforations
This study is a double blinded, placebo-controlled phase II study evaluating the efficacy of FGF-2 for the treatment of chronic non-healing tympanic membrane perforations (TMP).
- Trial name
- NCT04960384
- Testing
- FGF-2
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- NYU Langone Health
Tympanic Membrane Perforation, Chronic Otitis Media
Boomerang-Shaped Cartilage Graft in Endoscopic Tympanoplasty
This study evaluates the anatomical and functional outcomes of using a boomerang-shaped chondroperichondrial graft in endoscopic Type I tympanoplasty for repairing anterior or subtotal tympanic membrane perforations.
- Trial name
- NCT07823894
- Testing
- Endoscopic Type I Tympanoplasty with Boomerang-Shaped Chondroperichondrial Graft
- Volunteers
- 50 people
- Sponsor
- Assiut University
Chronic Otitis Media Tympanic Membrane Perforation
Effect of Platelet-Rich Plasma on Eardrum Healing and Hearing After Tympanoplasty in Adults
This single-center controlled trial evaluated whether intraoperative application of autologous platelet-rich plasma (PRP)-impregnated absorbable gelatin sponge improves graft take rates and audiological outcomes in adults…
- Trial name
- NCT07664319
- Testing
- Autologous platelet-rich plasma (PRP)-impregnated Spongostan, Dry Spongostan (absorbable gelatin sponge)
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ebubekir Toprak
Tympanic Membrane Perforation
A Study on the Regenerative Treatment of Tympanic Membrane With NPC-18 and FBG-18
To assess the efficacy and safety of the regeneration treatment of tympanic membrane with NPC-18 and FBG-18.
- Trial name
- NCT02550314
- Testing
- fiblast,gelatin sponge,fibrin glue
- Volunteers
- 20 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Middle Ear Effusion, Tympanic Membrane Perforation
PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothers to See if it Protects Their Babies From Ear Disease
PneuMum is a randomised controlled trial that aims to find out if pneumococcal vaccination for Australian Indigenous mothers, in the last few months of pregnancy or at delivery, can prevent ear disease in infants.
- Conditions
- Middle Ear Effusion, Tympanic Membrane Perforation, Acute Otitis Media, Pneumococcal Infections
- Trial name
- NCT00310349
- Testing
- 23 valent pneumococcal polysaccharide vaccine
- Where
- Australia
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Melbourne