Clinical trials: Type 1 Diabetes, completed
Patients
Drug Interaction Study Between Dorzagliatin and Empagliflozin
This is a Phase 1, open-label, sequential, multiple-dose, drug interaction study of glucokinase activator dorzagliatin and empagliflozin in subjects with T2DM.
- Trial name
- NCT03790787
- Testing
- Empagliflozin, Dorzagliatin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Hua Medicine Limited
Diabetes, Type I
Closing the Loop Between Glucose Sensor and Insulin Pump-developing an Algorithm
An open interventional data collection study in order to build a database to close the loop between glucose sensor and insulin pump.
- Trial name
- NCT00541515
- Testing
- continuous glucose sensors and insulin pump
- Where
- Israel
- Volunteers
- 38 people
- Sponsor
- Rabin Medical Center
Type1diabetes, Parents
Parents of Young Adults With Type 1 Diabetes: An Exploratory Study
The purpose of this mixed-methods study is to explore the lived experience of parents of young adults ages 18 to 25 years with type 1 diabetes who are transitioning to independence, and to test the preliminary efficacy of a…
- Trial name
- NCT03158415
- Testing
- T1DToolkit.org mobile diabetes education
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Florida
Type 1 Diabetes
Validation of a Biomathematical Model to Help Identify the Parameters of Flexible Insulin Therapy
Type 1 diabetes is an autoimmune disease that requires daily treatment with insulin. The use of subcutaneous pumps for continuous insulin delivery has been an important advance for diabetic patients.
- Trial name
- ModIF (NCT04572009)
- Testing
- Bio-mathematical model, Without bio-mathematical model
- Where
- France
- Volunteers
- 37 people
- Sponsor
- Nantes University Hospital
Type 1 Diabetes
Dose-effect Relationship of Low-dose IL-2 in Type 1 Diabetes
IL-2 is an inducer of regulatory T cells (Treg), a population of lymphocytes that fail to control the autoimmune destruction of beta-cells in patients with Type 1 Diabetes (T1D).
- Trial name
- DF-IL2 (NCT01353833)
- Testing
- Aldesleukin
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 2 Diabetes Mellitus
Pharmacokinetics Study of Dipeptidyl Peptidase 4 Inhibitor to Control Type 2 Diabetes Mellitus
The purpose of this study is to confirm the mechanism of reduced response to DPP-4 inhibitor in some patients with type 2 diabetes and evaluate appropriate patients to treat with DPP-4 inhibitor
- Trial name
- NCT01449747
- Testing
- Sitagliptin
- Where
- 2 sites in South Korea
- Volunteers
- 24 people
- Sponsor
- The Catholic University of Korea
Type 1 Diabetes Mellitus
Effects of Postprandial Exercise on Glycaemia and Metabolism in People with Type 1 Diabetes
A cornerstone in the management and treatment of people living with type 1 diabetes (T1D) is to engage in regular physical exercise for a variety of health and fitness reasons.
- Trial name
- PRANDEX-1 (NCT05179135)
- Testing
- Postprandial exercise of different modalities
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- University Hospital, Ghent
Type 1 Diabetes Mellitus
Intraperitoneal vs Subcutaneous Insulin Administration in Type 1 Diabetes Mellitus
Almost all patients with type 1 diabetes mellitus (T1DM) need insulin treatment permanently. For selected patients who are unable to achieve glycaemic targets with subcutaneous (SC) insulin treatment, continuous intraperitoneal…
- Trial name
- IPvsSC (NCT01621308)
- Testing
- Mode of insulin administration
- Where
- 2 sites in Netherlands
- Volunteers
- 190 people
- Sponsor
- Medical Research Foundation, The Netherlands
Diabetes
Evaluation of Cissus Verticillata L. Infusion in Controlling Type 2 Diabetes
The purpose of this study was to investigate whether the infusion of a medicinal plant (Cissus verticillata L.) would be effective in reducing glucose levels in blood and saliva of type 2 Diabetes patients.
- Trial name
- NCT01145534
- Testing
- glibenclamide, medicinal plant infusion
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- Federal University of Paraíba
Type 1 Diabetes Mellitus
Web-Based Follow-Up Using Cellular Phone in Type 1 Diabetic Patients Under Insulin Pump Therapy : The PumpNet Study
The purpose of this study is to determine if telecare using modern telecommunication devices can improve the metabolic control and the quality of life of type 1 diabetic patients.
- Trial name
- NCT00324584
- Testing
- Telemonitoring of glucose values using GlucoNet device
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Grenoble
Diabetes Mellitus, Diabetes Mellitus, Type 2
Effect of Pioglitazone Versus Metformin on Bone Health in Postmenopausal Women With Type 2 Diabetes
The study tests whether pioglitazone (PIO)as compared to metformin (MET)affects bone health including bone mineral density, bone turnover markers, and osteocyte biomarker in patients with type 2 diabetes (T2DM).
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 2, Glucose Metabolism Disorders
- Trial name
- Pioglitazone (NCT01935804)
- Testing
- Pioglitazone, Metformin
- Where
- Saudi Arabia
- Volunteers
- 440 people
- Sponsor
- King Abdulaziz University
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Clinical Trial of SB-509 in Subjects With Diabetic Neuropathy
The purpose of the study is to evaluate the clinical effects of the investigational drug, SB-509, in subjects with diabetic neuropathy.
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic Polyneuropathy
- Trial name
- NCT01079325
- Testing
- SB-509, Saline
- Where
- 31 sites in United States
- Volunteers
- 170 people
- Sponsor
- Sangamo Therapeutics
Diabetes, Diabetes Mellitus, Type 1
Comparison of Two Pen Systems in Patients With Diabetes Treated With Insulin
This trial is conducted in Europe. The aim of this trial is to compare two insulin delivery pens in the everyday life setting of patients with diabetes treated with insulin.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Delivery Systems
- Trial name
- NCT00569998
- Testing
- NovoPen™ 4, NovoPen® 3
- Where
- 23 sites in Austria, Germany and 3 more
- Volunteers
- 208 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 1
To Examine the Lung When People With Diabetes Take an Inhaled Form of Insulin, Compared to Subcutaneous Insulin.
To examine the lung when people with diabetes take an inhaled form of insulin, compared to subcutaneous insulin.
- Trial name
- NCT00143104
- Testing
- Inhaled insulin
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Pfizer
Type 1 Diabetes Mellitus
Outpatient Control-to-Range: System and Monitoring Testing
Automated closed-loop control (CLC) of blood glucose, known as "artificial pancreas" (AP) can have tremendous impact on the health and lives of people with type 1 diabetes (T1DM).
- Trial name
- NCT01697150
- Testing
- DiAs Diabetes Assistant Wearable Artificial Pancreas Platform
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Sansum Diabetes Research Institute
Type 1 Diabetes
In Clinic Evaluation of the PLGM Feature
This study is a multi-center, single arm and in-clinic study to evaluate the safety of the PLGM System and its algorithm with the Enlite 3 Sensor.
- Trial name
- PLGM (NCT02130284)
- Testing
- Predictive Low Glucose Management Feature in Insulin pump
- Where
- 8 sites in United States
- Volunteers
- 80 people
- Sponsor
- Medtronic MiniMed, Inc.
Type 1 Diabetes
The Effect of Gluten-free Diet on New Onset Type 1 Diabetes (T1D)
The primary aim of this pilot study is to test whether gluten-free diet (GFD) instituted in children shortly after onset of Type 1 Diabetes (T1D) can decelerate the decline in beta cell function as compared to age matched…
- Trial name
- NCT02867436
- Testing
- Gluten-free diet
- Where
- 2 sites in Czechia
- Volunteers
- 45 people
- Sponsor
- University Hospital, Motol
Type1diabetes, Hypoglycemia
Galactose - the Ideal Carbohydrate Supplement for Exercise in Type 1 Diabetes
In this study, 14 subjects with type 1 diabetes are studied in a randomized crossover study in which the subjects cycle at a fixed intensity at 60% of their maximum oxygen capacity (VO2 max) for 1 hour.
- Conditions
- Type1diabetes, Hypoglycemia, Hyperglycemia
- Trial name
- NCT05557227
- Testing
- 1-hour cycling
- Where
- Denmark
- Volunteers
- 14 people
- Sponsor
- University of Aarhus
Type 1 Diabetes Mellitus
A Study Evaluating Safety and Efficacy of BIOD-123 Compared to Insulin Lispro (Humalog®)
The purpose of this study is to evaluate the safety and efficacy of BIOD-123 compared to insulin lispro (Humalog®) when used as part of a basal-bolus regimen in patients with type 1 diabetes.
- Trial name
- NCT01686620
- Testing
- BIOD-123, Lispro (Humalog)
- Where
- 34 sites in United States
- Volunteers
- 132 people
- Sponsor
- Biodel
Type 1 Diabetes
Skype for Youth With Poorly Controlled Diabetes
Compared family-based skills training (aka, Behavioral Family Systems Therapy) to youth with poorly controlled type 1 diabetes and their parents either face-to-face or over SkypeTM.
- Trial name
- SKYPE (NCT02274103)
- Testing
- BFST
- Volunteers
- 92 people
- Sponsor
- Oregon Health and Science University